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ATE542913T1 - Promotorvarianten zur expression von genen in einer pilzzelle - Google Patents

Promotorvarianten zur expression von genen in einer pilzzelle

Info

Publication number
ATE542913T1
ATE542913T1 AT03789880T AT03789880T ATE542913T1 AT E542913 T1 ATE542913 T1 AT E542913T1 AT 03789880 T AT03789880 T AT 03789880T AT 03789880 T AT03789880 T AT 03789880T AT E542913 T1 ATE542913 T1 AT E542913T1
Authority
AT
Austria
Prior art keywords
seq
biological substance
variants
nucleic acid
fungal host
Prior art date
Application number
AT03789880T
Other languages
English (en)
Inventor
Debbie Yaver
Peter Nham
Original Assignee
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Inc filed Critical Novozymes Inc
Application granted granted Critical
Publication of ATE542913T1 publication Critical patent/ATE542913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
    • C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
    • C12Y107/01003—Nitrate reductase (NADPH) (1.7.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21004—Trypsin (3.4.21.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04002—CTP synthase (6.3.4.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT03789880T 2002-11-18 2003-11-18 Promotorvarianten zur expression von genen in einer pilzzelle ATE542913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42731402P 2002-11-18 2002-11-18
PCT/US2003/037139 WO2004046373A2 (en) 2002-11-18 2003-11-18 Promoter variants for expressing genes in a fungal cell

Publications (1)

Publication Number Publication Date
ATE542913T1 true ATE542913T1 (de) 2012-02-15

Family

ID=32326518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789880T ATE542913T1 (de) 2002-11-18 2003-11-18 Promotorvarianten zur expression von genen in einer pilzzelle

Country Status (8)

Country Link
US (6) US7368262B2 (de)
EP (1) EP1585822B1 (de)
JP (1) JP4490284B2 (de)
CN (2) CN100480391C (de)
AT (1) ATE542913T1 (de)
AU (1) AU2003294397A1 (de)
DK (1) DK1585822T3 (de)
WO (1) WO2004046373A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228906A1 (en) 2002-04-19 2003-12-11 Walker Jay S. Methods and apparatus for providing communications services at a gaming machine
JP4490284B2 (ja) 2002-11-18 2010-06-23 ノボザイムス，インコーポレイティド 菌類細胞において遺伝子を発現するためのプロモーター変異体
US7335106B2 (en) 2003-10-20 2008-02-26 Las Vegas Gaming, Inc. Closed-loop system for displaying promotional events and granting awards for electronic video games
US10202430B2 (en) * 2007-10-18 2019-02-12 Mayo Foundation For Medical Education And Research IgM-mediated receptor clustering and cell modulation
US20110195789A1 (en) 2010-02-10 2011-08-11 Leap Forward Gaming Device monitoring and wireless communications for vending machines
US8814681B2 (en) 2010-02-10 2014-08-26 Leap Forward Gaming, Inc. Candle device for generating display interfaces on the main display of a gaming machine
US9240100B2 (en) 2010-02-10 2016-01-19 Leap Forward Gaming Virtual players card
US9245419B2 (en) 2010-02-10 2016-01-26 Leap Forward Gaming, Inc. Lottery games on an electronic gaming machine
US8282480B2 (en) 2010-02-10 2012-10-09 Leap Forward Gaming Candle device for providing transaction verification on a gaming machine
US8968086B2 (en) 2010-02-10 2015-03-03 Leap Forward Gaming, Inc. Video processing and signal routing apparatus for providing picture in a picture capabilities on an electronic gaming machine
US8814706B2 (en) 2010-02-10 2014-08-26 Leap Forward Gaming, Inc. Radio candle mount
US8460091B2 (en) * 2010-02-10 2013-06-11 Leap Forward Gaming Remote power reset feature on a gaming machine
DK2646558T3 (en) * 2010-11-30 2016-10-03 Novozymes Inc Promoters for expression of genes in a fungal cell
EP2748321A2 (de) * 2011-08-24 2014-07-02 Novozymes, Inc. Verfahren zur gewinnung von positiven transformanten einer fadenpilzwirtszelle
JP5971661B2 (ja) * 2012-09-19 2016-08-17 国立大学法人 東京大学 神経活動依存的プロモータ活性を有するｄｎａ、及びこれを含むベクター
CN106636088B (zh) * 2016-09-22 2020-06-23 南京百斯杰生物工程有限公司 一种酵母上游激活元件在丝状真菌中的应用
JP7540709B2 (ja) 2020-11-30 2024-08-27 大関株式会社 糸状菌用プロモーターおよびその利用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
CA2172628A1 (en) * 1993-11-24 1995-06-01 Ellen Briskin Lawrence Method of controlling plant pathogens
FI964808L (fi) 1994-06-03 1996-12-02 Novo Nordisk Biotech Inc Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot
JP3167729B2 (ja) 1994-06-30 2001-05-21 ノボ ノルディスク バイオテック，インコーポレイティド 無毒、非毒素原性、非病原性の発現系、並びにその中で利用するためのプロモーター及びターミネーター
CN1062017C (zh) * 1995-09-01 2001-02-14 中国科学院遗传研究所 防御素基因的植物表达载体质粒
ATE294233T1 (de) 1996-01-19 2005-05-15 Novozymes Biotech Inc Morphologische mutanten von filamentösen pilzen
CN1190673A (zh) * 1996-04-29 1998-08-19 中国科学院微生物研究所 丝状真菌中独立复制的表达载体及表达系统
US5958727A (en) 1996-09-13 1999-09-28 Novo Nordisk Biotech, Inc Methods for modifying the production of a polypeptide
DE69938722D1 (de) 1998-05-20 2008-06-26 Novozymes Inc Verfahren zur herstellung von heterologen polypeptiden in trichothecene mangelmutanten filamentlösen pilzen
EP1124949B1 (de) 1998-10-26 2006-07-12 Novozymes A/S Erstellung und durchmusterung von interessierenden dna-banken in zellen von filamentösen pilzen
AU3915400A (en) 1999-03-22 2000-10-09 Novo Nordisk A/S Methods for monitoring multiple gene expression
US6361973B1 (en) * 1999-03-22 2002-03-26 Novozymes Biotech, Inc. Promoters for expressing genes in a fungal cell
JP4620253B2 (ja) * 1999-03-22 2011-01-26 ノボザイムス，インコーポレイティド 菌類細胞中で遺伝子を発現させるためのプロモーター
CN1253575C (zh) * 1999-11-30 2006-04-26 诺沃奇梅兹生物技术有限公司 用共有翻译起始区序列制备多肽的方法
JP4490284B2 (ja) * 2002-11-18 2010-06-23 ノボザイムス，インコーポレイティド 菌類細胞において遺伝子を発現するためのプロモーター変異体
DE102006003576B4 (de) * 2006-01-25 2007-10-25 Tridelta Überspannungsableiter Gmbh Überspannungsableiter mit Käfig-Design

Also Published As

Publication number Publication date
EP1585822A4 (de) 2005-12-28
CN101497908B (zh) 2014-05-21
US8138325B2 (en) 2012-03-20
US9873881B2 (en) 2018-01-23
US20140099669A1 (en) 2014-04-10
JP4490284B2 (ja) 2010-06-23
AU2003294397A1 (en) 2004-06-15
EP1585822A2 (de) 2005-10-19
US8604181B2 (en) 2013-12-10
DK1585822T3 (da) 2012-05-14
EP1585822B1 (de) 2012-01-25
US20040146975A1 (en) 2004-07-29
US7368262B2 (en) 2008-05-06
US9150856B2 (en) 2015-10-06
AU2003294397A8 (en) 2004-06-15
US9695429B2 (en) 2017-07-04
WO2004046373A3 (en) 2005-02-10
US20080274500A1 (en) 2008-11-06
CN100480391C (zh) 2009-04-22
CN1780917A (zh) 2006-05-31
US20170233751A1 (en) 2017-08-17
WO2004046373A2 (en) 2004-06-03
CN101497908A (zh) 2009-08-05
JP2006506095A (ja) 2006-02-23
US20150376630A1 (en) 2015-12-31
US20120190067A1 (en) 2012-07-26

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