ATE541843T1 - 2-acylamino-4-phenylthiazolderivate, ihre herstellung und anwendung als chemokin antagonisten - Google Patents

2-acylamino-4-phenylthiazolderivate, ihre herstellung und anwendung als chemokin antagonisten

Info

Publication number: ATE541843T1
Authority: AT; Austria
Prior art keywords: acylamino; production; chemokine antagonists; phenylthiazole derivatives; phenylthiazole
Prior art date: 2003-04-25

Application number

AT04742558T

Other languages

English (en)

Inventor

Pierre Carayon

Pierre Casellas

Daniel Floutard

Pierre Fraisse

Samir Jegham

Bernard Labeeuw

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-25

Filing date

2004-04-22

Publication date

2012-02-15

2004-04-22 Application filed by Sanofi Sa filed Critical Sanofi Sa

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE541843T1 publication Critical patent/ATE541843T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
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Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Diabetes (AREA)
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Immunology (AREA)
Communicable Diseases (AREA)
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Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Biotechnology (AREA)

AT04742558T 2003-04-25 2004-04-22 2-acylamino-4-phenylthiazolderivate, ihre herstellung und anwendung als chemokin antagonisten ATE541843T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0305213A FR2854158B1 (fr)	2003-04-25	2003-04-25	Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
PCT/FR2004/000981 WO2004096798A2 (fr)	2003-04-25	2004-04-22	Derives de 2-acylamino-4-phenylthiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ATE541843T1 true ATE541843T1 (de)	2012-02-15

Family

ID=33104460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04742558T ATE541843T1 (de)	2003-04-25	2004-04-22	2-acylamino-4-phenylthiazolderivate, ihre herstellung und anwendung als chemokin antagonisten

Country Status (24)

Country	Link
US (2)	US7504511B2 (de)
EP (1)	EP1656373B1 (de)
JP (2)	JP4839208B2 (de)
KR (1)	KR20060006935A (de)
CN (1)	CN1826339A (de)
AR (1)	AR044070A1 (de)
AT (1)	ATE541843T1 (de)
AU (1)	AU2004234101A1 (de)
BR (1)	BRPI0409716A (de)
CA (1)	CA2521158A1 (de)
CO (1)	CO5640106A2 (de)
CR (1)	CR8037A (de)
EC (1)	ECSP056111A (de)
FR (1)	FR2854158B1 (de)
MA (1)	MA27769A1 (de)
MX (1)	MXPA05011522A (de)
NO (1)	NO20054905L (de)
OA (1)	OA13049A (de)
RS (1)	RS20050769A (de)
RU (1)	RU2348630C2 (de)
TN (1)	TNSN05254A1 (de)
TW (1)	TW200510325A (de)
WO (1)	WO2004096798A2 (de)
ZA (1)	ZA200508608B (de)

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JO2527B1 (en) *	2004-04-06	2010-03-17	شركة جانسين فارماسوتيكا ان. في	Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines
FR2872813B1 (fr)	2004-07-09	2007-01-19	Sanofi Synthelabo	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0421908D0 (en) *	2004-10-01	2004-11-03	Angeletti P Ist Richerche Bio	New uses
FR2876692B1 (fr) *	2004-10-19	2007-02-23	Sanofi Aventis Sa	Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
EP1833807A1 (de) *	2005-01-05	2007-09-19	Rigel Pharmaceuticals, Inc.	Ubiquitinligasehemmer
EP1858896B1 (de)	2005-03-08	2010-08-18	Janssen Pharmaceutica NV	Diazaspiro-[4,4]-nonanderivate als neurokinin-(nk1)-antagonisten
SG159561A1 (en) *	2005-05-09	2010-03-30	Achillion Pharmaceuticals Inc	Thiazole compounds and methods of use
WO2007053495A2 (en) *	2005-11-01	2007-05-10	Millennium Pharmaceuticals, Inc.	Compounds useful as antagonists of ccr2
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FR2895989B1 (fr) *	2006-01-06	2010-04-30	Sanofi Aventis	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
JP2009533416A (ja) *	2006-04-12	2009-09-17	ファイザー・リミテッド	ケモカインｃｃｒ５受容体の調節剤としてのピロリジン誘導体
CN101096363B (zh)	2006-06-27	2011-05-11	中国人民解放军军事医学科学院毒物药物研究所	2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
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WO2008124000A2 (en) *	2007-04-02	2008-10-16	Ligand Pharmaceuticals Incorporated	Thiazole derivatives as androgen receptor modulator compounds
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CA2782464C (en)	2009-12-17	2016-11-29	Boehringer Ingelheim International Gmbh	New ccr2 receptor antagonists
EP2547676B1 (de) *	2010-03-17	2015-07-29	Taivex Therapeutics Inc.	Modulatoren der hec1-aktivität und verfahren dafür
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- 2004-04-22 CN CNA2004800180511A patent/CN1826339A/zh active Pending
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Publication number	Publication date
MXPA05011522A (es)	2006-01-23
AU2004234101A1 (en)	2004-11-11
TNSN05254A1 (en)	2007-07-10
FR2854158A1 (fr)	2004-10-29
BRPI0409716A (pt)	2006-05-02
US20090156574A1 (en)	2009-06-18
JP2006524669A (ja)	2006-11-02
RU2348630C2 (ru)	2009-03-10
RU2005136663A (ru)	2006-03-20
NO20054905L (no)	2006-01-25
MA27769A1 (fr)	2006-02-01
KR20060006935A (ko)	2006-01-20
US20060135575A1 (en)	2006-06-22
AR044070A1 (es)	2005-08-24
JP4839208B2 (ja)	2011-12-21
CO5640106A2 (es)	2006-05-31
RS20050769A (en)	2007-11-15
WO2004096798A3 (fr)	2006-01-26
WO2004096798A2 (fr)	2004-11-11
EP1656373B1 (de)	2012-01-18
OA13049A (fr)	2006-11-10
CA2521158A1 (fr)	2004-11-11
TW200510325A (en)	2005-03-16
CR8037A (es)	2008-07-29
CN1826339A (zh)	2006-08-30
ECSP056111A (es)	2006-03-01
US7777041B2 (en)	2010-08-17
EP1656373A2 (de)	2006-05-17
FR2854158B1 (fr)	2006-11-17
US7504511B2 (en)	2009-03-17
ZA200508608B (en)	2007-01-31
JP2011126891A (ja)	2011-06-30
NO20054905D0 (no)	2005-10-24

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