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ATE538212T1 - Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate - Google Patents

Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate

Info

Publication number
ATE538212T1
ATE538212T1 AT08728753T AT08728753T ATE538212T1 AT E538212 T1 ATE538212 T1 AT E538212T1 AT 08728753 T AT08728753 T AT 08728753T AT 08728753 T AT08728753 T AT 08728753T AT E538212 T1 ATE538212 T1 AT E538212T1
Authority
AT
Austria
Prior art keywords
modulators
assay
parkin
novel substrates
parkin activity
Prior art date
Application number
AT08728753T
Other languages
English (en)
Inventor
Jennifer Johnston
Alfred Goldberg
Original Assignee
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma Int Ltd filed Critical Elan Pharma Int Ltd
Application granted granted Critical
Publication of ATE538212T1 publication Critical patent/ATE538212T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/9015Ligases (6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT08728753T 2007-01-31 2008-01-31 Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate ATE538212T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89894707P 2007-01-31 2007-01-31
PCT/US2008/052700 WO2008095126A2 (en) 2007-01-31 2008-01-31 Assays for modulators of parkin activity using novel substrates

Publications (1)

Publication Number Publication Date
ATE538212T1 true ATE538212T1 (de) 2012-01-15

Family

ID=39645491

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08728753T ATE538212T1 (de) 2007-01-31 2008-01-31 Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate

Country Status (6)

Country Link
US (1) US7790365B2 (de)
EP (1) EP2115159B1 (de)
JP (2) JP5329434B2 (de)
AT (1) ATE538212T1 (de)
CA (1) CA2677231C (de)
WO (1) WO2008095126A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2115159B1 (de) 2007-01-31 2011-12-21 Elan Pharma International Limited Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate
EP2158487A1 (de) * 2007-05-21 2010-03-03 Elan Pharma International Limited Parkin-substrat und testverfahren
JP2011514148A (ja) * 2008-01-31 2011-05-06 エラン ファーマ インターナショナル リミテッド パーキンソン病の予防および処置用の候補化合物を同定するための熱変性スクリーニングアッセイ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA975137A (en) * 1969-04-08 1975-09-30 Howard K. Rae Deuterium-hydrogen monothermal exchange
ATE315645T1 (de) 1998-02-09 2006-02-15 Boehringer Ingelheim Int Dns oder gene, die an der parkinsonschen krankheit beteiligt sind
US20040247586A1 (en) * 2003-03-05 2004-12-09 Asa Abeliovich Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof
EP2115159B1 (de) 2007-01-31 2011-12-21 Elan Pharma International Limited Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate
EP2158487A1 (de) * 2007-05-21 2010-03-03 Elan Pharma International Limited Parkin-substrat und testverfahren

Also Published As

Publication number Publication date
WO2008095126A3 (en) 2008-12-31
EP2115159A2 (de) 2009-11-11
EP2115159B1 (de) 2011-12-21
US20080293089A1 (en) 2008-11-27
US7790365B2 (en) 2010-09-07
JP5329434B2 (ja) 2013-10-30
CA2677231A1 (en) 2008-08-07
JP2013215198A (ja) 2013-10-24
JP2010517535A (ja) 2010-05-27
WO2008095126A2 (en) 2008-08-07
CA2677231C (en) 2015-11-24

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