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DE602005016800D1 - Hif-prolylhydroxylase-aktivitätstest - Google Patents

Hif-prolylhydroxylase-aktivitätstest

Info

Publication number
DE602005016800D1
DE602005016800D1 DE602005016800T DE602005016800T DE602005016800D1 DE 602005016800 D1 DE602005016800 D1 DE 602005016800D1 DE 602005016800 T DE602005016800 T DE 602005016800T DE 602005016800 T DE602005016800 T DE 602005016800T DE 602005016800 D1 DE602005016800 D1 DE 602005016800D1
Authority
DE
Germany
Prior art keywords
hif
activity test
prolyl hydroxylase
hydroxylase activity
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005016800T
Other languages
English (en)
Inventor
Mitchell C Brenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fibrogen Inc
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of DE602005016800D1 publication Critical patent/DE602005016800D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE602005016800T 2004-05-28 2005-05-26 Hif-prolylhydroxylase-aktivitätstest Expired - Lifetime DE602005016800D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57532404P 2004-05-28 2004-05-28
PCT/US2005/018577 WO2005118836A2 (en) 2004-05-28 2005-05-26 Hif prolyl hydroxylase activity assay

Publications (1)

Publication Number Publication Date
DE602005016800D1 true DE602005016800D1 (de) 2009-11-05

Family

ID=34979114

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016800T Expired - Lifetime DE602005016800D1 (de) 2004-05-28 2005-05-26 Hif-prolylhydroxylase-aktivitätstest

Country Status (12)

Country Link
US (1) US20080113383A1 (de)
EP (1) EP1766047B1 (de)
JP (1) JP2008500834A (de)
AT (1) ATE443775T1 (de)
AU (1) AU2005250412B2 (de)
CA (1) CA2567619A1 (de)
DE (1) DE602005016800D1 (de)
ES (1) ES2332798T3 (de)
IL (1) IL179441A (de)
NZ (1) NZ551632A (de)
WO (1) WO2005118836A2 (de)
ZA (1) ZA200610164B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103382216B (zh) 2006-01-27 2016-04-20 菲布罗根有限公司 使低氧诱导因子（hif）稳定的氰基异喹啉化合物
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
CA2647596C (en) 2006-04-04 2012-06-12 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
EP4095127A1 (de) 2006-06-26 2022-11-30 Akebia Therapeutics Inc. Prolylhydroxylaseinhibitoren und verfahren zur verwendung
JP5599467B2 (ja) 2009-11-06 2014-10-01 エアーピオ セラピューティクス インコーポレイテッド プロリルヒドロキシラーゼ阻害剤
US8921389B2 (en) 2011-02-02 2014-12-30 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
EP3251671A1 (de) 2011-06-06 2017-12-06 Akebia Therapeutics Inc. Zusammensetzungen zur stabilisierung des durch hypoxie induzierbaren faktors-2 alpha als verfahren zur behandlung von krebs
NO2686520T3 (de) 2011-06-06 2018-03-17
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
CN104470899B (zh) 2012-03-09 2017-12-26 菲布罗根有限公司 作为hif羟化酶抑制剂的4‑羟基‑异喹啉化合物
PT2872487T (pt) 2012-07-16 2017-05-15 Fibrogen Inc Processo para a preparação de compostos isoquinolina
RS57795B1 (sr) 2012-07-16 2018-12-31 Fibrogen Inc Kristalni oblici inhibitora prolil hidroksilaze
NZ753905A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
EP3277270B1 (de) 2015-04-01 2021-10-27 Akebia Therapeutics, Inc. Zusammensetzungen und verfahren zur behandlung von anämie
JP7440989B2 (ja) 2018-05-09 2024-02-29 アケビア セラピューティクス インコーポレイテッド ２－［５－（３－クロロフェニル）－３－ヒドロキシピリジン－２－カルボニル］アミノ］酢酸を調製するための方法
CN114577945B (zh) * 2022-03-10 2023-06-02 中国科学院兰州化学物理研究所 一种从中药提取物中筛选脯氨酰羟化酶2抑制剂的胶束电动色谱方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4590157B2 (ja) * 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段
CA2467689C (en) * 2001-12-06 2013-10-01 Fibrogen, Inc. Stabilization of hypoxia inducible factor (hif) alpha using inhibitors of hif prolyl hydroxylase

Also Published As

Publication number Publication date
JP2008500834A (ja) 2008-01-17
EP1766047B1 (de) 2009-09-23
NZ551632A (en) 2009-09-25
HK1102197A1 (en) 2007-11-09
AU2005250412B2 (en) 2009-09-17
IL179441A0 (en) 2007-05-15
ZA200610164B (en) 2008-02-27
IL179441A (en) 2010-12-30
ES2332798T3 (es) 2010-02-12
ATE443775T1 (de) 2009-10-15
EP1766047A2 (de) 2007-03-28
WO2005118836A3 (en) 2006-04-06
AU2005250412A1 (en) 2005-12-15
WO2005118836A2 (en) 2005-12-15
US20080113383A1 (en) 2008-05-15
CA2567619A1 (en) 2005-12-15

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Legal Events

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