[go: up one dir, main page]

ATE532058T1 - Point-of-care-heparinbestimmungssystem - Google Patents

Point-of-care-heparinbestimmungssystem

Info

Publication number
ATE532058T1
ATE532058T1 AT05747397T AT05747397T ATE532058T1 AT E532058 T1 ATE532058 T1 AT E532058T1 AT 05747397 T AT05747397 T AT 05747397T AT 05747397 T AT05747397 T AT 05747397T AT E532058 T1 ATE532058 T1 AT E532058T1
Authority
AT
Austria
Prior art keywords
protamine
concentration
heparin
blood
ionophore
Prior art date
Application number
AT05747397T
Other languages
English (en)
Inventor
Kelvin Bonnema
Christopher Hobot
Randy Meyer
Douglas Nippoldt
Wei Qin
Narayanan Ramamurthy
Vitaly Sitko
Quingshan Sam Ye
Daniel S Cheek
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Application granted granted Critical
Publication of ATE532058T1 publication Critical patent/ATE532058T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333Ion-selective electrodes or membranes
    • G01N27/3335Ion-selective electrodes or membranes the membrane containing at least one organic component
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333Ion-selective electrodes or membranes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672Means preventing coagulation
    • A61M1/3675Deactivation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT05747397T 2004-05-17 2005-05-11 Point-of-care-heparinbestimmungssystem ATE532058T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57207104P 2004-05-17 2004-05-17
PCT/US2005/016463 WO2005116623A2 (en) 2004-05-17 2005-05-11 Point of care heparin determination system

Publications (1)

Publication Number Publication Date
ATE532058T1 true ATE532058T1 (de) 2011-11-15

Family

ID=34969581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05747397T ATE532058T1 (de) 2004-05-17 2005-05-11 Point-of-care-heparinbestimmungssystem

Country Status (8)

Country Link
US (2) US7699966B2 (de)
EP (1) EP1747451B1 (de)
JP (1) JP2007538257A (de)
AT (1) ATE532058T1 (de)
AU (1) AU2005248772B2 (de)
CA (1) CA2567137A1 (de)
ES (1) ES2375064T3 (de)
WO (1) WO2005116623A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10224750A1 (de) 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh Vorrichtung zur Behandlung einer medizinischen Flüssigkeit
US7935074B2 (en) 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US20070212786A1 (en) * 2005-09-29 2007-09-13 Scott Manalis Monitoring heparin by microelectronic devices
WO2009073861A1 (en) * 2007-12-05 2009-06-11 Hemosense, Inc. Methods and devices for the neutralization of heparin in a sample
US20090209911A1 (en) * 2008-02-14 2009-08-20 Honeywell International Inc. Apparatus and method for portable liquid drug delivery
US8192401B2 (en) 2009-03-20 2012-06-05 Fresenius Medical Care Holdings, Inc. Medical fluid pump systems and related components and methods
WO2011008858A1 (en) 2009-07-15 2011-01-20 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US8720913B2 (en) 2009-08-11 2014-05-13 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis carts and related systems
US8722413B1 (en) * 2010-08-23 2014-05-13 Jimmy Gracia Biodiesel automatic titration system
US8945094B2 (en) 2010-09-08 2015-02-03 Honeywell International Inc. Apparatus and method for medication delivery using single input-single output (SISO) model predictive control
DE102010053973A1 (de) 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh Medizinisches Gerät mit einer Heizung
WO2012087798A2 (en) 2010-12-20 2012-06-28 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9624915B2 (en) 2011-03-09 2017-04-18 Fresenius Medical Care Holdings, Inc. Medical fluid delivery sets and related systems and methods
WO2012154352A1 (en) 2011-04-21 2012-11-15 Fresenius Medical Care Holdings, Inc. Medical fluid pumping systems and related devices and methods
US8536626B2 (en) * 2011-04-28 2013-09-17 Honeywell International Inc. Electronic pH sensor die packaging
US9186449B2 (en) 2011-11-01 2015-11-17 Fresenius Medical Care Holdings, Inc. Dialysis machine support assemblies and related systems and methods
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9427184B2 (en) 2012-09-06 2016-08-30 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
CN111067547A (zh) 2012-09-06 2020-04-28 赛拉诺斯知识产权有限责任公司 用于体液样品收集的系统、装置和方法
US9636062B2 (en) 2012-09-06 2017-05-02 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
JP2014115256A (ja) 2012-12-12 2014-06-26 Sony Corp 電気的測定用容器、並びに電気的測定用装置および電気的測定方法
US9561323B2 (en) 2013-03-14 2017-02-07 Fresenius Medical Care Holdings, Inc. Medical fluid cassette leak detection methods and devices
MX365324B (es) 2013-03-15 2019-05-29 Theranos Ip Co Llc Metodos y dispositivos para recoleccion de muestras y separacion de muestras.
US10117985B2 (en) 2013-08-21 2018-11-06 Fresenius Medical Care Holdings, Inc. Determining a volume of medical fluid pumped into or out of a medical fluid cassette
ES2756124T3 (es) 2013-12-06 2020-04-27 Ortho Clinical Diagnostics Inc Dispositivo de ensayo que tiene un puerto de lavado
JP2017507730A (ja) 2014-03-12 2017-03-23 セラノス, インコーポレイテッドTheranos, Inc. 体液サンプル収集のためのシステム、機器、及び方法
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
FR3058524B1 (fr) * 2016-11-07 2019-01-25 Institut National De La Sante Et De La Recherche Medicale Procede de caracterisation d'un echantillon sanguin
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
US11231360B2 (en) * 2017-06-29 2022-01-25 Hydrite Chemical Co. Automatic titration device
US11378541B1 (en) * 2018-10-25 2022-07-05 Iowa State University Research Foundation, Inc. Self-contained, automated, long-term sensor system for monitoring of soil and water nutrients in fields
WO2021016140A1 (en) * 2019-07-19 2021-01-28 Micropoint Bioscience, Inc. Micro-assay cartridges
KR20240057868A (ko) * 2022-10-25 2024-05-03 에스케이케미칼 주식회사 고분자 말단기의 자동 분석 방법 및 자동 분석 시스템

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE339613C (de) 1915-07-13 1921-07-29 Chem Fab Verfahren zur Darstellung von Gerbsaeureverbindungen der Digitalisglykoside
US2129043A (en) * 1936-01-17 1938-09-06 Bortsch Robert Cement testing device
US2411316A (en) 1944-08-17 1946-11-19 Emil R Capita Airplane hangar
BE539480A (de) * 1954-07-01
US3077106A (en) * 1959-12-11 1963-02-12 Lilly Co Eli Coagulometer
US3038327A (en) * 1961-01-30 1962-06-12 American Petrochemical Corp Gel time meter
US3129911A (en) * 1962-01-31 1964-04-21 Aereon Corp Framework for rigid aircraft
US3302452A (en) * 1964-04-27 1967-02-07 Cutler Hammer Inc Coagulation detector and coagulability determination
US3307392A (en) * 1964-05-04 1967-03-07 Research Corp Automatic prothrombin timer apparatus and method
US3450501A (en) * 1966-03-28 1969-06-17 Bruce J Oberhardt Prothrombin time determination
US3492096A (en) * 1967-10-05 1970-01-27 Paul G Hattersley Apparatus for and method of detecting the coagulation of whole blood
GB1299363A (en) * 1968-09-27 1972-12-13 Amiram Ur Monitoring of chemical, bio-chemical and biological reactions, particularly blood-clotting
US3560162A (en) * 1968-11-27 1971-02-02 Armour Pharma Diagnostic device
US3560163A (en) * 1968-12-23 1971-02-02 Armour Pharma Diagnostic device
US3525254A (en) * 1969-02-19 1970-08-25 Jesus R Milanes Device and method for testing blood coagulation factors
US3587295A (en) * 1969-03-13 1971-06-28 Sanford L Simons Coagulation and viscosity test apparatus and method
CH533307A (fr) * 1969-03-19 1973-01-31 Micromedic Systems Inc Appareil pour mesurer le temps de coagulation d'un échantillon de sang
US3635678A (en) * 1969-06-13 1972-01-18 Baxter Laboratories Inc Clot-timing system and method
BE759811A (fr) * 1969-12-04 1971-06-03 Technicon Instr Appareil de determination automatique des vitesses de coagulation, agglutination ou floculation de liquides, et agent renforcateur de reactionutilisable avec cet appareil
US3695842A (en) * 1970-03-12 1972-10-03 Intern Technidyne Corp Method and system for analyzing a liquid
US3658480A (en) * 1970-04-13 1972-04-25 Bio Data Corp Coagulation timing apparatus, and method
US3719075A (en) * 1970-10-19 1973-03-06 Medical Sciences Int Inc Viscosity measuring device
US3713780A (en) * 1971-02-01 1973-01-30 Becton Dickinson Co Apparatus for chemical testing
US3854324A (en) 1971-10-27 1974-12-17 T Altshuler Blood clotting time and strength measuring system
BE756128A (fr) 1972-06-08 1971-03-15 Vnii Khirurgicheskoi Apparatur Recipient pour le sang de reserve et pour l'admission du sang coronair
US3814585A (en) * 1972-09-26 1974-06-04 R Bailly Method and apparatus for testing blood coagulation
GB1437091A (en) * 1972-10-02 1976-05-26 Radiometer As Calcium electrode and membrane and composition for use therein
FR2218803A5 (de) * 1973-02-19 1974-09-13 Daillet Ets
US3918908A (en) 1974-05-17 1975-11-11 Geomet Method for prothrombin testing
US3963349A (en) * 1974-08-27 1976-06-15 American Hospital Supply Corporation Method and apparatus for determining coagulation times
US4115209A (en) * 1974-10-30 1978-09-19 Research Corporation Method of determining ion activity using coated ion selective electrodes
US3923627A (en) 1974-11-01 1975-12-02 Gen Electric Miniature probe containing multifunctional electrochemical sensing electrodes
US3985618A (en) * 1975-05-02 1976-10-12 Irving Innerfield Method for detection of thrombosis and prethrombosis
FR2318421A1 (fr) * 1975-07-16 1977-02-11 Girolami Antoine Procede et appareil de mesure du temps de variation de l'etat physique d'un corps ou milieu
US3999333A (en) 1975-11-14 1976-12-28 Amarantos John G Inflatable enclosure
US4036231A (en) * 1975-11-20 1977-07-19 Sherwood Medical Industries Inc. Thoracic drainage unit with defoaming means
US4074971A (en) * 1976-01-16 1978-02-21 Hemotec, Inc. Apparatus and method for the pharmacological manipulation of the coagulation mechanism in blood and for signalling the event of blood coagulation
US4000972A (en) * 1976-01-16 1977-01-04 Hemotec, Inc. Measuring system for the pharmacological manipulation of the coagulation mechanism in blood and for the elapsed coagulation time
US4040788A (en) * 1976-04-05 1977-08-09 Sanford L. Simons Apparatus, instrumentation, and method for comparing samples
US4067777A (en) * 1976-05-13 1978-01-10 Innerfield Irving Determination of heparin in the blood
DE2621486A1 (de) * 1976-05-14 1977-12-01 Kaltenbach & Voigt Pneumatischer lamellenmotor
US4058367A (en) 1976-05-19 1977-11-15 Gilford Instrument Laboratories Inc. Automatic asynchronous fluid processing apparatus
US4026671A (en) * 1976-08-02 1977-05-31 Sanford L. Simons Test apparatus circuit
US4129131A (en) 1976-10-26 1978-12-12 Henry Naftulin Method and apparatus for defibrination of blood
US4116635A (en) * 1977-03-14 1978-09-26 Jaeger Mark A General purpose in vitro anticoagulant
US4131549A (en) 1977-05-16 1978-12-26 Ferrara Louis T Serum separation device
US4160801A (en) * 1977-10-19 1979-07-10 Surgikos Heat exchanger-blood oxygenator combination
US4210623A (en) * 1978-05-01 1980-07-01 Owens-Illinois, Inc. Fluid collection apparatus
US4197735A (en) * 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means
US4243671A (en) * 1979-04-16 1981-01-06 E. R. Squibb & Sons, Inc. Inhibition of thromboxane synthetase formation and arachidonic acid-induced platelet aggregation and bronchoconstriction
US4285906A (en) * 1979-05-11 1981-08-25 Warner-Lambert Company Rotatable detector
US4257199A (en) * 1979-05-31 1981-03-24 Kazuo Kuboyama Stadium cover
US4332264A (en) * 1980-03-03 1982-06-01 United Healthcare Association Automated cleaning system for dialyzers
US4362698A (en) 1980-03-07 1982-12-07 Sherman-Boosalis Corporation Closures for fluid sample cups
US4359463A (en) 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4540801A (en) * 1981-04-02 1985-09-10 G. D. Searle & Co. 5 Fluoro PGI compounds
US4391780A (en) * 1981-07-06 1983-07-05 Beckman Instruments, Inc. Container for sample testing
US4671939A (en) * 1981-07-09 1987-06-09 International Technidyne Corp. Apparatus for analyzing the influence of additive reagents upon the coagulation of blood and related methods
US4443408A (en) * 1981-07-09 1984-04-17 International Technidyne, Inc. Apparatus for analyzing the influence of additive reagents upon the coagulation of blood
US4551308A (en) 1981-07-09 1985-11-05 International Technidyne Corp. Apparatus for analyzing the influence of additive reagents upon the coagulation of blood and related methods
WO1983000228A1 (en) 1981-07-11 1983-01-20 Siegfried Jochimsen Apparatus for measuring the blood clotting time and method for taking and measuring the time
US4390499A (en) * 1981-08-13 1983-06-28 International Business Machines Corporation Chemical analysis system including a test package and rotor combination
US4599219A (en) * 1982-10-15 1986-07-08 Hemotec, Inc. Coagulation detection by plunger sensing technique
US4663127A (en) * 1982-10-15 1987-05-05 Hemotec, Inc. Gas flow cartridge having resilient flexible membrane with slit separating reaction and reagent chambers
US4534939A (en) * 1982-10-15 1985-08-13 Hemotec, Inc. Gas flow cartridge with improved coagulation detection and expanded analytical test capability
US4752449A (en) * 1982-10-15 1988-06-21 Hemotec, Inc. Apparatus for coagulation detection by gas flow or plunger sensing techniques
US4533519A (en) * 1983-07-20 1985-08-06 Hemotec, Inc. Gas flow coagulation test cartridge having movable member establishing communication between reagent and reaction chambers
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
FR2566908B1 (fr) * 1984-06-27 1986-07-18 Girolami Antoine Coagulometre et procede de mesure du temps de coagulation d'echantillons de produits fluides
GB8426004D0 (en) * 1984-10-15 1984-11-21 Ortho Diagnostic Systems Inc Coagulation monitoring
DE3438221A1 (de) 1984-10-18 1986-04-24 Ließ, Hans-Dieter, Prof. Dr.-Ing., 8014 Neubiberg Kohlenstoffelektroden, insbesondere mikroelektroden aus kohlenstoffasern
US4782026A (en) 1985-02-25 1988-11-01 Hemotec, Inc. Collection medium for whole blood
US4871677A (en) * 1985-02-25 1989-10-03 Hemotec, Inc. Method of collecting and analyzing a sample of blood when monitoring heparin therapy
US4797369A (en) * 1985-04-05 1989-01-10 International Technidyne Corp. Method and apparatus for detecting a blood clot
US4851336A (en) * 1985-09-05 1989-07-25 Yin E Thye Composition, kit, and method for assaying heparinano a method for making the composition
DE3541057A1 (de) * 1985-11-19 1987-05-21 Kratzer Michael Verfahren und einrichtung zur messung der aggregation der blutplaettchen bzw. der koagulation des blutes
US4795703A (en) * 1986-03-07 1989-01-03 The Children's Medical Center Corporation Heparin assay
US4770759A (en) * 1986-07-08 1988-09-13 Nova Biomedical Corporation Lithium ion-selective membrane electrode
DD261844A1 (de) 1986-07-09 1988-11-09 Adw Ddr Verfahren zur praezipitation von fibrinmonomeren
US4788139A (en) 1987-08-06 1988-11-29 Streck Laboratories, Inc. Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5165952A (en) 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5417835A (en) * 1989-06-23 1995-05-23 The Board Of Regents Of The University Of Michigan Solid state ion sensor with polyimide membrane
US5314601A (en) * 1989-06-30 1994-05-24 Eltech Systems Corporation Electrodes of improved service life
US5207988A (en) * 1989-07-06 1993-05-04 The Cleveland Clinic Foundation Apparatus for detecting and quantifying clot lysis and establishing optimum medication and dosages
WO1991001383A1 (en) * 1989-07-14 1991-02-07 Michigan State University Method for diagnosing blood clotting disorders
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5091304A (en) * 1989-08-21 1992-02-25 International Technidyne Corporation Whole blood activated partial thromboplastin time test and associated apparatus
DE3933027A1 (de) * 1989-09-29 1991-04-11 Schering Ag Kombinationspraeparat mit antithrombotischer wirkung
US5183549A (en) * 1990-01-26 1993-02-02 Commtech International Management Corporation Multi-analyte sensing electrolytic cell
US4986964A (en) * 1990-04-19 1991-01-22 Center For Innovative Technology Clot retractometer
CA2049655C (en) * 1990-09-17 1996-11-12 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
JP3094165B2 (ja) 1990-11-05 2000-10-03 バクスター、ダイアグノスチックス、インコーポレイテッド 抗凝固剤濃度測定方法
US5174961A (en) 1991-01-18 1992-12-29 Hemotec, Inc. High sensitivity coagulation detection apparatus
CA2047991A1 (en) * 1991-02-04 1992-08-05 John Musacchio Solid contact system for potentiometric sensors
US5064556A (en) 1991-02-13 1991-11-12 Provision, Inc. Golf club cleaning composition and method
US5262325A (en) 1991-04-04 1993-11-16 Ibex Technologies, Inc. Method for the enzymatic neutralization of heparin
US5314826A (en) * 1991-08-23 1994-05-24 Medtronic Hemotec, Inc. Platelet activation and function evaluation technique
AU2870992A (en) * 1991-10-04 1993-05-03 Board Of Regents Of The University Of Nebraska, The A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
JPH086650B2 (ja) * 1992-01-17 1996-01-29 株式会社マグ研究所 燃料の清浄装置
US5607567A (en) * 1992-03-10 1997-03-04 The Board Of Regents Acting For And On Behalf Of University Of Michigan Protamine-responsive polymeric membrane electrode
US5236570A (en) * 1992-03-10 1993-08-17 University Of Michigan Heparin-selective polymeric membrane electrode
US5453171A (en) * 1992-03-10 1995-09-26 The Board Of Regents Of The University Of Michigan Heparin-selective polymeric membrane electrode
US5266462A (en) 1992-06-03 1993-11-30 Baxter Diagnostics Inc. Measurement of platelet activities
US5441892A (en) * 1992-10-15 1995-08-15 Medtronic Hemptec, Inc. Blood clot mass measuring technique
US5248673A (en) * 1992-12-23 1993-09-28 Bristol-Myers Squibb Co. Bisamidine derivatives as thrombin inhibitors
US5401377A (en) * 1993-08-06 1995-03-28 Biomedix, Inc. Ion-selective sensor with polymeric membrane having phospholipid dispersed therein
US5911862A (en) * 1993-09-15 1999-06-15 Chiron Diagnostics Corporation Material for establishing solid state contact for ion selective electrodes
US5472852A (en) 1993-09-15 1995-12-05 Oklahoma Medical Research Foundation Assay for detection of selective Protein C inhibition by patients
US5505721A (en) * 1993-09-16 1996-04-09 Leach; Gregory L. Multiple tube perfusion sampler
DE4344919A1 (de) 1993-12-30 1995-07-06 Behringwerke Ag Verfahren zur Bestimmung der Thrombozytenaggregation
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5625976A (en) * 1994-05-31 1997-05-06 Flow Tek, Inc. Fly lines
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5602037A (en) * 1994-06-30 1997-02-11 Dade International, Inc. Combination reagent holding and test device
DE4427921C2 (de) 1994-08-06 2002-09-26 Forschungszentrum Juelich Gmbh Chemische Sensoren, insbesondere Biosensoren, auf Siliciumbasis
DE4437274C2 (de) 1994-10-18 1998-11-05 Inst Chemo Biosensorik Analytselektiver Sensor
FR2728901B1 (fr) * 1994-12-28 1997-03-28 Sanofi Sa Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5612378A (en) * 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5612369A (en) * 1995-06-07 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Thrombin inhibitors
US5674236A (en) 1996-04-30 1997-10-07 Medtronic, Inc. Lancet for capillary puncture blood samples
US5925319A (en) * 1996-04-30 1999-07-20 Medtronic, Inc. Test cartridge for evaluating blood platelet functionality
US5951951A (en) * 1997-04-30 1999-09-14 Medtronic, Inc. Platelet function evaluation technique for citrated whole blood
US6010911A (en) 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US20030057108A1 (en) * 1999-12-10 2003-03-27 Ramamurthi Sridharan Device and method for accelerated hydration of dry chemical sensors
EP1287345A2 (de) * 2000-05-18 2003-03-05 Medtronic, Inc. Ionenspezifische festkörperelektrode mit einer polymerischen membran
US6613286B2 (en) * 2000-12-21 2003-09-02 Walter J. Braun, Sr. Apparatus for testing liquid/reagent mixtures
US7569393B2 (en) * 2002-06-28 2009-08-04 International Technidyne Corporation Analytical test cartridge; and, methods
CN1846132B (zh) * 2003-07-09 2010-05-05 奥本大学 聚离子的可逆电化学传感器

Also Published As

Publication number Publication date
JP2007538257A (ja) 2007-12-27
ES2375064T3 (es) 2012-02-24
US8801918B2 (en) 2014-08-12
US7699966B2 (en) 2010-04-20
AU2005248772A1 (en) 2005-12-08
US20060016701A1 (en) 2006-01-26
EP1747451B1 (de) 2011-11-02
EP1747451A2 (de) 2007-01-31
CA2567137A1 (en) 2005-12-08
AU2005248772B2 (en) 2010-11-25
WO2005116623A2 (en) 2005-12-08
WO2005116623A3 (en) 2006-01-26
US20100181210A1 (en) 2010-07-22

Similar Documents

Publication Publication Date Title
ATE532058T1 (de) Point-of-care-heparinbestimmungssystem
US10866208B2 (en) Extensible, multimodal sensor fusion platform for remote, proximal terrain sensing
WO2008040998A3 (en) Systems and methods for determining a substantially hematocrit independent analyte concentration
CA2934333C (en) System and method for measuring an analyte in a sample
ATE539675T1 (de) System und verfahren zur bestimmung einer analytenkonzentration mit einer hämatokrit- korrektur
TW200736606A (en) Gated voltammetry
DE60317422D1 (de) Mediator-stabilisierende Verbindung und Methoden zur Verwendung zur Detektion elektrochemischer Analyte
ATE460661T1 (de) Messgerät zur verwendung in einem verfahren zur reduzierung von interferenzen in einem elektrochemischen sensor unter verwendung von zwei unterschiedlichen angelegten potentialen
ATE552494T1 (de) Reversible elektochemische sensoren für polyionen
EP2490014A3 (de) Elektrochemische Biosensorstruktur und Verfahren zur Herstellung derselben
BRPI0507322A (pt) biosensor eletroquìmico
MXPA02010106A (es) Determinacion de suficiencia de volumen de muestra en dispositivos biosensores.
MX2010004465A (es) Metodo y aparato para deteccion electroquimica.
GB2431013A (en) Method and apparatus for sensing a time varying current passing through an ion channel
MX355854B (es) Sistema y metodo para detectar sensores utilizados y secados.
BRPI0814202A2 (pt) Métodos e sistemas de determinação de concentração de produto de análise em amostra fluida e meio legível em computador
WO2009031375A1 (ja) 電気化学的センサ装置及びこれを用いた電気化学的測定方法
ATE493645T1 (de) Elektrochemischer sensor zur ermittlung einer analyt-konzentration
CY1115380T1 (el) Μεθοδος και διαταξη για την ενισχυση της ηλεκτροπαραγομενης χημιφωταυγειας νανοσωματιδιων
NO20063141L (no) System for differensiell bestemmelse av et proteolytisk ensymniva i et kroppsfluid
NO20083293L (no) Elektrokjemisk sensorsystem som anvender et substrat med en apning samt en fremgangsmate for fremstilling av samme
RU2013136826A (ru) Детекция протеолиза
ATE493505T1 (de) Verfahren zur messung der konzentration transienter proteolytischer aktivität in zellen enthaltenden zusammengesetzten biologischen medien
ATE445844T1 (de) Testverfahren mit einer sulfonsäure- und einer nitroverbindung
Kuczak et al. Reference electrodes with polymeric membranes containing ionic liquids of various physicochemical properties