ATE529750T1 - Stimulatorische autoantikörper gegen den pdgf- rezeptor als pathologische marker und therapeutisches target - Google Patents
Stimulatorische autoantikörper gegen den pdgf- rezeptor als pathologische marker und therapeutisches targetInfo
- Publication number
- ATE529750T1 ATE529750T1 AT06796239T AT06796239T ATE529750T1 AT E529750 T1 ATE529750 T1 AT E529750T1 AT 06796239 T AT06796239 T AT 06796239T AT 06796239 T AT06796239 T AT 06796239T AT E529750 T1 ATE529750 T1 AT E529750T1
- Authority
- AT
- Austria
- Prior art keywords
- pdgf receptor
- therapeutic target
- autoantibodies against
- pathological marker
- erk1
- Prior art date
Links
- 108091008606 PDGF receptors Proteins 0.000 title abstract 2
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title 1
- 230000001575 pathological effect Effects 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 208000024908 graft versus host disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rehabilitation Therapy (AREA)
- Zoology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70337705P | 2005-07-28 | 2005-07-28 | |
| PCT/IT2006/000587 WO2007013124A2 (en) | 2005-07-28 | 2006-07-28 | Stimulatory auto-antibodies to the pdgf receptor as pathology marker and therapeutic target |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529750T1 true ATE529750T1 (de) | 2011-11-15 |
Family
ID=37683748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06796239T ATE529750T1 (de) | 2005-07-28 | 2006-07-28 | Stimulatorische autoantikörper gegen den pdgf- rezeptor als pathologische marker und therapeutisches target |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090221481A1 (de) |
| EP (1) | EP1907851B1 (de) |
| JP (1) | JP2009503493A (de) |
| KR (1) | KR20080077347A (de) |
| CN (1) | CN101517414A (de) |
| AT (1) | ATE529750T1 (de) |
| CA (1) | CA2616963A1 (de) |
| WO (1) | WO2007013124A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2122348B1 (de) * | 2007-01-25 | 2014-08-13 | Mariarosaria Santillo | Verfahren zur diagnose einer autoimmunkrankheit und zur identifizierung und isolierung stimulierender moleküle |
| WO2012013813A1 (en) | 2010-07-30 | 2012-02-02 | Gianluca Moroncini | Epitopes of the human pdgf receptor able to bind human auto-antibodies, antibodies and uses thereof |
| CA2885721A1 (en) * | 2012-07-11 | 2014-01-16 | Biomimetic Therapeutics, Llc | Cell-based assay for neutralizing antibodies |
| EP2875356A1 (de) * | 2012-07-23 | 2015-05-27 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren zur diagnose von sklerodermie |
| CA2890483A1 (en) * | 2012-11-09 | 2014-05-15 | Robert ARCH | Platelet-derived growth factor b specific antibodies and compositions and uses thereof |
| WO2020037378A1 (en) * | 2018-08-24 | 2020-02-27 | The Flinders University Of South Australia | Detection of functional autoantibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2092468T3 (es) * | 1988-01-22 | 1996-12-01 | Zymogenetics Inc | Metodos para producir analogos de receptores secretados. |
| US5268358A (en) * | 1988-12-08 | 1993-12-07 | Cor Therapeutics, Inc. | PDGF receptor blocking peptides |
| CA2138932A1 (en) * | 1993-12-28 | 1995-06-29 | Masako Wagatsuma | Mutant proteins of human dna topoisomerase i |
| JP3472048B2 (ja) * | 1995-10-09 | 2003-12-02 | 鐘淵化学工業株式会社 | 自己免疫疾患の診断薬 |
| ATE316653T1 (de) * | 2000-10-17 | 2006-02-15 | Besst Test Aps | Test zum direkten nachweis eines inflammatorischen anzeiger in einer körperflüssigkeitsprobe |
| JP3455782B2 (ja) * | 2001-12-27 | 2003-10-14 | 学校法人慶應義塾 | 強皮症の診断薬 |
-
2006
- 2006-07-28 AT AT06796239T patent/ATE529750T1/de not_active IP Right Cessation
- 2006-07-28 EP EP06796239A patent/EP1907851B1/de active Active
- 2006-07-28 KR KR1020087002211A patent/KR20080077347A/ko not_active Application Discontinuation
- 2006-07-28 WO PCT/IT2006/000587 patent/WO2007013124A2/en active Application Filing
- 2006-07-28 CA CA002616963A patent/CA2616963A1/en not_active Abandoned
- 2006-07-28 CN CNA2006800337752A patent/CN101517414A/zh active Pending
- 2006-07-28 JP JP2008523550A patent/JP2009503493A/ja active Pending
- 2006-07-28 US US11/996,541 patent/US20090221481A1/en not_active Abandoned
-
2011
- 2011-09-28 US US13/247,127 patent/US20120252037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1907851A2 (de) | 2008-04-09 |
| EP1907851B1 (de) | 2011-10-19 |
| KR20080077347A (ko) | 2008-08-22 |
| CA2616963A1 (en) | 2007-02-01 |
| WO2007013124A2 (en) | 2007-02-01 |
| US20120252037A1 (en) | 2012-10-04 |
| US20090221481A1 (en) | 2009-09-03 |
| WO2007013124A8 (en) | 2007-09-27 |
| JP2009503493A (ja) | 2009-01-29 |
| WO2007013124A3 (en) | 2007-07-19 |
| CN101517414A (zh) | 2009-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |