ATE524450T1 - 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren - Google Patents
5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatorenInfo
- Publication number
- ATE524450T1 ATE524450T1 AT08786712T AT08786712T ATE524450T1 AT E524450 T1 ATE524450 T1 AT E524450T1 AT 08786712 T AT08786712 T AT 08786712T AT 08786712 T AT08786712 T AT 08786712T AT E524450 T1 ATE524450 T1 AT E524450T1
- Authority
- AT
- Austria
- Prior art keywords
- isoxazole
- acute
- carboxamide derivatives
- phenyl
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349307P | 2007-08-02 | 2007-08-02 | |
| US1370007P | 2007-12-14 | 2007-12-14 | |
| PCT/EP2008/060090 WO2009016241A1 (en) | 2007-08-02 | 2008-07-31 | 5-phenyl-isoxazole-3-carboxamide derivatives as trpv1 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524450T1 true ATE524450T1 (de) | 2011-09-15 |
Family
ID=39925074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08786712T ATE524450T1 (de) | 2007-08-02 | 2008-07-31 | 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8211927B2 (de) |
| EP (1) | EP2185530B1 (de) |
| JP (1) | JP2011511756A (de) |
| CN (1) | CN101796036A (de) |
| AT (1) | ATE524450T1 (de) |
| CA (1) | CA2694663A1 (de) |
| MX (1) | MX2010001236A (de) |
| WO (1) | WO2009016241A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9020111B2 (en) | 2008-05-27 | 2015-04-28 | Qualcomm Incorporated | Setting up a communication session within a wireless communications system |
| EP3116501A1 (de) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
| WO2015138934A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| TWI714528B (zh) | 2014-05-14 | 2021-01-01 | 瑞士商諾華公司 | 甲醯胺衍生物 |
| US9403833B2 (en) | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
| CA2952862A1 (en) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| US10865181B2 (en) | 2014-11-05 | 2020-12-15 | University Of Kansas | Small molecule inhibitors of the mitochondrial permeability transition pore (mtPTP) |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| CA2971835A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| CA2971855A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| CA2971850A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylthiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US20180147187A1 (en) * | 2015-01-12 | 2018-05-31 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| AU2016297886B2 (en) | 2015-07-24 | 2020-12-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing CFTR activity |
| CN108430994B (zh) | 2015-10-06 | 2022-04-12 | 蛋白质平衡治疗股份有限公司 | 用于调节cftr的化合物、组合物和方法 |
| US10662207B2 (en) | 2016-04-07 | 2020-05-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
| AU2017280206A1 (en) | 2016-06-21 | 2019-01-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| CN112204024B (zh) * | 2018-06-08 | 2024-03-29 | 贝达药业股份有限公司 | Erk抑制剂及其应用 |
| CN111518044A (zh) * | 2019-02-01 | 2020-08-11 | 华东师范大学 | 烷氧基异噁唑类衍生物及其制备方法与应用 |
| US20220298149A1 (en) * | 2019-09-27 | 2022-09-22 | Collaborations Pharmaceuticals, Inc. | Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection |
| CN115105503B (zh) * | 2022-07-20 | 2023-05-23 | 河南大学 | 一种trpv1拮抗/cox抑制双靶点药物或其药学上可接受的盐、药物制剂和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067710A1 (en) * | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certain chemical entities, compositions, and methods for modulating trpv1 |
-
2008
- 2008-07-31 EP EP08786712A patent/EP2185530B1/de not_active Not-in-force
- 2008-07-31 US US12/671,113 patent/US8211927B2/en not_active Expired - Fee Related
- 2008-07-31 AT AT08786712T patent/ATE524450T1/de not_active IP Right Cessation
- 2008-07-31 JP JP2010518682A patent/JP2011511756A/ja not_active Withdrawn
- 2008-07-31 MX MX2010001236A patent/MX2010001236A/es not_active Application Discontinuation
- 2008-07-31 WO PCT/EP2008/060090 patent/WO2009016241A1/en active Application Filing
- 2008-07-31 CN CN200880105334A patent/CN101796036A/zh active Pending
- 2008-07-31 CA CA2694663A patent/CA2694663A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011511756A (ja) | 2011-04-14 |
| MX2010001236A (es) | 2010-03-04 |
| US20110065764A1 (en) | 2011-03-17 |
| US8211927B2 (en) | 2012-07-03 |
| CN101796036A (zh) | 2010-08-04 |
| WO2009016241A1 (en) | 2009-02-05 |
| CA2694663A1 (en) | 2009-02-05 |
| EP2185530A1 (de) | 2010-05-19 |
| EP2185530B1 (de) | 2011-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |