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ATE506362T1 - 1-aza-bicycloä3.3.1ünonane - Google Patents

1-aza-bicycloä3.3.1ünonane

Info

Publication number
ATE506362T1
ATE506362T1 AT05771214T AT05771214T ATE506362T1 AT E506362 T1 ATE506362 T1 AT E506362T1 AT 05771214 T AT05771214 T AT 05771214T AT 05771214 T AT05771214 T AT 05771214T AT E506362 T1 ATE506362 T1 AT E506362T1
Authority
AT
Austria
Prior art keywords
aza
Prior art date
Application number
AT05771214T
Other languages
German (de)
English (en)
Inventor
Dominik Feuerbach
Werner Mueller
Bernard Roy
Thomas Troxler
Konstanze Hurth
Mathias Frederiksen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE506362T1 publication Critical patent/ATE506362T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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  • Organic Chemistry (AREA)
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  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05771214T 2004-06-18 2005-06-17 1-aza-bicycloä3.3.1ünonane ATE506362T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58102004P 2004-06-18 2004-06-18
PCT/EP2005/006566 WO2005123732A1 (en) 2004-06-18 2005-06-17 1-aza-bicyclo[3.3.1]nonanes

Publications (1)

Publication Number Publication Date
ATE506362T1 true ATE506362T1 (de) 2011-05-15

Family

ID=35045272

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05771214T ATE506362T1 (de) 2004-06-18 2005-06-17 1-aza-bicycloä3.3.1ünonane

Country Status (33)

Country Link
US (3) US20070249657A1 (no)
EP (2) EP1761533B8 (no)
JP (1) JP4944772B2 (no)
KR (3) KR101343654B1 (no)
CN (1) CN1964968A (no)
AR (1) AR049401A1 (no)
AT (1) ATE506362T1 (no)
AU (1) AU2005254689B2 (no)
BR (1) BRPI0510940A (no)
CA (1) CA2566155C (no)
CY (1) CY1111528T1 (no)
DE (1) DE602005027567D1 (no)
DK (1) DK1761533T3 (no)
EC (1) ECSP067053A (no)
ES (1) ES2364971T3 (no)
HK (1) HK1107559A1 (no)
HR (1) HRP20110535T1 (no)
IL (2) IL179611A (no)
MA (1) MA28684B1 (no)
MX (1) MXPA06014697A (no)
MY (1) MY147262A (no)
NO (1) NO20070339L (no)
NZ (1) NZ551198A (no)
PE (1) PE20060437A1 (no)
PL (1) PL1761533T3 (no)
PT (1) PT1761533E (no)
RU (1) RU2445313C2 (no)
SG (1) SG153834A1 (no)
SI (1) SI1761533T1 (no)
TN (1) TNSN06407A1 (no)
TW (1) TWI370128B (no)
WO (1) WO2005123732A1 (no)
ZA (1) ZA200609255B (no)

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GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US20120157464A1 (en) 2009-07-23 2012-06-21 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
MX2013003344A (es) 2010-09-23 2013-06-28 Abbvie Inc Monohidrato de un derivado de azaadamantano.
CA2825142A1 (en) 2011-01-27 2012-08-02 Novartis Ag Use of nicotinic acetylcholine receptor alpha 7 activators
BR112013023813A2 (pt) 2011-03-18 2016-12-13 Novartis Ag combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson
KR102043077B1 (ko) 2011-10-20 2019-11-11 노파르티스 아게 알파 ７ 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성을 예측하는 바이오마커
RU2017136693A (ru) * 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
RU2674249C2 (ru) * 2012-11-05 2018-12-06 НэнтБайо, Инк. Замещенные производные индол-5-ола и их терапевтическое применение
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
KR101879921B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 기면증의 치료를 위한 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
MX379289B (es) * 2013-01-15 2025-03-10 Novartis Ag Uso de agonistas del receptor nicotinico de acetilcolina alfa 7.
JP6338223B2 (ja) * 2013-01-15 2018-06-06 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
GB2579747B8 (en) 2017-08-04 2022-10-05 Skyhawk Therapeutics Inc Methods and compositions for modulating splicing
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN113677344A (zh) 2019-02-06 2021-11-19 斯基霍克疗法公司 用于调节剪接的方法和组合物

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