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ATE505559T1 - Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege - Google Patents

Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege

Info

Publication number
ATE505559T1
ATE505559T1 AT03749656T AT03749656T ATE505559T1 AT E505559 T1 ATE505559 T1 AT E505559T1 AT 03749656 T AT03749656 T AT 03749656T AT 03749656 T AT03749656 T AT 03749656T AT E505559 T1 ATE505559 T1 AT E505559T1
Authority
AT
Austria
Prior art keywords
coa
organism
aldehyde dehydrogenase
dependent aldehyde
pha
Prior art date
Application number
AT03749656T
Other languages
English (en)
Inventor
Frank Skraly
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of ATE505559T1 publication Critical patent/ATE505559T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • C12P7/625Polyesters of hydroxy carboxylic acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Prostheses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03749656T 2002-09-12 2003-09-12 Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege ATE505559T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41008702P 2002-09-12 2002-09-12
PCT/US2003/028842 WO2004024876A2 (en) 2002-09-12 2003-09-12 Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways

Publications (1)

Publication Number Publication Date
ATE505559T1 true ATE505559T1 (de) 2011-04-15

Family

ID=31994056

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03749656T ATE505559T1 (de) 2002-09-12 2003-09-12 Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege

Country Status (8)

Country Link
US (1) US8071355B2 (de)
EP (2) EP2365088B1 (de)
JP (2) JP4628103B2 (de)
AT (1) ATE505559T1 (de)
AU (1) AU2003267185A1 (de)
DE (2) DE10075400T8 (de)
ES (1) ES2395053T3 (de)
WO (1) WO2004024876A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100979694B1 (ko) * 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
EP3214179B1 (de) 2007-03-16 2021-03-03 Genomatica, Inc. Zusammensetzungen und verfahren für die biosynthese von 1,4-butandiol und dessen vorläufern
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
JP5541809B2 (ja) * 2008-06-24 2014-07-09 エルジー・ケム・リミテッド ポリラクテートとその共重合体生成能が改善された変異微生物を利用したポリラクテートとその共重合体の製造方法
EP3514242A3 (de) 2008-09-10 2019-08-28 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol
WO2010057022A1 (en) * 2008-11-14 2010-05-20 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
KR101886012B1 (ko) 2008-12-12 2018-08-06 씨제이제일제당 (주) 폴리(5hv)및 5 탄소 화학물질의 생산을 위한 녹색 공정 및 조성물
KR101293886B1 (ko) 2009-02-05 2013-08-07 주식회사 엘지화학 폴리락틱산 또는 폴리락틱산 공중합체 생성능을 지닌 재조합 랄스토니아 유트로파 및 이것을 이용하여 폴리락틱산 또는 폴리락틱산 공중합체를 제조하는 방법
PL2438178T3 (pl) 2009-06-04 2018-09-28 Genomatica Inc Mikroorganizmy do produkcji 1,4-butanodiolu i pokrewne sposoby
US8597918B2 (en) * 2009-06-04 2013-12-03 Genomatica, Inc. Process of separating components of a fermentation broth
KR20120083908A (ko) * 2009-10-13 2012-07-26 게노마티카 인코포레이티드 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-coa, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
FR2964014B1 (fr) * 2010-08-31 2013-04-05 Ifremer Nucleus enrobe d'un revetement filmogene aux proprietes antibacteriennes et cicatrisantes et procede d'obtention.
FR2968506B1 (fr) * 2010-12-14 2013-02-08 Ifremer Nucleus recouvert de pha
CN102212501B (zh) * 2011-03-31 2013-06-12 山东大学 一种重组大肠杆菌及应用其以单一碳源生产phbv的方法
US9663791B2 (en) * 2011-04-29 2017-05-30 Cj Research Center Llc Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock
BR112014003708A2 (pt) 2011-08-19 2017-03-07 Genomatica Inc microorganismos métodos para a produção de 2,4-pentadienoato, butadieno, propileno, 1,3-butanodiol e álcoois relacionados
MY197970A (en) 2011-11-02 2023-07-25 Genomatica Inc Microorganisms and methods for the production of caprolactone
TW201410865A (zh) 2012-06-04 2014-03-16 Genomatica Inc 製造4-羥基丁酸酯、1,4-丁二醇及相關化合物之微生物及方法
KR20230026539A (ko) 2012-10-15 2023-02-24 게노마티카 인코포레이티드 특정 길이의 지방 알콜 및 관련 화합물의 생산을 위한 미생물 및 방법
BR112015020904A2 (pt) 2013-03-15 2017-10-10 Genomatica Inc microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato
WO2015077752A1 (en) 2013-11-25 2015-05-28 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
WO2016007365A1 (en) 2014-07-11 2016-01-14 Genomatica, Inc. Microorganisms and methods for the production of butadiene using acetyl-coa
BR112017005665A2 (pt) 2014-09-18 2017-12-12 Genomatica Inc organismos microbianos não naturais com eficiência energética melhorada
EP3303421A4 (de) 2015-05-30 2019-03-27 Genomatica, Inc. Vinylisomerasedehydratasen, alkenoldehydratasen, linalooldehydratasen und crotylalkoholdehydratase und verfahren zur herstellung und verwendung davon
US11566250B2 (en) 2017-10-26 2023-01-31 Noroo Ic Co., Ltd. Production and separation of 3-hydroxypropionic acid
US11059769B2 (en) 2017-10-26 2021-07-13 Noroo Ic Co., Ltd. Production and separation of 3-hydroxypropionic acid
JP7209434B2 (ja) * 2019-10-31 2023-01-20 株式会社カネカ ポリヒドロキシアルカン酸の製造方法およびその利用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477654A (en) 1981-07-07 1984-10-16 Imperial Chemical Industries Plc 3-Hydroxybutyrate polymers
EP0145233B2 (de) 1983-11-23 1991-11-06 Imperial Chemical Industries Plc Trennungsverfahrenfür ein 3-hydroxybutyrat-Polymer
US5229279A (en) * 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5480794A (en) 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
GB9325952D0 (en) * 1993-12-20 1994-02-23 Zeneca Ltd Process for preparing films and coatings
ES2251716T3 (es) * 1994-01-28 2006-05-01 THE PROCTER & GAMBLE COMPANY Copolimeros biodegradables y articulos de plastico que comprenden copolimeros biodegradables de 3-hidroxihexanoato.
ZA95627B (en) * 1994-01-28 1995-10-05 Procter & Gamble Biodegradable copolymers and plastic articles comprising biodegradable copolymers
FR2719012B1 (fr) 1994-04-22 1996-07-12 Pomagalski Sa Pince débrayable d'un véhicule tracté par câble.
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
DE69733490T2 (de) 1997-03-03 2006-03-16 Metabolix, Inc., Cambridge Verfahren zur polyestern-biosynthese
WO1999014313A2 (en) * 1997-09-19 1999-03-25 Metabolix, Inc. Biological systems for manufacture of polyhydroxylalkanoate polymers containing 4-hydroxyacids
US7455999B2 (en) 1998-01-22 2008-11-25 Metabolix, Inc. Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate)
EP1105514B1 (de) * 1998-08-04 2008-02-06 Metabolix, Inc. Herstellung von polyhydroxyalkanoaten aus polyolen
US6593116B1 (en) * 1998-08-18 2003-07-15 Metabolix, Inc. Transgenic microbial polyhydroxyalkanoate producers
PT1163019E (pt) * 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
US20020164729A1 (en) * 2000-07-21 2002-11-07 Skraly Frank A. Production of polyhydroxyalkanoates from polyols
JP2004512419A (ja) * 2000-10-27 2004-04-22 メタボリックス・インコーポレーテッド 低分子量ポリヒドロキシアルカノエート含有組成物およびその使用方法

Also Published As

Publication number Publication date
DE60336757D1 (de) 2011-05-26
AU2003267185A1 (en) 2004-04-30
ES2395053T1 (es) 2013-02-07
AU2003267185A8 (en) 2004-04-30
EP2365088A2 (de) 2011-09-14
DE10075400T8 (de) 2013-04-25
JP2010268797A (ja) 2010-12-02
EP2365088B1 (de) 2015-05-27
JP2006507811A (ja) 2006-03-09
EP1581619A2 (de) 2005-10-05
US8071355B2 (en) 2011-12-06
WO2004024876A3 (en) 2006-05-26
EP1581619A4 (de) 2007-02-14
ES2395053T3 (es) 2015-10-08
JP4628103B2 (ja) 2011-02-09
DE10075400T1 (de) 2012-10-11
WO2004024876A2 (en) 2004-03-25
EP2365088A3 (de) 2012-01-11
US20040106176A1 (en) 2004-06-03
EP1581619B1 (de) 2011-04-13

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