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ATE505475T1 - Nukleosidderivate als inhibitoren viraler polymerasen - Google Patents

Nukleosidderivate als inhibitoren viraler polymerasen

Info

Publication number
ATE505475T1
ATE505475T1 AT08804247T AT08804247T ATE505475T1 AT E505475 T1 ATE505475 T1 AT E505475T1 AT 08804247 T AT08804247 T AT 08804247T AT 08804247 T AT08804247 T AT 08804247T AT E505475 T1 ATE505475 T1 AT E505475T1
Authority
AT
Austria
Prior art keywords
inhibitors
nucleoside derivatives
viral polymerases
formula
polymerases
Prior art date
Application number
AT08804247T
Other languages
English (en)
Inventor
Francesco Maria Di
Vincenzo Summa
Gabriella Dessole
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Application granted granted Critical
Publication of ATE505475T1 publication Critical patent/ATE505475T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT08804247T 2007-09-24 2008-09-16 Nukleosidderivate als inhibitoren viraler polymerasen ATE505475T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0718575.4A GB0718575D0 (en) 2007-09-24 2007-09-24 Nucleoside derivatives as inhibitors of viral polymerases
PCT/EP2008/062289 WO2009040269A1 (en) 2007-09-24 2008-09-16 Nucleoside derivatives as inhibitors of viral polymerases

Publications (1)

Publication Number Publication Date
ATE505475T1 true ATE505475T1 (de) 2011-04-15

Family

ID=38670393

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08804247T ATE505475T1 (de) 2007-09-24 2008-09-16 Nukleosidderivate als inhibitoren viraler polymerasen

Country Status (6)

Country Link
US (1) US8183216B2 (de)
EP (1) EP2195326B1 (de)
AT (1) ATE505475T1 (de)
DE (1) DE602008006227D1 (de)
GB (1) GB0718575D0 (de)
WO (1) WO2009040269A1 (de)

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CN102617571B (zh) * 2006-07-07 2015-06-10 吉里德科学公司 新的哒嗪化合物及其用途
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JP6385825B2 (ja) 2011-12-22 2018-09-05 アリオス バイオファーマ インク． 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
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US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
CA2887578A1 (en) 2012-10-08 2014-04-17 Idenix Pharamaceuticals, Inc. 2'-chloro nucleoside analogs for hcv infection
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
EP2935304A1 (de) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluor-nukleoside zur behandlung von hcv
EP3421482A1 (de) 2012-12-21 2019-01-02 Alios Biopharma, Inc. Substituierte nukleoside, nukleotide und analoga davon
EP2970358B1 (de) 2013-03-04 2021-06-30 Idenix Pharmaceuticals LLC 3'-deoxy-nukleoside zur behandlung von hcv
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
US20140271547A1 (en) 2013-03-13 2014-09-18 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
EP3027636B1 (de) 2013-08-01 2022-01-05 Idenix Pharmaceuticals LLC D-amino acid phosphoramidate pronucleotide of halogenierte pyrimidine verbindungen für leber krankheiten
EA201690526A1 (ru) 2013-10-11 2017-02-28 Алиос Биофарма, Инк. Замещенные нуклеозиды, нуклеотиды и их аналоги
EP3131914B1 (de) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituierte methyl- oder alkynylnukleoside zur behandlung von hcv

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Also Published As

Publication number Publication date
US20100210581A1 (en) 2010-08-19
EP2195326A1 (de) 2010-06-16
US8183216B2 (en) 2012-05-22
DE602008006227D1 (de) 2011-05-26
WO2009040269A1 (en) 2009-04-02
EP2195326B1 (de) 2011-04-13
GB0718575D0 (en) 2007-10-31

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