ATE500249T1 - Synthese von himbacinanaloga - Google Patents
Synthese von himbacinanalogaInfo
- Publication number
- ATE500249T1 ATE500249T1 AT06718299T AT06718299T ATE500249T1 AT E500249 T1 ATE500249 T1 AT E500249T1 AT 06718299 T AT06718299 T AT 06718299T AT 06718299 T AT06718299 T AT 06718299T AT E500249 T1 ATE500249 T1 AT E500249T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- himbacin
- analogs
- himbacin analogs
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- C07D307/885—3,3-Diphenylphthalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64393205P | 2005-01-14 | 2005-01-14 | |
| PCT/US2006/001208 WO2006076564A1 (en) | 2005-01-14 | 2006-01-12 | Synthesis of himbacine analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500249T1 true ATE500249T1 (de) | 2011-03-15 |
Family
ID=36228637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06718299T ATE500249T1 (de) | 2005-01-14 | 2006-01-12 | Synthese von himbacinanaloga |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1853592B1 (de) |
| JP (2) | JP4681617B2 (de) |
| CN (1) | CN101137647A (de) |
| AR (1) | AR052870A1 (de) |
| AT (1) | ATE500249T1 (de) |
| CA (1) | CA2594741A1 (de) |
| DE (1) | DE602006020414D1 (de) |
| ES (1) | ES2360721T3 (de) |
| MX (1) | MX2007008631A (de) |
| PT (1) | PT1853592E (de) |
| SG (1) | SG158885A1 (de) |
| WO (1) | WO2006076564A1 (de) |
| ZA (1) | ZA200705792B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20100218T1 (hr) * | 2005-01-14 | 2010-05-31 | Schering Corporation | Egzo- i dijastereoselektivna sinteza analoga himbacina |
| ES2527535T3 (es) | 2010-04-16 | 2015-01-26 | Sanofi | Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1 |
| ES2532902T3 (es) | 2010-04-16 | 2015-04-01 | Sanofi | Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1 |
| WO2015013083A1 (en) * | 2013-07-22 | 2015-01-29 | Merck Sharp & Dohme Corp. | Co-crystal of the par-1 receptor antagonist vorapaxar and aspirin |
| CN105330689B (zh) * | 2014-08-08 | 2018-08-17 | 博瑞生物医药（苏州）股份有限公司 | 制备Himbacine类似物中间体的制备方法 |
| CN105985303B (zh) * | 2015-02-13 | 2020-08-14 | 上海彩迩文生化科技有限公司 | 抗凝血剂的制备方法、中间体及其制备方法 |
| CN106478608A (zh) * | 2015-09-01 | 2017-03-08 | 博瑞生物医药（苏州）股份有限公司 | 沃拉帕沙的硫酸盐的结晶多晶型物 |
| CN105348241B (zh) * | 2015-12-11 | 2017-09-05 | 南京华威医药科技开发有限公司 | 一种硫酸沃拉帕沙中间体的合成方法 |
| ITUB20160876A1 (it) | 2016-02-19 | 2017-08-19 | Dambrosio Enzo Maria | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
| CN107129477A (zh) * | 2016-02-26 | 2017-09-05 | 上海星泰医药科技有限公司 | ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法 |
| CN106749138B (zh) * | 2016-12-07 | 2019-08-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种硫酸沃拉帕沙中间体醛的制备方法 |
| CN107955014B (zh) * | 2017-11-10 | 2019-06-28 | 南阳师范学院 | 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| ID24726A (id) * | 1997-11-25 | 2000-08-03 | Schering Corp | Antagonis-antagonis reseptor trombin |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| PE20030808A1 (es) * | 2001-10-18 | 2003-09-22 | Schering Corp | Derivados triciclicos heterociclicos como antagonistas receptores de trombina |
| DE60317493T3 (de) * | 2002-04-16 | 2018-07-12 | Merck Sharp & Dohme Corp. | Trizyklische thrombin rezeptor antagonisten |
| HRP20100218T1 (hr) * | 2005-01-14 | 2010-05-31 | Schering Corporation | Egzo- i dijastereoselektivna sinteza analoga himbacina |
-
2006
- 2006-01-12 SG SG201000275-6A patent/SG158885A1/en unknown
- 2006-01-12 PT PT06718299T patent/PT1853592E/pt unknown
- 2006-01-12 ES ES06718299T patent/ES2360721T3/es active Active
- 2006-01-12 DE DE602006020414T patent/DE602006020414D1/de active Active
- 2006-01-12 JP JP2007551396A patent/JP4681617B2/ja not_active Expired - Fee Related
- 2006-01-12 MX MX2007008631A patent/MX2007008631A/es active IP Right Grant
- 2006-01-12 CA CA002594741A patent/CA2594741A1/en not_active Abandoned
- 2006-01-12 AR ARP060100125A patent/AR052870A1/es not_active Application Discontinuation
- 2006-01-12 WO PCT/US2006/001208 patent/WO2006076564A1/en active Application Filing
- 2006-01-12 EP EP06718299A patent/EP1853592B1/de active Active
- 2006-01-12 CN CNA2006800080207A patent/CN101137647A/zh active Pending
- 2006-01-12 AT AT06718299T patent/ATE500249T1/de active
-
2007
- 2007-07-13 ZA ZA200705792A patent/ZA200705792B/xx unknown
-
2010
- 2010-12-09 JP JP2010275168A patent/JP2011046751A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011046751A (ja) | 2011-03-10 |
| EP1853592A1 (de) | 2007-11-14 |
| ES2360721T3 (es) | 2011-06-08 |
| SG158885A1 (en) | 2010-02-26 |
| CN101137647A (zh) | 2008-03-05 |
| CA2594741A1 (en) | 2006-07-20 |
| JP4681617B2 (ja) | 2011-05-11 |
| WO2006076564A1 (en) | 2006-07-20 |
| JP2008526981A (ja) | 2008-07-24 |
| ZA200705792B (en) | 2008-08-27 |
| MX2007008631A (es) | 2007-09-12 |
| DE602006020414D1 (en) | 2011-04-14 |
| AR052870A1 (es) | 2007-04-11 |
| PT1853592E (pt) | 2011-05-10 |
| EP1853592B1 (de) | 2011-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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