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ATE497013T1 - Verfahren zur herstellung von glutaminsäurederivaten - Google Patents

Verfahren zur herstellung von glutaminsäurederivaten

Info

Publication number
ATE497013T1
ATE497013T1 AT02783795T AT02783795T ATE497013T1 AT E497013 T1 ATE497013 T1 AT E497013T1 AT 02783795 T AT02783795 T AT 02783795T AT 02783795 T AT02783795 T AT 02783795T AT E497013 T1 ATE497013 T1 AT E497013T1
Authority
AT
Austria
Prior art keywords
acid derivatives
glutamine acid
producing glutamine
producing
general formula
Prior art date
Application number
AT02783795T
Other languages
English (en)
Inventor
Masakazu Sugiyama
Kunihiko Watanabe
Nao Funakoshi
Yusuke Amino
Shigeru Kawahara
Tadashi Takemoto
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26625318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE497013(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE497013T1 publication Critical patent/ATE497013T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT02783795T 2001-12-27 2002-12-09 Verfahren zur herstellung von glutaminsäurederivaten ATE497013T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001396471 2001-12-27
JP2002095760 2002-03-29
PCT/JP2002/012852 WO2003056026A1 (fr) 2001-12-27 2002-12-09 Procede de production de derives d'acide glutamique

Publications (1)

Publication Number Publication Date
ATE497013T1 true ATE497013T1 (de) 2011-02-15

Family

ID=26625318

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02783795T ATE497013T1 (de) 2001-12-27 2002-12-09 Verfahren zur herstellung von glutaminsäurederivaten

Country Status (10)

Country Link
EP (3) EP1445323B1 (de)
JP (1) JP4301003B2 (de)
KR (2) KR100673283B1 (de)
CN (2) CN100549182C (de)
AT (1) ATE497013T1 (de)
AU (1) AU2002349493A1 (de)
CA (1) CA2469012C (de)
DE (1) DE60239072D1 (de)
RU (2) RU2280078C2 (de)
WO (1) WO2003056026A1 (de)

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AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
NZ535297A (en) * 2002-04-23 2008-05-30 Cargill Inc A method of producing monatin by converting tyrptophan or indole-3-lactic acid to monatin
JP4670347B2 (ja) 2002-08-26 2011-04-13 味の素株式会社 新規アルドラーゼおよび置換α−ケト酸の製造方法
WO2004053125A1 (ja) 2002-12-09 2004-06-24 Ajinomoto Co., Inc. 変異型ｄ−アミノトランスフェラーゼおよびこれを用いた光学活性グルタミン酸誘導体の製造方法
CN102210852B (zh) 2003-05-15 2016-10-19 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
ES2285521T3 (es) * 2003-08-14 2007-11-16 Cargill, Incorporated Composiciones de goma de mascar que comprenden monatina y procedimientos para la preparacion de las mismas.
EP1657985A1 (de) * 2003-08-25 2006-05-24 Cargill Inc. Monatinhaltige getränkezusammensetzungen und verfahren zu ihrer herstellung
CN103555782B (zh) * 2003-10-21 2017-04-12 嘉吉有限公司 生产莫纳甜和莫纳甜前体
JP4500977B2 (ja) * 2003-11-05 2010-07-14 味の素株式会社 新規アミノ酸誘導体及び甘味剤
JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
CA2506247C (en) 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
JP4797452B2 (ja) * 2004-06-07 2011-10-19 味の素株式会社 新規アルドラーゼ並びに光学活性ｉｈｏｇ及びモナティンの製造方法
CA2583426A1 (en) 2004-10-05 2006-04-13 Ajinomoto Co., Inc. Process for producing amino acid derivative from hydroxyimino acid
CN101035442B (zh) * 2004-10-15 2012-04-11 味之素株式会社 甜味剂组合物
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
WO2006113897A2 (en) * 2005-04-20 2006-10-26 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
AU2006341528A1 (en) * 2005-04-26 2007-12-06 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8043837B2 (en) 2006-03-07 2011-10-25 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
WO2007140195A2 (en) 2006-05-24 2007-12-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
CN101239941B (zh) 2007-02-08 2012-02-29 味之素株式会社 光学活性化合物的制造方法
CN102027117B (zh) 2007-08-24 2012-11-07 味之素株式会社 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8076107B2 (en) 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
EP2107053A1 (de) 2008-03-11 2009-10-07 Ajinomoto Co., Inc. Hydratkristalle von (2R,4R)-Monatin Mononatrium-Salz
EP2300011A4 (de) 2008-05-27 2012-06-20 Dmi Life Sciences Inc Therapeutische verfahren und verbindungen
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
WO2012050125A1 (ja) 2010-10-14 2012-04-19 味の素株式会社 モナティンの製造方法
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
ES2795803T3 (es) 2011-10-10 2020-11-24 Ampio Pharmaceuticals Inc Tratamiento de artropatía degenerativa
JP6231484B2 (ja) 2011-10-28 2017-11-15 アンピオ ファーマシューティカルズ，インコーポレイテッド 鼻炎の処置
WO2013073679A1 (ja) * 2011-11-17 2013-05-23 味の素株式会社 （２ｒ，４ｒ）モナティン多価金属塩結晶の製造方法
CN102586343B (zh) * 2012-02-27 2013-07-17 重庆邮电大学 一种从l-丙氨酸制备丙酮酸的生物催化方法
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR20170045274A (ko) 2014-08-18 2017-04-26 앰피오 파마슈티컬스 인코퍼레이티드 관절 징후의 치료
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1148618B (it) 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
JPH0640832B2 (ja) 1985-05-10 1994-06-01 味の素株式会社 インタ−ロイキン２ポリペプチドの回収方法
IT1184282B (it) 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
IT1206078B (it) 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
GB2205834B (en) 1987-06-15 1990-10-31 South African Inventions 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds
IT1237472B (it) 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
ATE104961T1 (de) * 1990-01-19 1994-05-15 Technology Finance Corp Verfahren zur herstellung von 3-(1-amino-1,3dicarboxy-3-hydroxy-but-4-yl)-indol.
JP3052413B2 (ja) * 1990-05-25 2000-06-12 エヌオーケー株式会社 インド−ルピルビン酸の製造方法
DD297190A5 (de) 1990-08-06 1992-01-02 Ernst-Moritz-Arndt-Universitaet Greifswald,De Verfahren zur enzymatischen herstellung von indolpyruvat
CA2153561A1 (en) * 1994-07-11 1996-01-12 Ryoichi Katsumata Process for producing an optically active .gamma.-hydroxy-l-glutamic acid
US6358714B1 (en) 1995-04-03 2002-03-19 The Nutrasweet Company Materials and methods for the production of D-phenylalanine
US5994559A (en) 1998-08-06 1999-11-30 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Synthesis of monatin-A high intensity natural sweetener
CA2471847C (en) * 2001-12-27 2012-05-15 Ajinomoto Co., Inc. Processes of producing glutamic acid compounds and production intermediates therefor and novel intermediate for the processes
NZ535297A (en) * 2002-04-23 2008-05-30 Cargill Inc A method of producing monatin by converting tyrptophan or indole-3-lactic acid to monatin
JP4670347B2 (ja) * 2002-08-26 2011-04-13 味の素株式会社 新規アルドラーゼおよび置換α−ケト酸の製造方法
WO2004053125A1 (ja) * 2002-12-09 2004-06-24 Ajinomoto Co., Inc. 変異型ｄ−アミノトランスフェラーゼおよびこれを用いた光学活性グルタミン酸誘導体の製造方法

Also Published As

Publication number Publication date
AU2002349493A1 (en) 2003-07-15
JPWO2003056026A1 (ja) 2005-05-12
CA2469012A1 (en) 2003-07-10
EP1445323B1 (de) 2011-01-26
RU2004122914A (ru) 2005-03-27
EP1445323A1 (de) 2004-08-11
KR100775778B1 (ko) 2007-11-12
CA2469012C (en) 2013-06-04
EP1445323A4 (de) 2010-01-27
WO2003056026A1 (fr) 2003-07-10
EP2330211A3 (de) 2013-03-27
RU2280078C2 (ru) 2006-07-20
CN100549182C (zh) 2009-10-14
RU2006108992A (ru) 2007-10-10
KR20060060750A (ko) 2006-06-05
KR100673283B1 (ko) 2007-01-24
RU2325442C2 (ru) 2008-05-27
EP2330211A2 (de) 2011-06-08
DE60239072D1 (de) 2011-03-10
JP4301003B2 (ja) 2009-07-22
EP2460884A3 (de) 2013-03-27
EP2460884A2 (de) 2012-06-06
CN101671707A (zh) 2010-03-17
KR20040066830A (ko) 2004-07-27
CN1610749A (zh) 2005-04-27

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