ATE479425T1 - Sialsäure-derivate enthaltende feste dispersion - Google Patents
Sialsäure-derivate enthaltende feste dispersionInfo
- Publication number
- ATE479425T1 ATE479425T1 AT99916044T AT99916044T ATE479425T1 AT E479425 T1 ATE479425 T1 AT E479425T1 AT 99916044 T AT99916044 T AT 99916044T AT 99916044 T AT99916044 T AT 99916044T AT E479425 T1 ATE479425 T1 AT E479425T1
- Authority
- AT
- Austria
- Prior art keywords
- solid dispersion
- acid derivatives
- dispersion containing
- alpha
- alkyl group
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 229920002521 macromolecule Polymers 0.000 abstract 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 2
- 125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- -1 steroid compound Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9889998 | 1998-04-10 | ||
| PCT/JP1999/001907 WO1999052931A1 (fr) | 1998-04-10 | 1999-04-09 | Dispersion solide contenant un derive d'acide sialique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479425T1 true ATE479425T1 (de) | 2010-09-15 |
Family
ID=14231987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99916044T ATE479425T1 (de) | 1998-04-10 | 1999-04-09 | Sialsäure-derivate enthaltende feste dispersion |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6444649B1 (de) |
| EP (1) | EP1070725B9 (de) |
| JP (1) | JP4427900B2 (de) |
| KR (1) | KR100525275B1 (de) |
| CN (1) | CN1183154C (de) |
| AT (1) | ATE479425T1 (de) |
| CA (1) | CA2328085C (de) |
| DE (1) | DE69942721D1 (de) |
| WO (1) | WO1999052931A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307482T3 (es) | 1999-02-10 | 2008-12-01 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas. |
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US20090239834A1 (en) * | 2008-03-21 | 2009-09-24 | Braincells, Inc. | Mcc-257 modulation of neurogenesis |
| US9119866B2 (en) | 2008-04-08 | 2015-09-01 | Huiru Wang | Glycan-based drugs, therapies and biomarkers |
| EP2116139A1 (de) * | 2008-05-08 | 2009-11-11 | Nestec S.A. | Sialisäure zur Stärkung der Gehirngesundheit bei älteren Menschen |
| US9241896B2 (en) * | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| BRPI1008745A2 (pt) | 2009-02-05 | 2019-09-17 | Tokai Pharmaceuticals Inc | pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios |
| CN103370069A (zh) | 2010-07-13 | 2013-10-23 | 奥特吉尼克斯制药公司 | 用于治疗唾液酸缺乏的方法和制剂 |
| BR112014001440A2 (pt) * | 2011-07-18 | 2017-02-21 | Tokai Pharmaceuticals Inc | novas composições e métodos para o tratamento de câncer de próstata |
| AU2012328874B2 (en) | 2011-10-24 | 2017-08-31 | Ultragenyx Pharmaceutical Inc. | Sialic acid analogs |
| EP4066841A1 (de) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon |
| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| WO2017048817A1 (en) | 2015-09-14 | 2017-03-23 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
| CN110577557B (zh) * | 2018-06-08 | 2022-03-11 | 沈阳药科大学 | 唾液酸脂质衍生物及其制备方法和应用 |
| CN110478324B (zh) * | 2019-08-27 | 2022-02-08 | 嘉必优生物技术（武汉）股份有限公司 | 一种唾液酸微粒及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4229441A (en) | 1978-12-01 | 1980-10-21 | Merck & Co., Inc. | Immunologic adjuvant |
| JPS5877811A (ja) | 1981-11-04 | 1983-05-11 | Kanebo Ltd | 安定な易吸収性ニフエジピン製剤の製法 |
| JPH064671B2 (ja) | 1985-04-02 | 1994-01-19 | メクト株式会社 | シアル酸誘導体及びその製造方法 |
| JPH0631291B2 (ja) | 1985-06-07 | 1994-04-27 | 第一製薬株式会社 | Ｓ−ノイラミン酸誘導体 |
| JPS62209094A (ja) | 1986-03-10 | 1987-09-14 | Nippon Zoki Pharmaceut Co Ltd | 新規シアル酸誘導体及びその製造方法 |
| JPH07116216B2 (ja) | 1986-09-04 | 1995-12-13 | メクト株式会社 | シアロシルコレステロ−ルの製造方法 |
| WO1987006936A1 (fr) * | 1986-05-12 | 1987-11-19 | Mect Corporation | Sialosylcholesterol, procede de preparation et medicament contre les troubles du systeme nerveux |
| JPH0696535B2 (ja) | 1986-05-12 | 1994-11-30 | メクト株式会社 | シアロシルコレステロ−ルの神経障害疾患治療剤 |
| JPH07116206B2 (ja) | 1986-08-08 | 1995-12-13 | 和光純薬工業株式会社 | 新規なシアル酸誘導体 |
| JPH0714952B2 (ja) | 1986-08-08 | 1995-02-22 | 和光純薬工業株式会社 | シアル酸誘導体 |
| JPS6368526A (ja) | 1986-09-11 | 1988-03-28 | Mect Corp | シアリルグリセライドからなる神経障害疾患治療剤 |
| JPS6452794A (en) | 1987-05-29 | 1989-02-28 | Kanto Ishi Pharma Co Ltd | Sialic acid-containing thioglycerolipid derivative and production thereof |
| JPH0193529A (ja) | 1987-10-05 | 1989-04-12 | Mect Corp | シアロシルコレステロールの脱髄性疾患治療剤 |
| JP2729201B2 (ja) | 1988-01-21 | 1998-03-18 | メクト株式会社 | アミド結合を持ったシアル酸誘導体 |
| JPH0377898A (ja) | 1989-08-17 | 1991-04-03 | Mect Corp | シアロシルコレステロールからなる筋ジストロフィー症治療剤 |
| JP2793279B2 (ja) | 1989-08-22 | 1998-09-03 | メクト株式会社 | シアロシルコレステロールを含有する抗痴呆薬 |
| JPH03151398A (ja) | 1989-11-06 | 1991-06-27 | Mect Corp | シアル酸結合生理活性ペプチド及びその製造方法 |
| JPH07504884A (ja) | 1991-11-11 | 1995-06-01 | シムビコム アクティボラーグ | ガングリオシド類似体 |
| IT1260156B (it) | 1992-08-03 | 1996-03-28 | Fidia Spa | Derivati dell'acido neuraminico |
| JP3778372B2 (ja) | 1993-12-24 | 2006-05-24 | 三菱化学株式会社 | シアル酸誘導体 |
| DE4445580C1 (de) | 1994-12-20 | 1995-12-21 | Daimler Benz Ag | Hardtop-Fahrzeug |
| JPH092957A (ja) | 1995-06-22 | 1997-01-07 | Mitsubishi Chem Corp | 末梢性神経障害の治療、予防薬 |
-
1999
- 1999-04-09 AT AT99916044T patent/ATE479425T1/de not_active IP Right Cessation
- 1999-04-09 US US09/646,873 patent/US6444649B1/en not_active Expired - Fee Related
- 1999-04-09 DE DE69942721T patent/DE69942721D1/de not_active Expired - Lifetime
- 1999-04-09 JP JP2000543487A patent/JP4427900B2/ja not_active Expired - Fee Related
- 1999-04-09 WO PCT/JP1999/001907 patent/WO1999052931A1/ja not_active Ceased
- 1999-04-09 EP EP99916044A patent/EP1070725B9/de not_active Expired - Lifetime
- 1999-04-09 CA CA002328085A patent/CA2328085C/en not_active Expired - Fee Related
- 1999-04-09 KR KR10-2000-7011279A patent/KR100525275B1/ko not_active Expired - Fee Related
- 1999-04-09 CN CNB998071471A patent/CN1183154C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2328085A1 (en) | 1999-10-21 |
| JP4427900B2 (ja) | 2010-03-10 |
| KR20010042603A (ko) | 2001-05-25 |
| EP1070725A4 (de) | 2008-12-31 |
| WO1999052931A1 (fr) | 1999-10-21 |
| EP1070725A1 (de) | 2001-01-24 |
| CA2328085C (en) | 2006-08-22 |
| US6444649B1 (en) | 2002-09-03 |
| EP1070725B1 (de) | 2010-09-01 |
| HK1038023A1 (en) | 2002-03-01 |
| CN1183154C (zh) | 2005-01-05 |
| CN1305489A (zh) | 2001-07-25 |
| KR100525275B1 (ko) | 2005-11-02 |
| DE69942721D1 (de) | 2010-10-14 |
| EP1070725B9 (de) | 2011-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |