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ATE478055T1 - Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan - Google Patents

Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan

Info

Publication number
ATE478055T1
ATE478055T1 AT05015078T AT05015078T ATE478055T1 AT E478055 T1 ATE478055 T1 AT E478055T1 AT 05015078 T AT05015078 T AT 05015078T AT 05015078 T AT05015078 T AT 05015078T AT E478055 T1 ATE478055 T1 AT E478055T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
alkyl group
tetraazacyclododecan
monofunctionalized
Prior art date
Application number
AT05015078T
Other languages
English (en)
Inventor
Renato Geremia
Marcella Murru
Giorgio Ripa
Vittorio Valle
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Application granted granted Critical
Publication of ATE478055T1 publication Critical patent/ATE478055T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05015078T 1997-12-30 1998-12-18 Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan ATE478055T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI002896A IT1297035B1 (it) 1997-12-30 1997-12-30 Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Publications (1)

Publication Number Publication Date
ATE478055T1 true ATE478055T1 (de) 2010-09-15

Family

ID=11378474

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98966372T ATE299870T1 (de) 1997-12-30 1998-12-18 Verfahren zur herstellung von 1,4,7,10- tetraazadodecan-1,4-diessigsäurederivaten
AT05015078T ATE478055T1 (de) 1997-12-30 1998-12-18 Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98966372T ATE299870T1 (de) 1997-12-30 1998-12-18 Verfahren zur herstellung von 1,4,7,10- tetraazadodecan-1,4-diessigsäurederivaten

Country Status (9)

Country Link
US (1) US6342597B1 (de)
EP (2) EP1602649B1 (de)
JP (1) JP4536919B2 (de)
AT (2) ATE299870T1 (de)
AU (1) AU2274999A (de)
DE (2) DE69830931T2 (de)
ES (2) ES2350353T3 (de)
IT (1) IT1297035B1 (de)
WO (1) WO1999035133A2 (de)

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* Cited by examiner, † Cited by third party
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US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
JP4176155B2 (ja) * 1997-03-07 2008-11-05 ザ、プロクター、エンド、ギャンブル、カンパニー ブリーチ組成物
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
US20050187126A1 (en) * 2002-08-27 2005-08-25 Busch Daryle H. Catalysts and methods for catalytic oxidation
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
US20080124270A1 (en) * 2003-12-23 2008-05-29 Bracco Imaging S.P.A. Compounds Useful as Metal Chelators
JPWO2010029947A1 (ja) * 2008-09-09 2012-02-02 国立大学法人京都大学 造影剤組成物及びその製造方法
US11473032B2 (en) 2010-02-02 2022-10-18 Fuchs Petrolub Se Constant velocity joint having a boot
WO2015038943A1 (en) 2013-09-12 2015-03-19 The Research Foundation For The State University Of New York University At Buffalo Macrocycles, cobalt and iron complexes of same, and methods of making and using same
CN113956262B (zh) * 2021-10-18 2023-03-07 苏州百灵威超精细材料有限公司 一种四氮杂环烷类化合物及其中间体的合成方法
CN113801123B (zh) * 2021-10-18 2022-12-09 苏州百灵威超精细材料有限公司 一种1,4,8,11-四氮杂环十四烷类化合物及其中间体的制备方法

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DE3129906C3 (de) 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
NL194579C (nl) 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4615879A (en) 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
GB8413772D0 (en) 1984-05-30 1984-07-04 Nyegaard & Co As Chemical compounds
US4639365A (en) 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4826673A (en) 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
IT1213029B (it) 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
IT1224416B (it) 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
ES2086445T3 (es) * 1987-07-16 1996-07-01 Nycomed Imaging As Acidos aminocarboxilicos y sus derivados.
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4218744C2 (de) 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
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FR2736051B3 (fr) 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
EP0907379B1 (de) * 1996-04-01 2004-06-02 Epix Medical, Inc. Bioaktivierte diagnostische bilderzeugungskontrastmittel
IT1290457B1 (it) 1997-04-04 1998-12-03 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1293778B1 (it) 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
IT1297034B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Also Published As

Publication number Publication date
ITMI972896A1 (it) 1999-06-30
DE69830931T2 (de) 2006-01-12
DE69830931D1 (de) 2005-08-25
JP2002503644A (ja) 2002-02-05
EP1047677B1 (de) 2005-07-20
EP1602649B1 (de) 2010-08-18
AU2274999A (en) 1999-07-26
ATE299870T1 (de) 2005-08-15
JP4536919B2 (ja) 2010-09-01
DE69841852D1 (de) 2010-09-30
ES2244109T3 (es) 2005-12-01
US6342597B1 (en) 2002-01-29
WO1999035133A3 (en) 1999-08-26
IT1297035B1 (it) 1999-08-03
EP1602649A2 (de) 2005-12-07
ES2350353T3 (es) 2011-01-21
WO1999035133A2 (en) 1999-07-15
EP1047677A2 (de) 2000-11-02
EP1602649A3 (de) 2006-03-22

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