ATE465176T1 - Il-7-varianten mit reduzierter immunogenität - Google Patents
Il-7-varianten mit reduzierter immunogenitätInfo
- Publication number
- ATE465176T1 ATE465176T1 AT05850240T AT05850240T ATE465176T1 AT E465176 T1 ATE465176 T1 AT E465176T1 AT 05850240 T AT05850240 T AT 05850240T AT 05850240 T AT05850240 T AT 05850240T AT E465176 T1 ATE465176 T1 AT E465176T1
- Authority
- AT
- Austria
- Prior art keywords
- variants
- immunogenity
- reduced
- reduced immunogenity
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63447004P | 2004-12-09 | 2004-12-09 | |
| PCT/EP2005/013145 WO2006061219A2 (en) | 2004-12-09 | 2005-12-08 | Il-7 variants with reduced immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE465176T1 true ATE465176T1 (de) | 2010-05-15 |
Family
ID=36578271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05850240T ATE465176T1 (de) | 2004-12-09 | 2005-12-08 | Il-7-varianten mit reduzierter immunogenität |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7589179B2 (de) |
| EP (1) | EP1819728B1 (de) |
| JP (1) | JP4937132B2 (de) |
| KR (1) | KR20070085886A (de) |
| CN (1) | CN101072793B (de) |
| AT (1) | ATE465176T1 (de) |
| AU (1) | AU2005313492B2 (de) |
| BR (1) | BRPI0519000A2 (de) |
| CA (1) | CA2591297C (de) |
| DE (1) | DE602005020837D1 (de) |
| ES (1) | ES2342964T3 (de) |
| RU (1) | RU2437893C2 (de) |
| WO (1) | WO2006061219A2 (de) |
| ZA (1) | ZA200705559B (de) |
Families Citing this family (68)
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| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| US7091321B2 (en) | 2000-02-11 | 2006-08-15 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
| EP2295450B1 (de) | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Pegyliertes interleukin 10 |
| JP4234438B2 (ja) * | 2001-03-07 | 2009-03-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ハイブリッド・イソタイプ抗体部分を含有する蛋白質の発現技術 |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DE60239454D1 (de) * | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
| WO2003048334A2 (en) | 2001-12-04 | 2003-06-12 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| CA2551915C (en) * | 2003-12-30 | 2015-06-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Il-7 fusion proteins |
| DK1699821T3 (da) * | 2003-12-31 | 2012-07-16 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| JP4937132B2 (ja) | 2004-12-09 | 2012-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫原性の低下したｉｌ−７変種 |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| JP5175214B2 (ja) * | 2005-12-30 | 2013-04-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 改良された安定性を有するインターロイキン−１２ｐ４０変種 |
| WO2007076950A1 (en) | 2005-12-30 | 2007-07-12 | Merck Patent Gmbh | Anti-cd19 antibodies with reduced immunogenicity |
| EP2468293B1 (de) | 2006-09-28 | 2014-10-22 | Merck Sharp & Dohme Corp. | Verwendung von pegyliertem il-10 zur verhinderung von lungenkrebs metastasen |
| KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8Ｆｃ |
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| US10080799B2 (en) * | 2010-02-12 | 2018-09-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
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| RU2679889C2 (ru) | 2013-04-18 | 2019-02-14 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
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-
2005
- 2005-12-08 JP JP2007544816A patent/JP4937132B2/ja not_active Expired - Fee Related
- 2005-12-08 KR KR1020077012885A patent/KR20070085886A/ko not_active Application Discontinuation
- 2005-12-08 AU AU2005313492A patent/AU2005313492B2/en not_active Ceased
- 2005-12-08 RU RU2007125381/10A patent/RU2437893C2/ru not_active IP Right Cessation
- 2005-12-08 US US11/297,166 patent/US7589179B2/en not_active Expired - Fee Related
- 2005-12-08 EP EP05850240A patent/EP1819728B1/de not_active Not-in-force
- 2005-12-08 BR BRPI0519000-2A patent/BRPI0519000A2/pt not_active IP Right Cessation
- 2005-12-08 WO PCT/EP2005/013145 patent/WO2006061219A2/en active Application Filing
- 2005-12-08 ES ES05850240T patent/ES2342964T3/es active Active
- 2005-12-08 AT AT05850240T patent/ATE465176T1/de not_active IP Right Cessation
- 2005-12-08 CA CA2591297A patent/CA2591297C/en not_active Expired - Fee Related
- 2005-12-08 CN CN2005800422055A patent/CN101072793B/zh not_active Expired - Fee Related
- 2005-12-08 DE DE602005020837T patent/DE602005020837D1/de active Active
-
2007
- 2007-07-06 ZA ZA200705559A patent/ZA200705559B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0519000A2 (pt) | 2008-12-23 |
| CA2591297A1 (en) | 2006-06-15 |
| WO2006061219A2 (en) | 2006-06-15 |
| ZA200705559B (en) | 2008-10-29 |
| JP2008522600A (ja) | 2008-07-03 |
| RU2007125381A (ru) | 2009-01-20 |
| CA2591297C (en) | 2015-01-13 |
| US20060141581A1 (en) | 2006-06-29 |
| AU2005313492A1 (en) | 2006-06-15 |
| CN101072793B (zh) | 2012-06-20 |
| KR20070085886A (ko) | 2007-08-27 |
| EP1819728A2 (de) | 2007-08-22 |
| JP4937132B2 (ja) | 2012-05-23 |
| WO2006061219A3 (en) | 2007-01-11 |
| CN101072793A (zh) | 2007-11-14 |
| RU2437893C2 (ru) | 2011-12-27 |
| EP1819728B1 (de) | 2010-04-21 |
| ES2342964T3 (es) | 2010-07-20 |
| US7589179B2 (en) | 2009-09-15 |
| AU2005313492B2 (en) | 2011-12-15 |
| DE602005020837D1 (de) | 2010-06-02 |
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