ATE451915T1 - Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren - Google Patents

Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren

Info

Publication number: ATE451915T1
Authority: AT; Austria
Prior art keywords: release device; extended release; ocular administration; carboanhydrase inhibitors; carboanhydrase
Prior art date: 2003-01-24

Application number

AT04704793T

Other languages

English (en)

Inventor

Paul Ashton

Hong Guo

Original Assignee

Psivida Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-24

Filing date

2004-01-23

Publication date

2010-01-15

2004-01-23 Application filed by Psivida Inc filed Critical Psivida Inc

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE451915T1 publication Critical patent/ATE451915T1/de

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Transplantation (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Nanotechnology (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT04704793T 2003-01-24 2004-01-23 Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren ATE451915T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US44249903P	2003-01-24	2003-01-24
US48331603P	2003-06-26	2003-06-26
US48267703P	2003-06-26	2003-06-26
US50197503P	2003-09-11	2003-09-11
PCT/US2004/001719 WO2004066980A2 (en)	2003-01-24	2004-01-23	Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors

Publications (1)

Publication Number	Publication Date
ATE451915T1 true ATE451915T1 (de)	2010-01-15

Family

ID=32831099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04704793T ATE451915T1 (de)	2003-01-24	2004-01-23	Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren

Country Status (15)

Country	Link
EP (1)	EP1592407B1 (de)
JP (1)	JP2006516619A (de)
KR (1)	KR20050108345A (de)
AR (1)	AR043356A1 (de)
AT (1)	ATE451915T1 (de)
AU (1)	AU2004207507B2 (de)
BR (1)	BRPI0406880A (de)
CA (1)	CA2513752C (de)
DE (1)	DE602004024642D1 (de)
DK (1)	DK1592407T3 (de)
ES (1)	ES2338420T3 (de)
MX (1)	MXPA05007718A (de)
SI (1)	SI1592407T1 (de)
TW (1)	TWI345987B (de)
WO (1)	WO2004066980A2 (de)

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US20050048099A1 (en) *	2003-01-09	2005-03-03	Allergan, Inc.	Ocular implant made by a double extrusion process
AU2005247122C1 (en)	2004-04-30	2012-02-02	Eyegate Pharma S.A.	Irritation-reducing ocular iontophoretic device
FR2869531B1 (fr) *	2004-04-30	2006-07-14	Optis France Sa Sa	Dispositif de iontophorese oculaire diminuant les irritations
WO2006031658A2 (en) *	2004-09-10	2006-03-23	Allergan, Inc.	Therapeutic lacrimal canalicular inserts and related methods
AU2005309854A1 (en) *	2004-11-24	2006-06-01	Therakine Ltd.	An implant for intraocular drug delivery
JP4872076B2 (ja) *	2005-09-15	2012-02-08	国立大学法人長崎大学	硝子体可視化剤
EP3449873A1 (de) *	2006-03-31	2019-03-06	Mati Therapeutics Inc.	Wirkstofffreisetzungsstrukturen und zusammensetzungen für nasolacrimales system
SG138567A1 (en) *	2006-06-21	2008-01-28	Johnson & Johnson Vision Care	Punctal plugs for the delivery of active agents
US20080045911A1 (en) *	2006-06-21	2008-02-21	Borgia Maureen J	Punctal plugs for the delivery of active agents
US9474645B2 (en) *	2006-06-21	2016-10-25	Johnson & Johnson Vision Care, Inc.	Punctal plugs for the delivery of active agents
US9173773B2 (en) *	2006-06-21	2015-11-03	Johnson & Johnson Vision Care, Inc.	Punctal plugs for the delivery of active agents
UY30883A1 (es)	2007-01-31	2008-05-31	Alcon Res	Tapones punctales y metodos de liberacion de agentes terapeuticos
KR101696301B1 (ko) *	2007-09-07	2017-01-13	마티 테라퓨틱스 인코포레이티드	치료 약제의 서방성 약물 코어
US20100158980A1 (en) *	2008-12-18	2010-06-24	Casey Kopczynski	Drug delivery devices for delivery of therapeutic agents
US9180292B2 (en)	2008-12-31	2015-11-10	Eyegate Pharmaceuticals, Inc.	System and method for ocular iontophoresis with buffering
EP3785683B1 (de)	2009-05-18	2023-11-01	Dose Medical Corporation	Arzneimittelfreisetzendes augenimplantat
US10206813B2 (en)	2009-05-18	2019-02-19	Dose Medical Corporation	Implants with controlled drug delivery features and methods of using same
AU2011256259A1 (en) *	2010-05-17	2012-11-08	Novaer Holdings, Inc.	Drug delivery devices for delivery of ocular therapeutic agents
US8349005B2 (en)	2011-01-03	2013-01-08	Masatoshi Murata	Method for burying implant to choroid
EP2734261B1 (de)	2011-07-18	2018-02-21	Mor-Research Applications Ltd.	Vorrichtung zur einstellung des augeninnendrucks
EP2830553B1 (de)	2012-03-26	2017-12-27	Glaukos Corporation	Gerät zum einführen mehrerer augenimplantate
US10517759B2 (en)	2013-03-15	2019-12-31	Glaukos Corporation	Glaucoma stent and methods thereof for glaucoma treatment
WO2017040853A1 (en)	2015-09-02	2017-03-09	Glaukos Corporation	Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en)	2015-09-25	2017-03-30	Glaukos Corporation	Punctal implants with controlled drug delivery features and methods of using same
AU2017246889B2 (en) *	2016-04-05	2021-12-16	Forsight Vision4, Inc.	Implantable ocular drug delivery devices
US11219598B2 (en)	2016-05-06	2022-01-11	Public University Corporation Nagoya City University	Ophthalmic drug sustained release device
WO2019191700A1 (en) *	2018-03-29	2019-10-03	Mati Therapeutics	Ophthalmic drug sustained release formulation and uses for dry eye syndrome treatment
AU2021340733A1 (en) *	2020-09-14	2023-05-18	EyePoint Pharmaceuticals, Inc.	Bioerodible ocular drug delivery insert and therapeutic method

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
US5378475A (en) *	1991-02-21	1995-01-03	University Of Kentucky Research Foundation	Sustained release drug delivery devices
US5422116A (en) *	1994-02-18	1995-06-06	Ciba-Geigy Corporation	Liquid ophthalmic sustained release delivery system
US5902598A (en) *	1997-08-28	1999-05-11	Control Delivery Systems, Inc.	Sustained release drug delivery devices
US6196993B1 (en) *	1998-04-20	2001-03-06	Eyelab Group, Llc	Ophthalmic insert and method for sustained release of medication to the eye
US6375972B1 (en) *	2000-04-26	2002-04-23	Control Delivery Systems, Inc.	Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
EP1404297B1 (de) *	2001-06-12	2011-04-27	The Johns Hopkins University School Of Medicine	Reservoirvorrichtung für die intraokulare arzneimittelabgabe
BRPI0406879B1 (pt) *	2003-01-24	2015-12-22	Control Delivery Sys Inc	dispositivo de liberação de droga de liberação sustentada

2004
- 2004-01-23 AT AT04704793T patent/ATE451915T1/de not_active IP Right Cessation
- 2004-01-23 SI SI200431353T patent/SI1592407T1/sl unknown
- 2004-01-23 EP EP04704793A patent/EP1592407B1/de not_active Expired - Lifetime
- 2004-01-23 KR KR1020057013640A patent/KR20050108345A/ko not_active Application Discontinuation
- 2004-01-23 AR ARP040100202A patent/AR043356A1/es unknown
- 2004-01-23 BR BR0406880-7A patent/BRPI0406880A/pt not_active IP Right Cessation
- 2004-01-23 MX MXPA05007718A patent/MXPA05007718A/es active IP Right Grant
- 2004-01-23 JP JP2006502934A patent/JP2006516619A/ja active Pending
- 2004-01-23 AU AU2004207507A patent/AU2004207507B2/en not_active Ceased
- 2004-01-23 DK DK04704793.1T patent/DK1592407T3/da active
- 2004-01-23 WO PCT/US2004/001719 patent/WO2004066980A2/en active Application Filing
- 2004-01-23 ES ES04704793T patent/ES2338420T3/es not_active Expired - Lifetime
- 2004-01-23 CA CA2513752A patent/CA2513752C/en not_active Expired - Fee Related
- 2004-01-23 DE DE602004024642T patent/DE602004024642D1/de not_active Expired - Lifetime
- 2004-01-27 TW TW093101756A patent/TWI345987B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2513752C (en)	2012-01-03
JP2006516619A (ja)	2006-07-06
CA2513752A1 (en)	2004-08-12
BRPI0406880A (pt)	2006-01-03
TW200505507A (en)	2005-02-16
TWI345987B (en)	2011-08-01
EP1592407A2 (de)	2005-11-09
WO2004066980A3 (en)	2004-09-16
AU2004207507B2 (en)	2009-11-19
WO2004066980A2 (en)	2004-08-12
ES2338420T3 (es)	2010-05-07
AR043356A1 (es)	2005-07-27
KR20050108345A (ko)	2005-11-16
SI1592407T1 (sl)	2010-04-30
EP1592407B1 (de)	2009-12-16
DK1592407T3 (da)	2010-04-19
DE602004024642D1 (de)	2010-01-28
MXPA05007718A (es)	2005-09-30
AU2004207507A1 (en)	2004-08-12

Publication	Publication Date	Title
ATE451915T1 (de)	2010-01-15	Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren
DE602004022227D1 (de)	2009-09-10	Vorrichtung zur Extraktion und Mazeration von Gewebe
ATE512636T1 (de)	2011-07-15	System und verfahren zur identifizierung und kontrolle von ophthalmischen chirurgischen vorrichtungen und komponenten
ATE448756T1 (de)	2009-12-15	Vorrichtung zur temporären schienung von zehen
EP1701664A4 (de)	2010-11-24	System und verfahren zur behandlung von gewebe
DE602004011164D1 (de)	2008-02-21	Vorrichtung und Methode zur Anzeige von Informationen
ATE419830T1 (de)	2009-01-15	Methoden und darreichungsformen zur kontrollierten freisetzung von oxykodon
ATE307618T1 (de)	2005-11-15	Vorrichtung zur abgabe von flüchtigen stoffen
DE602004006105D1 (de)	2007-06-06	Vorrichtung zur auswertung und optimierung ventrikulärer synchronisation
DE602004019713D1 (de)	2009-04-09	Vorrichtung und verfahren zur synchronisierten antitachykarden stimulation
ATE403490T1 (de)	2008-08-15	Vorrichtung zur hydratisierung von trockenem polymer und verwendungsverfahren
DE60313297D1 (de)	2007-05-31	Gerät zum nachweis und zur behandlung von synkope
EP1893265A4 (de)	2011-11-16	Verfahren und gerät zur verbesserung der compliance von cpap-patienten
ATE440595T1 (de)	2009-09-15	Vorrichtung mit verlängerter freisetzung und verfahren zur okularen verabreichung von adrenergen wirkstoffen
DE602004010310D1 (de)	2008-01-03	Vorrichtung und verfahren zur leichteren handhabung von rohren
EP1816990A4 (de)	2009-10-14	Systeme, vorrichtungen und verfahren zur behandlung von bandscheibenerkrankungen
DE60304912D1 (de)	2006-06-08	Vorrichtung und Methode zur Detektion von Objekten
EP1881793A4 (de)	2011-03-09	Knochenimplantationsvorrichtung und anwendungsverfahren dafür
DE602005026984D1 (de)	2011-04-28	Chinolin-derivate zur behandlung von latenter tuberkulose
EP1590571A4 (de)	2010-12-01	Verfahren zur flüssigkeitsübertragung und mikroschlauchradpumpe
DE602004024362D1 (de)	2010-01-14	Chirurgische Zugangsvorrichtung und Verfahren zur Herstellung
DE602004032478D1 (de)	2011-06-09	Eidung und verfahren zur stromlosen metallabscheidung unter verwendung davon
ATE296628T1 (de)	2005-06-15	Integrinhemmer zur behandlung von augenkrankheiten
DE502004010500D1 (de)	2010-01-21	Vorrichtung zur koagulation von gewebe
EP1812012A4 (de)	2010-02-17	Protein-tyrosin-phosphatasehemmer und verfahren zu ihrer verwendung

Legal Events

Date	Code	Title	Description
2010-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties