ATE450514T1 - Piperazinylalkylpyrazol-derivate zur verwendung als selektive calciumkanalblocker des t-typs und verfahren zu ihrer herstellung - Google Patents
Piperazinylalkylpyrazol-derivate zur verwendung als selektive calciumkanalblocker des t-typs und verfahren zu ihrer herstellungInfo
- Publication number
- ATE450514T1 ATE450514T1 AT06254404T AT06254404T ATE450514T1 AT E450514 T1 ATE450514 T1 AT E450514T1 AT 06254404 T AT06254404 T AT 06254404T AT 06254404 T AT06254404 T AT 06254404T AT E450514 T1 ATE450514 T1 AT E450514T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazinylalkylpyrazole
- derivatives
- calcium channel
- production
- channel blockers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050079095A KR100654328B1 (ko) | 2005-08-26 | 2005-08-26 | 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450514T1 true ATE450514T1 (de) | 2009-12-15 |
Family
ID=37529291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06254404T ATE450514T1 (de) | 2005-08-26 | 2006-08-22 | Piperazinylalkylpyrazol-derivate zur verwendung als selektive calciumkanalblocker des t-typs und verfahren zu ihrer herstellung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7544686B2 (de) |
| EP (1) | EP1757590B1 (de) |
| KR (1) | KR100654328B1 (de) |
| AT (1) | ATE450514T1 (de) |
| DE (1) | DE602006010776D1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100882925B1 (ko) | 2007-06-14 | 2009-02-10 | 한국과학기술연구원 | 세로토닌 5-ｈｔ₃ａ 길항적 효과를 갖는 피라졸 유도체함유 약제 조성물 |
| KR101014887B1 (ko) | 2008-06-26 | 2011-02-15 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 이미다졸릴알킬카르보닐유도체 및 그의 제조방법 |
| KR101052065B1 (ko) | 2008-10-15 | 2011-07-27 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법 |
| ES2565193T3 (es) | 2010-07-15 | 2016-04-01 | Sumitomo Dainippon Pharma Co., Ltd. | Compuesto de pirazol |
| WO2012105594A1 (ja) | 2011-02-01 | 2012-08-09 | 協和発酵キリン株式会社 | 縮環複素環誘導体 |
| TW201410677A (zh) | 2012-07-31 | 2014-03-16 | Kyowa Hakko Kirin Co Ltd | 縮環雜環化合物 |
| CN105636445B (zh) | 2013-10-17 | 2018-12-07 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| JP2016539095A (ja) | 2013-10-17 | 2016-12-15 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| MX2016004941A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
| EP3057426A4 (de) | 2013-10-17 | 2017-03-29 | Dow AgroSciences LLC | Verfahren zur herstellung von pestizidverbindungen |
| MX2016004940A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
| JP2016535008A (ja) | 2013-10-17 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除化合物の調製法 |
| CA2925595A1 (en) * | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| AR100712A1 (es) * | 2014-06-03 | 2016-10-26 | Actelion Pharmaceuticals Ltd | Compuestos de pirazol como bloqueadores de los canales de calcio tipo t |
| WO2016018442A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| AR098108A1 (es) | 2014-07-31 | 2016-05-04 | Dow Agrosciences Llc | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina |
| CN106488908A (zh) | 2014-07-31 | 2017-03-08 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
| EP3183238A4 (de) | 2014-08-19 | 2018-01-10 | Dow AgroSciences LLC | Verfahren zur herstellung von 3(-3-chlor-1h-pyrazol-1-yl)pyridin |
| KR20170058388A (ko) | 2014-09-12 | 2017-05-26 | 다우 아그로사이언시즈 엘엘씨 | 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법 |
| WO2017070680A1 (en) | 2015-10-22 | 2017-04-27 | Cavion Llc | Methods for treating angelman syndrome and related disorders |
| EP3562807B1 (de) | 2016-12-29 | 2022-08-03 | Corteva Agriscience LLC | Verfahren zur herstellung von pestizidverbindungen |
| US10233155B2 (en) | 2016-12-29 | 2019-03-19 | Dow Agrosciences Llc | Processes for the preparation of pesticide compounds |
| JP7134178B2 (ja) | 2017-02-15 | 2022-09-09 | カビオン・インコーポレイテッド | カルシウムチャネル阻害剤 |
| US11324733B2 (en) | 2017-04-26 | 2022-05-10 | Cavion, Inc. | Methods for improving memory and cognition and for treating memory and cognitive disorders |
| WO2020072773A1 (en) | 2018-10-03 | 2020-04-09 | Cavion, Inc. | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| CN114340670A (zh) | 2019-07-11 | 2022-04-12 | 普拉克西斯精密药物股份有限公司 | T-型钙通道调节剂的制剂及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032526A (en) | 1975-10-02 | 1977-06-28 | American Cyanamid Company | 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts |
| PH22783A (en) | 1986-02-27 | 1988-12-12 | Duphar Int Res | New aryl-substituted (n-piperidinyl)methyl-and (n-piperazinyl)methylazoles and pharmaceutical compositions containing the same |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| JPH09227524A (ja) * | 1996-02-29 | 1997-09-02 | Taisho Pharmaceut Co Ltd | フェニルピラゾール誘導体 |
| US5808088A (en) | 1997-04-30 | 1998-09-15 | Roche Colorado Corporation | Preparation of mibefradil via an acetamide anion |
-
2005
- 2005-08-26 KR KR1020050079095A patent/KR100654328B1/ko not_active IP Right Cessation
-
2006
- 2006-08-22 AT AT06254404T patent/ATE450514T1/de not_active IP Right Cessation
- 2006-08-22 DE DE602006010776T patent/DE602006010776D1/de active Active
- 2006-08-22 EP EP06254404A patent/EP1757590B1/de not_active Not-in-force
- 2006-08-25 US US11/509,769 patent/US7544686B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070049604A1 (en) | 2007-03-01 |
| US7544686B2 (en) | 2009-06-09 |
| EP1757590B1 (de) | 2009-12-02 |
| EP1757590A1 (de) | 2007-02-28 |
| DE602006010776D1 (de) | 2010-01-14 |
| KR100654328B1 (ko) | 2006-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |