ATE448793T1 - Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens - Google Patents
Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergensInfo
- Publication number
- ATE448793T1 ATE448793T1 AT02713767T AT02713767T ATE448793T1 AT E448793 T1 ATE448793 T1 AT E448793T1 AT 02713767 T AT02713767 T AT 02713767T AT 02713767 T AT02713767 T AT 02713767T AT E448793 T1 ATE448793 T1 AT E448793T1
- Authority
- AT
- Austria
- Prior art keywords
- allergen
- immunogenicity
- allergenity
- constructs
- maintaining
- Prior art date
Links
- 230000005847 immunogenicity Effects 0.000 title abstract 2
- 239000013566 allergen Substances 0.000 title 2
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 101710204410 Scaffold protein Proteins 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27281801P | 2001-03-02 | 2001-03-02 | |
| PCT/US2002/006765 WO2002070665A2 (en) | 2001-03-02 | 2002-03-04 | Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448793T1 true ATE448793T1 (de) | 2009-12-15 |
Family
ID=23041432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02713767T ATE448793T1 (de) | 2001-03-02 | 2002-03-04 | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20030039660A1 (de) |
| EP (1) | EP1499349B1 (de) |
| JP (1) | JP2005508134A (de) |
| CN (1) | CN1610556A (de) |
| AT (1) | ATE448793T1 (de) |
| CA (1) | CA2441476A1 (de) |
| DE (1) | DE60234475D1 (de) |
| DK (1) | DK1499349T3 (de) |
| WO (1) | WO2002070665A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7384635B2 (en) * | 2002-11-01 | 2008-06-10 | Alk-Abello A/S | Protein variants of naturally occurring allergens |
| WO2004078965A1 (ja) * | 2003-03-05 | 2004-09-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 大腸菌における異種蛋白質の製造方法 |
| DE602004009818T2 (de) * | 2003-11-05 | 2008-09-18 | Intercell Ag | Zusammensetzungen, die von melittin abgeleitet sind und peptide enthalten, und verfahren zur potenzierung von immunreaktionen gegen target-antigene |
| WO2006097530A2 (en) | 2005-03-18 | 2006-09-21 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| EP2692732A1 (de) | 2012-08-03 | 2014-02-05 | Stallergenes S.A. | Neues Allergen aus Kreuzkrautpollen und Verwendung davon |
| US10799573B2 (en) * | 2016-03-30 | 2020-10-13 | Regents Of The University Of Minnesota | Pertussis vaccines and methods of making and using |
| US11492645B2 (en) * | 2018-08-29 | 2022-11-08 | Shanghaitech University | Composition and use of Cas protein inhibitors |
| WO2021168343A2 (en) * | 2020-02-19 | 2021-08-26 | Perfect Day, Inc. | Hypoallergenic recombinant milk proteins and compositions comprising the same |
| CN113173982B (zh) * | 2021-04-14 | 2022-09-06 | 中国海洋大学 | Rap v 2蛋白相关的抗原表位肽及其应用 |
| CN114685636B (zh) * | 2022-03-04 | 2024-03-01 | 首都医科大学附属北京同仁医院 | 蒿属植物花粉过敏原、应用及试剂盒 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
| US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| EP0550553B1 (de) | 1990-09-25 | 2000-07-12 | Cantab Pharmaceuticals Research Limited | Bei einer transkomplementenden zellinie erzeugter defektiver virenimpfstoff |
| US5593877A (en) | 1993-03-11 | 1997-01-14 | The Rockefeller University | Nucleic acid and recombinant production of vespid venom hyaluronidase |
| WO1994021807A2 (en) | 1993-03-19 | 1994-09-29 | Cantab Pharmaceuticals Research Limited | Defective mutant non-retroviral virus (e.g. hsv) as vaccine |
| FR2714830B1 (fr) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| JPH10501963A (ja) | 1994-04-15 | 1998-02-24 | ターゲテッド ジェネティクス コーポレイション | 遺伝子送達融合タンパク質 |
| FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| US5804201A (en) | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
| US6432699B1 (en) | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
| KR20010020571A (ko) | 1997-06-30 | 2001-03-15 | 자끄 사비나 | 횡문근중으로 개선된 핵산 전달방법 및 이를 위한콤비네이션 |
| ATE290403T1 (de) | 1997-06-30 | 2005-03-15 | Roussy Inst Gustave | Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens |
| BR9810500A (pt) | 1997-06-30 | 2000-09-05 | Rhone Poulenc Rorer Sa | Sistema e aparelho para a transferência de ácido nucléico in vivo para o interior de células de organismos eucarióticos pluricelulares |
| IL138339A0 (en) * | 1998-03-16 | 2001-10-31 | Alk Abello As | Mutant recombinant allergens |
| US6639054B1 (en) * | 2000-01-06 | 2003-10-28 | Monsanto Technology Llc | Preparation of deallergenized proteins and permuteins |
| US7384635B2 (en) * | 2002-11-01 | 2008-06-10 | Alk-Abello A/S | Protein variants of naturally occurring allergens |
-
2002
- 2002-03-04 US US10/091,135 patent/US20030039660A1/en not_active Abandoned
- 2002-03-04 DE DE60234475T patent/DE60234475D1/de not_active Expired - Lifetime
- 2002-03-04 WO PCT/US2002/006765 patent/WO2002070665A2/en active Application Filing
- 2002-03-04 CA CA002441476A patent/CA2441476A1/en not_active Abandoned
- 2002-03-04 AT AT02713767T patent/ATE448793T1/de not_active IP Right Cessation
- 2002-03-04 JP JP2002570693A patent/JP2005508134A/ja active Pending
- 2002-03-04 CN CNA02809204XA patent/CN1610556A/zh active Pending
- 2002-03-04 DK DK02713767.8T patent/DK1499349T3/da active
- 2002-03-04 EP EP02713767A patent/EP1499349B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030039660A1 (en) | 2003-02-27 |
| JP2005508134A (ja) | 2005-03-31 |
| EP1499349B1 (de) | 2009-11-18 |
| WO2002070665A8 (en) | 2004-12-16 |
| EP1499349A2 (de) | 2005-01-26 |
| WO2002070665A3 (en) | 2004-11-11 |
| DE60234475D1 (de) | 2009-12-31 |
| DK1499349T3 (da) | 2010-04-06 |
| CN1610556A (zh) | 2005-04-27 |
| EP1499349A4 (de) | 2005-11-16 |
| WO2002070665A2 (en) | 2002-09-12 |
| CA2441476A1 (en) | 2002-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |