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ATE447611T1 - Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon - Google Patents

Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Info

Publication number
ATE447611T1
ATE447611T1 AT04816813T AT04816813T ATE447611T1 AT E447611 T1 ATE447611 T1 AT E447611T1 AT 04816813 T AT04816813 T AT 04816813T AT 04816813 T AT04816813 T AT 04816813T AT E447611 T1 ATE447611 T1 AT E447611T1
Authority
AT
Austria
Prior art keywords
disclosed
production
display libraries
polypeptide display
expression vectors
Prior art date
Application number
AT04816813T
Other languages
English (en)
Inventor
Patrick Daugherty
Paul Bessette
Jeffrey Rice
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE447611T1 publication Critical patent/ATE447611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04816813T 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon ATE447611T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49569803P 2003-08-18 2003-08-18
PCT/US2004/026873 WO2005047461A2 (en) 2003-08-18 2004-08-18 Polypeptide display libraries and methods of making and using thereof

Publications (1)

Publication Number Publication Date
ATE447611T1 true ATE447611T1 (de) 2009-11-15

Family

ID=34590081

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04816813T ATE447611T1 (de) 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Country Status (6)

Country Link
US (8) US7256038B2 (de)
EP (1) EP1668114B1 (de)
JP (1) JP4809767B2 (de)
AT (1) ATE447611T1 (de)
DE (1) DE602004023956D1 (de)
WO (1) WO2005047461A2 (de)

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AU2013201000B2 (en) * 2005-08-31 2016-05-12 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
EP3896076A1 (de) 2005-08-31 2021-10-20 The Regents of the University of California Zelluläre peptidsequenzbibliotheken (clips) und verfahren zur verwendung davon
AU2016205006C1 (en) * 2005-08-31 2018-11-01 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
JP5571955B2 (ja) * 2006-10-13 2014-08-13 アーチャー−ダニエルズ−ミッドランド カンパニー 酵母細胞触媒支持体における細胞表面ディスプレイの使用
ATE555128T1 (de) 2006-11-30 2012-05-15 Res Dev Foundation Verbesserte immunglobulin-bibliotheken
US20090035317A1 (en) * 2007-01-12 2009-02-05 Daugherty Patrick S Peptides binding to vascular endothelial growth factor
WO2008118392A2 (en) * 2007-03-22 2008-10-02 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
US8293685B2 (en) 2007-07-26 2012-10-23 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
US8465981B2 (en) * 2007-08-06 2013-06-18 University Of Kentucky Research Foundation Polypeptides, systems, and methods useful for detecting glucose
EP3492488A1 (de) 2007-08-22 2019-06-05 The Regents of The University of California Aktivierbare bindende polypeptide und verfahren zu deren identifikation und anwendung
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
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WO2009111183A1 (en) * 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
CA2749339A1 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
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EP2546342A4 (de) * 2010-03-11 2013-12-04 Riken Verfahren zur auswahl einer polypeptidsequenz, metalloxid oder silicium mit einem bindungspeptid und verwendung davon
EP2882844B1 (de) 2012-08-10 2018-10-03 Cytomx Therapeutics Inc. Protease-resistente systeme für polypeptiddisplay sowie verfahren zu ihrer herstellung und verwendung
US9587001B2 (en) 2012-10-19 2017-03-07 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
PT3406633T (pt) 2013-07-25 2022-05-04 Cytomx Therapeutics Inc Anticorpos multi-específicos, anticorpos ativáveis multi-específicos e métodos de utilização dos mesmos
WO2015116665A2 (en) * 2014-01-28 2015-08-06 Los Alamos National Security, Llc Genetically engineered polymer libraries and methods of using them
EP2933263A1 (de) * 2014-04-17 2015-10-21 Universität Zu Köln Vektor und Verfahren zur Expression von Molekülen von Interesse in einer bakteriellen Zelle
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CA3071799C (en) * 2017-07-31 2022-12-13 The University Of Tokyo Super versatile method for presenting cyclic peptide motif on protein structure
BR112020007309A2 (pt) 2017-10-14 2020-09-29 Cytomx Therapeutics, Inc. anticorpos, anticorpos ativáveis, anticorpos biespecíficos e anticorpos ativáveis biespecíficos e métodos de uso dos mesmos
WO2019104529A1 (zh) * 2017-11-29 2019-06-06 深圳琅技生命科技有限公司 均相检测方法
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WO2025083029A1 (en) 2023-10-20 2025-04-24 Universita' Ca' Foscari Di Venezia Libraries of macrocyclic peptides displayed on the surface of yeast cells

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US20090035317A1 (en) 2007-01-12 2009-02-05 Daugherty Patrick S Peptides binding to vascular endothelial growth factor
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Also Published As

Publication number Publication date
US10041063B2 (en) 2018-08-07
US20050196406A1 (en) 2005-09-08
DE602004023956D1 (de) 2009-12-17
US11078479B2 (en) 2021-08-03
US20200318099A1 (en) 2020-10-08
US7256038B2 (en) 2007-08-14
EP1668114A2 (de) 2006-06-14
US20190264194A1 (en) 2019-08-29
JP4809767B2 (ja) 2011-11-09
US20160032279A1 (en) 2016-02-04
US7612019B2 (en) 2009-11-03
US10544410B2 (en) 2020-01-28
WO2005047461A2 (en) 2005-05-26
US9134309B2 (en) 2015-09-15
US20070099247A1 (en) 2007-05-03
US20100113303A1 (en) 2010-05-06
US20130210673A1 (en) 2013-08-15
US8361933B2 (en) 2013-01-29
US20220119802A1 (en) 2022-04-21
EP1668114B1 (de) 2009-11-04
WO2005047461A3 (en) 2006-05-11
JP2007513602A (ja) 2007-05-31
EP1668114A4 (de) 2007-02-28

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