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ATE440605T1 - Verfahren zur herstellung von camptothecin- derivaten - Google Patents

Verfahren zur herstellung von camptothecin- derivaten

Info

Publication number
ATE440605T1
ATE440605T1 AT05756335T AT05756335T ATE440605T1 AT E440605 T1 ATE440605 T1 AT E440605T1 AT 05756335 T AT05756335 T AT 05756335T AT 05756335 T AT05756335 T AT 05756335T AT E440605 T1 ATE440605 T1 AT E440605T1
Authority
AT
Austria
Prior art keywords
producing
derivatives
camptothecine
camptothecine derivatives
irinotecan
Prior art date
Application number
AT05756335T
Other languages
English (en)
Inventor
Ragina Naidu
Original Assignee
Chatham Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE440605(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chatham Biotec Ltd filed Critical Chatham Biotec Ltd
Application granted granted Critical
Publication of ATE440605T1 publication Critical patent/ATE440605T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AT05756335T 2004-05-28 2005-05-27 Verfahren zur herstellung von camptothecin- derivaten ATE440605T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/857,170 US20050267141A1 (en) 2004-05-28 2004-05-28 Process to prepare camptothecin derivatives
PCT/US2005/018793 WO2005117879A1 (en) 2004-05-28 2005-05-27 Process to prepare camptothecin derivatives

Publications (1)

Publication Number Publication Date
ATE440605T1 true ATE440605T1 (de) 2009-09-15

Family

ID=34971729

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05756335T ATE440605T1 (de) 2004-05-28 2005-05-27 Verfahren zur herstellung von camptothecin- derivaten

Country Status (8)

Country Link
US (2) US20050267141A1 (de)
EP (1) EP1791539B2 (de)
CN (1) CN101022805A (de)
AT (1) ATE440605T1 (de)
CA (1) CA2568523A1 (de)
DE (1) DE602005016282D1 (de)
TW (1) TW200607810A (de)
WO (1) WO2005117879A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
ATE446299T1 (de) 2005-02-07 2009-11-15 Fermion Oy Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
WO2006084940A1 (en) 2005-02-08 2006-08-17 Fermion Oy Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
US7767813B2 (en) 2005-02-08 2010-08-03 Fermion Oy Preparation method
EP2170329B1 (de) * 2007-06-25 2014-12-17 ScinoPharm Taiwan Ltd. Verfahren zur herstellung eines kristallinen polymorphs aus 7-ethyl-10-hydroxycamptothecin
CN101337966B (zh) * 2007-07-06 2011-05-18 江苏恒瑞医药股份有限公司 一种制备高纯度伊立替康的方法
US8993309B2 (en) * 2008-03-31 2015-03-31 Boston Medical Center Corporation Predictive marker for topoisomerase I inhibitors
US11467158B2 (en) 2012-10-29 2022-10-11 Boston Medical Center Corporation BRCA1 mutations as predictive markers for topoisomerase inhibitions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5391571A (en) 1989-11-15 1995-02-21 American Home Products Corporation Cholesterol ester hydrolase inhibitors
US5112859A (en) 1990-09-14 1992-05-12 American Home Products Corporation Biphenyl amide cholesterol ester hydrolase inhibitors
ES2137932T3 (es) 1990-09-28 2000-01-01 Smithkline Beecham Corp Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina.
IE913790A1 (en) 1990-10-31 1992-05-22 Smithkline Beecham Corp SUBSTITUTED INDOLIZINO [1,2-b]QUINOLINONES
IL117684A (en) * 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
WO1999055674A1 (fr) 1998-04-28 1999-11-04 Dainippon Pharmaceutical Co., Ltd. Derives de 1-[(1-substituee-4-piperidinyle)methyle]-4-piperidine, procede de production de ceux-ci, compositions medicinales contenant ces composes et intermediaires de ces composes
US6043367A (en) 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
ATE327974T1 (de) 2000-10-28 2006-06-15 Pfizer Prod Inc Modulatoren des glucocorticoid-rezeptors
DE10250082A1 (de) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof

Also Published As

Publication number Publication date
DE602005016282D1 (de) 2009-10-08
US8592588B2 (en) 2013-11-26
CA2568523A1 (en) 2005-12-15
US20080280935A1 (en) 2008-11-13
EP1791539B1 (de) 2009-08-26
EP1791539B2 (de) 2012-11-21
EP1791539A1 (de) 2007-06-06
US20050267141A1 (en) 2005-12-01
CN101022805A (zh) 2007-08-22
WO2005117879A1 (en) 2005-12-15
TW200607810A (en) 2006-03-01

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties