ATE44047T1 - Verfahren zur herstellung von interferonen. - Google Patents
Verfahren zur herstellung von interferonen.Info
- Publication number
- ATE44047T1 ATE44047T1 AT84114368T AT84114368T ATE44047T1 AT E44047 T1 ATE44047 T1 AT E44047T1 AT 84114368 T AT84114368 T AT 84114368T AT 84114368 T AT84114368 T AT 84114368T AT E44047 T1 ATE44047 T1 AT E44047T1
- Authority
- AT
- Austria
- Prior art keywords
- interferon
- interferons
- production
- culture
- expression vector
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title abstract 5
- 108010050904 Interferons Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940047124 interferons Drugs 0.000 title 1
- 229940079322 interferon Drugs 0.000 abstract 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- -1 iron ion Chemical class 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58227750A JPS60118196A (ja) | 1983-11-30 | 1983-11-30 | インタ−フェロンの製造法 |
| EP84114368A EP0144064B1 (de) | 1983-11-30 | 1984-11-28 | Verfahren zur Herstellung von Interferonen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE44047T1 true ATE44047T1 (de) | 1989-06-15 |
Family
ID=16865782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84114368T ATE44047T1 (de) | 1983-11-30 | 1984-11-28 | Verfahren zur herstellung von interferonen. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4656131A (de) |
| EP (1) | EP0144064B1 (de) |
| JP (1) | JPS60118196A (de) |
| KR (1) | KR920006868B1 (de) |
| AT (1) | ATE44047T1 (de) |
| CA (1) | CA1256814A (de) |
| DE (1) | DE3478699D1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| FI90990C (fi) * | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
| ATE81675T1 (de) * | 1985-04-30 | 1992-11-15 | Takeda Chemical Industries Ltd | Produktion eines proteins. |
| DE3532134A1 (de) * | 1985-09-10 | 1987-03-12 | Basf Ag | Verfahren zur herstellung von proteinen bestimmter n-terminaler struktur mit hilfe von prokaryonten |
| US5210029A (en) * | 1985-10-03 | 1993-05-11 | Takeda Chemical Industries, Ltd. | Method of producing interleukin-2 |
| DE3642096A1 (de) * | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| US5177011A (en) * | 1988-08-18 | 1993-01-05 | Calgene, Inc. | Plant elongation factor promoters, coding sequences and uses |
| WO1990002172A1 (en) * | 1988-08-18 | 1990-03-08 | Calgene, Inc. | Plant elongation factor, promoters, coding sequences and uses |
| US5508192A (en) * | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) * | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| DE69231306T2 (de) * | 1991-02-26 | 2001-01-11 | Zeneca Ltd., London | Fermentationsverfahren zur Herstellung von Peptiden durch einen Wirt |
| US5676942A (en) * | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| DE69324671D1 (de) * | 1992-02-10 | 1999-06-02 | Interferon Sciences Inc | Verbesserte alpha-interferon-zusammensetzung und verfahren zu ihrer herstellung aus leukocyten des menschlichen peripheren blute |
| US5487986A (en) * | 1994-03-10 | 1996-01-30 | Genzyme Corporation | Method for increasing plasmid yield |
| US5814485A (en) * | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
| US20030108997A1 (en) * | 2001-09-20 | 2003-06-12 | Mahr Klaus Di. | Optimizing temperature shifting in high cell density fermentations |
| JP4149253B2 (ja) * | 2002-12-17 | 2008-09-10 | 忠行 今中 | 微生物の低温培養方法 |
| MX2009009240A (es) * | 2007-03-02 | 2009-09-08 | Wyeth Corp | Uso de cobre y glutamato en el cultivo celular para la produccion de polipeptidos. |
| RU2631001C2 (ru) * | 2010-08-30 | 2017-09-15 | Ф.Хоффманн-Ля Рош Аг | Способ получения полипептида |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065156A (en) * | 1961-08-29 | 1962-11-20 | Organon | Electrolytic ph regulator |
| JPS57194787A (en) * | 1981-05-28 | 1982-11-30 | Ajinomoto Co Inc | Culture medium for animal cell |
| GB2108510B (en) * | 1981-10-03 | 1984-12-12 | Ciba Geigy Ag | Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof |
| US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
| JPS59181224A (ja) * | 1983-03-29 | 1984-10-15 | Sumitomo Chem Co Ltd | 安定なインタ−フエロン製剤の製法 |
| US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
-
1983
- 1983-11-30 JP JP58227750A patent/JPS60118196A/ja active Granted
-
1984
- 1984-11-26 US US06/674,598 patent/US4656131A/en not_active Expired - Lifetime
- 1984-11-28 DE DE8484114368T patent/DE3478699D1/de not_active Expired
- 1984-11-28 EP EP84114368A patent/EP0144064B1/de not_active Expired
- 1984-11-28 AT AT84114368T patent/ATE44047T1/de not_active IP Right Cessation
- 1984-11-29 CA CA000468911A patent/CA1256814A/en not_active Expired
- 1984-11-29 KR KR1019840007522A patent/KR920006868B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0515435B2 (de) | 1993-03-01 |
| DE3478699D1 (en) | 1989-07-20 |
| KR920006868B1 (ko) | 1992-08-21 |
| KR850003735A (ko) | 1985-06-26 |
| EP0144064B1 (de) | 1989-06-14 |
| JPS60118196A (ja) | 1985-06-25 |
| EP0144064A2 (de) | 1985-06-12 |
| US4656131A (en) | 1987-04-07 |
| CA1256814A (en) | 1989-07-04 |
| EP0144064A3 (en) | 1986-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |