ATE433746T1 - Insulinzusammensetzungen mit verbesserter wirkstoffabsorption - Google Patents

Insulinzusammensetzungen mit verbesserter wirkstoffabsorption

Info

Publication number: ATE433746T1
Authority: AT; Austria
Prior art keywords: formulations; acid; improved active; drug; insulin compositions
Prior art date: 2004-03-12

Application number

AT05728268T

Other languages

English (en)

Inventor

Roderike Pohl

Solomon Steiner

Original Assignee

Biodel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-12

Filing date

2005-03-11

Publication date

2009-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34963134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE433746(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-03-11 Application filed by Biodel Inc filed Critical Biodel Inc

2009-07-15 Application granted granted Critical

2009-07-15 Publication of ATE433746T1 publication Critical patent/ATE433746T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 3
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000010521 absorption reaction Methods 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
239000000546 pharmaceutical excipient Substances 0.000 abstract 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
239000002738 chelating agent Substances 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
238000012377 drug delivery Methods 0.000 abstract 1
239000013583 drug formulation Substances 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1
238000010254 subcutaneous injection Methods 0.000 abstract 1
239000007929 subcutaneous injection Substances 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Zoology (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Dermatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT05728268T 2004-03-12 2005-03-11 Insulinzusammensetzungen mit verbesserter wirkstoffabsorption ATE433746T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US55263704P	2004-03-12	2004-03-12
US60919404P	2004-09-09	2004-09-09
PCT/US2005/008187 WO2005089722A1 (en)	2004-03-12	2005-03-11	Rapid acting drug delivery compositions

Publications (1)

Publication Number	Publication Date
ATE433746T1 true ATE433746T1 (de)	2009-07-15

Family

ID=34963134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05728268T ATE433746T1 (de)	2004-03-12	2005-03-11	Insulinzusammensetzungen mit verbesserter wirkstoffabsorption

Country Status (15)

Country	Link
US (2)	US7279457B2 (de)
EP (3)	EP2106790B1 (de)
JP (2)	JP5022213B2 (de)
AT (1)	ATE433746T1 (de)
AU (1)	AU2005222613B2 (de)
CA (1)	CA2558835C (de)
CY (1)	CY1109235T1 (de)
DE (1)	DE602005014962D1 (de)
DK (2)	DK1740154T3 (de)
ES (3)	ES2328048T3 (de)
HK (2)	HK1099707A1 (de)
PL (2)	PL1740154T3 (de)
PT (2)	PT2319500E (de)
SI (1)	SI1740154T1 (de)
WO (1)	WO2005089722A1 (de)

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2005
- 2005-03-11 ES ES05728268T patent/ES2328048T3/es not_active Expired - Lifetime
- 2005-03-11 SI SI200530737T patent/SI1740154T1/sl unknown
- 2005-03-11 US US11/077,604 patent/US7279457B2/en active Active
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- 2007-07-10 HK HK07107365.5A patent/HK1099707A1/xx not_active IP Right Cessation
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2010
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Publication number	Publication date
ES2398838T3 (es)	2013-03-22
JP2012087153A (ja)	2012-05-10
US20050214251A1 (en)	2005-09-29
AU2005222613B2 (en)	2009-12-17
EP2319500A1 (de)	2011-05-11
CY1109235T1 (el)	2014-07-02
HK1099707A1 (en)	2007-08-24
JP5272086B2 (ja)	2013-08-28
PT1740154E (pt)	2009-09-11
HK1136215A1 (en)	2010-06-25
EP2106790A1 (de)	2009-10-07
CA2558835A1 (en)	2005-09-29
EP2319500B1 (de)	2012-10-24
US20070235365A1 (en)	2007-10-11
CA2558835C (en)	2011-06-28
ES2328048T3 (es)	2009-11-06
AU2005222613A1 (en)	2005-09-29
DK2319500T3 (da)	2013-02-04
ES2398318T3 (es)	2013-03-15
SI1740154T1 (sl)	2009-10-31
JP5022213B2 (ja)	2012-09-12
EP1740154A1 (de)	2007-01-10
JP2007528902A (ja)	2007-10-18
EP2106790B1 (de)	2012-10-24
EP1740154B1 (de)	2009-06-17
PL2319500T3 (pl)	2013-05-31
PL1740154T3 (pl)	2009-11-30
WO2005089722A1 (en)	2005-09-29
DE602005014962D1 (de)	2009-07-30
US7279457B2 (en)	2007-10-09
DK1740154T3 (da)	2009-08-31
PT2319500E (pt)	2013-01-23

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