ATE433491T1 - Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential - Google Patents
Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potentialInfo
- Publication number
- ATE433491T1 ATE433491T1 AT02722030T AT02722030T ATE433491T1 AT E433491 T1 ATE433491 T1 AT E433491T1 AT 02722030 T AT02722030 T AT 02722030T AT 02722030 T AT02722030 T AT 02722030T AT E433491 T1 ATE433491 T1 AT E433491T1
- Authority
- AT
- Austria
- Prior art keywords
- chimeric proteins
- immunogenic potential
- oligomeric complexes
- enhanced immunogenic
- complexes
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title 1
- 102000007474 Multiprotein Complexes Human genes 0.000 abstract 1
- 108010085220 Multiprotein Complexes Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200193 | 2001-01-18 | ||
| PCT/EP2002/000628 WO2002074795A2 (en) | 2001-01-18 | 2002-01-18 | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433491T1 true ATE433491T1 (de) | 2009-06-15 |
Family
ID=8179773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02722030T ATE433491T1 (de) | 2001-01-18 | 2002-01-18 | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7449188B2 (de) |
| EP (1) | EP1362109B1 (de) |
| AT (1) | ATE433491T1 (de) |
| AU (1) | AU2002252978B9 (de) |
| CA (1) | CA2435000C (de) |
| DE (1) | DE60232577D1 (de) |
| DK (1) | DK1362109T3 (de) |
| ES (1) | ES2327719T3 (de) |
| WO (1) | WO2002074795A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2672319T3 (es) | 2002-12-16 | 2018-06-13 | Globeimmune, Inc. | Vacunas basadas en levadura como inmunoterapia |
| ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
| ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| CN106237316A (zh) * | 2006-03-07 | 2016-12-21 | 法克斯因内特公司 | 包含血细胞凝集素的组合物、制造其的方法与使用其的方法 |
| CA2659592C (en) | 2006-07-14 | 2016-10-04 | Konstantin V. Pugachev | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
| EP2069483A4 (de) * | 2006-09-29 | 2010-10-27 | Sanofi Pasteur Biologics Co | Rekombinante rhinovirus-vektoren |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| EP2238253B1 (de) | 2007-11-27 | 2012-09-12 | Medicago Inc. | In transgenen hämagglutinin exprimierenden pflanzen produzierte rekombinante influenza-virus-ähnliche partikel (vlps) |
| JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
| WO2009133463A1 (en) * | 2008-04-30 | 2009-11-05 | University Of Copenhagen | Soluble influenza vaccine |
| DK2294202T3 (en) * | 2008-07-08 | 2015-08-31 | Medicago Inc | SOLUBLE RECOMBINANT INFLUENZA ANTIGENES |
| EP3228627A1 (de) | 2009-06-24 | 2017-10-11 | Medicago Inc. | Chimärische influenza-virus-ähnliche partikel mit hämagglutinin |
| RU2012107702A (ru) | 2009-07-31 | 2013-09-10 | Пэксвэкс, Инк. | Векторы на основе аденовирусов |
| HUE058165T2 (hu) | 2009-09-22 | 2022-07-28 | Medicago Inc | Növényi eredetû fehérjék elõállításának eljárása |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US20130034578A1 (en) * | 2010-04-09 | 2013-02-07 | Petrus Josephus Marie Rottier | Recombinant multimeric influenza proteins |
| RU2583297C2 (ru) * | 2010-07-23 | 2016-05-10 | Исконова Аб | Противогриппозная вакцина |
| DK2689016T3 (en) * | 2011-03-22 | 2015-04-27 | Mucosis Bv | Immunogenic formations in particle form and fremgangmsåder for the production thereof |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| WO2014018858A2 (en) | 2012-07-26 | 2014-01-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Multimeric fusion protein vaccine and immunotherapeutic |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| WO2014070848A1 (en) * | 2012-11-05 | 2014-05-08 | Georgia State University Research Foundation | Universal influenza vaccine based on heterologous multiple m2e proteins |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP6967578B2 (ja) | 2017-11-30 | 2021-11-17 | グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド | 免疫チェックポイント阻害剤ｐｄ−１及びｐｄ−ｌ１に対する抗体治療をモニタリングするためのイムノアッセイ及び操作されたタンパク質 |
| EP3840780A1 (de) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vektoren zur auslösung von immunantworten auf nicht-dominante epitope im hämagglutinin (ha)-protein |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| WO2021150874A1 (en) * | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2022155373A2 (en) * | 2021-01-13 | 2022-07-21 | Purdue Research Foundation | Supramolecular assemblies, compositions and methods for producing and using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
| CA2146559A1 (en) | 1992-10-23 | 1994-05-11 | Melanie K. Spriggs | Methods of preparing soluble, oligomeric proteins |
| US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
| WO1999062953A1 (en) * | 1998-06-04 | 1999-12-09 | Shanghai Second Medical University | A human leucine zipper protein gene (bmh) (cblayd06) |
| CN100534529C (zh) * | 1998-11-30 | 2009-09-02 | 希托斯生物技术股份公司 | 抗原的有序分子呈递，制备及使用的方法 |
| WO2000069907A1 (en) * | 1999-05-14 | 2000-11-23 | Medical Research Council | Protein scaffold and its use to multimerise monomeric polypeptides |
| EP1194451A1 (de) * | 1999-07-02 | 2002-04-10 | Genentech, Inc. | Fusionspeptide die eine peptid-bindende-domäne und eine multimerisierungsdomäne enthalten |
| DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
2002
- 2002-01-18 AT AT02722030T patent/ATE433491T1/de active
- 2002-01-18 DK DK02722030T patent/DK1362109T3/da active
- 2002-01-18 ES ES02722030T patent/ES2327719T3/es not_active Expired - Lifetime
- 2002-01-18 CA CA2435000A patent/CA2435000C/en not_active Expired - Lifetime
- 2002-01-18 DE DE60232577T patent/DE60232577D1/de not_active Expired - Lifetime
- 2002-01-18 AU AU2002252978A patent/AU2002252978B9/en not_active Expired
- 2002-01-18 US US10/466,655 patent/US7449188B2/en not_active Expired - Lifetime
- 2002-01-18 EP EP02722030A patent/EP1362109B1/de not_active Expired - Lifetime
- 2002-01-18 WO PCT/EP2002/000628 patent/WO2002074795A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1362109T3 (da) | 2009-07-27 |
| WO2002074795A3 (en) | 2003-09-04 |
| AU2002252978B9 (en) | 2007-02-01 |
| WO2002074795A2 (en) | 2002-09-26 |
| CA2435000C (en) | 2014-03-25 |
| EP1362109A2 (de) | 2003-11-19 |
| AU2002252978A1 (en) | 2002-10-03 |
| US7449188B2 (en) | 2008-11-11 |
| EP1362109B1 (de) | 2009-06-10 |
| AU2002252978B2 (en) | 2006-12-07 |
| US20040116664A1 (en) | 2004-06-17 |
| DE60232577D1 (de) | 2009-07-23 |
| ES2327719T3 (es) | 2009-11-03 |
| CA2435000A1 (en) | 2002-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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