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ATE424204T1 - Neue indenoisoquinoline als antineoplastische mittel - Google Patents

Neue indenoisoquinoline als antineoplastische mittel

Info

Publication number
ATE424204T1
ATE424204T1 AT99970323T AT99970323T ATE424204T1 AT E424204 T1 ATE424204 T1 AT E424204T1 AT 99970323 T AT99970323 T AT 99970323T AT 99970323 T AT99970323 T AT 99970323T AT E424204 T1 ATE424204 T1 AT E424204T1
Authority
AT
Austria
Prior art keywords
indeno
methylenedioxy
isoquinoline
dioxo
dimethoxy
Prior art date
Application number
AT99970323T
Other languages
English (en)
Inventor
Mark Cushman
Pamela Nagafuji
Muthusamy Jayaraman
Yves Pommier
Original Assignee
Purdue Research Foundation
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Us Gov Health & Human Serv filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ATE424204T1 publication Critical patent/ATE424204T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99970323T 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel ATE424204T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10422698P 1998-10-14 1998-10-14

Publications (1)

Publication Number Publication Date
ATE424204T1 true ATE424204T1 (de) 2009-03-15

Family

ID=22299324

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99970323T ATE424204T1 (de) 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel

Country Status (8)

Country Link
US (1) US6509344B1 (de)
EP (2) EP2050452A1 (de)
JP (1) JP4580556B2 (de)
AT (1) ATE424204T1 (de)
AU (1) AU765135B2 (de)
CA (1) CA2347100C (de)
DE (1) DE69940523D1 (de)
WO (1) WO2000021537A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US6956035B2 (en) 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
EP1453506B1 (de) 2001-11-14 2008-04-02 Rutgers, The State University Topoisomerase-giftmittel
ATE405568T1 (de) * 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
DE60235287D1 (de) * 2001-11-14 2010-03-25 Univ Rutgers Löslich gemachte topoisomerase-gifte
DE60231426D1 (de) * 2001-11-14 2009-04-16 Univ Rutgers Solubilisierte topoisomerase-gift-mittel
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
JP2007501857A (ja) * 2003-02-28 2007-02-01 イノテック ファーマシューティカルズ コーポレーション 四環系ベンズアミド誘導体およびその使用方法
AU2004238329A1 (en) * 2003-05-12 2004-11-25 Purdue Research Foundation Cytotoxic indeno and isoindoloisoquinolones
JP2007527872A (ja) * 2004-02-26 2007-10-04 イノテック ファーマシューティカルズ コーポレイション イソキノリン誘導体及びその使用方法
WO2005089294A2 (en) * 2004-03-17 2005-09-29 Purdue Research Foundation Synthesis of indenoisoquinoliniums and methods of use
US7495100B2 (en) 2004-05-07 2009-02-24 Purdue Research Foundation Synthesis of indenoisoquinolines
CN101137377A (zh) 2005-02-25 2008-03-05 伊诺泰克制药公司 四环氨基和甲酰胺基化合物及其用法
CA2620052A1 (en) 2005-08-24 2007-03-01 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
EP1960366B1 (de) 2005-11-14 2016-07-20 Purdue Research Foundation N-substituierte indenoisochinoline und synthesen davon
US9399660B2 (en) 2005-11-14 2016-07-26 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
CA2677046A1 (en) 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
WO2010077663A2 (en) * 2008-12-08 2010-07-08 Inotek Pharmaceuticals Corporation Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof
ES2401563T3 (es) 2009-03-06 2013-04-22 Rutgers, The State University Of New Jersey Derivados de metilendioxibenzo [I]fenantridina usados para tratar el cáncer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CA2788213A1 (en) * 2010-01-27 2011-08-04 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
US9073920B2 (en) 2010-08-17 2015-07-07 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
US9682990B2 (en) 2011-05-25 2017-06-20 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US9328073B2 (en) 2011-05-25 2016-05-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US8912213B2 (en) 2012-04-13 2014-12-16 Purdue Research Foundation Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
US8686146B2 (en) 2012-07-13 2014-04-01 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
US9034870B2 (en) 2012-07-13 2015-05-19 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
WO2017160898A1 (en) 2016-03-15 2017-09-21 Purdue Research Foundation Aza-a-ring indenoisoquinoline topoisomerase i poisons
CA3019945A1 (en) 2016-04-04 2017-10-12 Rutgers, The State University Of New Jersey Topoisomerase poisons
US10875860B2 (en) 2016-12-22 2020-12-29 Purdue Research Foundation Azaindenoisoquinoline compounds and uses thereof
WO2019182886A1 (en) * 2018-03-20 2019-09-26 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isoquinoline carboxylic acids as sting inhibitors
WO2020023700A2 (en) * 2018-07-25 2020-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
US5597831A (en) * 1991-08-29 1997-01-28 Vufb A.S 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents
CZ281473B6 (cs) * 1991-08-29 1996-10-16 Vúfb, A.S. Deriváty 6-/X-(2-hydroxyethyl)aminoalkyl/-5,11 -dioxo-5,6-dihydro-11H-indeno/1,2-c/-isochinolinu a způsob jejich výroby
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
JP3643916B2 (ja) * 1995-11-17 2005-04-27 大鵬薬品工業株式会社 新規な縮合インデン誘導体又はその塩

Also Published As

Publication number Publication date
EP1123099A1 (de) 2001-08-16
US6509344B1 (en) 2003-01-21
CA2347100A1 (en) 2000-04-20
AU765135B2 (en) 2003-09-11
DE69940523D1 (de) 2009-04-16
EP2050452A1 (de) 2009-04-22
JP4580556B2 (ja) 2010-11-17
AU1204300A (en) 2000-05-01
CA2347100C (en) 2010-12-14
EP1123099A4 (de) 2002-08-21
JP2002527396A (ja) 2002-08-27
EP1123099B1 (de) 2009-03-04
WO2000021537A1 (en) 2000-04-20

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