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NZ335938A - Prodrug forms and new analogues of camptothecin, their use as medicaments - Google Patents

Prodrug forms and new analogues of camptothecin, their use as medicaments

Info

Publication number
NZ335938A
NZ335938A NZ335938A NZ33593897A NZ335938A NZ 335938 A NZ335938 A NZ 335938A NZ 335938 A NZ335938 A NZ 335938A NZ 33593897 A NZ33593897 A NZ 33593897A NZ 335938 A NZ335938 A NZ 335938A
Authority
NZ
New Zealand
Prior art keywords
camptothecin
medicaments
quinolein
oxepino
indolizino
Prior art date
Application number
NZ335938A
Inventor
Dennis Bigg
Olivier Lavergne
Jerry Harnett
Alain Rolland
Anne-Marie Liberatore
Chistophe Lanco
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9615775A external-priority patent/FR2757515B1/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NZ335938A publication Critical patent/NZ335938A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The disclosure concerns counterparts of camptothecin and in particular products complying with the following formulae: 8-ethyl-8,9-dihydro-8-hydroxy-1-benzyl-2H,10H,12H-[1,3]oxazino[5,6-f]oxepino[3',4':6,7]indolizino[1,2-b]quinolein-10,13(15H)-dione; 5-ethyl-9,10-difluoro-4,5-dihydro-5-(2-amino-1-oxoethoxy)-1H-oxepino[3',4':6,7]indolizino[1,2-b]quinolein-3,15(4H,13H)-dione; 5-ethyl-9,10-difluoro-4,5-dihydro-5-(2-amino-1-oxopropoxy)-1H-oxepino[3',4':6,7]indolizino[1,2-b]quinolein-3,15(4H,13H)-dione as pictured. The disclosure also concerns their method of preparation, their application as medicines, the pharmaceutical compositions containing them and their use in producing tumoricidal, antiviral and parasitical medicines.
NZ335938A 1996-12-20 1997-12-05 Prodrug forms and new analogues of camptothecin, their use as medicaments NZ335938A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615775A FR2757515B1 (en) 1996-12-20 1996-12-20 PRODROUGAL FORMS AND NEW CAMPTOTHECIN ANALOGS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR9615945 1996-12-24

Publications (1)

Publication Number Publication Date
NZ335938A true NZ335938A (en) 2000-04-28

Family

ID=26233188

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ335938A NZ335938A (en) 1996-12-20 1997-12-05 Prodrug forms and new analogues of camptothecin, their use as medicaments

Country Status (24)

Country Link
EP (1) EP0946566B1 (en)
JP (1) JP3576174B2 (en)
KR (1) KR100516873B1 (en)
CN (1) CN1090634C (en)
AR (1) AR005849A1 (en)
AT (1) ATE253582T1 (en)
AU (1) AU734512B2 (en)
BR (1) BR9713977B1 (en)
CA (1) CA2275345C (en)
CZ (1) CZ299794B6 (en)
DE (1) DE69726007T2 (en)
DK (1) DK0946566T3 (en)
ES (1) ES2206760T3 (en)
HK (1) HK1024694A1 (en)
HU (1) HUP0001385A3 (en)
IL (2) IL129892A0 (en)
MY (1) MY122042A (en)
NO (1) NO324973B1 (en)
NZ (1) NZ335938A (en)
PL (1) PL188109B1 (en)
PT (1) PT946566E (en)
TW (1) TW410224B (en)
UA (1) UA57757C2 (en)
WO (1) WO1998028304A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
JP2002523495A (en) * 1998-09-02 2002-07-30 ファーマジェネシス， インコーポレイテッド Triptolide prodrug with high water solubility
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2801309B1 (en) * 1999-11-18 2002-01-04 Adir NOVEL CAMPTOTHECIN-LIKE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
WO2003101998A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
CA2548543C (en) * 2003-12-17 2012-01-03 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
BRPI0509732A (en) * 2004-04-09 2007-09-25 Chugai Pharmaceutical Co Ltd water soluble prodrug, pharmaceutical composition, therapeutic agent, antifungal agent and use of said prodrug
ITRM20040288A1 (en) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
FR2892418B1 (en) * 2005-10-24 2010-10-22 Servier Lab NOVEL CAMPTOTHECIN-LIKE HYDROCARBON E-CYCLATE AMINOESTERIFIED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2892417B1 (en) * 2005-10-24 2010-10-22 Servier Lab NOVEL AMINOESTERIFIED 7-CYPROCARBON HYDROCARBON COMPOUNDS COMPRISING CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
CN100465175C (en) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-position substituted homocamptothecin compound and its use as medicine
CN100441580C (en) * 2006-07-14 2008-12-10 中山大学 Quinolinedione derivatives and their application in the preparation of antibacterial drugs
CN102746314B (en) * 2011-04-18 2016-07-06 华东师范大学 Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
WO2023232145A1 (en) * 2022-06-02 2023-12-07 华东师范大学 Small molecule of homocamptothecins and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
WO1997000876A1 (en) * 1995-06-21 1997-01-09 Societe De Conseils De Recherches Et D'applications Scientifiques (Scras) Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

Also Published As

Publication number Publication date
DK0946566T3 (en) 2004-03-15
HUP0001385A2 (en) 2000-10-28
DE69726007D1 (en) 2003-12-11
PL188109B1 (en) 2004-12-31
EP0946566A1 (en) 1999-10-06
AU5326498A (en) 1998-07-17
MY122042A (en) 2006-03-31
PT946566E (en) 2004-03-31
CN1090634C (en) 2002-09-11
IL129892A0 (en) 2000-02-29
NO992997L (en) 1999-08-18
WO1998028304A1 (en) 1998-07-02
BR9713977B1 (en) 2010-06-29
EP0946566B1 (en) 2003-11-05
CA2275345C (en) 2010-01-26
KR100516873B1 (en) 2005-09-26
AR005849A1 (en) 1999-07-21
JP2001506270A (en) 2001-05-15
CA2275345A1 (en) 1998-07-02
BR9713977A (en) 2000-04-11
ATE253582T1 (en) 2003-11-15
AU734512B2 (en) 2001-06-14
NO324973B1 (en) 2008-01-14
KR20000062260A (en) 2000-10-25
HK1024694A1 (en) 2000-10-20
NO992997D0 (en) 1999-06-18
TW410224B (en) 2000-11-01
CZ209299A3 (en) 1999-09-15
CZ299794B6 (en) 2008-11-26
IL129892A (en) 2007-09-20
ES2206760T3 (en) 2004-05-16
DE69726007T2 (en) 2004-06-03
JP3576174B2 (en) 2004-10-13
HUP0001385A3 (en) 2002-12-28
PL334092A1 (en) 2000-01-31
CN1241192A (en) 2000-01-12
UA57757C2 (en) 2003-07-15

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