ATE419873T1 - Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüs - Google Patents
Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüsInfo
- Publication number
- ATE419873T1 ATE419873T1 AT03704133T AT03704133T ATE419873T1 AT E419873 T1 ATE419873 T1 AT E419873T1 AT 03704133 T AT03704133 T AT 03704133T AT 03704133 T AT03704133 T AT 03704133T AT E419873 T1 ATE419873 T1 AT E419873T1
- Authority
- AT
- Austria
- Prior art keywords
- vaccines
- lipopolysaccharide
- lipid
- region
- protein
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 239000002158 endotoxin Substances 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- 229940031348 multivalent vaccine Drugs 0.000 abstract 2
- 229920001542 oligosaccharide Polymers 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 1
- 229940031670 conjugate vaccine Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35838402P | 2002-02-22 | 2002-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419873T1 true ATE419873T1 (de) | 2009-01-15 |
Family
ID=27757735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03704133T ATE419873T1 (de) | 2002-02-22 | 2003-02-24 | Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050147624A1 (de) |
| EP (1) | EP1476197B1 (de) |
| AT (1) | ATE419873T1 (de) |
| AU (1) | AU2003206532A1 (de) |
| CA (1) | CA2477068A1 (de) |
| DE (1) | DE60325696D1 (de) |
| ES (1) | ES2320334T3 (de) |
| WO (1) | WO2003070282A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001078787A2 (en) * | 2000-04-18 | 2001-10-25 | Endobiologics, Incorporated | Lipopolysaccharide-conjugate vaccine for sepsis treatment |
| US7749511B2 (en) | 2000-04-18 | 2010-07-06 | Endobiologics, Incorporated | Anti-sepsis conjugate vaccine |
| HUP0700044A2 (en) | 2004-05-14 | 2009-03-30 | Ca Nat Research Council | Conserved inner core lipopolysaccharide epitopes as multi-species vaccine candidates |
| CA2630404C (en) | 2005-11-23 | 2015-04-14 | National Research Council Of Canada | Method for de-esterification of the lipopolysaccharide layer of neisseria meningitidis and mannheimia haemolytica |
| WO2008013735A2 (en) * | 2006-07-21 | 2008-01-31 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-d-manno-octulsonic acid |
| WO2008133645A2 (en) * | 2006-10-31 | 2008-11-06 | President And Fellows Of Harvard College | Combination vaccine for prevention of tularemia |
| US20090124573A1 (en) | 2007-11-09 | 2009-05-14 | Sarkis Mazmanian | Immunomodulating compounds and related compositions and methods |
| CA2736134A1 (en) * | 2008-09-05 | 2010-03-11 | National Research Council Of Canada | Lps based vaccines |
| AU2010227220B2 (en) | 2009-03-24 | 2014-11-13 | Glaxosmithkline Biologicals S.A. | Combinations of meningococcal factor H binding protein and pneumococcal saccharide conjugates |
| CN104548082A (zh) | 2009-03-24 | 2015-04-29 | 诺华股份有限公司 | 为脑膜炎球菌因子h结合蛋白添加佐剂 |
| WO2011014771A1 (en) * | 2009-07-31 | 2011-02-03 | Wayne State University | Monophosphorylated lipid a derivatives |
| US9259476B2 (en) | 2009-07-31 | 2016-02-16 | Wayne State University | Monophosphorylated lipid A derivatives |
| BR112012004276A2 (pt) | 2009-08-27 | 2017-10-24 | Novartis Ag | adjuvante compreendendo alumínio, oligonucleotídeo e policátion |
| BR112012022896A2 (pt) | 2010-03-18 | 2018-03-27 | Novartis Ag | vacinas adjuvantes para meningococos do sorogrupo b |
| HUE040658T2 (hu) * | 2010-04-07 | 2019-03-28 | California Inst Of Techn | Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek |
| WO2011161653A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
| JP2015505309A (ja) | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
| US11052142B2 (en) * | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| WO2016201342A1 (en) | 2015-06-10 | 2016-12-15 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| JP6918365B2 (ja) * | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US6416763B1 (en) * | 1998-08-28 | 2002-07-09 | Hawaii Biotechnology Group, Inc. | Recombinant nonstructural protein subunit vaccine against flaviviral infection |
| US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| WO2001078787A2 (en) * | 2000-04-18 | 2001-10-25 | Endobiologics, Incorporated | Lipopolysaccharide-conjugate vaccine for sepsis treatment |
| US7537766B2 (en) * | 2004-08-30 | 2009-05-26 | Wyeth | Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof |
| JP4546846B2 (ja) * | 2005-01-24 | 2010-09-22 | 株式会社リコー | 画像形成装置 |
-
2003
- 2003-02-24 CA CA002477068A patent/CA2477068A1/en not_active Abandoned
- 2003-02-24 DE DE60325696T patent/DE60325696D1/de not_active Expired - Lifetime
- 2003-02-24 US US10/505,276 patent/US20050147624A1/en not_active Abandoned
- 2003-02-24 WO PCT/CA2003/000254 patent/WO2003070282A2/en not_active Application Discontinuation
- 2003-02-24 EP EP03704133A patent/EP1476197B1/de not_active Expired - Lifetime
- 2003-02-24 AT AT03704133T patent/ATE419873T1/de not_active IP Right Cessation
- 2003-02-24 ES ES03704133T patent/ES2320334T3/es not_active Expired - Lifetime
- 2003-02-24 AU AU2003206532A patent/AU2003206532A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003206532A1 (en) | 2003-09-09 |
| ES2320334T3 (es) | 2009-05-21 |
| US20050147624A1 (en) | 2005-07-07 |
| CA2477068A1 (en) | 2003-08-28 |
| WO2003070282A2 (en) | 2003-08-28 |
| EP1476197B1 (de) | 2009-01-07 |
| WO2003070282A3 (en) | 2004-02-05 |
| EP1476197A2 (de) | 2004-11-17 |
| DE60325696D1 (de) | 2009-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |