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ATE412414T1 - 3,11b-cis-dihydrotetrabenazin zur behandlung von proliferativen krankheiten oder entzündungen - Google Patents

3,11b-cis-dihydrotetrabenazin zur behandlung von proliferativen krankheiten oder entzündungen

Info

Publication number
ATE412414T1
ATE412414T1 AT06765213T AT06765213T ATE412414T1 AT E412414 T1 ATE412414 T1 AT E412414T1 AT 06765213 T AT06765213 T AT 06765213T AT 06765213 T AT06765213 T AT 06765213T AT E412414 T1 ATE412414 T1 AT E412414T1
Authority
AT
Austria
Prior art keywords
dihydrotetrabenazine
cis
treatment
inflammation
proliferative diseases
Prior art date
Application number
AT06765213T
Other languages
English (en)
Inventor
Andrew Duffield
Jean Elisabeth Yarrow
Original Assignee
Cambridge Lab Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Lab Ireland Ltd filed Critical Cambridge Lab Ireland Ltd
Application granted granted Critical
Publication of ATE412414T1 publication Critical patent/ATE412414T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT06765213T 2005-08-05 2006-08-04 3,11b-cis-dihydrotetrabenazin zur behandlung von proliferativen krankheiten oder entzündungen ATE412414T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0516168.2A GB0516168D0 (en) 2005-08-05 2005-08-05 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ATE412414T1 true ATE412414T1 (de) 2008-11-15

Family

ID=34984180

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06765213T ATE412414T1 (de) 2005-08-05 2006-08-04 3,11b-cis-dihydrotetrabenazin zur behandlung von proliferativen krankheiten oder entzündungen

Country Status (24)

Country Link
US (1) US20090275605A1 (de)
EP (2) EP1964565A1 (de)
JP (1) JP2009503045A (de)
KR (1) KR20080033501A (de)
CN (1) CN101321528B (de)
AT (1) ATE412414T1 (de)
AU (1) AU2006277836B8 (de)
CA (1) CA2620952A1 (de)
CY (1) CY1108729T1 (de)
DE (1) DE602006003415D1 (de)
DK (1) DK1861100T3 (de)
ES (1) ES2317564T3 (de)
GB (1) GB0516168D0 (de)
HK (1) HK1111084A1 (de)
HR (1) HRP20090017T3 (de)
MX (1) MX2008001546A (de)
NZ (1) NZ566010A (de)
PL (1) PL1861100T3 (de)
PT (1) PT1861100E (de)
RS (1) RS50720B (de)
RU (1) RU2409364C2 (de)
SI (1) SI1861100T1 (de)
WO (1) WO2007017643A1 (de)
ZA (2) ZA200801170B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
US8039627B2 (en) 2006-11-08 2011-10-18 Neurocrine Biosciences, Inc. Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol compounds and methods relating thereto
GB0721669D0 (en) * 2007-11-02 2007-12-12 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
GB2463451A (en) 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
CN104744456A (zh) 2010-06-01 2015-07-01 奥斯拜客斯制药有限公司 Vmat2的苯并喹啉酮抑制剂
CN102285984B (zh) * 2010-11-25 2012-10-10 江苏威凯尔医药科技有限公司 (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法
EP3099299A4 (de) 2014-01-27 2017-10-04 Auspex Pharmaceuticals, Inc. Benzochinolinhemmer des vesikel-monoamin-transporters 2
MA41177A (fr) * 2014-12-15 2017-10-24 Esteve Labor Dr Utilisation de ligands des récepteurs sigma dans l'arthrose
US10550120B2 (en) 2016-03-25 2020-02-04 Tohoku University Indole alkaloid compound having immune checkpoint inhibitory action
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109283263B (zh) * 2017-07-21 2019-06-25 南京正大天晴制药有限公司 用于雷替曲塞合成质量控制的检测分析方法

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US3132147A (en) * 1964-05-05
US3079395A (en) * 1963-02-26 Novel z-oxq-benzoquinoliaine
US3009918A (en) * 1961-11-21 Chz ch
US2830993A (en) 1958-04-15 Quinolizine derivatives
US3209005A (en) * 1965-09-28 Hexahydro-llbh-benzo[a] quinolizines and processes therefor
US2843591A (en) 1958-07-15 Method for preparing same
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GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
KR100682506B1 (ko) * 2005-01-18 2007-02-15 (주)젠크로스 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DK1861100T3 (da) 2008-12-15
PL1861100T3 (pl) 2009-06-30
CN101321528A (zh) 2008-12-10
ZA200801170B (en) 2009-12-30
EP1964565A1 (de) 2008-09-03
NZ566010A (en) 2010-05-28
CY1108729T1 (el) 2014-04-09
HK1111084A1 (en) 2008-08-01
EP1861100B1 (de) 2008-10-29
US20090275605A1 (en) 2009-11-05
AU2006277836A1 (en) 2007-02-15
ZA200801171B (en) 2009-08-26
JP2009503045A (ja) 2009-01-29
GB0516168D0 (en) 2005-09-14
KR20080033501A (ko) 2008-04-16
RU2008108516A (ru) 2009-09-10
MX2008001546A (es) 2008-04-04
RU2409364C2 (ru) 2011-01-20
RS50720B (sr) 2010-08-31
AU2006277836B2 (en) 2011-11-10
DE602006003415D1 (de) 2008-12-11
PT1861100E (pt) 2008-12-26
AU2006277836B8 (en) 2011-12-08
CA2620952A1 (en) 2007-02-15
ES2317564T3 (es) 2009-04-16
CN101321528B (zh) 2011-05-25
EP1861100A1 (de) 2007-12-05
SI1861100T1 (sl) 2009-04-30
WO2007017643A1 (en) 2007-02-15
HRP20090017T3 (en) 2009-03-31

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