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ATE404583T1 - FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY - Google Patents

FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY

Info

Publication number
ATE404583T1
ATE404583T1 AT99965744T AT99965744T ATE404583T1 AT E404583 T1 ATE404583 T1 AT E404583T1 AT 99965744 T AT99965744 T AT 99965744T AT 99965744 T AT99965744 T AT 99965744T AT E404583 T1 ATE404583 T1 AT E404583T1
Authority
AT
Austria
Prior art keywords
hedgehog
functional antagonists
variants
ability
hedgehog activity
Prior art date
Application number
AT99965744T
Other languages
German (de)
Inventor
Kevin Williams
Paul Rayhorn
Ellen Garber
Blake Pepinsky
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of ATE404583T1 publication Critical patent/ATE404583T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the functional antagonists are also described.
AT99965744T 1998-11-02 1999-11-02 FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY ATE404583T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10670398P 1998-11-02 1998-11-02

Publications (1)

Publication Number Publication Date
ATE404583T1 true ATE404583T1 (en) 2008-08-15

Family

ID=22312815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965744T ATE404583T1 (en) 1998-11-02 1999-11-02 FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY

Country Status (9)

Country Link
US (1) US8410061B2 (en)
EP (1) EP1133519B1 (en)
JP (1) JP4574012B2 (en)
AT (1) ATE404583T1 (en)
AU (1) AU765485B2 (en)
CA (1) CA2348773C (en)
DE (1) DE69939327D1 (en)
IL (2) IL142905A0 (en)
WO (1) WO2000025725A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE449836T1 (en) 1997-02-10 2009-12-15 Harvard College METHOD FOR MODULATING HEMATOPOASIS AND VASCULAR GROWTH
JP2001525341A (en) * 1997-11-28 2001-12-11 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング Active hedgehog protein variants, their preparation and application to medicine
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
JP2003502292A (en) * 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド Polymer conjugates and uses of hedgehog proteins
ES2233383T3 (en) * 1999-06-08 2005-06-16 Lorantis Limited THERAPEUTIC USE OF A HEDGEHOG SIGNALING ROAD IHIBITOR.
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
IL149202A0 (en) * 1999-11-05 2002-11-10 Biogen Inc Hedgehog fusion proteins and uses
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US20030022819A1 (en) * 2000-06-16 2003-01-30 Ling Leona E. Angiogenesis-modulating compositions and uses
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001276722A1 (en) * 2000-08-04 2002-02-18 Takeda Chemical Industries Ltd. Use of gli1 gene
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
EP1387674B1 (en) * 2000-10-13 2017-01-18 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
EP1730280B1 (en) 2004-03-26 2018-10-24 Curis, Inc. Rna interference modulators of hedgehog signaling and uses thereof
EP2511298B1 (en) 2005-10-31 2019-01-16 Oncomed Pharmaceuticals, Inc. Compositions and Methods for Treating Cancer based on human FZD receptors
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US8026354B2 (en) 2005-11-23 2011-09-27 Institut Pasteur Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
BRPI0919473A2 (en) 2008-09-26 2017-08-29 Oncomed Pharm Inc FRIZZLED BINDING AGENTS AND THEIR USES
ES2577024T3 (en) 2009-08-25 2016-07-12 Abraxis Bioscience, Llc Therapy combined with compositions of taxane nanoparticles and Hedgehog inhibitors
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
NZ602700A (en) 2010-04-01 2014-10-31 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
JP2015536933A (en) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Methods of treating neuroendocrine tumors using Wnt pathway binding agents
AU2014212081A1 (en) 2013-02-04 2015-08-13 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6384192B1 (en) 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
US6884775B1 (en) 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6165747A (en) 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6261786B1 (en) 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6566092B1 (en) 1994-02-25 2003-05-20 The Trustees Of Columbia University In The City Of New York DNA encoding a vertebrate homolog of hedgehog, Vhh-1, expressed by the notochord, and uses thereof
ATE335819T1 (en) 1996-09-20 2006-09-15 Harvard College HEDGEHOG INTERACTING PROTEINS AND THEIR RELATED APPLICATIONS
US5759811A (en) * 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
WO1999000117A2 (en) * 1997-06-27 1999-01-07 Ontogeny, Inc. Neuroprotective methods and reagents
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6897297B1 (en) 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
CA2309806A1 (en) * 1997-12-03 1999-06-10 Biogen, Inc. Hydrophobically-modified protein compositions and methods
AU773044B2 (en) 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
JP2003502292A (en) 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド Polymer conjugates and uses of hedgehog proteins

Also Published As

Publication number Publication date
IL142905A0 (en) 2002-04-21
CA2348773A1 (en) 2000-05-11
AU765485B2 (en) 2003-09-18
WO2000025725A3 (en) 2000-11-30
CA2348773C (en) 2010-04-13
US20030166543A1 (en) 2003-09-04
DE69939327D1 (en) 2008-09-25
EP1133519A2 (en) 2001-09-19
EP1133519B1 (en) 2008-08-13
WO2000025725A2 (en) 2000-05-11
JP4574012B2 (en) 2010-11-04
IL142905A (en) 2009-12-24
JP2002534060A (en) 2002-10-15
AU2144500A (en) 2000-05-22
US8410061B2 (en) 2013-04-02

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