ATE402707T1 - Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen - Google Patents
Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungenInfo
- Publication number
- ATE402707T1 ATE402707T1 AT05797208T AT05797208T ATE402707T1 AT E402707 T1 ATE402707 T1 AT E402707T1 AT 05797208 T AT05797208 T AT 05797208T AT 05797208 T AT05797208 T AT 05797208T AT E402707 T1 ATE402707 T1 AT E402707T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoä1
- derivatives
- treatment
- cognitive disorders
- formula
- Prior art date
Links
- 208000010877 cognitive disease Diseases 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- MEYXEJCDZRDIFZ-UHFFFAOYSA-N imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine Chemical class C=1N2N=CN=C2C2=CC=CC=C2N2CN=CC2=1 MEYXEJCDZRDIFZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105000 | 2004-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402707T1 true ATE402707T1 (de) | 2008-08-15 |
Family
ID=35427599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05797208T ATE402707T1 (de) | 2004-10-12 | 2005-10-04 | Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7671048B2 (de) |
| EP (1) | EP1809297B1 (de) |
| JP (1) | JP5117192B2 (de) |
| KR (1) | KR100869388B1 (de) |
| CN (1) | CN101039678B (de) |
| AT (1) | ATE402707T1 (de) |
| AU (1) | AU2005293820B2 (de) |
| BR (1) | BRPI0517412A (de) |
| CA (1) | CA2581918A1 (de) |
| DE (1) | DE602005008633D1 (de) |
| ES (1) | ES2312022T3 (de) |
| MX (1) | MX2007004250A (de) |
| RU (1) | RU2007112675A (de) |
| WO (1) | WO2006040038A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007042421A1 (en) * | 2005-10-11 | 2007-04-19 | F. Hoffmann-La Roche Ag | Imidazo benzodiazepine derivatives |
| US10994357B2 (en) * | 2006-12-20 | 2021-05-04 | Lincoln Global, Inc. | System and method for creating or modifying a welding sequence |
| US8538675B2 (en) | 2009-06-01 | 2013-09-17 | Raytheon Company | Non-kinematic behavioral mapping |
| EP3034079B1 (de) | 2010-11-15 | 2018-01-10 | Agenebio, Inc. | Pyridazinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen |
| CA2817988A1 (en) * | 2010-11-15 | 2012-05-24 | Agenebio, Inc. | Benzodiazepine derivatives, compositions and methods for treating cognitive impairment |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2015095783A1 (en) * | 2013-12-20 | 2015-06-25 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| WO2016205739A1 (en) | 2015-06-19 | 2016-12-22 | Belew Mekonnen | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CA3064840A1 (en) * | 2017-06-02 | 2018-12-06 | Xeris Pharmaceuticals, Inc. | Precipitation resistant small molecule drug formulations |
| BR112020026062B1 (pt) | 2018-06-19 | 2023-04-04 | Agenebio, Inc | Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson |
| CN111606926B (zh) * | 2020-05-13 | 2021-10-15 | 大连理工大学 | 一种苯并咪唑[1,3]氮硫杂卓类化合物的制备方法 |
| CN112979658B (zh) * | 2021-02-22 | 2022-05-31 | 南湖实验室 | 一种氟马西尼的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1143728A (en) | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| IL74070A (en) | 1984-01-19 | 1988-12-30 | Hoffmann La Roche | Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them |
| DK174086D0 (da) | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| US4897392A (en) | 1989-07-03 | 1990-01-30 | Hoechst-Roussel Pharmaceuticals, Inc. | 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines |
| TW201311B (de) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
| TWI239333B (en) * | 2000-11-16 | 2005-09-11 | Hoffmann La Roche | Benzodiazepine derivatives as GABA A receptor modulators |
-
2005
- 2005-10-04 JP JP2007536039A patent/JP5117192B2/ja not_active Expired - Fee Related
- 2005-10-04 EP EP05797208A patent/EP1809297B1/de not_active Not-in-force
- 2005-10-04 AT AT05797208T patent/ATE402707T1/de active
- 2005-10-04 ES ES05797208T patent/ES2312022T3/es active Active
- 2005-10-04 MX MX2007004250A patent/MX2007004250A/es active IP Right Grant
- 2005-10-04 KR KR1020077008246A patent/KR100869388B1/ko not_active Expired - Fee Related
- 2005-10-04 DE DE602005008633T patent/DE602005008633D1/de active Active
- 2005-10-04 CN CN2005800348517A patent/CN101039678B/zh not_active Expired - Fee Related
- 2005-10-04 WO PCT/EP2005/010655 patent/WO2006040038A1/en active IP Right Grant
- 2005-10-04 AU AU2005293820A patent/AU2005293820B2/en not_active Ceased
- 2005-10-04 CA CA002581918A patent/CA2581918A1/en not_active Abandoned
- 2005-10-04 RU RU2007112675/15A patent/RU2007112675A/ru not_active Application Discontinuation
- 2005-10-04 BR BRPI0517412-0A patent/BRPI0517412A/pt not_active IP Right Cessation
- 2005-10-07 US US11/245,736 patent/US7671048B2/en not_active Expired - Fee Related
-
2009
- 2009-11-16 US US12/618,802 patent/US8293730B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8293730B2 (en) | 2012-10-23 |
| CN101039678A (zh) | 2007-09-19 |
| WO2006040038A1 (en) | 2006-04-20 |
| BRPI0517412A (pt) | 2008-10-07 |
| US20100075954A1 (en) | 2010-03-25 |
| AU2005293820A1 (en) | 2006-04-20 |
| US20060079507A1 (en) | 2006-04-13 |
| EP1809297A1 (de) | 2007-07-25 |
| DE602005008633D1 (de) | 2008-09-11 |
| MX2007004250A (es) | 2007-06-12 |
| US7671048B2 (en) | 2010-03-02 |
| CN101039678B (zh) | 2011-06-15 |
| CA2581918A1 (en) | 2006-04-20 |
| JP2008515941A (ja) | 2008-05-15 |
| EP1809297B1 (de) | 2008-07-30 |
| AU2005293820B2 (en) | 2010-11-25 |
| KR100869388B1 (ko) | 2008-11-21 |
| KR20070053324A (ko) | 2007-05-23 |
| JP5117192B2 (ja) | 2013-01-09 |
| ES2312022T3 (es) | 2009-02-16 |
| RU2007112675A (ru) | 2008-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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