ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents

Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Info

Publication number: ATE396993T1
Authority: AT; Austria
Prior art keywords: chemokine receptor; tetrahydropyranyl; cyclopentyl; receptor activity; modulators
Prior art date: 2002-04-29

Application number

AT03724241T

Other languages

English (en)

Inventor

Richard Jiao

Gregori Morriello

Lihu Yang

Stephen Goble

Sander Mills

Alexander Pasternak

Changyou Zhou

Gabor Butora

Shankaran Kothandaraman

Deodialsingh Guiadeen

Cheng Tang

Christopher Moyes

Original Assignee

Merck & Co Inc

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-25

Publication date

2008-06-15

2003-04-25 Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396993T1 publication Critical patent/ATE396993T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03724241T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität ATE396993T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37618002P	2002-04-29	2002-04-29

Publications (1)

Publication Number	Publication Date
ATE396993T1 true ATE396993T1 (de)	2008-06-15

Family

ID=29401316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03724241T ATE396993T1 (de)	2002-04-29	2003-04-25	Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Country Status (15)

Country	Link
US (1)	US6812234B2 (de)
EP (1)	EP1501507B1 (de)
JP (1)	JP3780291B2 (de)
AT (1)	ATE396993T1 (de)
AU (1)	AU2003231114B8 (de)
CA (1)	CA2483752C (de)
CY (1)	CY1110399T1 (de)
DE (1)	DE60321333D1 (de)
DK (1)	DK1501507T3 (de)
ES (1)	ES2306867T3 (de)
NZ (1)	NZ536477A (de)
PT (1)	PT1501507E (de)
SI (1)	SI1501507T1 (de)
WO (1)	WO2003092586A2 (de)
ZA (1)	ZA200407940B (de)

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JO2479B1 (en)	2002-04-29	2009-01-20	ميرك شارب اند دوم ليمتد	Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
US20060030582A1 (en) *	2002-04-29	2006-02-09	Demartino Julie	Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
SG173922A1 (en)	2002-11-27	2011-09-29	Incyte Corp	3-aminopyrrolidine derivatives as modulators of chemokine receptors
CN1826334A (zh) *	2003-03-18	2006-08-30	麦克公司	趋化因子受体活性的四氢吡喃基环戊基杂环酰胺调节剂
RU2301802C2 (ru) *	2003-04-15	2007-06-27	Мерк Энд Ко., Инк.	Бензоксазинил-амидоциклопентил-гетероциклические модуляторы хемокиновых рецепторов
JP2006523704A (ja) *	2003-04-17	2006-10-19	メルク　エンド　カムパニー　インコーポレーテッド	ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター
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KR20060101476A (ko) *	2003-10-27	2006-09-25	머크 앤드 캄파니 인코포레이티드	Ｃｃｒ-2 길항제 염
OA13338A (en)	2003-12-18	2007-04-13	Incyte Corp	3-cycloalkylaminopyrrolidine derivates as modulators of chemokine receptors.
WO2005067502A2 (en) *	2004-01-02	2005-07-28	Merck & Co., Inc.	Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
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EP1742915A4 (de) *	2004-04-26	2009-12-02	Merck & Co Inc	Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokinrezeptoraktivität
JP2007534758A (ja) *	2004-04-26	2007-11-29	メルク　エンド　カムパニー　インコーポレーテッド	ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル１−置換及び１，１−二置換テトラヒドロイソキノリン
EP1755603A4 (de) *	2004-04-28	2009-03-11	Merck & Co Inc	3,3-disubstituierte tetrahydropyranyl cyclopentyl amide modulatoren der chemokin-rezeptor-aktivität
NZ550511A (en)	2004-05-11	2010-07-30	Incyte Corp	3-(4-Heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
CA2571397C (en) *	2004-06-28	2012-05-22	Incyte Corporation	3-aminocyclopentanecarboxamides as modulators of chemokine receptors
BRPI0512352A (pt) *	2004-06-28	2008-03-04	Incyte Corp	3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas
US20070238723A1 (en) *	2004-10-15	2007-10-11	Goble Stephen D	Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
AU2006204038A1 (en) *	2005-01-06	2006-07-13	Merck & Co., Inc.	Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
CN101137637A (zh) *	2005-03-11	2008-03-05	默克公司	制备(r)-4,4-二烷氧基-吡喃-3-醇例如(r)-4,4-二甲氧基-吡喃-3-醇的方法
US8067415B2 (en)	2005-11-01	2011-11-29	Millennium Pharmaceuticals, Inc.	Compounds useful as antagonists of CCR2
WO2007053498A1 (en)	2005-11-01	2007-05-10	Millennium Pharmaceuticals, Inc.	Compounds useful as antagonists of ccr2
US20080076120A1 (en) *	2006-09-14	2008-03-27	Millennium Pharmaceuticals, Inc.	Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
EA020470B1 (ru) *	2008-11-26	2014-11-28	Пфайзер Инк.	3-аминоциклопентанкарбоксамиды в качестве модуляторов рецептора хемокина
EP2379525B1 (de)	2008-12-19	2015-07-29	Boehringer Ingelheim International GmbH	Cyclische pyrimidin-4-carbonsäureamide als antagonisten des ccr2-rezeptors zur behandlung von entzündungen, asthma und copd
PE20121614A1 (es)	2009-12-17	2012-12-21	Boehringer Ingelheim Int	Derivados de 6-amino,4-carbonil-pirimidina sustituida como antagonistas del receptor ccr2
EP2516445B1 (de)	2009-12-22	2015-03-11	Cephalon, Inc.	Tricyclische derivate, ihre pharmazeutische verwendung und zusammensetzungen
US9040526B2 (en)	2010-02-09	2015-05-26	Bristol-Myers Squibb Company	Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
JP5636094B2 (ja) *	2010-05-25	2014-12-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２受容体アンタゴニスト
EP2685978A2 (de) *	2011-03-17	2014-01-22	Merck Sharp & Dohme Corp.	Cyclohexan-substituierte amino-cyclopentan-derivate als nützliche ccr2-antagonisten
US8822460B2 (en) *	2012-04-06	2014-09-02	Janssen Pharmaceutica Nv	Fused cyclopentyl antagonists of CCR2
WO2014133072A1 (ja)	2013-02-28	2014-09-04	参天製薬株式会社	テトラヒドロピラニルアミノシクロペンチルカルボニルテトラヒドロピリドピリジン誘導体を有効成分として含有する後眼部疾患の予防または治療剤
ES2904252T3 (es) *	2015-05-21	2022-04-04	Chemocentryx Inc	Moduladores de CCR2
CN108026087B (zh)	2015-07-02	2021-06-04	中枢疗法公司	氨基嘧啶甲酮衍生物的柠檬酸盐
EP3570893A1 (de)	2017-01-17	2019-11-27	GlaxoSmithKline Intellectual Property Development Ltd	Nicht-peptidische heterobivalente moleküle zur behandlung von entzündlichen erkrankungen
AR112831A1 (es)	2017-09-25	2019-12-18	Chemocentryx Inc	Terapia de combinación usando un antagonista del receptor 2 de quimiocina (ccr2) y un inhibidor de pd-1 / pd-l1
US11154556B2 (en)	2018-01-08	2021-10-26	Chemocentryx, Inc.	Methods of treating solid tumors with CCR2 antagonists
US20190269664A1 (en)	2018-01-08	2019-09-05	Chemocentryx, Inc.	Methods of treating solid tumors with ccr2 antagonists
CN119925562B (zh) *	2023-11-03	2025-11-28	中国科学院上海药物研究所	趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用

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AU5473400A (en) *	1999-06-11	2001-01-02	Merck & Co., Inc.	Cyclopentyl modulators of chemokine receptor activity
CA2419194C (en) *	2000-08-17	2007-10-16	Lihu Yang	Cyclopentyl modulators of chemokine receptor activity
EP1368354A1 (de)	2001-03-07	2003-12-10	Pfizer Products Inc.	Modulatoren der aktivität von chemokin-rezeptoren
JO2479B1 (en) *	2002-04-29	2009-01-20	ميرك شارب اند دوم ليمتد	Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine

2003
- 2003-04-25 DE DE60321333T patent/DE60321333D1/de not_active Expired - Lifetime
- 2003-04-25 DK DK03724241T patent/DK1501507T3/da active
- 2003-04-25 ES ES03724241T patent/ES2306867T3/es not_active Expired - Lifetime
- 2003-04-25 WO PCT/US2003/012929 patent/WO2003092586A2/en not_active Ceased
- 2003-04-25 CA CA2483752A patent/CA2483752C/en not_active Expired - Lifetime
- 2003-04-25 SI SI200331285T patent/SI1501507T1/sl unknown
- 2003-04-25 AU AU2003231114A patent/AU2003231114B8/en not_active Ceased
- 2003-04-25 NZ NZ536477A patent/NZ536477A/en not_active IP Right Cessation
- 2003-04-25 PT PT03724241T patent/PT1501507E/pt unknown
- 2003-04-25 JP JP2004500771A patent/JP3780291B2/ja not_active Expired - Fee Related
- 2003-04-25 AT AT03724241T patent/ATE396993T1/de active
- 2003-04-25 EP EP03724241A patent/EP1501507B1/de not_active Expired - Lifetime
- 2003-04-29 US US10/425,167 patent/US6812234B2/en not_active Expired - Lifetime
2004
- 2004-10-01 ZA ZA200407940A patent/ZA200407940B/en unknown
2008
- 2008-08-26 CY CY20081100915T patent/CY1110399T1/el unknown

Also Published As

Publication number	Publication date
CA2483752C (en)	2011-03-29
EP1501507A2 (de)	2005-02-02
WO2003092586A3 (en)	2004-09-16
SI1501507T1 (sl)	2008-12-31
AU2003231114B2 (en)	2008-07-24
ZA200407940B (en)	2006-06-28
US20040167156A1 (en)	2004-08-26
JP3780291B2 (ja)	2006-05-31
JP2005523929A (ja)	2005-08-11
EP1501507A4 (de)	2006-05-17
WO2003092586A2 (en)	2003-11-13
PT1501507E (pt)	2008-08-12
ES2306867T3 (es)	2008-11-16
DE60321333D1 (de)	2008-07-10
EP1501507B1 (de)	2008-05-28
CY1110399T1 (el)	2014-04-09
US6812234B2 (en)	2004-11-02
AU2003231114B8 (en)	2008-08-14
NZ536477A (en)	2005-05-27
CA2483752A1 (en)	2003-11-13
DK1501507T3 (da)	2008-09-29
AU2003231114A1 (en)	2003-11-17

Publication	Publication Date	Title
ATE396993T1 (de)	2008-06-15	Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
ATE404538T1 (de)	2008-08-15	Tetrahydropyranylcyclopentyltetrahydroisochino- linmodulatoren der chemokinrezeptoraktivität
ES2271063T3 (es)	2007-04-16	Moduladores ciclopentilos de la actividad del receptor de la quimioquina.
WO2004042351A3 (en)	2004-11-04	Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
JO2479B1 (en)	2009-01-20	Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
WO2004041777A3 (en)	2004-07-29	Heteroarylpiperidine modulators of chemokine receptor activity
EA200601007A1 (ru)	2006-10-27	7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
WO2000059497A8 (en)	2001-02-15	Pyrrolidine modulators of chemokine receptor activity
DK1313721T3 (da)	2006-06-26	Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander
WO2004094371A3 (en)	2005-03-24	Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004041163A3 (en)	2004-07-15	Piperidinyl cyclopentyl aryl benzylamide modulators of chemokine receptor activity
ATE255584T1 (de)	2003-12-15	Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität
SE9901077D0 (sv)	1999-03-23	Novel use
DE69920455D1 (de)	2004-10-28	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
AP2001002188A0 (en)	2001-06-30	5HT1 antagonists for antidepressant therapy.
MXPA03003942A (es)	2004-05-24	Compuestos bis-heterociclicos con actividad antitumoral y quimiosensibilizante.
SE9903290D0 (sv)	1999-09-15	Novel compounds
DE60316436D1 (de)	2007-10-31	Amidderivate als inhibitoren der enzymatischen aktivität von renin
ATE344242T1 (de)	2006-11-15	N-cyclopentylmodulatoren der chemokine rezeptoraktivität
DE60041001D1 (de)	2009-01-15	Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
CO5680420A2 (es)	2006-09-29	Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4
WO2005010154A3 (en)	2005-08-25	7 and 8 membered heterocyclic cyclopentyl benzylamide modulators of chemokine receptor activity
ATE213236T1 (de)	2002-02-15	Substituierte benzyloxyimino-verbindungen
ATE374751T1 (de)	2007-10-15	3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
UA83142C2 (en)	2008-06-10	3-aminocyclopentane carboxyamidine as modulators of chemokine receptors

Legal Events

Date	Code	Title	Description
2008-12-15	UEP	Publication of translation of european patent specification	Ref document number: 1501507 Country of ref document: EP
2010-11-15	EEFA	Change of the company name

Date

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2008-12-15

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Publication of translation of european patent specification

Ref document number: 1501507

Country of ref document: EP

2010-11-15

EEFA

Change of the company name