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ATE394697T1 - Optische konfokale abtastvorrichtung - Google Patents

Optische konfokale abtastvorrichtung

Info

Publication number
ATE394697T1
ATE394697T1 AT01969915T AT01969915T ATE394697T1 AT E394697 T1 ATE394697 T1 AT E394697T1 AT 01969915 T AT01969915 T AT 01969915T AT 01969915 T AT01969915 T AT 01969915T AT E394697 T1 ATE394697 T1 AT E394697T1
Authority
AT
Austria
Prior art keywords
light
scanning device
confocal scanning
optical confocal
image plane
Prior art date
Application number
AT01969915T
Other languages
English (en)
Inventor
Vincent Lauer
Original Assignee
Vincent Lauer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0011879A external-priority patent/FR2814247A1/fr
Priority claimed from FR0101138A external-priority patent/FR2819896A1/fr
Priority claimed from FR0101906A external-priority patent/FR2820829A1/fr
Priority claimed from FR0102254A external-priority patent/FR2821169A1/fr
Priority claimed from FR0103860A external-priority patent/FR2822551A1/fr
Priority claimed from FR0104841A external-priority patent/FR2823315A1/fr
Priority claimed from FR0108516A external-priority patent/FR2826736A1/fr
Application filed by Vincent Lauer filed Critical Vincent Lauer
Application granted granted Critical
Publication of ATE394697T1 publication Critical patent/ATE394697T1/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0044—Scanning details, e.g. scanning stages moving apertures, e.g. Nipkow disks, rotating lens arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0068—Optical details of the image generation arrangements using polarisation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/005—Diaphragms

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Microscoopes, Condenser (AREA)
  • Geophysics And Detection Of Objects (AREA)
AT01969915T 2000-09-18 2001-09-18 Optische konfokale abtastvorrichtung ATE394697T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR0011879A FR2814247A1 (fr) 2000-09-18 2000-09-18 Microscope confocal a balayage laser avec formation optique de l'image
FR0101138A FR2819896A1 (fr) 2001-01-23 2001-01-23 Microscope confocal rapide
FR0101906A FR2820829A1 (fr) 2001-02-13 2001-02-13 Mircroscope confocal rapide
FR0102254A FR2821169A1 (fr) 2001-02-20 2001-02-20 Microscope confocal rapide
FR0103860A FR2822551A1 (fr) 2001-03-22 2001-03-22 Microscope confocal rapide
FR0104841A FR2823315A1 (fr) 2001-04-10 2001-04-10 Ensemble modifiable de trous microscopiques
FR0108516A FR2826736A1 (fr) 2001-06-28 2001-06-28 Dispositif a balayage optique confocal

Publications (1)

Publication Number Publication Date
ATE394697T1 true ATE394697T1 (de) 2008-05-15

Family

ID=27562423

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01969915T ATE394697T1 (de) 2000-09-18 2001-09-18 Optische konfokale abtastvorrichtung

Country Status (7)

Country Link
US (1) US7391565B2 (de)
EP (2) EP1953580B1 (de)
JP (1) JP5000839B2 (de)
AT (1) ATE394697T1 (de)
AU (1) AU2001290043A1 (de)
DE (1) DE60133916D1 (de)
WO (1) WO2002023247A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836727B1 (fr) * 2002-03-04 2006-02-24 Vincent Lauer Dispositif de balayage optique confocal
DE10235388A1 (de) 2002-08-02 2004-02-19 Carl Zeiss Jena Gmbh Optische Anordnung mit telezentrischem Strahlenbereich
EP1411345B1 (de) * 2002-10-17 2006-09-06 Direvo Biotech AG Fluorimetrische Multi-Parameter-Analyse in einer parallelen Multi-Fokus-Anordnung
JP2006106378A (ja) * 2004-10-06 2006-04-20 Yokogawa Electric Corp 共焦点顕微鏡
CA2587674A1 (en) * 2004-11-16 2006-05-26 Illumina, Inc. Method and apparatus for reading coded microbeads
JP4755441B2 (ja) * 2005-04-25 2011-08-24 株式会社日立製作所 設計支援方法及びシステム
JP4887989B2 (ja) * 2005-12-02 2012-02-29 ナノフォトン株式会社 光学顕微鏡及びスペクトル測定方法
GB0608923D0 (en) * 2006-05-05 2006-06-14 Visitech Internat Ltd 2-d array laser confocal scanning microscope and methods of improving image quality in such microscope
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
JP5259154B2 (ja) * 2007-10-24 2013-08-07 オリンパス株式会社 走査型レーザ顕微鏡
BRPI0819304A2 (pt) * 2007-11-23 2015-05-12 Koninkl Philips Electronics Nv Gerador de ponto de luz, microscópio de varredura de múltiplos pontos de luz, e, método para gerar uma imagem de uma amostra microscópica
US20100277580A1 (en) * 2007-11-23 2010-11-04 Koninklijke Philips Electronics N.V. Multi-modal spot generator and multi-modal multi-spot scanning microscope
EP2225598A1 (de) * 2007-12-21 2010-09-08 Koninklijke Philips Electronics N.V. Rastermikroskop und verfahren zum abbilden einer probe
CN107132185B (zh) * 2008-02-05 2020-05-29 普凯尔德诊断技术有限公司 用于鉴定生物样品中细菌的系统
NL2001464C2 (nl) * 2008-04-10 2009-10-13 Amc Amsterdam Werkwijze voor het vormen van een afbeelding van een object.
JP2009288321A (ja) * 2008-05-27 2009-12-10 Olympus Corp 顕微鏡
JP5921548B2 (ja) * 2010-09-08 2016-05-24 エーエスエムエル ネザーランズ ビー．ブイ． リソグラフィ装置、ｅｕｖ放射発生装置、およびデバイス製造方法
WO2012099521A1 (en) * 2011-01-20 2012-07-26 Applied Precision, Inc. Light-scanning systems
WO2012118530A1 (en) * 2011-03-01 2012-09-07 Applied Precision, Inc. Variable orientation illumination-pattern rotator
US9164247B2 (en) * 2011-07-28 2015-10-20 Source Photonics, Inc. Apparatuses for reducing the sensitivity of an optical signal to polarization and methods of making and using the same
EP2745070A4 (de) * 2011-08-18 2015-08-19 Newport Corp System und verfahren zur charakterisierung von materialschrumpfung unter verwendung von cars-mikroskopie
KR101300733B1 (ko) * 2012-01-12 2013-08-27 연세대학교 산학협력단 다중 병렬 공초점 시스템
US10025082B2 (en) * 2012-02-23 2018-07-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Multi-focal structured illumination microscopy systems and methods
WO2013126762A1 (en) * 2012-02-23 2013-08-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Multi-focal structured illumination microscopy systems and methods
DE102012102983A1 (de) * 2012-04-05 2013-10-10 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zum Bestimmen eines kritischen Winkels eines Anregungslichtstrahls
JP2013238789A (ja) * 2012-05-16 2013-11-28 Olympus Corp 観察ユニット、及びこの観察ユニットを備えた顕微鏡システム
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9488823B2 (en) * 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
DE102012216979A1 (de) * 2012-09-21 2014-04-17 Trumpf Laser Gmbh + Co. Kg Scannervorrichtung zum 2-dimensionalen Ablenken eines Laserstrahls
JP6131448B2 (ja) * 2012-12-04 2017-05-24 三星電子株式会社Ｓａｍｓｕｎｇ Ｅｌｅｃｔｒｏｎｉｃｓ Ｃｏ．，Ｌｔｄ． 共焦点光学式検査装置および共焦点光学式検査方法
WO2014133481A1 (en) * 2013-02-26 2014-09-04 Hewlett-Packard Development Company, L.P. Multiview 3d telepresence
JP6454677B2 (ja) * 2013-03-15 2019-01-16 ニューロビジョン イメージング，インコーポレーテッド ヒトの生体内網膜から集光したアフォーカル光を排除するためのシステム
DE102013005927B4 (de) * 2013-03-28 2025-02-20 Friedrich-Schiller-Universität Jena Verfahren zum optisch hochaufgelösten Rasterscanning eines Objekts und Verwendung des Verfahrens
US9720218B2 (en) * 2013-08-06 2017-08-01 Howard Hughes Medical Institute Volume imaging
WO2015046440A1 (ja) 2013-09-27 2015-04-02 株式会社ニコン 解析装置、顕微鏡装置、解析方法、及びプログラム
JP5999121B2 (ja) 2014-02-17 2016-09-28 横河電機株式会社 共焦点光スキャナ
JP2015161719A (ja) * 2014-02-26 2015-09-07 ソニー株式会社 レーザー走査型顕微鏡システム及びサンプリング装置
WO2015164843A1 (en) * 2014-04-24 2015-10-29 Vutara, Inc. Galvo scanning mirror for super-resolution microscopy
WO2015164844A1 (en) * 2014-04-24 2015-10-29 Vutara, Inc. Super resolution microscopy
EP2963672A1 (de) * 2014-06-30 2016-01-06 FEI Company Computergestützte Rastermikroskopie mit verbesserter Auflösung
JP6342842B2 (ja) 2015-04-30 2018-06-13 オリンパス株式会社 走査型顕微鏡システム
US10130249B2 (en) 2015-05-01 2018-11-20 Canon Kabushiki Kaisha Inspection apparatus, image processing apparatus, method of operating inspection apparatus, image processing method, and recording medium
DE102015217908A1 (de) * 2015-09-18 2017-03-23 Robert Bosch Gmbh Lidarsensor
CN113532286A (zh) * 2015-12-25 2021-10-22 株式会社基恩士 共焦位移计
TWI584778B (zh) * 2016-02-04 2017-06-01 慈濟學校財團法人慈濟大學 光學檢測裝置及其系統
US10222441B2 (en) 2016-04-03 2019-03-05 Q Bio, Inc. Tensor field mapping
CN108614351B (zh) * 2016-12-12 2020-07-10 凝辉(天津)科技有限责任公司 一种具有可旋转式物镜的显微镜
US11650195B2 (en) 2017-02-03 2023-05-16 Q Bio, Inc. Iterative medical testing of biological samples
US11086113B2 (en) 2017-06-06 2021-08-10 The United States Of America Multi-focal structured illumination microscopy systems and methods
CN110023813B (zh) * 2017-06-06 2022-04-29 美利坚合众国,由健康及人类服务部部长代表 多焦结构化照明显微系统和方法
US10382668B2 (en) * 2017-11-14 2019-08-13 Conary Enterprise Co., Ltd. Laser collimator module on a mobile device for image measurement
CN109211854B (zh) * 2018-08-10 2021-07-02 国家纳米科学中心 多光束多光子重扫描显微成像装置
US11354586B2 (en) 2019-02-15 2022-06-07 Q Bio, Inc. Model parameter determination using a predictive model
US11360166B2 (en) 2019-02-15 2022-06-14 Q Bio, Inc Tensor field mapping with magnetostatic constraint
US11614509B2 (en) 2019-09-27 2023-03-28 Q Bio, Inc. Maxwell parallel imaging
CN114450599B (zh) 2019-09-27 2023-07-07 Q生物公司 麦克斯韦并行成像
FR3112866B1 (fr) * 2020-07-22 2022-07-22 Damae Medical Systèmes et procédés d’analyse microscopique d’un échantillon
CN112505044B (zh) * 2020-11-26 2022-06-07 暨南大学 一种宽场照明共焦显微成像系统及方法
US11614508B1 (en) 2021-10-25 2023-03-28 Q Bio, Inc. Sparse representation of measurements
DE102021134384A1 (de) * 2021-12-22 2023-06-22 Abberior Instruments Gmbh Verfahren und Vorrichtungen zur Überprüfung der lateralen und axialen Konfokalität einer scannenden und entscannenden Mikroskopbaugruppe
LT7019B (lt) 2023-01-24 2023-08-25 Vilniaus Gedimino technikos universitetas Erdvinio mikroobjekto matmenų ir jo paviršiaus reljefo nustatymo sistema ir būdas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806004A (en) * 1987-07-10 1989-02-21 California Institute Of Technology Scanning microscopy
JPH03172815A (ja) * 1989-12-01 1991-07-26 Fuji Photo Film Co Ltd 共焦点走査型顕微鏡
JP2994703B2 (ja) * 1990-07-23 1999-12-27 興和株式会社 眼科測定装置
US5162941A (en) * 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
US5587832A (en) * 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
JPH07333510A (ja) * 1994-06-02 1995-12-22 Nikon Corp レーザ走査顕微鏡装置
JP3350918B2 (ja) * 1996-03-26 2002-11-25 株式会社高岳製作所 ２次元配列型共焦点光学装置
US6002509A (en) * 1995-10-21 1999-12-14 Leica Lasertechnik Gmbh Beam scanner for confocal microscopes
JPH09265049A (ja) * 1996-03-28 1997-10-07 Dainippon Screen Mfg Co Ltd 光学的読取り領域制限板およびモジュールならびにこれらを適用した画像読取り装置
JP3816632B2 (ja) * 1997-05-14 2006-08-30 オリンパス株式会社 走査型顕微鏡
JP4372996B2 (ja) * 1997-10-29 2009-11-25 ディジタル オプティカル イメージング コーポレイション 空間的に光変調された顕微鏡法に関する装置及び方法
US6603537B1 (en) * 1998-08-21 2003-08-05 Surromed, Inc. Optical architectures for microvolume laser-scanning cytometers
US7209287B2 (en) * 2000-09-18 2007-04-24 Vincent Lauer Confocal optical scanning device

Also Published As

Publication number Publication date
DE60133916D1 (de) 2008-06-19
US20070146869A1 (en) 2007-06-28
EP1953580A3 (de) 2009-03-25
EP1953580B1 (de) 2014-09-17
AU2001290043A1 (en) 2002-03-26
US7391565B2 (en) 2008-06-24
EP1330671A1 (de) 2003-07-30
WO2002023247A1 (fr) 2002-03-21
JP2004509370A (ja) 2004-03-25
EP1953580A2 (de) 2008-08-06
EP1330671B1 (de) 2008-05-07
JP5000839B2 (ja) 2012-08-15

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