ATE390447T1 - Konjugationsreaktionen - Google Patents
KonjugationsreaktionenInfo
- Publication number
- ATE390447T1 ATE390447T1 AT04702752T AT04702752T ATE390447T1 AT E390447 T1 ATE390447 T1 AT E390447T1 AT 04702752 T AT04702752 T AT 04702752T AT 04702752 T AT04702752 T AT 04702752T AT E390447 T1 ATE390447 T1 AT E390447T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- bromo
- initiator
- methyl
- propionic acid
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title 1
- 230000021615 conjugation Effects 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 239000003999 initiator Substances 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- LMSBQWCDGNYDMY-UHFFFAOYSA-N 2-bromo-2-methylpropanoic acid;1-hydroxypyrrolidine-2,5-dione Chemical compound CC(C)(Br)C(O)=O.ON1C(=O)CCC1=O LMSBQWCDGNYDMY-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- ZBOFPFMPPSLOGQ-UHFFFAOYSA-N azane;ethyl dihydrogen phosphate Chemical compound [NH4+].CCOP(O)([O-])=O ZBOFPFMPPSLOGQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F4/00—Polymerisation catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0301014.7A GB0301014D0 (en) | 2003-01-16 | 2003-01-16 | Conjugation reactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE390447T1 true ATE390447T1 (de) | 2008-04-15 |
Family
ID=9951273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04702752T ATE390447T1 (de) | 2003-01-16 | 2004-01-16 | Konjugationsreaktionen |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8053520B2 (de) |
| EP (1) | EP1592719B1 (de) |
| AT (1) | ATE390447T1 (de) |
| DE (1) | DE602004012713T2 (de) |
| GB (1) | GB0301014D0 (de) |
| WO (1) | WO2004063237A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1465933B1 (de) * | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Polymerkonjugate |
| EP1480619B1 (de) | 2002-03-07 | 2013-08-07 | Biocompatibles UK Limited | Wirkstoffträger enthaltend amphiphile blockcopolymere |
| AU2003217009A1 (en) | 2002-03-07 | 2003-09-16 | Biocompatibles Uk Limited | Compositions of polymers |
| US7820753B2 (en) * | 2003-02-05 | 2010-10-26 | Biocompatibles Uk Limited | Block copolymers |
| GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| EP1784430A1 (de) * | 2004-07-06 | 2007-05-16 | Warwick Effect Polymers Limited | Initiator für die lebende radikalische polymerisation mit einer zur reaktion mit polypeptiden oder dergleichen befähigten funktionellen gruppe, damit erhaltenes kammpolymer, polypetidkonjugate und daraus erhaltene arzneistoffe |
| US20070123646A1 (en) * | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
| SI1988910T1 (en) * | 2006-02-28 | 2018-02-28 | Kodiak Sciences Inc. | Polymeric conjugates containing acryloyloxyethylphosphorylcholine and their preparations |
| US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| WO2009053700A1 (en) * | 2007-10-23 | 2009-04-30 | Cancer Research Technology Limited | Modification of nucleic acid-containing biological entities |
| EP2260873B1 (de) | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylierung von proteinen |
| US8765432B2 (en) * | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| EP3549963B1 (de) * | 2010-04-15 | 2022-01-12 | Kodiak Sciences Inc. | Zwitterionenhaltige polymere von hohem molekulargewicht |
| WO2015035342A2 (en) | 2013-09-08 | 2015-03-12 | Oligasis Llc | Factor viii zwitterionic polymer conjugates |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP6849590B2 (ja) | 2014-10-17 | 2021-03-24 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート |
| EP3397276A4 (de) | 2015-12-30 | 2019-12-18 | Kodiak Sciences Inc. | Antikörper und konjugate davon |
| KR20200140817A (ko) | 2018-03-02 | 2020-12-16 | 코디악 사이언시스 인코포레이티드 | Il-6 항체 그리고 이의 융합 작제물 및 접합체 |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260373A (en) * | 1987-03-13 | 1993-11-09 | Repligen Corporation | Immobilized immunoglobulin-binding proteins |
| EP0394318A1 (de) * | 1987-12-09 | 1990-10-31 | Medical Research Council | Polymere und polymer-peptid-konjugate |
| US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| SE466754B (sv) * | 1990-09-13 | 1992-03-30 | Berol Nobel Ab | Saett att kovalent binda biopolymerer till hydrofila ytor |
| US5286846A (en) * | 1991-06-14 | 1994-02-15 | The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| RU2167886C2 (ru) | 1991-07-05 | 2001-05-27 | Биокомпэтиблз Лимитед. | Полимер, способ получения полимера, поверхность с покрытием, способ покрытия поверхности |
| JPH05220218A (ja) | 1992-02-13 | 1993-08-31 | Norio Nakabayashi | 抗血栓性再生セルロース系膜及びその製造方法 |
| IL104734A0 (en) * | 1993-02-15 | 1993-06-10 | Univ Bar Ilan | Bioactive conjugates of cellulose with amino compounds |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| JPH10509976A (ja) | 1994-11-30 | 1998-09-29 | アムール リサーチ コーポレーション | ホスホコリン薬物誘導体 |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5763548A (en) * | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| US5807937A (en) * | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US6310149B1 (en) | 1996-06-12 | 2001-10-30 | University Of Warwick | Polymerization catalyst and process |
| JP2002514183A (ja) * | 1996-09-17 | 2002-05-14 | スーパージェン・インコーポレーテッド | リン脂質薬剤誘導体 |
| US5830432A (en) | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| EP0922446A1 (de) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten |
| DK1054906T3 (da) * | 1997-12-18 | 2007-03-26 | Du Pont | Polymerisationsproces med levende karakteristika og polymerer fremstillet derved |
| US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| JP4145403B2 (ja) * | 1998-09-29 | 2008-09-03 | 日油株式会社 | 免疫学的活性物質測定用高分子／酵素結合体 |
| CN1230131C (zh) | 1998-11-13 | 2005-12-07 | 生物相容英国有限公司 | 聚合物的治疗用途 |
| ATE323113T1 (de) * | 1999-07-02 | 2006-04-15 | Symyx Technologies Inc | Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US7160924B2 (en) * | 2002-07-19 | 2007-01-09 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| AU7025600A (en) * | 1999-09-08 | 2001-04-10 | School Of Pharmacy, University Of London, The | Uniform molecular weight polymers |
| GB9924502D0 (en) | 1999-10-15 | 1999-12-15 | Biocompatibles Ltd | Polymer blend materials |
| DE60010644T2 (de) * | 2000-02-07 | 2005-05-19 | Biocompatibles Uk Ltd., Farnham | Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere |
| EP1151994A1 (de) * | 2000-05-01 | 2001-11-07 | Ethyl Corporation | Succinimid-Säure-Verbindungen und Derivate davon |
| ES2262653T3 (es) * | 2000-05-29 | 2006-12-01 | Bio Merieux | Polimero biocompatible para la fijacion de ligandos biologicos. |
| DE60129148T2 (de) | 2000-10-06 | 2008-02-28 | Biocompatibles Uk Ltd., Farnham | Zwitterionische polymere |
| US6652886B2 (en) * | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| JP4577747B2 (ja) * | 2001-06-05 | 2010-11-10 | 和光純薬工業株式会社 | 免疫学的測定法用凝集促進剤 |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| MXPA04004336A (es) * | 2001-11-07 | 2005-05-16 | Nektar Therapeutics Al Corp | Polimeros ramificados y sus conjugados. |
| EP1465933B1 (de) | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Polymerkonjugate |
| AU2003217009A1 (en) | 2002-03-07 | 2003-09-16 | Biocompatibles Uk Limited | Compositions of polymers |
| EP1480619B1 (de) | 2002-03-07 | 2013-08-07 | Biocompatibles UK Limited | Wirkstoffträger enthaltend amphiphile blockcopolymere |
| WO2004007449A1 (en) * | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| JP2004075823A (ja) * | 2002-08-15 | 2004-03-11 | Fuji Xerox Co Ltd | 非架橋重合体粒子の製造方法 |
| US7556969B2 (en) * | 2002-12-19 | 2009-07-07 | Northeastern University | Intensified neutral loss tags and use thereof in mass spectrometry |
| US7820753B2 (en) | 2003-02-05 | 2010-10-26 | Biocompatibles Uk Limited | Block copolymers |
| WO2004074345A2 (en) * | 2003-02-19 | 2004-09-02 | Pharmacia Corporation | Carbonate esters of polyethylene glycol activated by means of oxalate esters |
| DK1596887T3 (da) * | 2003-02-26 | 2022-06-20 | Nektar Therapeutics | Polymer-Faktor VIII-konjugat |
| GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| EP1653991A2 (de) * | 2003-08-08 | 2006-05-10 | Fresenius Kabi Deutschland GmbH | Durch oxime als bindungsgruppe verbundene konjugate eines polymers mit einem protein |
| US7786213B2 (en) * | 2003-10-15 | 2010-08-31 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| US7179874B2 (en) * | 2003-11-21 | 2007-02-20 | Chia Nan University Of Pharmacy And Science | Biodegradable cationic polymer |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| US20070123646A1 (en) * | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
| SI1988910T1 (en) | 2006-02-28 | 2018-02-28 | Kodiak Sciences Inc. | Polymeric conjugates containing acryloyloxyethylphosphorylcholine and their preparations |
-
2003
- 2003-01-16 GB GBGB0301014.7A patent/GB0301014D0/en not_active Ceased
-
2004
- 2004-01-16 AT AT04702752T patent/ATE390447T1/de not_active IP Right Cessation
- 2004-01-16 WO PCT/GB2004/000140 patent/WO2004063237A1/en not_active Ceased
- 2004-01-16 US US10/542,333 patent/US8053520B2/en active Active
- 2004-01-16 EP EP04702752A patent/EP1592719B1/de not_active Expired - Lifetime
- 2004-01-16 DE DE602004012713T patent/DE602004012713T2/de not_active Expired - Lifetime
-
2011
- 2011-09-23 US US13/243,923 patent/US8445612B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20060135714A1 (en) | 2006-06-22 |
| EP1592719A1 (de) | 2005-11-09 |
| US8445612B2 (en) | 2013-05-21 |
| DE602004012713D1 (de) | 2008-05-08 |
| US8053520B2 (en) | 2011-11-08 |
| EP1592719B1 (de) | 2008-03-26 |
| WO2004063237A1 (en) | 2004-07-29 |
| US20120016082A1 (en) | 2012-01-19 |
| DE602004012713T2 (de) | 2009-04-09 |
| GB0301014D0 (en) | 2003-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |