ATE386743T1 - Pyrimidoverbindungen mit antiproliferativer wirkung - Google Patents
Pyrimidoverbindungen mit antiproliferativer wirkungInfo
- Publication number
- ATE386743T1 ATE386743T1 AT03792269T AT03792269T ATE386743T1 AT E386743 T1 ATE386743 T1 AT E386743T1 AT 03792269 T AT03792269 T AT 03792269T AT 03792269 T AT03792269 T AT 03792269T AT E386743 T1 ATE386743 T1 AT E386743T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimid
- compounds
- antiproliferative effect
- antiproliferative
- effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40351902P | 2002-08-14 | 2002-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386743T1 true ATE386743T1 (de) | 2008-03-15 |
Family
ID=31946709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03792269T ATE386743T1 (de) | 2002-08-14 | 2003-08-07 | Pyrimidoverbindungen mit antiproliferativer wirkung |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7084270B2 (de) |
| EP (1) | EP1556384B1 (de) |
| JP (1) | JP2005538141A (de) |
| KR (1) | KR20070087687A (de) |
| CN (1) | CN1323080C (de) |
| AR (1) | AR040971A1 (de) |
| AT (1) | ATE386743T1 (de) |
| AU (1) | AU2003255389A1 (de) |
| BR (1) | BR0313732A (de) |
| CA (1) | CA2494127A1 (de) |
| DE (1) | DE60319255T2 (de) |
| ES (1) | ES2300644T3 (de) |
| MX (1) | MXPA05001629A (de) |
| PA (1) | PA8580001A1 (de) |
| PL (1) | PL375588A1 (de) |
| RU (1) | RU2336275C2 (de) |
| TW (1) | TW200407326A (de) |
| UY (1) | UY27937A1 (de) |
| WO (1) | WO2004018472A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE425166T1 (de) | 2004-08-31 | 2009-03-15 | Hoffmann La Roche | Amidderivate von 3-phenyldihydropyrimidoä4,5- düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel |
| BRPI0514750A (pt) | 2004-08-31 | 2008-06-24 | Hoffmann La Roche | derivados amida de 7-amino-3-fenil-diidropirimido[4, 5-d]pirimidinonas, sua fabricação e uso como inibidores de proteìna cinase |
| EP2400985A2 (de) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Kombination eines anti-igf-1r-antikörpers oder eines igf-bindungsproteins und eines kleinmoleküligen igf-1r-kinase-inhibitors |
| EP2401613A2 (de) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Verfahren zur identifizierung von mesenchymähnlichen tumorzellen oder deren bildung hemmenden stoffen |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2702173A1 (de) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Verwendung von emt-gensignaturen bei der entdeckung von krebswirkstoffen, -diagnostika und -behandlungen |
| CN102816162B (zh) * | 2011-06-10 | 2016-04-27 | 中国科学院广州生物医药与健康研究院 | 嘧啶并嘧啶酮类化合物及其药用组合物和应用 |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| CN104968664A (zh) * | 2012-12-12 | 2015-10-07 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的并环化合物 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP2968337B1 (de) | 2013-03-15 | 2021-07-21 | Celgene CAR LLC | Heteroarylverbindungen und verwendungen davon |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| CN104418860B (zh) * | 2013-08-20 | 2016-09-07 | 中国科学院广州生物医药与健康研究院 | 嘧啶并杂环类化合物及其药用组合物和应用 |
| AU2015292818B2 (en) | 2014-07-21 | 2020-01-16 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| EP3172213B1 (de) | 2014-07-21 | 2021-09-22 | Dana-Farber Cancer Institute, Inc. | Makrocyclische kinasehemmer und verwendungen davon |
| EP3536323A1 (de) | 2014-08-08 | 2019-09-11 | Dana Farber Cancer Institute, Inc. | Verwendungen von hemmern der salzinduzierbaren kinase (sik) |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| EP4047001A3 (de) | 2016-07-05 | 2022-11-30 | The Broad Institute, Inc. | Bicyclische harnstoffkinaseinhibitoren und verwendungen davon |
| WO2018053373A1 (en) | 2016-09-16 | 2018-03-22 | The General Hospital Corporation | Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis |
| JP7296318B2 (ja) * | 2017-02-28 | 2023-06-22 | ザ ジェネラル ホスピタル コーポレイション | Ｓｉｋインヒビターとしてのピリミドピリミジノンの使用 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CR20200591A (es) | 2018-05-04 | 2021-03-31 | Incyte Corp | Sales de un inhibidor de fgfr |
| BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
| MA54609A (fr) * | 2018-12-27 | 2022-04-06 | Les Laboratoires Servier Sas | Inhibiteurs aza-hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN115835908A (zh) | 2019-10-14 | 2023-03-21 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP2023505257A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4323405A1 (de) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Kombinationstherapie mit einem fgfr-inhibitor und einem auf nectin-4 abzielenden mittel |
| EP4352059A1 (de) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949466A (en) * | 1958-03-04 | 1960-08-16 | Parke Davis & Co | Pyrimidine compounds and means of producing the same |
| NL6704601A (de) * | 1966-04-06 | 1967-10-09 | ||
| US4425346A (en) * | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
| JPS60226882A (ja) * | 1984-04-24 | 1985-11-12 | Nippon Zoki Pharmaceut Co Ltd | 新規ピリミドピリミジン誘導体 |
| AU7622698A (en) | 1996-12-05 | 1998-06-29 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| ATE402177T1 (de) | 1998-05-26 | 2008-08-15 | Warner Lambert Co | Bicyclische pyrimidine und bicyclische 3,4- dihydropyrimidine als inhibitoren der zellvermehrung |
| EP1123295B1 (de) * | 1998-10-23 | 2004-09-29 | F. Hoffmann-La Roche Ag | Bicyclische stickstoffheteroaryl verbindungen |
| CZ20021744A3 (cs) * | 1999-10-21 | 2002-08-14 | F. Hoffmann-La Roche Ag | Bicyklické dusíkové heterocykly substituované heteroalkylaminoskupinou jako inhibitory P38 proteinkinázy |
| TR200201058T2 (tr) | 1999-10-21 | 2002-07-22 | F.Hoffmann-La Roche Ag | P38 protein kinaz inhibitörleri olarak, alkilaminoyla ornatılmış bisiklik, azotlu heterosikller |
| MY141144A (en) | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| WO2002018380A1 (en) | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
| PA8577501A1 (es) | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
-
2003
- 2003-07-21 US US10/623,972 patent/US7084270B2/en not_active Expired - Fee Related
- 2003-08-07 KR KR1020077017079A patent/KR20070087687A/ko not_active Application Discontinuation
- 2003-08-07 JP JP2004530098A patent/JP2005538141A/ja active Pending
- 2003-08-07 BR BR0313732-5A patent/BR0313732A/pt not_active IP Right Cessation
- 2003-08-07 ES ES03792269T patent/ES2300644T3/es not_active Expired - Lifetime
- 2003-08-07 AT AT03792269T patent/ATE386743T1/de not_active IP Right Cessation
- 2003-08-07 PL PL03375588A patent/PL375588A1/xx not_active Application Discontinuation
- 2003-08-07 EP EP03792269A patent/EP1556384B1/de not_active Expired - Lifetime
- 2003-08-07 WO PCT/EP2003/008744 patent/WO2004018472A2/en active IP Right Grant
- 2003-08-07 CA CA002494127A patent/CA2494127A1/en not_active Abandoned
- 2003-08-07 RU RU2005107314/04A patent/RU2336275C2/ru not_active IP Right Cessation
- 2003-08-07 DE DE60319255T patent/DE60319255T2/de not_active Expired - Fee Related
- 2003-08-07 MX MXPA05001629A patent/MXPA05001629A/es active IP Right Grant
- 2003-08-07 AU AU2003255389A patent/AU2003255389A1/en not_active Abandoned
- 2003-08-07 CN CNB038191601A patent/CN1323080C/zh not_active Expired - Fee Related
- 2003-08-11 PA PA20038580001A patent/PA8580001A1/es unknown
- 2003-08-12 AR ARP030102914A patent/AR040971A1/es not_active Application Discontinuation
- 2003-08-12 UY UY27937A patent/UY27937A1/es not_active Application Discontinuation
- 2003-08-13 TW TW092122274A patent/TW200407326A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1556384B1 (de) | 2008-02-20 |
| CA2494127A1 (en) | 2004-03-04 |
| CN1323080C (zh) | 2007-06-27 |
| AU2003255389A1 (en) | 2004-03-11 |
| US20040038995A1 (en) | 2004-02-26 |
| DE60319255T2 (de) | 2009-03-05 |
| PA8580001A1 (es) | 2004-03-10 |
| ES2300644T3 (es) | 2008-06-16 |
| RU2005107314A (ru) | 2005-11-20 |
| UY27937A1 (es) | 2004-02-27 |
| KR20070087687A (ko) | 2007-08-28 |
| WO2004018472A2 (en) | 2004-03-04 |
| DE60319255D1 (de) | 2008-04-03 |
| MXPA05001629A (es) | 2005-04-25 |
| EP1556384A2 (de) | 2005-07-27 |
| CN1675214A (zh) | 2005-09-28 |
| BR0313732A (pt) | 2005-09-27 |
| RU2336275C2 (ru) | 2008-10-20 |
| TW200407326A (en) | 2004-05-16 |
| PL375588A1 (en) | 2005-11-28 |
| JP2005538141A (ja) | 2005-12-15 |
| WO2004018472A3 (en) | 2004-04-29 |
| AR040971A1 (es) | 2005-04-27 |
| US7084270B2 (en) | 2006-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE386743T1 (de) | Pyrimidoverbindungen mit antiproliferativer wirkung | |
| DE60332125D1 (de) | Indole mit antidiabetischer wirkung | |
| DE60318287D1 (de) | Zerstäuber mit diskreten Strahlen | |
| DE602004029705D1 (de) | 5,7-diaminopyrazoloä4,3-düpyrimidine mit pde-5-hemmender wirkung | |
| EP1546115A4 (de) | Substituierte pyrimidine | |
| EP1567871A4 (de) | Sondenstation mit niederinduktivitätsweg | |
| FI20020394A (fi) | Valotutka | |
| DK1487805T3 (da) | Pyrimidinderivater | |
| DE60319260D1 (de) | Pyrimidoderivate mit antiproliferativer aktivität (ii) | |
| ATE473985T1 (de) | Tricyclische tetrahydrochinoline mit antibakterieller wirkung | |
| EP1548905A4 (de) | Lichtemittierendes element | |
| ATE446750T1 (de) | 3-cyano-chinolin-derivate mit antiproliferativer wirkung | |
| ATE435863T1 (de) | Diazabicycloalkan-derivate mit nk1- antagonistischer wirkung | |
| DE60315984D1 (de) | Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung | |
| IS7421A (is) | Frásogshvati | |
| DE602004017199D1 (de) | Silikonverbindungen mit mikrobizider wirkung | |
| FR2844817B1 (fr) | Element de coffrage | |
| FI5659U1 (fi) | Lana | |
| ITUD20020026U1 (it) | Profilo luminoso polifunzionale | |
| ITUD20020081A1 (it) | Profilo luminoso polifunzionale | |
| FI5717U1 (fi) | Kynttiläteline | |
| ITRE20020018A1 (it) | Denocciolatrice | |
| DK1539233T3 (da) | Humaniserede super-antistoffer | |
| UA6188S (uk) | Профіль | |
| UA6918S (uk) | Профіль |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1556384 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |