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ATE386525T1 - 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel - Google Patents

3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel

Info

Publication number
ATE386525T1
ATE386525T1 AT02796217T AT02796217T ATE386525T1 AT E386525 T1 ATE386525 T1 AT E386525T1 AT 02796217 T AT02796217 T AT 02796217T AT 02796217 T AT02796217 T AT 02796217T AT E386525 T1 ATE386525 T1 AT E386525T1
Authority
AT
Austria
Prior art keywords
sup
derivatives
dihydroxytetrahydroisocinoline
antibateral
substituted
Prior art date
Application number
AT02796217T
Other languages
English (en)
Inventor
Kaspar Burri
Laurent Schmitt
Khalid Islam
Original Assignee
Arpida Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arpida Ag filed Critical Arpida Ag
Application granted granted Critical
Publication of ATE386525T1 publication Critical patent/ATE386525T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02796217T 2001-08-27 2002-08-09 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel ATE386525T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0109846 2001-08-27

Publications (1)

Publication Number Publication Date
ATE386525T1 true ATE386525T1 (de) 2008-03-15

Family

ID=8164565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02796217T ATE386525T1 (de) 2001-08-27 2002-08-09 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel

Country Status (12)

Country Link
US (1) US7371762B2 (de)
EP (1) EP1427417B1 (de)
JP (1) JP4383166B2 (de)
CN (1) CN1549716B (de)
AT (1) ATE386525T1 (de)
CA (1) CA2458477A1 (de)
DE (1) DE60225155T2 (de)
ES (1) ES2301701T3 (de)
MX (1) MXPA04001773A (de)
NO (1) NO20040821L (de)
PT (1) PT1427417E (de)
WO (1) WO2003018017A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0419192D0 (en) * 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
CN100386319C (zh) * 2005-12-05 2008-05-07 中国人民解放军第二军医大学 具有抗生育和抗真菌活性的四氢异喹啉类化合物或其盐类
CA2751892A1 (en) 2009-01-15 2010-07-22 Rutgers, The State University Of New Jersey Benzo [c] phenanthridines as antimicrobial agents
US20120059026A1 (en) 2009-04-30 2012-03-08 University Of Medicine And Dentistry Of New Jersey Antimicrobial agents
US8933096B2 (en) 2010-06-09 2015-01-13 Rugers, The State University of New Jersey Antimicrobial agents
US9102617B2 (en) 2010-06-25 2015-08-11 Rutgers, The State University Of New Jersey Antimicrobial agents
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
US9475783B2 (en) 2012-03-21 2016-10-25 Rutgers, The State University Of New Jersey Antimicrobial agents
CN102731328B (zh) * 2012-06-18 2014-11-05 迪沙药业集团有限公司 一种盐酸安非他酮的制备方法
RS58040B1 (sr) 2012-12-21 2019-02-28 Epizyme Inc Prmt5 inhibitori i njihove upotrebe
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
US10513528B2 (en) 2016-02-25 2019-12-24 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
WO2018183917A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2351027A1 (de) 1973-10-11 1975-04-24 Boehringer Sohn Ingelheim Propanolderivate
FR2662940B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Utilisation de derives de la tetrahydro isoquinoleine pour la preparation de medicaments anti-tumoraux, application a titre de medicaments de derives de la tetrahydro isoquinoleine et produits derives de cette structure.
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase

Also Published As

Publication number Publication date
CN1549716B (zh) 2010-05-26
US20040266817A1 (en) 2004-12-30
CN1549716A (zh) 2004-11-24
US7371762B2 (en) 2008-05-13
EP1427417B1 (de) 2008-02-20
JP4383166B2 (ja) 2009-12-16
ES2301701T3 (es) 2008-07-01
MXPA04001773A (es) 2004-05-31
EP1427417A1 (de) 2004-06-16
WO2003018017A1 (en) 2003-03-06
DE60225155T2 (de) 2009-03-05
NO20040821L (no) 2004-04-26
JP2005503392A (ja) 2005-02-03
PT1427417E (pt) 2008-06-02
CA2458477A1 (en) 2003-03-06
DE60225155D1 (de) 2008-04-03

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties