ATE384800T1 - Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten - Google Patents
Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheitenInfo
- Publication number
- ATE384800T1 ATE384800T1 AT01988344T AT01988344T ATE384800T1 AT E384800 T1 ATE384800 T1 AT E384800T1 AT 01988344 T AT01988344 T AT 01988344T AT 01988344 T AT01988344 T AT 01988344T AT E384800 T1 ATE384800 T1 AT E384800T1
- Authority
- AT
- Austria
- Prior art keywords
- fusion proteins
- treatment
- protease
- protease inhibitors
- diseases
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 5
- 108020001507 fusion proteins Proteins 0.000 abstract 5
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 102000004002 Secretory Leukocyte Peptidase Inhibitor Human genes 0.000 abstract 2
- 108010082545 Secretory Leukocyte Peptidase Inhibitor Proteins 0.000 abstract 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 abstract 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 abstract 2
- 229940024142 alpha 1-antitrypsin Drugs 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25669900P | 2000-12-18 | 2000-12-18 | |
| US33196601P | 2001-11-20 | 2001-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384800T1 true ATE384800T1 (de) | 2008-02-15 |
Family
ID=26945535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01988344T ATE384800T1 (de) | 2000-12-18 | 2001-12-18 | Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1366175B1 (de) |
| JP (2) | JP4426179B2 (de) |
| AT (1) | ATE384800T1 (de) |
| AU (2) | AU2002241661B2 (de) |
| CA (1) | CA2430973A1 (de) |
| DE (1) | DE60132632T2 (de) |
| WO (1) | WO2002050287A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006510657A (ja) * | 2002-12-06 | 2006-03-30 | アライバ ファーマシューティカルズ，インコーポレイティド | 中耳炎の処置のための方法および組成物 |
| US20070098635A1 (en) * | 2003-04-08 | 2007-05-03 | Genova Ltd. | Secreted polypeptide species associatedwith cardiovascular disorders |
| AU2004263900A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| SE0302559D0 (sv) * | 2003-09-25 | 2003-09-25 | Astrazeneca Ab | Method |
| EP1737499A4 (de) | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | Behandlung von chronisch obstruktiver lungenerkrankung durch inhalation von niedrigen dosen eines proteasehemmers |
| JP2007037434A (ja) * | 2005-08-02 | 2007-02-15 | Yamaguchi Univ | 膵β細胞特異的に発現される人工タンパク質、該タンパク質をコードしたレポーター遺伝子及び膵β細胞量の計測方法 |
| WO2007117440A2 (en) * | 2006-03-30 | 2007-10-18 | Research Foundation Of City University Of New York | Stimulation of neuron regeneration by secretory leukocyte protease inhibitor |
| EP2341138B1 (de) * | 2008-10-09 | 2017-11-22 | Oriental Yeast Co., Ltd. | FUSIONSPROTEIN AUS EINEM MATRIXMETALLOPROTEINASE-2-HEMMER-PEPTID AUS EINEM AMYLIOD-ß-VORLÄUFERPROTEIN UND GEWEBEHEMMER DER METALLOPROTEINASE-2 |
| ES2535704T3 (es) | 2010-09-14 | 2015-05-14 | F. Hoffmann-La Roche Ag | Polipéptido de fusión serpina-dedo |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| MX356517B (es) | 2011-06-28 | 2018-06-01 | Inhibrx Llc | Polipéptidos de fusión de serpina y métodos de uso de los mismos. |
| CN107596359A (zh) | 2011-12-30 | 2018-01-19 | 基立福有限公司 | 用于延迟肺部症状加重的发作或进展的α1‑蛋白酶抑制剂 |
| WO2014179408A1 (en) * | 2013-04-30 | 2014-11-06 | The Trustees Of Columbia University In The City Of New York | Analyzing elastic fiber injury markers |
| US10822395B2 (en) | 2013-09-18 | 2020-11-03 | James Cook University | Modified anti-inflammatory proteins and method of use |
| WO2015039188A1 (en) * | 2013-09-18 | 2015-03-26 | James Cook University | Anti-inflammatory proteins and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900400A (en) * | 1984-12-06 | 1999-05-04 | Amgen Inc. | Serine protease inhibitor analogs |
| DE3709255A1 (de) * | 1987-03-20 | 1988-09-29 | Hoechst Ag | Hybridserpine und dafuer kodierende dna |
| US5633227A (en) * | 1994-09-12 | 1997-05-27 | Miles, Inc. | Secretory leukocyte protease inhibitor as an inhibitor of tryptase |
| NZ500656A (en) * | 1997-05-12 | 2001-11-30 | Tno | Vector containing a nucleic acid insertion expressing a hybrid polypeptide with a protease inhibitor domain and a receptor binding domain |
| AU1101501A (en) * | 1999-10-27 | 2001-05-08 | K-Quay Enterprises, Llc | Methods and compositions for treatment of keratoconus using protease inhibitors |
-
2001
- 2001-12-18 CA CA002430973A patent/CA2430973A1/en not_active Abandoned
- 2001-12-18 AT AT01988344T patent/ATE384800T1/de not_active IP Right Cessation
- 2001-12-18 EP EP01988344A patent/EP1366175B1/de not_active Expired - Lifetime
- 2001-12-18 WO PCT/US2001/049256 patent/WO2002050287A2/en active IP Right Grant
- 2001-12-18 JP JP2002552164A patent/JP4426179B2/ja not_active Expired - Fee Related
- 2001-12-18 DE DE60132632T patent/DE60132632T2/de not_active Expired - Lifetime
- 2001-12-18 AU AU2002241661A patent/AU2002241661B2/en not_active Ceased
- 2001-12-18 AU AU4166102A patent/AU4166102A/xx active Pending
-
2009
- 2009-08-07 JP JP2009184874A patent/JP2009297031A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU4166102A (en) | 2002-07-01 |
| JP4426179B2 (ja) | 2010-03-03 |
| JP2009297031A (ja) | 2009-12-24 |
| EP1366175B1 (de) | 2008-01-23 |
| CA2430973A1 (en) | 2002-06-27 |
| DE60132632T2 (de) | 2009-01-22 |
| AU2002241661B2 (en) | 2007-05-31 |
| WO2002050287A3 (en) | 2003-09-18 |
| WO2002050287A2 (en) | 2002-06-27 |
| JP2004537970A (ja) | 2004-12-24 |
| EP1366175A2 (de) | 2003-12-03 |
| DE60132632D1 (de) | 2008-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |