ATE383368T1 - Verfahren zur rückgewinnung von beta-interferon - Google Patents

Verfahren zur rückgewinnung von beta-interferon

Info

Publication number: ATE383368T1
Authority: AT; Austria
Prior art keywords: ifn; renaturation; hcl; purification method; beta interferon
Prior art date: 2000-10-27

Application number

AT01985190T

Other languages

English (en)

Inventor

Sid Wolfe

Irina Esikova

Susan Babuka

Bret Shirley

Dennis Fordham

Original Assignee

Novartis Vaccines & Diagnostic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2001-10-26

Publication date

2008-01-15

2001-10-26 Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE383368T1 publication Critical patent/ATE383368T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

AT01985190T 2000-10-27 2001-10-26 Verfahren zur rückgewinnung von beta-interferon ATE383368T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US24396500P	2000-10-27	2000-10-27
US28260701P	2001-04-09	2001-04-09
US33037501P	2001-10-18	2001-10-18
US10/035,420 US7544354B2 (en)	2000-10-27	2001-10-25	Methods of protein purification and recovery

Publications (1)

Publication Number	Publication Date
ATE383368T1 true ATE383368T1 (de)	2008-01-15

Family

ID=27488301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01985190T ATE383368T1 (de)	2000-10-27	2001-10-26	Verfahren zur rückgewinnung von beta-interferon

Country Status (16)

Country	Link
US (3)	US7544354B2 (de)
EP (1)	EP1366060B1 (de)
JP (1)	JP3946139B2 (de)
CN (1)	CN100493601C (de)
AT (1)	ATE383368T1 (de)
AU (1)	AU2002234161B2 (de)
BG (1)	BG66119B1 (de)
CA (1)	CA2427088C (de)
CZ (1)	CZ301360B6 (de)
DE (1)	DE60132366T2 (de)
ES (1)	ES2299528T3 (de)
IL (1)	IL155577A0 (de)
NO (1)	NO326288B1 (de)
PL (1)	PL206428B1 (de)
PT (1)	PT1366060E (de)
WO (1)	WO2002034791A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7544354B2 (en) *	2000-10-27	2009-06-09	Novartis Vaccines And Diagnostics	Methods of protein purification and recovery
US20050079579A1 (en) *	2001-02-28	2005-04-14	Guangwen Wei	Uses of spatial configuration to modulate protein function
US20060035327A1 (en) *	2001-02-28	2006-02-16	Guangwen Wei	Recombinant super-compound interferon and uses thereof
CN1245215C (zh)	2001-02-28	2006-03-15	四川省生物工程研究中心	重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
US6887462B2 (en)	2001-04-09	2005-05-03	Chiron Corporation	HSA-free formulations of interferon-beta
US20050029194A1 (en) *	2003-08-07	2005-02-10	Hall David Bruce	Method for removal of guanidine compound from aqueous media
US7585647B2 (en) *	2003-08-28	2009-09-08	Guangwen Wei	Nucleic acid encoding recombinant interferon
EP2537527A3 (de) *	2005-03-09	2013-02-20	Guangwen Wei	Verwendung rekombinanter Superverbindungs-Interferone
CA2602951A1 (en) *	2005-03-23	2006-09-28	Bio-Rad Laboratories, Inc.	Diverse chemical libraries bound to small particles with paramagnetic properties
US20090247421A1 (en) *	2005-03-23	2009-10-01	Egisto Boschetti	Diverse chemical libraries bound to small particles with paramagnetic properties
KR20080040674A (ko) *	2005-07-29	2008-05-08	노파르티스 아게	시험관내 단백질 접힘을 위한 방법과 장치
US7858661B2 (en)	2005-08-16	2010-12-28	Sanyo Chemical Industries, Ltd.	Protein refolding agent and refolding method
JP2007126391A (ja) *	2005-11-02	2007-05-24	Sanyo Chem Ind Ltd	タンパク質のリフォールディング剤
JP4786303B2 (ja) *	2005-11-02	2011-10-05	三洋化成工業株式会社	タンパク質のリフォールディング剤
JP5274795B2 (ja) *	2006-07-27	2013-08-28	三洋化成工業株式会社	タンパク質のリフォールディング方法
KR20100019467A (ko)	2007-05-02	2010-02-18	암브룩스, 인코포레이티드	변형된 인터페론 베타 폴리펩티드 및 그의 용도
EP2207890A4 (de) *	2007-10-05	2010-12-15	Barofold Inc	Hochdruckbehandlung aggregierter interferone
KR101113495B1 (ko)	2008-01-23	2012-02-29	한미홀딩스 주식회사	인간 인터페론 베타의 정제방법
GB0821010D0 (en) *	2008-11-17	2008-12-24	Univ Warwick	Plant development control composition
CN101885767B (zh) *	2010-06-13	2013-03-13	深圳科兴生物工程有限公司	一种取代单克隆抗体亲和层析的分离纯化重组人干扰素α1b的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5702699A (en)	1982-09-23	1997-12-30	Cetus Corporation	Process for the recovery of lipophilic proteins
US5643566A (en)	1982-09-23	1997-07-01	Cetus Corporation	Formulation processes for lipophilic proteins
US4462940A (en)	1982-09-23	1984-07-31	Cetus Corporation	Process for the recovery of human β-interferon-like polypeptides
US4992271A (en)	1982-09-23	1991-02-12	Cetus Corporation	Formulation for lipophilic IL-2 proteins
US4816440A (en)	1985-09-26	1989-03-28	Cetus Corporation	Stable formulation of biologically active proteins for parenteral injection
CA1294215C (en)	1986-10-27	1992-01-14	Ze'ev Shaked	Pharmaceutical compositions of recombinant beta-interferon and formulation processes
US5183746A (en) *	1986-10-27	1993-02-02	Schering Aktiengesellschaft	Formulation processes for pharmaceutical compositions of recombinant β-
US4894330A (en)	1986-12-23	1990-01-16	Cetus Corporation	Purification of recombinant beta-interferon incorporating RP-HPLC
US4931543A (en)	1987-05-11	1990-06-05	Cetus Corporation	Process for recovering microbially produced interleukin-2
US5162507A (en)	1987-05-11	1992-11-10	Cetus Corporation	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US5004605A (en) *	1987-12-10	1991-04-02	Cetus Corporation	Low pH pharmaceutical compositions of recombinant β-interferon
CA1340586C (en)	1988-09-23	1999-06-08	Cetus Corporation	Process for recovering microbially produced interferon-beta
KR930006706B1 (ko)	1991-04-29	1993-07-23	주식회사 럭키	인간 인터페론 베타의 정제방법
DE4407325B4 (de) *	1994-03-04	2006-06-29	Basf Ag	Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
MX9605717A (es)	1994-05-18	1998-05-31	Inhale Therapeutic Syst	Metodos y composiciones para la formulacion de polvo seco de interferones.
US5814485A (en) *	1995-06-06	1998-09-29	Chiron Corporation	Production of interferon-β (IFN-β) in E. coli
BR9606270A (pt)	1996-12-18	1998-09-22	Univ Minas Gerais	Processo para a produção da proteína do interferon beta-cis humano recombinante e proteína de interferon beta-cis humano recombinante
US20030190307A1 (en) *	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
US7544354B2 (en) *	2000-10-27	2009-06-09	Novartis Vaccines And Diagnostics	Methods of protein purification and recovery
US6887462B2 (en)	2001-04-09	2005-05-03	Chiron Corporation	HSA-free formulations of interferon-beta

2001
- 2001-10-25 US US10/035,420 patent/US7544354B2/en not_active Expired - Lifetime
- 2001-10-26 ES ES01985190T patent/ES2299528T3/es not_active Expired - Lifetime
- 2001-10-26 CZ CZ20031157A patent/CZ301360B6/cs not_active IP Right Cessation
- 2001-10-26 DE DE60132366T patent/DE60132366T2/de not_active Expired - Lifetime
- 2001-10-26 IL IL15557701A patent/IL155577A0/xx active IP Right Grant
- 2001-10-26 PT PT01985190T patent/PT1366060E/pt unknown
- 2001-10-26 PL PL365896A patent/PL206428B1/pl unknown
- 2001-10-26 CN CNB018199836A patent/CN100493601C/zh not_active Expired - Lifetime
- 2001-10-26 JP JP2002537777A patent/JP3946139B2/ja not_active Expired - Lifetime
- 2001-10-26 WO PCT/US2001/051038 patent/WO2002034791A2/en active IP Right Grant
- 2001-10-26 AU AU2002234161A patent/AU2002234161B2/en not_active Expired
- 2001-10-26 AT AT01985190T patent/ATE383368T1/de active
- 2001-10-26 CA CA2427088A patent/CA2427088C/en not_active Expired - Lifetime
- 2001-10-26 EP EP01985190A patent/EP1366060B1/de not_active Expired - Lifetime
2003
- 2003-04-24 NO NO20031839A patent/NO326288B1/no not_active IP Right Cessation
- 2003-05-23 BG BG107844A patent/BG66119B1/bg unknown
- 2003-12-31 US US10/750,076 patent/US20040115169A1/en not_active Abandoned
2008
- 2008-04-29 US US12/150,530 patent/US8388942B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2002034791A2 (en)	2002-05-02
IL155577A0 (en)	2003-11-23
CN100493601C (zh)	2009-06-03
DE60132366D1 (de)	2008-02-21
CN1479627A (zh)	2004-03-03
US20040115169A1 (en)	2004-06-17
AU2002234161B2 (en)	2006-10-19
JP3946139B2 (ja)	2007-07-18
BG66119B1 (bg)	2011-05-31
US20090123424A1 (en)	2009-05-14
DE60132366T2 (de)	2009-01-29
PL365896A1 (en)	2005-01-10
ES2299528T3 (es)	2008-06-01
PL206428B1 (pl)	2010-08-31
EP1366060A2 (de)	2003-12-03
US7544354B2 (en)	2009-06-09
CZ301360B6 (cs)	2010-01-27
BG107844A (bg)	2004-07-30
CZ20031157A3 (en)	2004-03-17
PT1366060E (pt)	2008-03-17
JP2004512343A (ja)	2004-04-22
WO2002034791A3 (en)	2003-10-09
CA2427088A1 (en)	2002-05-02
US20020137895A1 (en)	2002-09-26
NO20031839D0 (no)	2003-04-24
NO326288B1 (no)	2008-11-03
US8388942B2 (en)	2013-03-05
CA2427088C (en)	2011-06-21
EP1366060B1 (de)	2008-01-09
NO20031839L (no)	2003-05-28

Publication	Publication Date	Title
ATE383368T1 (de)	2008-01-15	Verfahren zur rückgewinnung von beta-interferon
DE60034707D1 (de)	2007-06-14	Allgemeines verfahren zur rückfaltung rekombinanter proteine
DE60129432D1 (de)	2007-08-30	Verfahren zur rückfaltung von proteinen mit freien cysteinresten
DK1095056T3 (da)	2007-04-23	Höjtryksrefoldning af proteinaggregater og inklusionslegemer
CN1039330C (zh)	1998-07-29	一种从含有无活性蛋白的溶液中回收生物活性形式重组蛋白的方法
ATE86627T1 (de)	1993-03-15	Isolierung von bioaktivem, monomerem wachstumshormon.
NO920777L (no)	1992-08-31	Anti-thrombinpolypeptider
DE69121742D1 (de)	1996-10-10	Verfahren zur Herstellung von Somatotropinmonomeren in reiner Form
ATE96805T1 (de)	1993-11-15	Verfahren zur rueckgewinnung rekombinanter proteine.
ES2370019T3 (es)	2011-12-12	Procedimiento de purificación de interferón beta.
DK1115420T3 (da)	2002-11-04	Behandling af hepatitis B med thymosin-alpha-1 og lamivudin
EA200401618A1 (ru)	2005-06-30	Лечение гепатита с в азиатской популяции подкожным введением бета-интерферона
DE60027581D1 (de)	2006-06-01	Design von immunogene
CA2534224A1 (en)	2005-02-17	Preparation of somatostatin peptides
ES2369911T3 (es)	2011-12-09	Procedimiento de purificación de interferón beta.
DE60044812D1 (de)	2010-09-23	Methode zur reinigung von proteinen
ATE369427T1 (de)	2007-08-15	Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine
BG60405B2 (bg)	1995-02-28	Фармацевтични състави от микробно произведен интерлевкин-2

Legal Events

Date	Code	Title	Description
2008-08-15	UEP	Publication of translation of european patent specification	Ref document number: 1366060 Country of ref document: EP

Date

Code

Title

Description

2008-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1366060

Country of ref document: EP