ATE364083T1 - Immunogene zusammensetzungen gegen eine helicobacterinfektion, verwendung von polypeptiden in diesen zusammensetzungen und nukleinsäurendie besagte polypeptide kodieren - Google Patents
Immunogene zusammensetzungen gegen eine helicobacterinfektion, verwendung von polypeptiden in diesen zusammensetzungen und nukleinsäurendie besagte polypeptide kodierenInfo
- Publication number
- ATE364083T1 ATE364083T1 AT94917653T AT94917653T ATE364083T1 AT E364083 T1 ATE364083 T1 AT E364083T1 AT 94917653 T AT94917653 T AT 94917653T AT 94917653 T AT94917653 T AT 94917653T AT E364083 T1 ATE364083 T1 AT E364083T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptides
- fragment
- helicobacter
- compositions
- nucleic acids
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title abstract 3
- 206010019375 Helicobacter infections Diseases 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 5
- 108010046334 Urease Proteins 0.000 abstract 4
- 241000590017 Helicobacter felis Species 0.000 abstract 2
- 241000590002 Helicobacter pylori Species 0.000 abstract 2
- 229940037467 helicobacter pylori Drugs 0.000 abstract 2
- 108050001186 Chaperonin Cpn60 Proteins 0.000 abstract 1
- 102000052603 Chaperonins Human genes 0.000 abstract 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 241000589989 Helicobacter Species 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93401309 | 1993-05-19 | ||
| PCT/EP1993/003259 WO1995014093A1 (en) | 1993-05-19 | 1993-11-19 | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364083T1 true ATE364083T1 (de) | 2007-06-15 |
Family
ID=26070083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94917653T ATE364083T1 (de) | 1993-05-19 | 1994-05-19 | Immunogene zusammensetzungen gegen eine helicobacterinfektion, verwendung von polypeptiden in diesen zusammensetzungen und nukleinsäurendie besagte polypeptide kodieren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6248330B1 (de) |
| EP (1) | EP0703981B1 (de) |
| JP (4) | JPH08509873A (de) |
| AT (1) | ATE364083T1 (de) |
| AU (1) | AU689779B2 (de) |
| CA (1) | CA2144307C (de) |
| DE (1) | DE69434985T2 (de) |
| DK (1) | DK0703981T3 (de) |
| ES (1) | ES2288753T3 (de) |
| SG (1) | SG52480A1 (de) |
| WO (2) | WO1995014093A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014093A1 (en) | 1993-05-19 | 1995-05-26 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides |
| US5874405A (en) * | 1994-12-16 | 1999-02-23 | Birnbaum; Gary | Heat shock protein peptides that share sequences with cyclic nucleotide phosphodiesterase and methods for modulating autoimmune central nervous system disease |
| US6762295B2 (en) * | 1995-04-21 | 2004-07-13 | Csl Limited | Protective helicobacter antigens |
| DE69637947D1 (de) * | 1995-04-28 | 2009-07-23 | Merieux Oravax Snc | Multimerer, rekombinanter urease impfstoff |
| AU5693496A (en) * | 1995-05-02 | 1996-11-21 | Institut National De La Sante Et De La Recherche Medicale | Immunogenic compositions against helicobacter infection, pol ypeptides for use in the compositions, and nucleic acid sequ ences encoding said polypeptides |
| CN1145697C (zh) * | 1995-11-30 | 2004-04-14 | 维多利亚农业服务控股公司 | 治疗和诊断组合物 |
| GB2307987A (en) * | 1995-12-06 | 1997-06-11 | Univ Manchester | Epitopes of the urease of Helicobacter pylori as dignostic agents; pharmaceuticals comprising such epitopes or the antibodies thereto |
| DE69737413T2 (de) * | 1996-01-04 | 2007-10-31 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Bakterioferritin aus helicobacter pylori |
| DE19630390A1 (de) * | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
| EP0835928A1 (de) * | 1996-10-11 | 1998-04-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | Helicobacter Pylori Lebendimpfstoff |
| US6248551B1 (en) * | 1997-03-28 | 2001-06-19 | Institut Pasteur | Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides |
| JP3430853B2 (ja) | 1997-04-11 | 2003-07-28 | 株式会社ゲン・コーポレーション | 胃炎、胃潰瘍および十二指腸潰瘍の予防剤並びに治療剤 |
| AU7537598A (en) * | 1997-04-30 | 1998-11-24 | Pasteur Merieux Serums Et Vaccins | Dna based anti-(helicobacter) vaccine composition |
| US5985631A (en) * | 1997-09-12 | 1999-11-16 | Oravax-Merieux Co. | Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease |
| US20020151462A1 (en) * | 1998-02-19 | 2002-10-17 | Ling Lissolo | Helicobacter pylori membrane proteins |
| US6190667B1 (en) | 1998-06-30 | 2001-02-20 | Institut Pasteur | Methods of inhibiting Helicobacter pylori |
| CA2351110A1 (en) * | 2000-07-17 | 2002-01-17 | Akzo Nobel N.V. | Helicobacter felis vaccine |
| GB0021757D0 (en) * | 2000-09-04 | 2000-10-18 | Colaco Camilo | Vaccine against microbial pathogens |
| AU2003250658B2 (en) * | 2002-07-18 | 2009-07-16 | Helix Biopharma Corp. | Use of urease for inhibiting cancer cell growth |
| US7264800B2 (en) * | 2002-07-18 | 2007-09-04 | Helix Biopharma Corporation | Method and composition for inhibiting cancer cell growth |
| US7790143B2 (en) | 2005-06-16 | 2010-09-07 | Universiteit Gent | Vaccines for immunization against helicobacter |
| ATE516817T1 (de) | 2005-06-16 | 2011-08-15 | Univ Gent | Impfstoffe zur immunisierung gegen helicobacter |
| CN105247047A (zh) | 2013-04-08 | 2016-01-13 | 赫利克斯生物药品公司 | 抗体-尿素酶偶联物在诊断和治疗中的应用 |
| JP6876618B2 (ja) | 2015-01-23 | 2021-06-02 | へリックス バイオファーマ コープ． | 治療目的のための抗体−ウレアーゼコンジュゲート |
| CN118414162A (zh) * | 2021-12-23 | 2024-07-30 | 英特维特国际股份有限公司 | 抗利什曼病的dna疫苗 |
| CN116052799B (zh) * | 2022-04-06 | 2026-01-23 | 大连理工江苏研究院有限公司 | 一种基于机器学习的幽门螺杆菌抗体药物制备方法及其研发用区块链应用系统 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459041A (en) * | 1988-02-18 | 1995-10-17 | Enteric Research Laboratories, Inc. | Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection |
| FR2637612B1 (fr) * | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
| GB8928625D0 (en) * | 1989-12-19 | 1990-02-21 | 3I Res Expl Ltd | H.pylori dna probes |
| US5262156A (en) * | 1991-08-12 | 1993-11-16 | Hycor Biomedical, Inc. | Antigenic compositions and their use for the detection of Helicobacter pylori |
| FR2682122B1 (fr) * | 1991-10-03 | 1995-06-09 | Pasteur Institut | Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori. |
| JP3920320B2 (ja) | 1992-02-26 | 2007-05-30 | ヴァンダービルト ユニバーシティ | 精製されたＨｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ由来の空胞形成毒素およびその使用方法 |
| DE69334197T2 (de) * | 1992-03-02 | 2008-12-11 | Novartis Vaccines And Diagnostics S.R.L. | Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik |
| MX9301706A (es) | 1992-04-13 | 1994-05-31 | Oravax Inc | Composicion de vacuna para el tratamiento de la infeccion por helicobacter. |
| DK0661990T3 (da) * | 1992-08-26 | 2002-06-17 | Celtrix Pharma | Fremgangsmåde til systemisk behandling af kataboliske tilstande og systemisk vævsbeskadigelse |
| AU4924893A (en) * | 1992-09-16 | 1994-04-12 | Galagen, Inc. | Antibody treatment of (helicobacter pylori) |
| US5972336A (en) | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
| WO1995014093A1 (en) | 1993-05-19 | 1995-05-26 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides |
| CA2154063C (en) | 1993-07-27 | 2006-11-21 | Christopher Vincent Doidge | Treatment of h. pylori associated gastroduodenal disease |
| AR003125A1 (es) | 1995-06-01 | 1998-07-08 | Astra Ab | Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la |
| SK165197A3 (en) | 1995-06-07 | 1999-01-11 | Astra Ab | Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics |
-
1993
- 1993-11-19 WO PCT/EP1993/003259 patent/WO1995014093A1/en not_active Ceased
- 1993-11-19 JP JP7514170A patent/JPH08509873A/ja active Pending
-
1994
- 1994-05-19 EP EP94917653A patent/EP0703981B1/de not_active Expired - Lifetime
- 1994-05-19 SG SG1996005085A patent/SG52480A1/en unknown
- 1994-05-19 DK DK94917653T patent/DK0703981T3/da active
- 1994-05-19 ES ES94917653T patent/ES2288753T3/es not_active Expired - Lifetime
- 1994-05-19 AU AU69290/94A patent/AU689779B2/en not_active Ceased
- 1994-05-19 DE DE69434985T patent/DE69434985T2/de not_active Expired - Fee Related
- 1994-05-19 JP JP52499794A patent/JP3955317B2/ja not_active Expired - Fee Related
- 1994-05-19 WO PCT/EP1994/001625 patent/WO1994026901A1/en not_active Ceased
- 1994-05-19 CA CA002144307A patent/CA2144307C/en not_active Expired - Fee Related
- 1994-05-19 AT AT94917653T patent/ATE364083T1/de not_active IP Right Cessation
-
1995
- 1995-05-02 US US08/432,697 patent/US6248330B1/en not_active Expired - Fee Related
-
2004
- 2004-06-02 JP JP2004164306A patent/JP2004337170A/ja active Pending
-
2007
- 2007-09-27 JP JP2007252748A patent/JP2008086316A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995014093A1 (en) | 1995-05-26 |
| EP0703981A1 (de) | 1996-04-03 |
| AU689779B2 (en) | 1998-04-09 |
| EP0703981B1 (de) | 2007-06-06 |
| WO1994026901A1 (en) | 1994-11-24 |
| DE69434985D1 (de) | 2007-07-19 |
| JP3955317B2 (ja) | 2007-08-08 |
| DE69434985T2 (de) | 2008-02-21 |
| CA2144307C (en) | 2008-09-02 |
| JP2004337170A (ja) | 2004-12-02 |
| ES2288753T3 (es) | 2008-01-16 |
| JP2008086316A (ja) | 2008-04-17 |
| DK0703981T3 (da) | 2007-10-08 |
| AU6929094A (en) | 1994-12-12 |
| CA2144307A1 (en) | 1994-11-24 |
| US6248330B1 (en) | 2001-06-19 |
| SG52480A1 (en) | 1998-09-28 |
| JPH08510120A (ja) | 1996-10-29 |
| JPH08509873A (ja) | 1996-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0703981 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |