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ATE347615T1 - Nukleinsäuresammlung - Google Patents

Nukleinsäuresammlung

Info

Publication number
ATE347615T1
ATE347615T1 AT98918325T AT98918325T ATE347615T1 AT E347615 T1 ATE347615 T1 AT E347615T1 AT 98918325 T AT98918325 T AT 98918325T AT 98918325 T AT98918325 T AT 98918325T AT E347615 T1 ATE347615 T1 AT E347615T1
Authority
AT
Austria
Prior art keywords
nucleic acid
solid phase
irreversibly
bound
amplification
Prior art date
Application number
AT98918325T
Other languages
English (en)
Inventor
John C Gerdes
Jeffrey M Marmaro
Christopher A Roehl
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE347615T1 publication Critical patent/ATE347615T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98918325T 1997-04-16 1998-04-16 Nukleinsäuresammlung ATE347615T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4199997P 1997-04-16 1997-04-16

Publications (1)

Publication Number Publication Date
ATE347615T1 true ATE347615T1 (de) 2006-12-15

Family

ID=21919507

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98918325T ATE347615T1 (de) 1997-04-16 1998-04-16 Nukleinsäuresammlung

Country Status (8)

Country Link
US (1) US6291166B1 (de)
EP (1) EP1003908B1 (de)
JP (1) JP3666604B2 (de)
AT (1) ATE347615T1 (de)
AU (1) AU745126B2 (de)
CA (1) CA2286573C (de)
DE (1) DE69836587T2 (de)
WO (1) WO1998046797A1 (de)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399386B1 (en) * 1994-07-22 2002-06-04 President And Fellows Of Harvard College Method of isolating receptor and ligand DNA
US6872527B2 (en) * 1997-04-16 2005-03-29 Xtrana, Inc. Nucleic acid archiving
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1999067641A2 (en) 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
DE69938976D1 (de) * 1999-03-11 2008-08-07 Whatman Inc Festmedium sowie verfahren zur speicherung und schnellen aufreinigung von nukleinsäuren
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
EP2351853A1 (de) 2000-06-06 2011-08-03 Life Technologies Corporation Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen
US6605451B1 (en) * 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
MXPA02012735A (es) * 2000-06-26 2004-04-20 Nugen Tgechnologies Inc Metodos y composiciones para la amplificacion de acido nucleico a base de transcripcion.
EP1186886A3 (de) * 2000-09-04 2004-01-07 Fuji Photo Film Co., Ltd. Verfahren zur biochemischen Analyse und dazu geeignetes Gerät
US6858413B2 (en) 2000-12-13 2005-02-22 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
KR20030082535A (ko) 2001-03-09 2003-10-22 뉴젠 테크놀로지스 인코포레이티드 Ｒｎａ 서열의 증폭을 위한 방법 및 조성물
US6869532B2 (en) 2001-06-04 2005-03-22 Cuno Incorporated Nucleic acid binding matrix
US6638722B2 (en) * 2001-06-13 2003-10-28 Invitrogen Corporation Method for rapid amplification of DNA
ATE424468T1 (de) * 2001-07-11 2009-03-15 Baylor College Medicine Verfahren und vorrichtungen auf grundlage einer neuen form eines nukleinsäureduplex auf einer oberfläche
US10272409B2 (en) 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
DE10154317B4 (de) 2001-10-26 2005-06-09 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in immobilisierten DNA Proben
DE60234464D1 (de) * 2001-11-28 2009-12-31 Applied Biosystems Llc Zusammensetzungen und Verfahren zur selektiven Nukleinsäureisolierung
DE10222234A1 (de) * 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Kontroll- und Kalibrationsmaterial für Blutgerinnungstests
US9394332B2 (en) * 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
WO2004048936A2 (en) * 2002-11-26 2004-06-10 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
EP2194147B1 (de) 2002-12-04 2015-07-22 Applied Biosystems, LLC Multiplexverstärkung von Polynucleotiden
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
EP1613778B1 (de) 2003-04-14 2014-11-26 Nugen Technologies, Inc. Globale amplifizierung unter verwendung von zufallsgeprimeten zusammen gesetzten primern
WO2004104181A2 (en) * 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US7390622B2 (en) * 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106602A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Simplified methods for isolating nucleic acids from cellular materials
US20050136477A1 (en) * 2003-11-17 2005-06-23 Hashem Akhavan-Tafti Methods for isolating nucleic acids from biological and cellular materials
US20050106577A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Cleavable solid phases for isolating nucleic acids
US7846333B2 (en) 2003-11-24 2010-12-07 Effendorf AG Porous media
KR20050071751A (ko) * 2004-01-02 2005-07-08 삼성전자주식회사 탄소나노튜브를 이용한 핵산의 정제 방법
KR101077603B1 (ko) * 2004-01-28 2011-10-27 삼성전자주식회사 카르복실기 또는 아미노기로 코팅된 고체상 물질을 이용한핵산의 증폭 방법
AU2005200670B2 (en) * 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
KR100624452B1 (ko) * 2004-12-21 2006-09-18 삼성전자주식회사 고정화된 히드로겔 또는 ｐｅｇ－히드로겔 공중합체를이용한 핵산의 분리 및 정제 방법
KR100745750B1 (ko) * 2005-01-25 2007-08-02 삼성전자주식회사 인터컬레이터를 이용한 핵산의 분리 방법
KR100647315B1 (ko) * 2005-02-02 2006-11-23 삼성전자주식회사 실란화된 고상 물질을 이용한 핵산의 분리 및 증폭 방법
KR101217549B1 (ko) * 2005-02-03 2013-01-02 삼성전자주식회사 광전 변환 소자를 구비한 핵산 분리 장치, 미세 유체 장치및 그 정제 방법
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
EP1712284B1 (de) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Methode zur Zelltrennung mit Benutzung hydrophober fester Träger
US20060257907A1 (en) * 2005-04-19 2006-11-16 The Regents Of The University Of California Packed bed for nucleic acid capture and amplification
KR100682947B1 (ko) * 2005-06-04 2007-02-15 삼성전자주식회사 고정화된 금속-리간드 복합체에 의한 핵산 정제 방법 및장치
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
KR100754399B1 (ko) * 2006-04-05 2007-08-31 삼성전자주식회사 단일 챔버를 이용한 세포 파괴 및 핵산의 정제 방법 및장치
KR100785010B1 (ko) * 2006-04-06 2007-12-11 삼성전자주식회사 수소 결합을 이용하여 고체 지지체의 친수성 표면 상에서핵산 정제 방법 및 장치
KR100785016B1 (ko) 2006-05-22 2007-12-12 삼성전자주식회사 단일 마이크로 챔버에서 핵산의 농축 및 증폭을 수행하는방법 및 장치
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US20080070282A1 (en) * 2006-08-21 2008-03-20 Samsung Electronics Co., Ltd. Method and device for obtaining or amplifying nucleic acid from a cell using a nonplanar solid substrate
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US9683256B2 (en) * 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US20090053704A1 (en) * 2007-08-24 2009-02-26 Natalia Novoradovskaya Stabilization of nucleic acids on solid supports
JP5299986B2 (ja) 2007-11-01 2013-09-25 国立大学法人山口大学 核酸の定量方法
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
WO2009117698A2 (en) * 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
CN102203282B (zh) 2008-06-25 2014-04-30 生命技术公司 使用大规模fet阵列测量分析物的方法和装置
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
JP5587909B2 (ja) * 2008-12-22 2014-09-10 マイクロピュア・インコーポレーテッド 歯の脱灰を低減するための組成物および方法
EP2385979B1 (de) * 2009-01-28 2017-08-16 QIAGEN Gaithersburg, Inc. Sequenzspezifisches verfahren zur vorbereitung grossvolumiger proben und assay
WO2010088517A1 (en) * 2009-01-30 2010-08-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods and systems for purifying transferring and/or manipulating nucleic acids
US20100233101A1 (en) 2009-02-13 2010-09-16 Micropure, Inc. Composition and method for the oxidative consumption of salivary biomolecules
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
TWI547688B (zh) 2010-06-30 2016-09-01 生命技術公司 離子感測電荷累積電路及方法
CN109449171A (zh) 2010-06-30 2019-03-08 生命科技公司 用于检测和测量化学反应和化合物的晶体管电路
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
CN105911126B (zh) 2010-09-24 2018-12-18 生命科技公司 匹配的晶体管对电路
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
EP2972280B1 (de) 2013-03-15 2021-09-29 Life Technologies Corporation Chemischer sensor mit stetigen sensoroberflächen
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
JP6581074B2 (ja) 2013-03-15 2019-09-25 ライフ テクノロジーズ コーポレーション 一貫性のあるセンサ表面積を有する化学センサ
US20140264471A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US10605767B2 (en) 2014-12-18 2020-03-31 Life Technologies Corporation High data rate integrated circuit with transmitter configuration
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN111505087A (zh) 2014-12-18 2020-08-07 生命科技公司 使用大规模 fet 阵列测量分析物的方法和装置
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10850276B2 (en) 2017-02-24 2020-12-01 VisuGen Global LLC Systems and methods for capture and detection of low copy targets from large sample volumes
CA3020197C (en) 2017-09-01 2024-06-04 Micropure, Inc. Aliphatic anionic compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions
CN119510370A (zh) 2019-03-14 2025-02-25 因斯利克萨公司 基于时间门控的荧光检测的方法和系统

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567133A1 (fr) * 1984-07-06 1986-01-10 Inst Nat Sante Rech Med Procede de fixation de molecules, notamment biologiques, sur un support et filtres obtenus
JPH02503983A (ja) * 1987-06-26 1990-11-22 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 捕捉ビーズを用いる組み換えクローン化ｎａからの混入配列のアフイニテイ除去
EP0446260B1 (de) * 1988-11-21 1994-03-02 Dynal A.S. Sonden aus nukleinsäuren
US5234809A (en) * 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
CA2011929A1 (en) * 1989-04-03 1990-10-03 Rex M. Bitner Metal oxide supports for nucleic acids
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
ES2116977T3 (es) * 1990-05-11 1998-08-01 Microprobe Corp Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.
AU1978692A (en) * 1991-04-12 1992-11-17 Minnesota Mining And Manufacturing Company Purification of nucleic acids using metal oxide supports
US5506105A (en) * 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
US5503816A (en) * 1993-09-27 1996-04-02 Becton Dickinson And Company Silicate compounds for DNA purification
EP0821726B1 (de) * 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Mehrfaches, mehr-spezifisches elektrochemilumineszenz-testen
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5578179A (en) * 1995-07-12 1996-11-26 The Perkin-Elmer Corporation Method and silicate composition for conditioning silica surfaces
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation

Also Published As

Publication number Publication date
DE69836587T2 (de) 2007-10-11
CA2286573C (en) 2004-10-26
JP3666604B2 (ja) 2005-06-29
US6291166B1 (en) 2001-09-18
AU745126B2 (en) 2002-03-14
JP2002512688A (ja) 2002-04-23
EP1003908A1 (de) 2000-05-31
EP1003908A4 (de) 2004-05-12
DE69836587D1 (de) 2007-01-18
WO1998046797A1 (en) 1998-10-22
CA2286573A1 (en) 1998-10-22
AU7127198A (en) 1998-11-11
EP1003908B1 (de) 2006-12-06

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