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ATE347599T1 - Tuberkulose impfstoff - Google Patents

Tuberkulose impfstoff

Info

Publication number
ATE347599T1
ATE347599T1 AT98947427T AT98947427T ATE347599T1 AT E347599 T1 ATE347599 T1 AT E347599T1 AT 98947427 T AT98947427 T AT 98947427T AT 98947427 T AT98947427 T AT 98947427T AT E347599 T1 ATE347599 T1 AT E347599T1
Authority
AT
Austria
Prior art keywords
nucleic acid
acid molecules
present
tuberculosis vaccine
novel recombinant
Prior art date
Application number
AT98947427T
Other languages
English (en)
Inventor
Stefan H E Kaufmann
Juergen Hess
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE347599T1 publication Critical patent/ATE347599T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT98947427T 1997-08-22 1998-08-12 Tuberkulose impfstoff ATE347599T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97114614A EP0902086A1 (de) 1997-08-22 1997-08-22 Tuberkolose Impfstoff

Publications (1)

Publication Number Publication Date
ATE347599T1 true ATE347599T1 (de) 2006-12-15

Family

ID=8227261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98947427T ATE347599T1 (de) 1997-08-22 1998-08-12 Tuberkulose impfstoff

Country Status (13)

Country Link
US (1) US6673353B1 (de)
EP (2) EP0902086A1 (de)
JP (1) JP4255209B2 (de)
AT (1) ATE347599T1 (de)
AU (1) AU9435098A (de)
CA (1) CA2301879C (de)
CY (1) CY1106350T1 (de)
DE (1) DE69836588T2 (de)
DK (1) DK1007686T3 (de)
ES (1) ES2274580T3 (de)
PT (1) PT1007686E (de)
SI (1) SI1007686T1 (de)
WO (1) WO1999010496A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820180B2 (en) * 2004-09-24 2010-10-26 The Trustees Of The University Of Pennsylvania Listeria-based and LLO-based vaccines
US7662396B2 (en) 2001-03-26 2010-02-16 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
US8114414B2 (en) 1994-11-08 2012-02-14 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical cancer
US8791237B2 (en) 1994-11-08 2014-07-29 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of non-hodgkins lymphoma
US7794729B2 (en) 1994-11-08 2010-09-14 The Trustees Of The University Of Pennsylvania Methods and compositions for immunotherapy of cancer
US8956621B2 (en) 1994-11-08 2015-02-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical dysplasia
US6051237A (en) 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
CA2348475A1 (en) 1998-11-04 2000-05-11 Isis Innovation Limited Tuberculosis diagnostic test
GB0006693D0 (en) * 2000-03-20 2000-05-10 Glaxo Group Ltd Vaccine
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
EP1303299B1 (de) * 2000-03-29 2010-07-28 The Trustees of The University of Pennsylvania Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen
US6855320B2 (en) 2000-03-29 2005-02-15 The Trustees Of The University Of Pennsylvania Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity
US7700344B2 (en) 2001-03-26 2010-04-20 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
ES2382332T3 (es) * 2003-02-06 2012-06-07 Aduro Biotech Listeria atenuada para entrar en células no fagocíticas, vacunas que comprenden esta listeria y métodos de uso de las mismas
US7988980B2 (en) 2003-04-23 2011-08-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenshaften E. V. Tuberculosis vaccine with improved efficacy
EP1649869A1 (de) * 2004-10-21 2006-04-26 Vakzine Projekt Management GmbH Kombination von rekombinanten Mycobakterien und einem biologisch aktiven Agent als Vakzine
CA2589204C (en) * 2004-12-01 2013-10-29 Aeras Global Tb Vaccine Foundation Recombinant bcg strains with enhanced ability to escape the endosome
EP3284478A1 (de) 2006-08-15 2018-02-21 The Trustees of the University of Pennsylvania Zusammensetzungen mit hmw-maa und fragmenten davon zur behandlung von krebs
US8268326B2 (en) 2006-08-15 2012-09-18 The Trustees Of The University Of Pennsylvania Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
WO2009143167A2 (en) 2008-05-19 2009-11-26 Advaxis Dual delivery system for heterologous antigens
ES2637068T3 (es) 2009-03-04 2017-10-10 The Trustees Of The University Of Pennsylvania Composiciones que comprenden factores angiogénicos y métodos de uso de las mismas
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
DK2618837T3 (en) 2010-09-20 2018-10-01 Vakzine Projekt Man Gmbh RECOMBINANT MYCOBACTERY AS A VACCINE FOR USE OF HUMANS
US9226958B2 (en) 2010-10-01 2016-01-05 University Of Georgia Research Foundation, Inc. Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
KR101882040B1 (ko) * 2010-12-21 2018-07-25 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 항-마이코박테리아 백신접종의 효능 측정
US9328350B2 (en) * 2010-12-21 2016-05-03 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Recombinant mycobacterium as a vaccine
CA2829960A1 (en) 2011-03-11 2012-09-20 John Rothman Listeria-based adjuvants
BR102012003790A2 (pt) 2012-02-17 2014-04-22 Fundacao Butantan Cepa de mycobacterium recombinante, composição imunogênica e uso
AU2013232291B8 (en) 2012-03-12 2016-07-21 Advaxis, Inc. Suppressor cell function inhibition following listeria vaccine treatment
WO2013151731A1 (en) * 2012-04-02 2013-10-10 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium for induction of cellular immune response

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504005A (en) * 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine

Also Published As

Publication number Publication date
EP1007686B1 (de) 2006-12-06
EP1007686A1 (de) 2000-06-14
JP2001514000A (ja) 2001-09-11
US6673353B1 (en) 2004-01-06
AU9435098A (en) 1999-03-16
DK1007686T3 (da) 2007-04-10
EP0902086A1 (de) 1999-03-17
WO1999010496A1 (en) 1999-03-04
SI1007686T1 (sl) 2007-04-30
DE69836588T2 (de) 2007-04-05
CY1106350T1 (el) 2011-10-12
JP4255209B2 (ja) 2009-04-15
CA2301879C (en) 2014-02-04
ES2274580T3 (es) 2007-05-16
DE69836588D1 (de) 2007-01-18
CA2301879A1 (en) 1999-03-04
PT1007686E (pt) 2007-03-30

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