ATE346850T1 - 5-ht4-rezeptor-antagonisten - Google Patents
5-ht4-rezeptor-antagonistenInfo
- Publication number
- ATE346850T1 ATE346850T1 AT94917637T AT94917637T ATE346850T1 AT E346850 T1 ATE346850 T1 AT E346850T1 AT 94917637 T AT94917637 T AT 94917637T AT 94917637 T AT94917637 T AT 94917637T AT E346850 T1 ATE346850 T1 AT E346850T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- sup
- alkyl
- hydrogen
- line
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939310582A GB9310582D0 (en) | 1993-05-22 | 1993-05-22 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346850T1 true ATE346850T1 (de) | 2006-12-15 |
Family
ID=10735954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94917637T ATE346850T1 (de) | 1993-05-22 | 1994-05-16 | 5-ht4-rezeptor-antagonisten |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US5741801A (de) |
| EP (1) | EP0699194B1 (de) |
| JP (1) | JP3981406B2 (de) |
| CN (1) | CN1126472A (de) |
| AT (1) | ATE346850T1 (de) |
| AU (1) | AU693449B2 (de) |
| CA (1) | CA2163372A1 (de) |
| DE (1) | DE69434888T2 (de) |
| ES (1) | ES2277330T3 (de) |
| GB (1) | GB9310582D0 (de) |
| NZ (1) | NZ267099A (de) |
| WO (1) | WO1994027987A1 (de) |
| ZA (1) | ZA943493B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| EP0664794A1 (de) * | 1992-10-16 | 1995-08-02 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl-carbonsäure ester/amide von kondensierten ring-systemen als 5-ht4-rezeptor antagonisten |
| GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
| US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
| IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
| AU1767997A (en) * | 1996-02-15 | 1997-09-02 | Janssen Pharmaceutica N.V. | Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| EP1112270B1 (de) * | 1998-09-10 | 2007-03-21 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten |
| GB9820294D0 (en) * | 1998-09-17 | 1998-11-11 | Smithkline Beecham Plc | Pharmaceuticals |
| US20030220907A1 (en) * | 2001-08-24 | 2003-11-27 | Sorensen Jens Erik | Organizing ideas accumulated in a computer database |
| GB0211230D0 (en) * | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| WO2006052640A1 (en) * | 2004-11-05 | 2006-05-18 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
| US7396933B2 (en) * | 2004-11-05 | 2008-07-08 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| BRPI0519708A2 (pt) * | 2004-12-22 | 2009-03-10 | Theravance Inc | compostos de indazol-carboxamida |
| KR20070107807A (ko) * | 2005-03-02 | 2007-11-07 | 세라밴스 인코포레이티드 | 5-ｈｔ4 수용체 아고니스트인 퀴놀리논 화합물 |
| WO2010065743A2 (en) * | 2008-12-03 | 2010-06-10 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| EP2990140B1 (de) * | 2014-08-27 | 2019-01-02 | SLM Solutions Group AG | Verfahren zur herstellung einer komponente mit einem eisenlegierungsmaterial, komponent und eisenlegierungsmaterial. |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3445472A (en) * | 1965-12-03 | 1969-05-20 | American Home Prod | Mono- and di-aroyl pyridylethyl and piperidylethyl indoles |
| FR2334358A1 (fr) * | 1975-12-12 | 1977-07-08 | Sogeras | Nouveaux medicaments derives de l'indole |
| FR2560873B1 (fr) * | 1984-03-09 | 1986-09-26 | Rhone Poulenc Sante | Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation |
| EP0242973B1 (de) * | 1986-03-17 | 1991-07-17 | Glaxo Group Limited | Indol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| EP0387431A1 (de) * | 1989-03-14 | 1990-09-19 | Beecham Group Plc | Imidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als pharmazeutische Mittel |
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| AU2363492A (en) * | 1991-08-03 | 1993-03-02 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| NZ243993A (en) * | 1991-08-20 | 1994-10-26 | Smithkline Beecham Plc | Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity |
| JP3294611B2 (ja) * | 1991-09-12 | 2002-06-24 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ４レセプター・アンタゴニスト |
| JPH07500588A (ja) * | 1991-10-24 | 1995-01-19 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ↓４拮抗薬としてのイミダゾピリジンおよびインドリジン |
| GB9204565D0 (en) * | 1992-03-03 | 1992-04-15 | Smithkline Beecham Plc | Pharmaceuticals |
| ATE266033T1 (de) * | 1992-03-12 | 2004-05-15 | Smithkline Beecham Plc | N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h- 1,3 oxazino 3,2-a indol-10-carboxamid oder ein pharmazeutisch annehmbares salz davon |
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| CA2092112A1 (en) * | 1992-03-23 | 1993-09-24 | Nobuyoshi Iwata | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use |
| GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
| JP3935199B2 (ja) * | 1993-05-26 | 2007-06-20 | シンテックス（ユー・エス・エイ）・インコーポレイテッド | 新規１−フェニルアルカノン５−ｈｔ▲４▼レセプターリガンド類 |
| EP1112270B1 (de) * | 1998-09-10 | 2007-03-21 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten |
-
1993
- 1993-05-22 GB GB939310582A patent/GB9310582D0/en active Pending
-
1994
- 1994-05-16 DE DE69434888T patent/DE69434888T2/de not_active Expired - Fee Related
- 1994-05-16 AU AU69283/94A patent/AU693449B2/en not_active Ceased
- 1994-05-16 WO PCT/EP1994/001583 patent/WO1994027987A1/en active IP Right Grant
- 1994-05-16 US US08/553,390 patent/US5741801A/en not_active Expired - Fee Related
- 1994-05-16 EP EP94917637A patent/EP0699194B1/de not_active Expired - Lifetime
- 1994-05-16 AT AT94917637T patent/ATE346850T1/de not_active IP Right Cessation
- 1994-05-16 NZ NZ267099A patent/NZ267099A/en unknown
- 1994-05-16 CA CA002163372A patent/CA2163372A1/en not_active Abandoned
- 1994-05-16 CN CN94192690A patent/CN1126472A/zh active Pending
- 1994-05-16 ES ES94917637T patent/ES2277330T3/es not_active Expired - Lifetime
- 1994-05-16 JP JP50016995A patent/JP3981406B2/ja not_active Expired - Lifetime
- 1994-05-20 ZA ZA943493A patent/ZA943493B/xx unknown
-
1998
- 1998-01-26 US US09/013,385 patent/US6114329A/en not_active Expired - Fee Related
- 1998-01-26 US US09/013,138 patent/US5872134A/en not_active Expired - Fee Related
-
2001
- 2001-08-27 US US09/939,914 patent/US20020019386A1/en not_active Abandoned
-
2002
- 2002-12-11 US US10/317,159 patent/US20030139389A1/en not_active Abandoned
-
2005
- 2005-12-15 US US11/304,110 patent/US20060094702A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2163372A1 (en) | 1994-12-08 |
| JP3981406B2 (ja) | 2007-09-26 |
| US20030139389A1 (en) | 2003-07-24 |
| GB9310582D0 (en) | 1993-07-07 |
| US5872134A (en) | 1999-02-16 |
| DE69434888T2 (de) | 2007-06-14 |
| US6114329A (en) | 2000-09-05 |
| US5741801A (en) | 1998-04-21 |
| US20020019386A1 (en) | 2002-02-14 |
| ZA943493B (en) | 1995-11-20 |
| AU6928394A (en) | 1994-12-20 |
| DE69434888D1 (de) | 2007-01-11 |
| ES2277330T3 (es) | 2007-07-01 |
| CN1126472A (zh) | 1996-07-10 |
| WO1994027987A1 (en) | 1994-12-08 |
| EP0699194B1 (de) | 2006-11-29 |
| EP0699194A1 (de) | 1996-03-06 |
| JPH08510266A (ja) | 1996-10-29 |
| US20060094702A1 (en) | 2006-05-04 |
| AU693449B2 (en) | 1998-07-02 |
| NZ267099A (en) | 1997-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |