[go: up one dir, main page]

ATE334392T1 - DEVICES AND METHOD FOR SEPARATING CELLULAR BLOOD COMPONENTS FROM LIQUID BLOOD COMPONENTS - Google Patents

DEVICES AND METHOD FOR SEPARATING CELLULAR BLOOD COMPONENTS FROM LIQUID BLOOD COMPONENTS

Info

Publication number
ATE334392T1
ATE334392T1 AT96915543T AT96915543T ATE334392T1 AT E334392 T1 ATE334392 T1 AT E334392T1 AT 96915543 T AT96915543 T AT 96915543T AT 96915543 T AT96915543 T AT 96915543T AT E334392 T1 ATE334392 T1 AT E334392T1
Authority
AT
Austria
Prior art keywords
blood
pad
blood components
cellular components
liquid portion
Prior art date
Application number
AT96915543T
Other languages
German (de)
Inventor
Wayne H Schrier
Corey L Jaseph
Ronald J Schoengold
Franco Ruggeri
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of ATE334392T1 publication Critical patent/ATE334392T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G01N33/54389—Immunochromatographic test strips based on lateral flow with bidirectional or multidirectional lateral flow, e.g. wherein the sample flows from a single, common sample application point into multiple strips, lanes or zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)

Abstract

A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate supporting the pad; and (3) means, attached to the pad, for facilitating the flow of the liquid portion of the blood: (i) through interstices around the trapped cellular components of the blood and (ii) from the pad of porous material. The separation of the liquid portion of blood from the cellular components of the blood occurs by flow through the pad of porous material without significant hemolysis. The device can be incorporated into a device for the performance of specific binding assays such as immunoassays. The pad of porous material can contain an agglutinating agent such as a lectin or an anti-blood cell antibody, or a carbohydrate such as mannitol. Other devices and methods for the separation of the liquid portion of blood from the cellular components of the blood are also disclosed.
AT96915543T 1995-05-09 1996-05-07 DEVICES AND METHOD FOR SEPARATING CELLULAR BLOOD COMPONENTS FROM LIQUID BLOOD COMPONENTS ATE334392T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43785095A 1995-05-09 1995-05-09

Publications (1)

Publication Number Publication Date
ATE334392T1 true ATE334392T1 (en) 2006-08-15

Family

ID=23738175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915543T ATE334392T1 (en) 1995-05-09 1996-05-07 DEVICES AND METHOD FOR SEPARATING CELLULAR BLOOD COMPONENTS FROM LIQUID BLOOD COMPONENTS

Country Status (10)

Country Link
US (3) US6008059A (en)
EP (1) EP0832430B1 (en)
JP (3) JPH11505327A (en)
CN (1) CN1155827C (en)
AT (1) ATE334392T1 (en)
CA (1) CA2217210A1 (en)
DE (1) DE69636389T2 (en)
DK (1) DK0832430T3 (en)
ES (1) ES2268706T3 (en)
WO (1) WO1996035952A1 (en)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100241928B1 (en) * 1997-03-31 2000-03-02 박종근 Determination device in which the electrode is integrally formed on the porous thin film and the quantification method using the same
ATE297016T1 (en) * 1997-10-07 2005-06-15 Ucb Sa TEST DEVICE AND METHOD FOR DETERMINING ANALYTES IN A LIQUID MILK PRODUCT
GB9821526D0 (en) * 1998-10-02 1998-11-25 Genosis Inc Capture assay
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6551842B1 (en) 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6511814B1 (en) * 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
GB9929272D0 (en) * 1999-12-10 2000-02-02 Diagnology Limited Assay
US6316205B1 (en) * 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
JP4681198B2 (en) * 2000-03-17 2011-05-11 株式会社三和化学研究所 Test paper
JP3655283B2 (en) * 2000-06-01 2005-06-02 松下電器産業株式会社 Biosensor and blood component analysis method
JP3543000B2 (en) * 2000-06-28 2004-07-14 松下電器産業株式会社 Biosensor
US6612447B1 (en) * 2000-07-24 2003-09-02 Baxter International Inc. Blood collection systems and filters using a porous membrane element
US20020036170A1 (en) * 2000-08-11 2002-03-28 Harvey Michael A. Lateral flower plasma separation device
KR100848636B1 (en) * 2001-01-12 2008-07-28 도레이 가부시끼가이샤 Selective binding substance immobilized fiber, fiber array including the bundle of the fiber, selective binding reaction method, apparatus and substrate therefor
EP1387170B1 (en) 2001-04-12 2012-03-21 ARKRAY, Inc. Specimen analyzing implement
US7011852B2 (en) * 2001-05-07 2006-03-14 Hemogenesis, Llc Separation of platelets from whole blood for use as a healant
US8101077B2 (en) * 2001-05-07 2012-01-24 Sivaprasad Sukavaneshvar Device for separating platelets from fluid suspensions
KR20010085007A (en) * 2001-07-12 2001-09-07 김희태 A semi-quantitative membrane immunochromatographe and a method for the preparation thereof
US7569184B2 (en) * 2002-04-23 2009-08-04 Home Access Health Corporation Quantitative analysis of a biological sample of unknown quantity
US7611670B2 (en) * 2002-04-23 2009-11-03 Home Access Health Corporation Quantitative analysis of a biological sample of unknown quantity
CA2488933C (en) 2002-04-23 2016-11-01 Home Access Health Corporation Quantitative analysis of a biological sample of unknown quantity
WO2004008146A2 (en) * 2002-07-12 2004-01-22 Strategic Diagnostics Inc. Test strips moveable by magnetic fields
JP4339570B2 (en) * 2002-10-25 2009-10-07 株式会社エスアールエル Blood sample carrier component
CN101819198B (en) * 2003-03-10 2012-07-18 爱科来株式会社 Blood cell separation membrane
US8454566B2 (en) * 2003-07-10 2013-06-04 Medtronic Minimed, Inc. Methods and compositions for the inhibition of biofilms on medical devices
US20050025823A1 (en) * 2003-07-29 2005-02-03 Fong Andy A.T. Methods of use of herbal compositions
US7625721B2 (en) 2004-02-03 2009-12-01 Polymer Technology Systems, Inc. Non-precipitating bodily fluid analysis system
US8465696B2 (en) * 2004-02-03 2013-06-18 Polymer Technology Systems, Inc. Dry test strip with controlled flow and method of manufacturing same
US20060062688A1 (en) * 2004-02-03 2006-03-23 Polymer Technology Systems, Inc. Bodily fluid analysis system
CN100359314C (en) * 2004-02-17 2008-01-02 陈格 Method and device for drying and preserving liquid sample
ATE489625T1 (en) * 2004-06-07 2010-12-15 Denka Seiken Kk CHROMATOGRAPHIC DETECTION DEVICE
JP4956705B2 (en) * 2004-07-02 2012-06-20 株式会社三和化学研究所 Immunoassay apparatus and method
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
US7896167B2 (en) * 2004-08-05 2011-03-01 Akers Biosciences, Inc. Blood separator and method of separating a fluid fraction from whole blood
US20060062690A1 (en) * 2004-08-17 2006-03-23 Polymer Technology Systems, Inc. Apparatus and method of manufacturing bodily fluid test strip
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US7442557B1 (en) 2004-10-22 2008-10-28 Idexx Laboratories, Inc. Bi-directional flow assay device with reagent bridge
JP2006133143A (en) * 2004-11-08 2006-05-25 Japan Vilene Co Ltd Plasma or serum holding material and blood separation device
NL1027737C2 (en) * 2004-12-14 2006-06-16 Teststrip B V Chromatographic analysis device and test kit.
EP1871870B1 (en) * 2005-04-08 2010-12-01 Medical Discovery Partners LLC Method for enriching rare cell subpopulations from blood
ES2368863T3 (en) * 2005-05-23 2011-11-23 Phadia Ab METHODS AND DEVICES OF SIDE FLOW TESTING IN TWO STAGES.
WO2007000048A1 (en) * 2005-06-28 2007-01-04 Zbx Corporation Membrane array and analytical device
US7618810B2 (en) * 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US8377379B2 (en) * 2006-12-15 2013-02-19 Kimberly-Clark Worldwide, Inc. Lateral flow assay device
JP2008249606A (en) * 2007-03-30 2008-10-16 Sysmex Corp Testing implement for chromatography
JP4990692B2 (en) * 2007-06-22 2012-08-01 株式会社ビーエル Immunochromatographic assay and kit
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
US9968931B2 (en) * 2007-12-12 2018-05-15 Nan Zhang Rapid and efficient filtering whole blood in capillary flow device
WO2009075709A1 (en) * 2007-12-12 2009-06-18 Micropoint Bioscience Inc Rapid and efficient filtering whole blood in a capillary flow device
US8613214B2 (en) * 2008-01-09 2013-12-24 Orono Spectral Solutions, Inc. Apparatus and method for determining analyte content in a fluid
US8393198B2 (en) * 2008-01-09 2013-03-12 OronoSpectral Solutions, Inc. Apparatus and method for determining analyte content in a fluid
JP4428670B2 (en) 2008-03-06 2010-03-10 Ｔａｎａｋａホールディングス株式会社 Immunological assay, kit and developing solvent
WO2009109997A1 (en) 2008-03-07 2009-09-11 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
JP2009236685A (en) * 2008-03-27 2009-10-15 Sysmex Corp Chromatographic test device
WO2009121043A2 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
JP5117928B2 (en) * 2008-05-27 2013-01-16 富士フイルム株式会社 Immunochromatographic device
WO2010007613A1 (en) 2008-06-29 2010-01-21 Realbio Technologies Ltd. Liquid–transfer device particularly useful as a capturing device in a biological assay process
KR101032691B1 (en) * 2009-04-17 2011-05-06 (주)디지탈옵틱 Biosensor for diagnosis of disease that can rapidly separate blood cells
WO2010129302A1 (en) * 2009-04-28 2010-11-11 Innovative Laboratory Technologies, Inc. Lateral-flow immuno-chromatographic assay devices
US9475914B2 (en) * 2010-01-08 2016-10-25 University Of Tasmania Porous polymer monoliths, processes for preparation and use thereof
WO2012015926A2 (en) * 2010-07-27 2012-02-02 Northwestern University Devices and methods for filtering blood plasma
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CN102375055A (en) * 2010-08-19 2012-03-14 中国人民解放军军事医学科学院微生物流行病研究所 Multiplex detection immune chromatography chip
EP2785429A4 (en) 2011-11-30 2015-10-28 Wellstat Diagnostics Llc FILTRATION MODULE
CN105833925B (en) * 2011-12-22 2018-11-13 瑞尔比奥技术有限公司 sequential lateral flow capillary device for analyte determination
AU2013203281A1 (en) 2012-02-03 2013-08-22 Axxin Pty Ltd Nucleic acid amplification and detection apparatus and method
US9880164B2 (en) 2012-03-30 2018-01-30 Sekisui Medical Co., Ltd. Immunochromatographic test strip and detection method using immunochromatography for detecting object in red blood cell-containing sample
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
BR112014029814B1 (en) 2012-06-13 2020-12-08 Asahi Kasei Kabushiki Kaisha method for detecting specific substance in milk
CN104541166B (en) * 2012-08-08 2017-06-13 皇家飞利浦有限公司 Separated using the blood plasma for bleeding realization
US9285336B2 (en) * 2012-08-09 2016-03-15 The Board Of Trustees Of The Leland Stanford Junior University Sensing platform for quantum transduction of chemical information
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
CN105209880B (en) * 2013-03-15 2020-03-17 赛拉诺斯知识产权有限责任公司 Method and apparatus for sample collection and sample separation
US10101293B2 (en) 2013-08-09 2018-10-16 The Board Of Trustees Of The Leland Stanford Junio Sensing platform for transduction of information
JP2017507335A (en) * 2014-03-05 2017-03-16 セラノス， インコーポレイテッドＴｈｅｒａｎｏｓ， Ｉｎｃ． Sample collection and sample separation methods and equipment
WO2016001795A1 (en) * 2014-07-03 2016-01-07 Abionic Sa Capsule for rapid molecular quantification of a fluid sample such as whole blood
US10111610B2 (en) 2014-11-04 2018-10-30 Wainamics, Inc. Microscale plasma separator
US10463290B2 (en) 2014-11-14 2019-11-05 Axxin Pty Ltd. Biological sample collection and storage assembly
WO2016180990A1 (en) * 2015-05-14 2016-11-17 General Electric Company Device for separation and collection of plasma
AU2016295422B2 (en) 2015-07-17 2022-01-06 Axxin Pty Ltd Diagnostic test assembly, apparatus, method
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
US11247208B2 (en) 2015-09-09 2022-02-15 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
CN105445454B (en) * 2015-11-20 2016-11-30 广州瑞博奥生物科技有限公司 A kind of can be quantitative device for immunochromatography
US10983119B2 (en) * 2016-01-25 2021-04-20 General Electric Company Device for rapid diagnostic tests to detect antigens with improved sensitivity
EP3449206B1 (en) 2016-04-28 2022-11-30 The Board of Trustees of the Leland Stanford Junior University Mesoscale system feedback-induced dissipation and noise suppression
JP6366025B2 (en) 2016-10-03 2018-08-01 セルスペクト株式会社 Plasma separator and plasma separation method
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
WO2018175169A1 (en) 2017-03-20 2018-09-27 Wainamics, Inc. Small volume self-metered blood separation device
CN111386465B (en) 2017-09-27 2024-03-22 艾可辛私人有限公司 Diagnostic testing systems and methods
IL281102B2 (en) 2018-09-05 2024-04-01 Hero Scient Ltd Test for particle detection
CN109541215A (en) * 2018-12-20 2019-03-29 中国人民解放军陆军军医大学 A kind of lesion detection object and the preparation method and application thereof
US11885568B2 (en) 2019-01-09 2024-01-30 Lawrence Livermore National Security, Llc Systems and methods for periodic nodal surface based reactors, distributors, contactors and heat exchangers
US11389765B2 (en) * 2019-01-09 2022-07-19 Lawrence Livermore National Security, Llc Hierarchical triply periodic minimal surface structures as heat exchangers and reactors
US11850583B2 (en) 2019-06-12 2023-12-26 Siemens Healthcare Diagnostics Inc. Plasma separation and sample metering device and kits and methods of use related thereto
CN111721880B (en) * 2020-07-02 2023-01-10 江中药业股份有限公司 Method for establishing fingerprint of sarcandra glabra by using double-column tandem HPLC-MS
JPWO2022114031A1 (en) * 2020-11-25 2022-06-02
EP4165385B1 (en) 2021-01-06 2024-04-17 Hero Scientific Ltd Filtration sampling devices
US20240286139A1 (en) * 2021-08-12 2024-08-29 Siemens Healthcare Diagnostics Inc. Apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer
CN118202245A (en) * 2021-09-10 2024-06-14 奎多公司 Agglutinating agents, devices and methods for whole blood assays
US12030045B1 (en) 2023-01-05 2024-07-09 Sequitur Health Corp. Devices, methods, and systems for deriving ammonia gas from whole blood
US12140534B2 (en) * 2023-01-05 2024-11-12 Sequitur Health Corp. Devices, methods, and systems for deriving a permeate from a feed solution

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3768978A (en) 1971-03-01 1973-10-30 Hamilton Co Disposable pipette
US3723064A (en) * 1971-07-26 1973-03-27 L Liotta Method and device for determining the concentration of a material in a liquid
BE792129A (en) 1971-12-06 1973-05-30 Takeda Chemical Industries Ltd PYRIMIDO (4,5-D) DERIVATIVES PYRIDAZINE AND THEIR PRODUCTION PROCESS
US3902964A (en) * 1971-12-13 1975-09-02 U S Medical Research And Dev I Method of and apparatus for chemically separating plasma or serum from formed elements of blood
CA1054034A (en) * 1975-06-20 1979-05-08 Barbara J. Bruschi Multilayer analytical element
US3990850A (en) * 1976-01-06 1976-11-09 Akzona Incorporated Diagnostic test card
US4110079A (en) 1977-06-09 1978-08-29 Eastman Kodak Company Analytical element for clinical analysis
US4160008A (en) 1978-01-26 1979-07-03 Miles Laboratories, Inc. Multilayered test device for determining the presence of a liquid sample component, and method of use
JPS587332Y2 (en) * 1978-06-06 1983-02-08 富士写真フイルム株式会社 Multilayer blood chemistry analysis material
US4255384A (en) * 1978-08-14 1981-03-10 Fuji Photo Film Co., Ltd. Multilayered integral element for the chemical analysis of the blood
JPH0142041Y2 (en) * 1978-12-11 1989-12-11
US4288228A (en) * 1979-01-31 1981-09-08 Technicon Instruments Corporation Whole blood analyses and diffusion apparatus therefor
US4271119A (en) * 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
US4816224A (en) 1980-08-05 1989-03-28 Boehringer Mannheim Gmbh Device for separating plasma or serum from whole blood and analyzing the same
DE3029579C2 (en) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Method and means for separating plasma or serum from whole blood
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
DE3323973A1 (en) * 1983-07-02 1985-01-03 Boehringer Mannheim Gmbh, 6800 Mannheim ERYTHROCYTE RETENTION SUBSTRATES
US4594327A (en) * 1983-11-02 1986-06-10 Syntex (U.S.A.) Inc. Assay method for whole blood samples
US4678757A (en) * 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
DE3523439A1 (en) 1985-06-29 1987-01-08 Boehringer Mannheim Gmbh TEST CARRIER
US4790979A (en) * 1986-08-29 1988-12-13 Technimed Corporation Test strip and fixture
DE3630999A1 (en) 1986-09-12 1988-03-17 Boehringer Mannheim Gmbh MULTI-LAYER TEST CARRIER
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US5135719A (en) * 1986-10-29 1992-08-04 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
DE3643516A1 (en) * 1986-12-19 1988-06-30 Boehringer Mannheim Gmbh TEST CARRIER FOR THE ANALYTICAL DETERMINATION OF INGREDIENTS OF BODY LIQUIDS
DE3715485A1 (en) 1987-05-09 1988-11-17 Boehringer Mannheim Gmbh STABILIZATION OF SS GALACTOSIDASE
US4943522A (en) * 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
US5215886A (en) * 1987-06-22 1993-06-01 Patel P Jivan HDL determination in whole blood
US4987085A (en) * 1987-06-22 1991-01-22 Chemtrak Inc. Blood filtering metering device
JPH0623759B2 (en) * 1987-07-08 1994-03-30 富士写真フイルム株式会社 Whole blood analysis element
US4883764A (en) * 1987-07-20 1989-11-28 Kloepfer Mary A Blood test strip
US5209904A (en) * 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
NL8800796A (en) * 1988-03-29 1989-10-16 X Flow Bv METHOD FOR THE CHEMICAL ANALYSIS OF BODY FLUID COMPONENTS, AND A TESTING DEVICE AND TEST PACKAGE FOR SUCH ANALYSIS.
DE3814370A1 (en) 1988-04-28 1989-11-09 Boehringer Mannheim Gmbh TEST PROVIDER FOR THE ANALYSIS OF A SAMPLING FLUID, METHOD FOR CARRYING OUT SUCH ANALYSIS AND METHOD OF PRODUCTION
US4963325A (en) * 1988-05-06 1990-10-16 Hygeia Sciences, Inc. Swab expressor immunoassay device
US5096809A (en) * 1988-07-25 1992-03-17 Pacific Biotech, Inc. Whole blood assays using porous membrane support devices
US5418129A (en) * 1989-01-30 1995-05-23 The Biomembrane Institute Blood treatment method
US5064541A (en) * 1989-04-07 1991-11-12 Abbott Laboratories Devices and methods for the collection of a predetermined volume of plasma or serum
US4933092A (en) * 1989-04-07 1990-06-12 Abbott Laboratories Methods and devices for the separation of plasma or serum from whole blood
NL8901090A (en) * 1989-04-28 1990-11-16 X Flow Bv METHOD FOR MANUFACTURING A MICROPOROUS MEMBRANE AND SUCH MEMBRANE
DE3922495A1 (en) * 1989-07-08 1991-01-17 Miles Inc ANALYSIS METHOD FOR SUBSTANCES FROM BIOLOGICAL FLUIDS, IN PARTICULAR FULLBLOOD
US5306623A (en) * 1989-08-28 1994-04-26 Lifescan, Inc. Visual blood glucose concentration test strip
EP0427534B1 (en) * 1989-11-08 1995-08-02 Chemtrak, Inc. Improvement in non-instrumental diagnostic assay distance determination
US5435970A (en) * 1989-12-18 1995-07-25 Environmental Diagnostics, Inc. Device for analysis for constituents in biological fluids
JP2618727B2 (en) * 1990-01-19 1997-06-11 富士写真フイルム株式会社 Method for quantifying test components in whole blood
US5212060A (en) * 1990-04-27 1993-05-18 Genesis Labs, Inc. Dry test strip comprising a dextran barrier for excluding erythrocytes
DE4015589A1 (en) * 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh DEVICE AND THE USE THEREOF FOR SEPARATING PLASMA FROM WHOLE BLOOD
US5118428A (en) * 1990-11-13 1992-06-02 Quidel Method to remove red blood cells from whole blood samples
US5468648A (en) * 1991-05-29 1995-11-21 Smithkline Diagnostics, Inc. Interrupted-flow assay device
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
EP0535485B1 (en) * 1991-10-03 1997-07-16 Bayer Corporation Device and method of separating and assaying whole blood
US5215102A (en) * 1991-10-25 1993-06-01 La Mina Ltd. Capillary blood antigen testing apparatus
JPH05188053A (en) * 1992-01-10 1993-07-27 Sanwa Kagaku Kenkyusho Co Ltd Instrument for separating serum or plasma component from blood
DE69329377T2 (en) * 1992-03-10 2001-04-05 Quidel Corp., San Diego RELEASE AGENT FOR RED BLOOD CELLS IN EXAMINATIONS WITH SPECIFIC BINDING
GR1002549B (en) * 1992-05-12 1997-01-28 Lifescan Inc. Fluid conducting test strip with Transport Medium
CA2104976A1 (en) * 1992-09-02 1994-03-03 Stephan D. Daubney Separation of plasma or serum from whole blood using a red blood cell binding component and a polymer containing multiple cationic sites
US5354692A (en) * 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
US5460974A (en) * 1992-10-13 1995-10-24 Miles Inc. Method of assaying whole blood for HDL cholesterol
WO1994018559A1 (en) * 1993-02-11 1994-08-18 Radiometer Medical A/S Asymmetric membrane sensor
US5652148A (en) * 1993-04-20 1997-07-29 Actimed Laboratories, Inc. Method and apparatus for red blood cell separation
US5397479A (en) * 1993-04-26 1995-03-14 International Remote Imaging Systems, Inc. Composition and method for enrichment of white blood cells from whole human blood
US5441698A (en) * 1993-09-10 1995-08-15 Beckman Instruments, Inc. Bevel closure and device

Also Published As

Publication number Publication date
US6197598B1 (en) 2001-03-06
WO1996035952A1 (en) 1996-11-14
JPH11505327A (en) 1999-05-18
EP0832430B1 (en) 2006-07-26
US6069014A (en) 2000-05-30
CA2217210A1 (en) 1996-11-14
JP3831403B2 (en) 2006-10-11
EP0832430A1 (en) 1998-04-01
CN1190464A (en) 1998-08-12
CN1155827C (en) 2004-06-30
ES2268706T3 (en) 2007-03-16
DK0832430T3 (en) 2006-11-20
DE69636389D1 (en) 2006-09-07
DE69636389T2 (en) 2006-11-23
JP2006177970A (en) 2006-07-06
JP2005055451A (en) 2005-03-03
EP0832430A4 (en) 2000-12-06
US6008059A (en) 1999-12-28

Similar Documents

Publication Publication Date Title
ATE334392T1 (en) DEVICES AND METHOD FOR SEPARATING CELLULAR BLOOD COMPONENTS FROM LIQUID BLOOD COMPONENTS
ES8702661A1 (en) Method and apparatus for immunoassays.
FI932150A0 (en) Analyssystem Foer glycerande blodproteiner
NO890659D0 (en) DEVICE AND PROCEDURE FOR SEPARATING LEUKOCYTES FROM BLOOD PLATE CONCENTRATE.
GB2345964B (en) Assay using porosity-reduction to inhibit migration
ATE47155T1 (en) MONOCLONAL ANTIBODY.
MX9705535A (en) Volume- independent diagnostic test carrier and methods wherein it is used for determining an analyte or substance which is to be analized.
ES2185704T3 (en) PROCEDURE AND APPARATUS FOR COLLECTION, STORAGE AND ANALYSIS IN REAL BLOOD TIME AND OTHER BODY FLUIDS.
DK0533727T3 (en) Adsorption material for selective removal of LDL or / and vLDL
EP0096375A3 (en) Device for separating serum from blood sample
CA2014119A1 (en) Methods and devices for the separation of plasma or serum from whole blood, collection of plasma or serum, and reagent delivery system
DK180186A (en) PROCEDURE FOR CLEANING IMMUNOGLOBULIN G
EP0385953A3 (en) Apparatus for separating mononuclear cells from blood and method of manufacturing and using the same
DE60011456D1 (en) LATERAL FLOW DEVICE WITH PARTICULAR CARRIER
DE3070502D1 (en) Process for the separation of a proteinic substance starting from a solution containing it upon affinity filtration, and application of the process to enzymatic analyses
ES2014475B3 (en) IMPROVED APPARATUS AND IMMUNO ASSAY PROCESS
NO964983D0 (en) Fiber-coated filter element and manufacture thereof
DK1003832T3 (en) Method and apparatus for separating particulate matter from a liquid sample
CA2111350A1 (en) Method for the separation of high density lipoprotein from blood samples
CA2285219A1 (en) Detection of low level analytes in samples
DE69018482D1 (en) SEPARATION METHOD FOR SEPARATING HEMATOPOEITIC PRECELLER CELLS.
EP0143412A3 (en) Immunochemical quick-test
Weliky et al. A simple method for recovering and concentrating fractionated sample components from cylindrical gels
Bröcker et al. Specific separation of cytotoxic T lymphocytes on immunoadsorptive films
DK57483A (en) PROCEDURE FOR FILTERING A FLUIDUM, PREFERRED A LIQUID, AND FILTERING DEVICE

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0832430

Country of ref document: EP

REN Ceased due to non-payment of the annual fee