[go: up one dir, main page]

ATE334391T1 - Isolierung und analyse von proteinen - Google Patents

Isolierung und analyse von proteinen

Info

Publication number
ATE334391T1
ATE334391T1 AT00911077T AT00911077T ATE334391T1 AT E334391 T1 ATE334391 T1 AT E334391T1 AT 00911077 T AT00911077 T AT 00911077T AT 00911077 T AT00911077 T AT 00911077T AT E334391 T1 ATE334391 T1 AT E334391T1
Authority
AT
Austria
Prior art keywords
proteins
isolation
analysis
sequencing
methods
Prior art date
Application number
AT00911077T
Other languages
English (en)
Inventor
Francis J Carr
Original Assignee
Biovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9906551.8A external-priority patent/GB9906551D0/en
Priority claimed from GBGB9907057.5A external-priority patent/GB9907057D0/en
Priority claimed from GBGB9907641.6A external-priority patent/GB9907641D0/en
Priority claimed from GBGB9914874.4A external-priority patent/GB9914874D0/en
Priority claimed from GBGB9915363.7A external-priority patent/GB9915363D0/en
Priority claimed from GBGB9915677.0A external-priority patent/GB9915677D0/en
Priority claimed from GBGB9916511.0A external-priority patent/GB9916511D0/en
Priority claimed from GBGB9920503.1A external-priority patent/GB9920503D0/en
Priority claimed from GBGB9922285.3A external-priority patent/GB9922285D0/en
Application filed by Biovation Ltd filed Critical Biovation Ltd
Application granted granted Critical
Publication of ATE334391T1 publication Critical patent/ATE334391T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT00911077T 1999-03-23 2000-03-17 Isolierung und analyse von proteinen ATE334391T1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9906551.8A GB9906551D0 (en) 1999-03-23 1999-03-23 Display of proteins
GBGB9907057.5A GB9907057D0 (en) 1999-03-29 1999-03-29 Protein analysis
GBGB9907641.6A GB9907641D0 (en) 1999-04-06 1999-04-06 Protein analysis
GBGB9914874.4A GB9914874D0 (en) 1999-06-28 1999-06-28 Protein analysis
GBGB9915363.7A GB9915363D0 (en) 1999-07-02 1999-07-02 Protein analysis
GBGB9915677.0A GB9915677D0 (en) 1999-07-06 1999-07-06 Protein analysis
GBGB9916511.0A GB9916511D0 (en) 1999-07-14 1999-07-14 Protein analysis
GBGB9920503.1A GB9920503D0 (en) 1999-08-31 1999-08-31 Protein analysis
GBGB9922285.3A GB9922285D0 (en) 1999-09-21 1999-09-21 Protein analysis

Publications (1)

Publication Number Publication Date
ATE334391T1 true ATE334391T1 (de) 2006-08-15

Family

ID=27576378

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00911077T ATE334391T1 (de) 1999-03-23 2000-03-17 Isolierung und analyse von proteinen

Country Status (18)

Country Link
EP (1) EP1163519B1 (de)
JP (1) JP2003536048A (de)
KR (1) KR20020021779A (de)
CN (1) CN1344370A (de)
AT (1) ATE334391T1 (de)
AU (1) AU772069B2 (de)
BR (1) BR0009206A (de)
CA (1) CA2366559C (de)
CZ (1) CZ20013399A3 (de)
DE (1) DE60029572T2 (de)
ES (1) ES2265917T3 (de)
HK (1) HK1045561A1 (de)
HU (1) HUP0200400A3 (de)
MX (1) MXPA01009567A (de)
NO (1) NO20014584L (de)
PL (1) PL350318A1 (de)
SK (1) SK13242001A3 (de)
WO (1) WO2000057183A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001670D0 (sv) * 2000-05-04 2000-05-04 Forskarpatent I Syd Ab Mass-spectrometry-based biosensor
AU2002231339A1 (en) * 2000-10-23 2002-05-06 Altus Biologics Inc. High throughput screening for protein formulations
WO2003052101A1 (en) * 2001-12-14 2003-06-26 Rosetta Inpharmatics, Inc. Sample tracking using molecular barcodes
EP1361438A1 (de) * 2002-05-10 2003-11-12 Proteome Factory AG Festphasenassistierte spektroskopische und spektrometrische Analyse komplexer Peptidgemische
DE50308797D1 (de) * 2002-05-10 2008-01-24 Proteome Factory Ag Festphasenassisitierte spektroskopische und spektrometrische analyse komplexer biopolymergemische
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
CN1314968C (zh) * 2004-03-11 2007-05-09 复旦大学 痕量多肽或蛋白质富集及其直接分析方法
CA2616552A1 (en) * 2005-07-28 2007-02-01 Biosystems International Sas Normalization of complex analyte mixtures
CN103435697A (zh) * 2006-05-15 2013-12-11 航道生物技术有限责任公司 流感病毒的中和抗体
US8148085B2 (en) 2006-05-15 2012-04-03 Sea Lane Biotechnologies, Llc Donor specific antibody libraries
KR100698466B1 (ko) * 2006-11-30 2007-03-21 한국정보통신대학교 산학협력단 질량 변화량 목록을 이용한 상향식 단백질 변형 탐색 방법및 프로그램 저장 매체
EP2232258A4 (de) * 2007-12-05 2011-01-05 Govt Of The U S A As Represented By The Secretary Of The Dept Of Health & Human Services Verbesserte virale proteinquantifizierung und impfstoffqualitätskontrolle damit
WO2011020247A1 (en) * 2009-08-21 2011-02-24 Cyagen Biosciences (Guangzhou) Inc. Replica barcode selection assay
CN102483408A (zh) * 2009-09-07 2012-05-30 弗·哈夫曼-拉罗切有限公司 用于糖基化分析的糖肽的es-ms
EP2436766A1 (de) * 2010-09-29 2012-04-04 Deutsches Krebsforschungszentrum Mittel und Verfahren für eine verbesserte Untersuchung der Proteininteraktion
KR20140006846A (ko) * 2010-12-29 2014-01-16 다우 아그로사이언시즈 엘엘씨 Dna 서열의 데이터 분석
PL3418380T3 (pl) * 2011-04-28 2022-09-19 The Board Of Trustees Of The Leland Stanford Junior University Identyfikacja polinukleotydów powiązanych z próbką
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CN102703442A (zh) * 2012-05-08 2012-10-03 中国农业科学院北京畜牧兽医研究所 一种检测犬细小病毒的生物条形码及其应用
US10968446B2 (en) 2012-11-01 2021-04-06 Massachusetts Institute Of Technology Directed evolution of synthetic gene cluster
WO2015163744A1 (ko) * 2014-04-25 2015-10-29 재단법인 의약바이오컨버젼스연구단 다수의 단백질-단백질 상호작용 동시 분석을 위한 백터
EP3155426B1 (de) 2014-06-13 2023-07-19 Immudex ApS Allgemeiner nachweis und isolierung spezifischer zellen durch binden markierter moleküle
CN105277638A (zh) * 2014-07-22 2016-01-27 沈鹤霄 一种单克隆抗体IgG质谱测序方法
KR102197507B1 (ko) 2015-07-13 2020-12-31 피벗 바이오, 인크. 식물 형질 개선을 위한 방법 및 조성물
CN108291219B (zh) 2015-10-05 2023-02-17 麻省理工学院 使用重构nif簇的氮固定
CN106855477A (zh) * 2015-12-09 2017-06-16 中国科学院大连化学物理研究所 基于埃德曼降解的蛋白质c-末端肽富集方法
CN105651852A (zh) * 2016-01-11 2016-06-08 南昌大学 一种利用质谱数据分析蛋白交联位点的方法
AU2017259794B2 (en) 2016-05-02 2023-04-13 Encodia, Inc. Macromolecule analysis employing nucleic acid encoding
EP3532612B1 (de) * 2016-10-31 2022-06-29 Universität Zürich Kollektion von tags und verfahren zur detektion von proteinen, bevorzugt bei massenspektrometrie
CA3049258A1 (en) 2017-01-12 2018-07-19 Pivot Bio, Inc. Methods and compositions for improving plant traits
RU2020116764A (ru) 2017-10-25 2021-11-25 Пивот Байо, Инк. Способы и композиции для улучшения сконструированных микроорганизмов, фиксирующих азот
US12151988B2 (en) 2017-10-25 2024-11-26 Pivot Bio, Inc. Gene targets for nitrogen fixation targeting for improving plant traits
WO2019089851A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
CA3081441C (en) 2017-10-31 2023-08-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
EP3752832A1 (de) 2018-02-12 2020-12-23 10X Genomics, Inc. Verfahren zur charakterisierung mehrerer analyten aus einzelnen zellen oder zellpopulationen
GB2577150B (en) * 2018-06-06 2022-11-23 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry
EP3814302A4 (de) 2018-06-27 2022-06-29 Pivot Bio, Inc. Landwirtschaftliche zusammensetzungen mit remodellierten stickstofffixierenden mikroben
AU2019302747B2 (en) 2018-07-11 2025-11-20 Pivot Bio, Inc. Temporally and spatially targeted dynamic nitrogen delivery by remodeled microbes
AU2019301750A1 (en) 2018-07-12 2021-01-28 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
WO2020072907A1 (en) 2018-10-05 2020-04-09 Board Of Regents, The University Of Texas System Solid-phase n-terminal peptide capture and release
CA3123940A1 (en) 2019-01-07 2020-07-16 Pivot Bio, Inc. Plant colonization assays using natural microbial barcodes
US12281299B2 (en) 2019-03-19 2025-04-22 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
WO2020223000A1 (en) 2019-04-30 2020-11-05 Encodia, Inc. Methods for preparing analytes and related kits
US20220334124A1 (en) * 2019-09-03 2022-10-20 Sung Sub Kim Method for ultra-rapidly selecting signal peptide to which individual barcode system for increasing protein productivity is introduced
KR20220131221A (ko) * 2019-11-13 2022-09-27 아뮤닉스 파마슈티컬스, 인크. 바코드화된 xten 폴리펩티드 및 이의 조성물, 및 이의 제조 방법 및 사용 방법
EP4073263A4 (de) 2020-01-07 2023-11-08 Encodia, Inc. Verfahren zur stabilen komplexbildung und entsprechende kits
WO2021222643A1 (en) 2020-05-01 2021-11-04 Pivot Bio, Inc. Stable liquid formulations for nitrogen-fixing microorganisms
AU2020445067A1 (en) 2020-05-01 2022-12-01 Pivot Bio, Inc. Measurement of nitrogen fixation and incorporation
US20250035639A1 (en) * 2023-07-25 2025-01-30 Quantum-Si Incorporated Protein quantification, tracking, and identification via peptide barcodes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2330052T3 (es) * 1991-03-01 2009-12-03 Dyax Corporation Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
HUT75223A (en) * 1993-12-09 1997-04-28 Ciba Geigy Ag Process for the production of combinatorial compound libraries

Also Published As

Publication number Publication date
HUP0200400A2 (hu) 2002-05-29
CA2366559C (en) 2011-03-08
NO20014584L (no) 2001-11-19
DE60029572D1 (de) 2006-09-07
WO2000057183A1 (en) 2000-09-28
EP1163519A1 (de) 2001-12-19
HK1045561A1 (zh) 2002-11-29
CN1344370A (zh) 2002-04-10
KR20020021779A (ko) 2002-03-22
MXPA01009567A (es) 2003-08-19
NO20014584D0 (no) 2001-09-21
SK13242001A3 (sk) 2002-09-10
BR0009206A (pt) 2001-12-26
AU772069B2 (en) 2004-04-08
DE60029572T2 (de) 2007-07-26
CA2366559A1 (en) 2000-09-28
ES2265917T3 (es) 2007-03-01
JP2003536048A (ja) 2003-12-02
HUP0200400A3 (en) 2006-06-28
CZ20013399A3 (cs) 2002-01-16
EP1163519B1 (de) 2006-07-26
AU3307300A (en) 2000-10-09
PL350318A1 (en) 2002-12-02

Similar Documents

Publication Publication Date Title
DE60029572D1 (de) Isolierung und analyse von proteinen
NO20035010L (no) Fremgangsmåter og blandinger for analysering av proteiner
ATE319855T1 (de) Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
ATE332368T1 (de) Selektion von proteinen mittels rns-protein fusionen
DE69837703D1 (de) Methoden zum nachweis und zur analyse von virus
DE69714630D1 (de) Biosensor und Verfahren zur quantitaven Analyse von biochemischen Substraten
DE69632447D1 (de) Analysator zur Analyse von Urinbestandteilen
AU2003224674A8 (en) Compounds and methods for analyzing the proteome
ATE344456T1 (de) Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
WO2003062402A3 (en) Use of collections of binding sites for sample profiling and other applications
DE69932845D1 (de) Methoden zur quantifizierung von hla-dr und cd11b
DE69731762D1 (de) Verfahren zur Chromosom-Klassifizierung mittels statistischer Dekorrelationsanalyse und Hardware dafür
ATE332919T1 (de) Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen
DE69531958D1 (de) (1-3)-beta-d-glukon-bindungsprotein, antikörper der dieses protein erkennt undverwendung des proteins und antikörper
IL145689A0 (en) Methods
DE69622978D1 (de) Analysator zur Analyse von Urinbestandteilen
WO2002048403A3 (en) Multiplexed protein expression and activity assay
DE50105263D1 (de) Verfahren zur analyse von proteinen
NO20013563D0 (no) Fremgangsmåter og prövesett for sekvensering av polypeptider
ATE302413T1 (de) Schnelle bestimmung des verhältnisses von biologischen molekülen
ATE306666T1 (de) Verfahren zur eiweissanalyse
DE69726573D1 (de) Gerät zur frequenzanalyse von vorhofflimmern
AU8742301A (en) Methods and kits for separation and detection of proteins in biological samples
WO2002094992A3 (en) Directed evolution of protein in mammalian cells
DE69632826D1 (de) Nukleinsaeure erkennung von hepatitis gb virus

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties