ATE311891T1 - Cytidin-diphosphocholin gegen diabetische neuropathie - Google Patents
Cytidin-diphosphocholin gegen diabetische neuropathieInfo
- Publication number
- ATE311891T1 ATE311891T1 AT02765405T AT02765405T ATE311891T1 AT E311891 T1 ATE311891 T1 AT E311891T1 AT 02765405 T AT02765405 T AT 02765405T AT 02765405 T AT02765405 T AT 02765405T AT E311891 T1 ATE311891 T1 AT E311891T1
- Authority
- AT
- Austria
- Prior art keywords
- neuropathy
- diphosphocholine
- diabetic neuropathy
- cytidine
- against diabetic
- Prior art date
Links
- RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 title abstract 4
- 208000032131 Diabetic Neuropathies Diseases 0.000 title abstract 3
- 229960001284 citicoline Drugs 0.000 title 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 3
- 201000001119 neuropathy Diseases 0.000 abstract 2
- 230000007823 neuropathy Effects 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 208000019479 dysautonomia Diseases 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 208000018290 primary dysautonomia Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001268156 | 2001-09-05 | ||
| JP2001340838 | 2001-11-06 | ||
| PCT/JP2002/008916 WO2003022290A1 (fr) | 2001-09-05 | 2002-09-03 | Compositions pharmaceutiques pour traiter la neuropathie diabetique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311891T1 true ATE311891T1 (de) | 2005-12-15 |
Family
ID=26621670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02765405T ATE311891T1 (de) | 2001-09-05 | 2002-09-03 | Cytidin-diphosphocholin gegen diabetische neuropathie |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6924272B2 (de) |
| EP (1) | EP1362593B1 (de) |
| JP (1) | JP3968347B2 (de) |
| KR (1) | KR100740079B1 (de) |
| CN (1) | CN1551778A (de) |
| AT (1) | ATE311891T1 (de) |
| CA (1) | CA2459469A1 (de) |
| DE (1) | DE60207824T2 (de) |
| EA (1) | EA006776B1 (de) |
| ES (1) | ES2249616T3 (de) |
| HU (1) | HU225988B1 (de) |
| MX (1) | MXPA04002099A (de) |
| WO (1) | WO2003022290A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05000451A (es) * | 2002-07-11 | 2005-03-23 | Yamasa Corp | Composicion medicinal para neuropatia inducida por farmaco. |
| JP2007525984A (ja) | 2004-03-05 | 2007-09-13 | ディーエスエム アイピー アセッツ ビー．ブイ． | 連続的灌流および交互接線流による細胞培養の方法 |
| EP2634250B1 (de) | 2006-07-14 | 2017-04-05 | Patheon Holdings I B.V. | Verbessertes Verfahren zur Zellkultivierung |
| KR100812274B1 (ko) * | 2006-10-30 | 2008-03-13 | 한양대학교 산학협력단 | Ｇ-ｃｓｆ를 유효성분으로 하는 당뇨성 말초신경병 예방 및치료제 |
| US7836540B2 (en) | 2007-08-02 | 2010-11-23 | 3M Innovative Properties Company | Broom with particle capture sheet |
| ITMI20121223A1 (it) * | 2012-07-13 | 2014-01-14 | Gregorio Fabio De | Nuova composizione farmacologica comprendente citicolina in combinazione con glicerolo e/o acetazolamide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1188178B (it) * | 1985-07-05 | 1988-01-07 | Bioresearch Spa | Sali della citidin-difospocolina particolarmente idonei per uso orale |
| JPH0631306B2 (ja) * | 1985-07-12 | 1994-04-27 | 武田薬品工業株式会社 | シチジン―５′―ジリン酸コリン１水和物結晶の製造法 |
| DE3883374T2 (de) | 1987-10-28 | 1993-12-09 | Pro Neuron Inc | Acylatiertes uridin und cytidin und deren verwendungen. |
| US6057301A (en) * | 1997-12-24 | 2000-05-02 | Interneuron Pharmaceuticals, Inc. | Hyperhydrated citicoline, process and use |
| JP2000044472A (ja) * | 1998-07-30 | 2000-02-15 | Kikkoman Corp | 糖尿病性合併症の予防または治療薬剤 |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
-
2002
- 2002-09-03 EA EA200400394A patent/EA006776B1/ru not_active IP Right Cessation
- 2002-09-03 WO PCT/JP2002/008916 patent/WO2003022290A1/ja active IP Right Grant
- 2002-09-03 DE DE60207824T patent/DE60207824T2/de not_active Expired - Fee Related
- 2002-09-03 CA CA002459469A patent/CA2459469A1/en not_active Abandoned
- 2002-09-03 EP EP02765405A patent/EP1362593B1/de not_active Expired - Lifetime
- 2002-09-03 ES ES02765405T patent/ES2249616T3/es not_active Expired - Lifetime
- 2002-09-03 AT AT02765405T patent/ATE311891T1/de not_active IP Right Cessation
- 2002-09-03 MX MXPA04002099A patent/MXPA04002099A/es active IP Right Grant
- 2002-09-03 CN CNA028173015A patent/CN1551778A/zh active Pending
- 2002-09-03 HU HU0401940A patent/HU225988B1/hu unknown
- 2002-09-03 JP JP2003526418A patent/JP3968347B2/ja not_active Expired - Fee Related
- 2002-09-03 US US10/381,716 patent/US6924272B2/en not_active Expired - Fee Related
- 2002-09-03 KR KR1020047003171A patent/KR100740079B1/ko not_active Expired - Fee Related
-
2005
- 2005-04-05 US US11/098,439 patent/US7074773B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1551778A (zh) | 2004-12-01 |
| CA2459469A1 (en) | 2003-03-20 |
| DE60207824T2 (de) | 2006-07-06 |
| JPWO2003022290A1 (ja) | 2004-12-24 |
| KR100740079B1 (ko) | 2007-07-18 |
| KR20040033002A (ko) | 2004-04-17 |
| HUP0401940A2 (hu) | 2005-01-28 |
| US7074773B2 (en) | 2006-07-11 |
| US20050171051A1 (en) | 2005-08-04 |
| EP1362593A4 (de) | 2004-06-30 |
| US6924272B2 (en) | 2005-08-02 |
| EP1362593A1 (de) | 2003-11-19 |
| EA006776B1 (ru) | 2006-04-28 |
| EP1362593B1 (de) | 2005-12-07 |
| WO2003022290A1 (fr) | 2003-03-20 |
| MXPA04002099A (es) | 2004-06-07 |
| US20040014711A1 (en) | 2004-01-22 |
| EA200400394A1 (ru) | 2004-08-26 |
| HU225988B1 (en) | 2008-02-28 |
| JP3968347B2 (ja) | 2007-08-29 |
| DE60207824D1 (de) | 2006-01-12 |
| ES2249616T3 (es) | 2006-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |