ATE309229T1 - Seitenkette tragende taxanen und deren zwischenprodukten - Google Patents

Seitenkette tragende taxanen und deren zwischenprodukten

Info

Publication number: ATE309229T1
Authority: AT; Austria
Prior art keywords: oxazoline; side chain; bearing; intermediate products; sidechain
Prior art date: 1992-12-23

Application number

AT02014813T

Other languages

English (en)

Inventor

Michael A Poss

David J Kucera

Jerome L Moniot

John K Thottathil

Ivan D Trifunovich

Shu-Hui Chen

Jianmei Wei

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-15

Publication date

2005-11-15

1993-12-15 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE309229T1 publication Critical patent/ATE309229T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02014813T 1992-12-23 1993-12-15 Seitenkette tragende taxanen und deren zwischenprodukten ATE309229T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US99544392A	1992-12-23	1992-12-23

Publications (1)

Publication Number	Publication Date
ATE309229T1 true ATE309229T1 (de)	2005-11-15

Family

ID=25541806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02014813T ATE309229T1 (de)	1992-12-23	1993-12-15	Seitenkette tragende taxanen und deren zwischenprodukten

Country Status (22)

Country	Link
EP (2)	EP0626953A4 (de)
JP (2)	JP3492690B2 (de)
KR (3)	KR100378612B1 (de)
CN (4)	CN1590386A (de)
AT (1)	ATE309229T1 (de)
AU (3)	AU679206B2 (de)
CA (1)	CA2119261C (de)
CZ (1)	CZ292993B6 (de)
DE (1)	DE69333905T2 (de)
DK (1)	DK1251127T3 (de)
ES (1)	ES2252362T3 (de)
FI (2)	FI115056B (de)
HK (1)	HK1048310B (de)
HU (3)	HU0203995D0 (de)
IL (13)	IL145280A (de)
NO (7)	NO304521B1 (de)
NZ (1)	NZ261070A (de)
PL (1)	PL186176B1 (de)
RU (1)	RU2125042C1 (de)
TW (1)	TW247908B (de)
WO (1)	WO1994014787A1 (de)
ZA (1)	ZA939672B (de)

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US5973160A (en) *	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
US5840929A (en) *	1995-04-14	1998-11-24	Bristol-Myers Squibb Company	C4 methoxy ether derivatives of paclitaxel
CA2231750C (en) *	1995-09-12	2006-07-11	The Liposome Company, Inc.	Hydrolysis-promoting taxane hydrophobic derivatives
FR2740451B1 (fr) *	1995-10-27	1998-01-16	Seripharm	Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) *	1996-06-14	1998-06-30	Industrial Technology Research Institute	Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) *	1996-07-08	1997-06-03	Bristol-Myers Squibb Company	3'-aminocarbonyloxy paclitaxels
US5773464A (en) *	1996-09-30	1998-06-30	Bristol-Myers Squibb Company	C-10 epoxy taxanes
US5977386A (en) *	1996-12-24	1999-11-02	Bristol-Myers Squibb Company	6-thio-substituted paclitaxels
US5902822A (en) *	1997-02-28	1999-05-11	Bristol-Myers Squibb Company	7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) *	1997-04-24	2000-01-25	Bristol-Myers Squibb Company	7-sulfur substituted paclitaxels
EP1067923A4 (de)	1997-12-31	2002-11-13	Bristol Myers Squibb Co	2-aroyl-4-acyl paclitaxel (taxol) analoge
EP1391459A1 (de) *	1999-08-11	2004-02-25	Bristol-Myers Squibb Company	Verfahren zur Herstellung eines Paclitaxel C-4 Methyl-Carbonat Analogen und Zwischenprodukte
DK1206461T3 (da)	1999-08-11	2004-08-16	Bristol Myers Squibb Co	Fremgangsmåde til fremstilling af en paclitaxel C-4-methylcarbonatanalog
AR030188A1 (es)	2000-02-02	2003-08-13	Univ Florida State Res Found	Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
US6916942B2 (en)	2000-02-03	2005-07-12	Bristol-Myers Squibb Company	Process for the preparation of C-4 carbonate taxanes
AU2001290636A1 (en) *	2000-09-22	2002-04-02	Bristol-Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
AU2001288805A1 (en) *	2000-09-22	2002-04-02	Bristol-Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
US7063977B2 (en)	2001-08-21	2006-06-20	Bristol-Myers Squibb Company	Enzymatic resolution of t-butyl taxane derivatives
AU2003256861C1 (en) *	2002-08-04	2008-08-28	Phyton Holdings, Llc	Methods and compositions for converting taxane amides to paclitaxel or other taxanes
US8703982B2 (en)	2003-03-17	2014-04-22	Phyton Holdings Llc	Purification of taxanes
JP4499383B2 (ja) *	2003-07-11	2010-07-07	良明木曽	水溶性プロドラッグ
US7371759B2 (en)	2003-09-25	2008-05-13	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
JP2007527432A (ja)	2004-03-05	2007-09-27	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ７ラクチルオキシ置換タキサン
CA2599888C (en) *	2005-03-31	2010-06-15	Bioxel Pharma Inc.	Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
PL217731B1 (pl)	2006-06-01	2014-08-29	Tomasz Byrski	Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en)	2007-04-02	2008-10-09	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Selenocysteine mediated hybrid antibody molecules
KR20100047282A (ko) *	2007-08-22	2010-05-07	6570763 캐나다 인크.	９디히드로１３아세틸박카틴ⅲ을 도세탁셀 또는 파클리탁셀로 전환하는 방법
LT2833905T (lt)	2012-04-04	2018-07-10	Halozyme, Inc.	Derinių terapija su hialuronidaze ir į naviką nukreiptu taksanu
US9353150B2 (en)	2012-12-04	2016-05-31	Massachusetts Institute Of Technology	Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
EP2972394A4 (de)	2013-03-15	2016-11-02	Sloan Kettering Inst Cancer	Hsp90-anzielende herzbildgebung und -therapie
WO2017197045A1 (en)	2016-05-11	2017-11-16	Movassaghi Mohammad	Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en)	2017-05-11	2018-11-15	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
US20190351031A1 (en)	2018-05-16	2019-11-21	Halozyme, Inc.	Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
US11535634B2 (en)	2019-06-05	2022-12-27	Massachusetts Institute Of Technology	Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en)	2021-02-24	2022-09-01	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof

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US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JP2847584B2 (ja) *	1991-06-21	1999-01-20	高砂香料工業株式会社	シクロヘキシル酪酸誘導体及びその製造法
ATE349424T1 (de) *	1991-09-23	2007-01-15	Univ Florida State	Beta-lactame verwendbar zur herstellung von substituierten isoserinestern mit metallalkoxiden
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1993
- 1993-12-15 AT AT02014813T patent/ATE309229T1/de not_active IP Right Cessation
- 1993-12-15 HU HU0203995A patent/HU0203995D0/hu not_active IP Right Cessation
- 1993-12-15 WO PCT/US1993/012173 patent/WO1994014787A1/en active IP Right Grant
- 1993-12-15 EP EP94906439A patent/EP0626953A4/de not_active Withdrawn
- 1993-12-15 DE DE69333905T patent/DE69333905T2/de not_active Expired - Fee Related
- 1993-12-15 KR KR10-2002-7002728A patent/KR100378612B1/ko not_active IP Right Cessation
- 1993-12-15 ES ES02014813T patent/ES2252362T3/es not_active Expired - Lifetime
- 1993-12-15 HU HU9401449A patent/HU222175B1/hu not_active IP Right Cessation
- 1993-12-15 DK DK02014813T patent/DK1251127T3/da active
- 1993-12-15 EP EP02014813A patent/EP1251127B1/de not_active Expired - Lifetime
- 1993-12-15 CZ CZ19941465A patent/CZ292993B6/cs not_active IP Right Cessation
- 1993-12-15 CA CA002119261A patent/CA2119261C/en not_active Expired - Fee Related
- 1993-12-15 KR KR1020017008427A patent/KR100356448B1/ko not_active IP Right Cessation
- 1993-12-15 NZ NZ261070A patent/NZ261070A/en not_active IP Right Cessation
- 1993-12-15 RU RU94040189A patent/RU2125042C1/ru not_active IP Right Cessation
- 1993-12-15 AU AU60146/94A patent/AU679206B2/en not_active Ceased
- 1993-12-15 PL PL93304337A patent/PL186176B1/pl not_active IP Right Cessation
- 1993-12-15 KR KR1019940702930A patent/KR100327625B1/ko not_active IP Right Cessation
- 1993-12-15 HU HU0203995A patent/HU225294B1/hu unknown
- 1993-12-15 JP JP51526694A patent/JP3492690B2/ja not_active Expired - Fee Related
- 1993-12-23 IL IL145280A patent/IL145280A/en unknown
- 1993-12-23 IL IL10816193A patent/IL108161A/en not_active IP Right Cessation
- 1993-12-23 TW TW082110923A patent/TW247908B/zh active
- 1993-12-23 IL IL12153993A patent/IL121539A/en not_active IP Right Cessation
- 1993-12-23 CN CNA031082432A patent/CN1590386A/zh active Pending
- 1993-12-23 ZA ZA939672A patent/ZA939672B/xx unknown
- 1993-12-23 IL IL12154093A patent/IL121540A/xx not_active IP Right Cessation
- 1993-12-23 IL IL12154193A patent/IL121541A/xx not_active IP Right Cessation
- 1993-12-23 CN CN93121758A patent/CN1089761C/zh not_active Expired - Fee Related
- 1993-12-23 IL IL12154293A patent/IL121542A/xx not_active IP Right Cessation
1994
- 1994-08-16 NO NO943021A patent/NO304521B1/no unknown
- 1994-08-22 FI FI943852A patent/FI115056B/fi active IP Right Grant
1997
- 1997-07-14 NO NO19973254A patent/NO313802B1/no unknown
- 1997-07-14 NO NO973255A patent/NO309426B1/no unknown
- 1997-07-14 NO NO19973256A patent/NO316071B1/no unknown
- 1997-07-14 NO NO19973253A patent/NO314355B1/no unknown
- 1997-08-04 AU AU32464/97A patent/AU697836B2/en not_active Ceased
- 1997-08-04 AU AU32463/97A patent/AU715633B2/en not_active Ceased
- 1997-08-13 IL IL12154197A patent/IL121541A0/xx unknown
- 1997-08-13 IL IL12153997A patent/IL121539A0/xx active IP Right Grant
- 1997-08-13 IL IL12154297A patent/IL121542A0/xx unknown
- 1997-08-13 IL IL12154097A patent/IL121540A0/xx unknown
- 1997-11-16 IL IL12220997A patent/IL122209A0/xx unknown
- 1997-11-16 IL IL12220897A patent/IL122208A0/xx unknown
1998
- 1998-06-15 NO NO19982744A patent/NO311217B1/no unknown
1999
- 1999-01-12 CN CNB991010655A patent/CN1150178C/zh not_active Expired - Fee Related
- 1999-01-12 CN CN99101066A patent/CN1109026C/zh not_active Expired - Fee Related
2001
- 2001-09-04 IL IL14528001A patent/IL145280A0/xx not_active IP Right Cessation
2002
- 2002-09-12 JP JP2002267305A patent/JP2003113166A/ja active Pending
2003
- 2003-01-10 HK HK03100278.0A patent/HK1048310B/zh not_active IP Right Cessation
- 2003-09-01 NO NO20033865A patent/NO20033865D0/no not_active Application Discontinuation
- 2003-10-07 FI FI20031464A patent/FI20031464A/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1590386A (zh)	2005-03-09
HK1048310B (zh)	2006-02-17
NO943021D0 (no)	1994-08-16
CN1235973A (zh)	1999-11-24
KR100378612B1 (ko)	2003-04-03
IL121541A (en)	2000-11-21
AU3246397A (en)	1997-10-30
NO304521B1 (no)	1999-01-04
NO316071B1 (no)	2003-12-08
NO20033865D0 (no)	2003-09-01
IL108161A (en)	1999-03-12
TW247908B (de)	1995-05-21
CN1150178C (zh)	2004-05-19
CN1109026C (zh)	2003-05-21
AU679206B2 (en)	1997-06-26
NO314355B1 (no)	2003-03-10
EP0626953A4 (de)	1995-05-03
CZ292993B6 (cs)	2004-01-14
HU222175B1 (hu)	2003-04-28
FI943852A (fi)	1994-08-22
FI943852A0 (fi)	1994-08-22
KR100356448B1 (ko)	2002-10-19
RU2125042C1 (ru)	1999-01-20
NO313802B1 (no)	2002-12-02
AU697836B2 (en)	1998-10-15
NO20033865L (no)	1994-08-16
AU3246497A (en)	1997-10-09
HU0203995D0 (en)	2003-04-28
HK1048310A1 (en)	2003-03-28
IL121542A (en)	2001-03-19
NO973255D0 (no)	1997-07-14
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IL108161A0 (en)	1994-04-12
CN1094725A (zh)	1994-11-09
CN1230542A (zh)	1999-10-06
CA2119261A1 (en)	1994-06-24
NO973253L (no)	1994-08-16
ES2252362T3 (es)	2006-05-16
NO982744L (no)	1994-08-16
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NO973255L (no)	1994-08-16
FI20031464A (fi)	2003-10-07
IL145280A0 (en)	2002-06-30
CN1089761C (zh)	2002-08-28
NO973253D0 (no)	1997-07-14
JPH07504444A (ja)	1995-05-18
FI115056B (fi)	2005-02-28
NO311217B1 (no)	2001-10-29
DE69333905T2 (de)	2006-08-03
KR100327625B1 (ko)	2002-11-07
WO1994014787A1 (en)	1994-07-07
EP0626953A1 (de)	1994-12-07
AU715633B2 (en)	2000-02-10
KR950700269A (ko)	1995-01-16
IL121540A (en)	2005-05-17
HU225294B1 (en)	2006-09-28
DK1251127T3 (da)	2006-03-06
IL121540A0 (en)	1998-02-08
EP1251127B1 (de)	2005-11-09
JP2003113166A (ja)	2003-04-18
ZA939672B (en)	1995-06-23
NO309426B1 (no)	2001-01-29
DE69333905D1 (de)	2005-12-15
NZ261070A (en)	1997-10-24
NO973254L (no)	1994-08-16
EP1251127A1 (de)	2002-10-23
IL122209A0 (en)	1998-04-05
NO973256D0 (no)	1997-07-14
HU9401449D0 (en)	1994-09-28
JP3492690B2 (ja)	2004-02-03
NO982744D0 (no)	1998-06-15
IL121539A (en)	2004-07-25
IL145280A (en)	2007-05-15
IL122208A0 (en)	1998-04-05
NO943021L (no)	1994-08-16
PL186176B1 (pl)	2003-11-28
IL121541A0 (en)	1998-02-08
NO973254D0 (no)	1997-07-14
CA2119261C (en)	2006-01-31
NO973256L (no)	1994-08-16
IL121542A0 (en)	1998-02-08

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ATE309229T1 (de)	2005-11-15	Seitenkette tragende taxanen und deren zwischenprodukten
RU94040189A (ru)	1996-01-10	Новые таксаны с боковой цепью, промежуточные соединения, способ получения
NO930774L (no)	1993-09-07	Baccatin-iii-derivater
EE9800149A (et)	1998-12-15	Meetod taksaanide külgahela prekursorite valmistamiseks, sellel meetodil saadud ühendid, ning taksaanide valmistamismeetod ja nende derivaadid
FI952294A (fi)	1995-05-11	Menetelmä taksaanijohdannaisten valmistamiseksi, näin saadut uudet taksaanit ja niitä sisältävät kasvainvastaiset ja leukemiavastaiset koostumukset

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