ATE307111T1 - Serinprotease-inhibitoren - Google Patents
Serinprotease-inhibitorenInfo
- Publication number
- ATE307111T1 ATE307111T1 AT00911572T AT00911572T ATE307111T1 AT E307111 T1 ATE307111 T1 AT E307111T1 AT 00911572 T AT00911572 T AT 00911572T AT 00911572 T AT00911572 T AT 00911572T AT E307111 T1 ATE307111 T1 AT E307111T1
- Authority
- AT
- Austria
- Prior art keywords
- serine protease
- protease inhibitors
- compounds
- factor
- kallikrein
- Prior art date
Links
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 229940012414 factor viia Drugs 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11577299P | 1999-01-13 | 1999-01-13 | |
| US15202999P | 1999-09-01 | 1999-09-01 | |
| PCT/US2000/000673 WO2000041531A2 (en) | 1999-01-13 | 2000-01-11 | Serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307111T1 true ATE307111T1 (de) | 2005-11-15 |
Family
ID=26813550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00911572T ATE307111T1 (de) | 1999-01-13 | 2000-01-11 | Serinprotease-inhibitoren |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6472393B1 (de) |
| EP (1) | EP1144373B1 (de) |
| JP (1) | JP2002534449A (de) |
| KR (1) | KR100838418B1 (de) |
| CN (1) | CN100488947C (de) |
| AT (1) | ATE307111T1 (de) |
| AU (1) | AU771776B2 (de) |
| BR (1) | BR0008755A (de) |
| CA (1) | CA2356934A1 (de) |
| CZ (1) | CZ20012508A3 (de) |
| DE (1) | DE60023266T2 (de) |
| ES (1) | ES2251363T3 (de) |
| HU (1) | HUP0105077A3 (de) |
| IL (2) | IL144032A0 (de) |
| MX (1) | MXPA01007038A (de) |
| NO (1) | NO20013462L (de) |
| NZ (1) | NZ512736A (de) |
| PL (1) | PL350042A1 (de) |
| WO (1) | WO2000041531A2 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE307111T1 (de) * | 1999-01-13 | 2005-11-15 | Genentech Inc | Serinprotease-inhibitoren |
| AU7447500A (en) * | 1999-09-30 | 2001-04-30 | Mitsubishi Chemical Corporation | Acylsulfonamide derivatives |
| CA2426430C (en) | 2000-10-20 | 2014-10-07 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
| US7001887B2 (en) * | 2001-02-02 | 2006-02-21 | Chugai Seiyaku Kabushiki Kaisha | Peptide derivatives |
| DE10130374A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| ATE399175T1 (de) * | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| GB0207637D0 (en) * | 2002-04-02 | 2002-05-15 | Karobio Ab | Novel compound |
| WO2003101941A2 (en) * | 2002-05-31 | 2003-12-11 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| DE10301300B4 (de) * | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| WO2004072102A2 (en) * | 2003-02-11 | 2004-08-26 | Bristol-Myers Squibb Company | Benzene acetamide compounds useful as serine protease inhibitors |
| EP1594505A4 (de) * | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | Phenylglycin-derivate als serin-protease-hemmer |
| US7250447B2 (en) * | 2003-05-20 | 2007-07-31 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
| US7273886B2 (en) | 2003-05-20 | 2007-09-25 | Genentech, Inc. | Benzofuran inhibitors of factor VIIa |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| TW200637843A (en) * | 2005-01-10 | 2006-11-01 | Bristol Myers Squibb Co | Phenylglycinamide derivatives useful as anticoagulants |
| US7514410B2 (en) | 2005-03-29 | 2009-04-07 | Biocryst Pharmaceuticals, Inc. | Hepatitis C therapies |
| US7964619B2 (en) * | 2005-06-03 | 2011-06-21 | The University Of North Carolina At Chapel Hill | Teraryl components as antiparasitic agents |
| US8101636B2 (en) * | 2005-06-03 | 2012-01-24 | The University Of North Carolina At Chapel Hill | Linear dicationic terphenyls and their aza analogues as antiparasitic agents |
| EP1910298B1 (de) * | 2005-06-24 | 2010-01-13 | Brystol-Myers Squibb Company | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
| KR101362024B1 (ko) | 2006-03-24 | 2014-02-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 트리아졸론 유도체 |
| US7776832B2 (en) | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| DE102006050672A1 (de) * | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| BRPI0810897A2 (pt) | 2007-04-13 | 2016-07-26 | Southern Res Inst | método de inibição ou redução da angiogênese, do crescimento ou metástase de tumor dependente da mesma e de tratamento de doença ou desordem associada a angiogênese. |
| JP2010535240A (ja) * | 2007-07-31 | 2010-11-18 | マリンクロッド・インコーポレイテッド | 一体化光活性薬剤およびその使用 |
| US7807690B2 (en) | 2007-09-21 | 2010-10-05 | Eisai R&D Management Co., Ltd. | 2,3-dihydro-iminoisoindole derivatives |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| WO2010036407A2 (en) | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| ES2534832T3 (es) | 2009-03-10 | 2015-04-29 | Med Discovery Sa | Uso de inhibidores de serina proteasa en el tratamiento de la neutropenia |
| TW201206905A (en) | 2010-05-20 | 2012-02-16 | Eisai R & Amp D Man Co Ltd | Prodrug of triazolone compound |
| EP2590945B1 (de) | 2010-07-07 | 2014-04-30 | The Medicines Company (Leipzig) GmbH | Serinproteasehemmer |
| EP2844660B1 (de) | 2012-05-02 | 2017-11-01 | Southern Research Institute | Triazolopyridazinverbindungen, verwendung als hemmer von kinase-lrrk2 und verfahren zur herstellung davon |
| EP3104706B1 (de) | 2014-02-11 | 2022-03-23 | Mitokinin, Inc. | Zusammensetzungen und verfahren damit zur behandlung von neurodegenerativer und mitochondrialer erkrankung |
| JP2018537502A (ja) | 2015-12-16 | 2018-12-20 | サウザーン リサーチ インスチチュート | ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法 |
| EP3541391A4 (de) | 2016-11-17 | 2020-06-17 | The University of North Carolina at Chapel Hill | Alkyl-pyrrolopyrimidin-analoga und verfahren zur herstellung und verwendung davon |
| US10450263B2 (en) | 2017-02-10 | 2019-10-22 | Southern Research Institute | Benzo annulenes as antiviral agents |
| US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
| WO2018237145A1 (en) | 2017-06-21 | 2018-12-27 | Mitokinin, Inc. | COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE |
| US11046729B2 (en) | 2017-10-26 | 2021-06-29 | Southern Research Institute | Dipeptide analogs as TGF-beta inhibitors |
| WO2019089693A1 (en) | 2017-10-31 | 2019-05-09 | Southern Research Institute | Substituted quinazoline sulfonamides as thioredoxin interacting protein (txnip) inhibitors |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| US20210363170A1 (en) | 2018-04-19 | 2021-11-25 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| AU2019351731A1 (en) | 2018-10-02 | 2021-05-20 | The United States Government As Represented By The Department Of Veterans Affairs | Spak kinase inhibitors as neuroprotective agents |
| US20220251134A1 (en) | 2019-06-14 | 2022-08-11 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| US11339173B2 (en) | 2019-09-17 | 2022-05-24 | University Of Utah Research Foundation | Benzimidazoles and methods of using same |
| AR120173A1 (es) | 2019-10-09 | 2022-02-02 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
| AU2020396100A1 (en) | 2019-12-04 | 2022-06-16 | Southern Research Institute | Modulators of Programmed Death-Ligand-1 and/or Programmed Death-Ligand-2 |
| EP4125845A4 (de) | 2020-04-02 | 2024-05-15 | Southern Research Institute | Neue 2-pyrimidonanaloga als wirksame antivirale mittel gegen alphaviren |
| AR121715A1 (es) | 2020-04-03 | 2022-06-29 | Biocryst Pharm Inc | Pirrolopirimidinaminas como inhibidores del sistema del complemento |
| EP4146627A4 (de) | 2020-04-30 | 2024-06-19 | United States Government as represented by the Department of Veterans Affairs | Kleinmolekülige krüppel-like-faktor 15 (klf15)-agonisten bei nierenerkrankungen |
| US11753374B2 (en) | 2020-11-18 | 2023-09-12 | Southern Reserach Institute | Compounds for the treatment of acute and chronic kidney disease |
| US11623918B2 (en) | 2020-11-18 | 2023-04-11 | Southern Research Institute | Compounds for the treatment of acute and chronic kidney disease |
| WO2023076392A1 (en) | 2021-10-26 | 2023-05-04 | Southern Research Institute | Development of novel clofarabine analogs for cancer therapy |
| WO2023122212A2 (en) | 2021-12-21 | 2023-06-29 | Southern Research Institute | Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of sars virus |
| IL314442A (en) | 2022-01-27 | 2024-09-01 | Trilink Biotechnologies Llc | Trinucleotide cap analogs and methods of using them |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| DE4342154A1 (de) | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien |
| CN1087736C (zh) | 1994-12-02 | 2002-07-17 | 山之内制药株式会社 | 新型的脒基萘基衍生物或其盐 |
| WO1996028427A1 (en) * | 1995-03-10 | 1996-09-19 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| AU3496297A (en) * | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| TW542822B (en) * | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
| NZ500352A (en) * | 1997-04-14 | 2001-10-26 | Cor Therapeutics Inc | Cyclic diaza selective factor Xa inhibitors |
| EP0977772A1 (de) * | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | Selektive faktor xa-inhibitoren |
| NZ500354A (en) | 1997-04-14 | 2001-11-30 | Cor Therapeutics Inc | Cyclic diaza compounds as selective factor Xa inhibitors for treating thrombotic related disorders |
| JP2001521524A (ja) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Ｘａ因子阻害剤 |
| DE19718181A1 (de) * | 1997-04-30 | 1998-11-05 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| EP0987274A1 (de) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Faktor VIIa Inhibitore |
| ATE307111T1 (de) * | 1999-01-13 | 2005-11-15 | Genentech Inc | Serinprotease-inhibitoren |
-
2000
- 2000-01-11 AT AT00911572T patent/ATE307111T1/de not_active IP Right Cessation
- 2000-01-11 CZ CZ20012508A patent/CZ20012508A3/cs unknown
- 2000-01-11 IL IL14403200A patent/IL144032A0/xx active IP Right Grant
- 2000-01-11 WO PCT/US2000/000673 patent/WO2000041531A2/en active IP Right Grant
- 2000-01-11 BR BRPI0008755-6A patent/BR0008755A/pt not_active Application Discontinuation
- 2000-01-11 PL PL00350042A patent/PL350042A1/xx not_active Application Discontinuation
- 2000-01-11 NZ NZ512736A patent/NZ512736A/en not_active IP Right Cessation
- 2000-01-11 MX MXPA01007038A patent/MXPA01007038A/es active IP Right Grant
- 2000-01-11 JP JP2000593153A patent/JP2002534449A/ja active Pending
- 2000-01-11 HU HU0105077A patent/HUP0105077A3/hu not_active Application Discontinuation
- 2000-01-11 CA CA002356934A patent/CA2356934A1/en not_active Abandoned
- 2000-01-11 CN CNB008044228A patent/CN100488947C/zh not_active Expired - Fee Related
- 2000-01-11 US US09/509,104 patent/US6472393B1/en not_active Expired - Fee Related
- 2000-01-11 ES ES00911572T patent/ES2251363T3/es not_active Expired - Lifetime
- 2000-01-11 AU AU33451/00A patent/AU771776B2/en not_active Ceased
- 2000-01-11 EP EP00911572A patent/EP1144373B1/de not_active Expired - Lifetime
- 2000-01-11 DE DE60023266T patent/DE60023266T2/de not_active Expired - Lifetime
- 2000-01-11 KR KR1020017008804A patent/KR100838418B1/ko not_active Expired - Fee Related
-
2001
- 2001-06-27 IL IL144032A patent/IL144032A/en not_active IP Right Cessation
- 2001-07-12 NO NO20013462A patent/NO20013462L/no not_active Application Discontinuation
-
2002
- 2002-08-19 US US10/224,114 patent/US6919369B2/en not_active Expired - Fee Related
-
2005
- 2005-03-24 US US11/088,511 patent/US20050186198A1/en not_active Abandoned
-
2006
- 2006-09-29 US US11/537,482 patent/US20070037813A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2251363T3 (es) | 2006-05-01 |
| CA2356934A1 (en) | 2000-07-20 |
| EP1144373A2 (de) | 2001-10-17 |
| BR0008755A (pt) | 2007-05-29 |
| US6919369B2 (en) | 2005-07-19 |
| EP1144373B1 (de) | 2005-10-19 |
| US6472393B1 (en) | 2002-10-29 |
| DE60023266T2 (de) | 2006-07-13 |
| CZ20012508A3 (cs) | 2002-02-13 |
| IL144032A (en) | 2006-06-11 |
| US20050186198A1 (en) | 2005-08-25 |
| NO20013462L (no) | 2001-09-12 |
| PL350042A1 (en) | 2002-10-21 |
| EP1144373A3 (de) | 2002-01-02 |
| DE60023266D1 (de) | 2005-11-24 |
| CN100488947C (zh) | 2009-05-20 |
| IL144032A0 (en) | 2002-04-21 |
| JP2002534449A (ja) | 2002-10-15 |
| AU771776B2 (en) | 2004-04-01 |
| US20030212071A1 (en) | 2003-11-13 |
| WO2000041531A2 (en) | 2000-07-20 |
| HUP0105077A2 (hu) | 2002-05-29 |
| US20070037813A1 (en) | 2007-02-15 |
| WO2000041531A3 (en) | 2001-08-16 |
| CN1342139A (zh) | 2002-03-27 |
| AU3345100A (en) | 2000-08-01 |
| NO20013462D0 (no) | 2001-07-12 |
| HUP0105077A3 (en) | 2005-04-28 |
| KR100838418B1 (ko) | 2008-06-13 |
| NZ512736A (en) | 2003-11-28 |
| KR20010101852A (ko) | 2001-11-15 |
| MXPA01007038A (es) | 2002-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE307111T1 (de) | Serinprotease-inhibitoren | |
| MXPA03009130A (es) | Compuestos de biarilo que funcionan como inhibidores de proteasa serina. | |
| EP1383731A4 (de) | Biarylverbindungen als serinproteaseinhibitoren | |
| ATE268766T1 (de) | Stickstoff enthaltende heterobicyclen als factor xa inhibitoren | |
| WO2002000651A3 (en) | Factor xa inhibitors | |
| ATE338030T1 (de) | Amidine-inhibitoren der serine-proteasen | |
| PL343321A1 (en) | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin | |
| NO20015462D0 (no) | Anvendelse av fthalazinderivater | |
| MXPA02011411A (es) | Inhibidores de proteasa de serina. | |
| IS2552B (is) | Hindrar á Þátt Xa og aðra serín próteasa sem tengjast storknunarkeðjuverkun | |
| PL319782A1 (en) | Inhibitors of serinic proteases and anticoagulative protecins extracted from nematodes | |
| WO2004113278A3 (en) | Acylsulfamide inhibitors of factor viia | |
| TR199801569T2 (xx) | Serin proteaz inhibit�rleri. | |
| SE9602646D0 (sv) | Pharmaceutically-useful compounds | |
| DE60113412D1 (de) | Inhibitoren von serin proteasen | |
| DE60105418D1 (de) | Serinprotease-inhibitoren | |
| IS5511A (is) | Ný efnasambönd | |
| TR199801704T2 (xx) | Serin proteaz inhibit�rleri. | |
| DE60113252D1 (de) | Inhibitoren von serin proteasen | |
| SE0001803D0 (sv) | New compounds i | |
| WO2002002519A3 (en) | THROMBIN OR FACTOR Xa INHIBITORS | |
| IS7162A (is) | Nýjar möndlusýruafleiður og notkun þeirra sem þrombínhemla | |
| BR0017074A (pt) | Combinações de inibidor de ace-antagonista de vasopressina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |