ATE298746T1 - Verfahren zur herstellung von substituierten benzimidazolverbindungen - Google Patents
Verfahren zur herstellung von substituierten benzimidazolverbindungenInfo
- Publication number
- ATE298746T1 ATE298746T1 AT01929529T AT01929529T ATE298746T1 AT E298746 T1 ATE298746 T1 AT E298746T1 AT 01929529 T AT01929529 T AT 01929529T AT 01929529 T AT01929529 T AT 01929529T AT E298746 T1 ATE298746 T1 AT E298746T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted benzimidazole
- benzimidazole compounds
- producing substituted
- compounds
- producing
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- KEZMBKQTCPNSOF-UHFFFAOYSA-N 2-bromo-5,6-dichloro-1h-benzimidazole Chemical compound C1=C(Cl)C(Cl)=CC2=C1NC(Br)=N2 KEZMBKQTCPNSOF-UHFFFAOYSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0008939.1A GB0008939D0 (en) | 2000-04-11 | 2000-04-11 | Process for preparing substituted benzimidazole compounds |
| PCT/EP2001/004080 WO2001077083A1 (en) | 2000-04-11 | 2001-04-10 | Process for preparing substituted benzimidazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE298746T1 true ATE298746T1 (de) | 2005-07-15 |
Family
ID=9889715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01929529T ATE298746T1 (de) | 2000-04-11 | 2001-04-10 | Verfahren zur herstellung von substituierten benzimidazolverbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7101994B2 (de) |
| EP (2) | EP1272473B1 (de) |
| JP (2) | JP4841793B2 (de) |
| AT (1) | ATE298746T1 (de) |
| AU (1) | AU2001256272A1 (de) |
| DE (1) | DE60111732T2 (de) |
| ES (1) | ES2243488T3 (de) |
| GB (1) | GB0008939D0 (de) |
| WO (1) | WO2001077083A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034248A1 (en) | 1998-12-04 | 2000-06-15 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| CN101675927A (zh) * | 2002-06-07 | 2010-03-24 | 科蒂科股份有限公司 | 治疗分子及方法-1 |
| ES2432361T3 (es) * | 2005-12-02 | 2013-12-03 | Bayer Healthcare, Llc | Derivados de pirrolotriazina útiles para el tratamiento de cáncer por inhibición de cinasa Aurora |
| US7655004B2 (en) | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
| US8888792B2 (en) | 2008-07-14 | 2014-11-18 | Ethicon Endo-Surgery, Inc. | Tissue apposition clip application devices and methods |
| US8157834B2 (en) | 2008-11-25 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Rotational coupling device for surgical instrument with flexible actuators |
| US20110098704A1 (en) | 2009-10-28 | 2011-04-28 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8546344B2 (en) | 2010-10-28 | 2013-10-01 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole |
| US9233241B2 (en) | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9254169B2 (en) | 2011-02-28 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| CN102952104A (zh) * | 2011-08-17 | 2013-03-06 | 黑龙江省松花江药业有限公司 | 一种呋喃类化合物 |
| US9427255B2 (en) | 2012-05-14 | 2016-08-30 | Ethicon Endo-Surgery, Inc. | Apparatus for introducing a steerable camera assembly into a patient |
| US9545290B2 (en) | 2012-07-30 | 2017-01-17 | Ethicon Endo-Surgery, Inc. | Needle probe guide |
| US10314649B2 (en) | 2012-08-02 | 2019-06-11 | Ethicon Endo-Surgery, Inc. | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
| US9277957B2 (en) | 2012-08-15 | 2016-03-08 | Ethicon Endo-Surgery, Inc. | Electrosurgical devices and methods |
| US10098527B2 (en) | 2013-02-27 | 2018-10-16 | Ethidcon Endo-Surgery, Inc. | System for performing a minimally invasive surgical procedure |
| AU2023361470A1 (en) | 2022-10-12 | 2024-09-19 | Takeda Pharmaceutical Company Limited | Method of preparing maribavir |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3839743A1 (de) * | 1988-11-25 | 1990-05-31 | Hoechst Ag | Verfahren zur herstellung von benzimidazolonen |
| DE69016430T2 (de) | 1989-06-09 | 1995-06-01 | Upjohn Co | Heterozyklische amine mit zns-wirksamkeit. |
| US5248672A (en) | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
| GB9205071D0 (en) | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| GB9413724D0 (en) | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| AP741A (en) | 1994-09-09 | 1999-04-26 | The Wellcome Foundation Ltd | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring. |
| WO1997007125A1 (en) | 1995-08-18 | 1997-02-27 | The Regents Of The University Of Michigan | 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents |
| GB9600142D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
| GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
| AU1702597A (en) | 1996-01-23 | 1997-08-20 | Glaxo Group Limited | Modified benzimidazole nucleosides as antiviral agents |
| CA2280761A1 (en) | 1997-02-13 | 1998-08-20 | Stanley Dawes Chamberlain | Benzimidazole derivatives |
| NZ501415A (en) | 1997-06-10 | 2001-10-26 | Glaxo Group Ltd | Benzimidazole derivatives (optionally with saccharide substituents) useful for the treatment or prophylaxis of viral infections (particularly herpes, cytomegalovirus and Hepatitis B) or for the treatment or prophylaxis of restenosis |
| PL338454A1 (en) | 1997-07-30 | 2000-11-06 | Univ Michigan | Lixofuranosilbenzimidazoles as antiviral agents |
| GB9807355D0 (en) * | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| GB9807354D0 (en) * | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| GB9815696D0 (en) | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
-
2000
- 2000-04-11 GB GBGB0008939.1A patent/GB0008939D0/en not_active Ceased
-
2001
- 2001-04-10 EP EP01929529A patent/EP1272473B1/de not_active Expired - Lifetime
- 2001-04-10 AT AT01929529T patent/ATE298746T1/de not_active IP Right Cessation
- 2001-04-10 JP JP2001575558A patent/JP4841793B2/ja not_active Expired - Lifetime
- 2001-04-10 DE DE60111732T patent/DE60111732T2/de not_active Expired - Lifetime
- 2001-04-10 AU AU2001256272A patent/AU2001256272A1/en not_active Abandoned
- 2001-04-10 ES ES01929529T patent/ES2243488T3/es not_active Expired - Lifetime
- 2001-04-10 WO PCT/EP2001/004080 patent/WO2001077083A1/en active IP Right Grant
- 2001-04-10 US US10/240,906 patent/US7101994B2/en not_active Expired - Lifetime
- 2001-04-10 EP EP05013909A patent/EP1584620A1/de not_active Withdrawn
-
2005
- 2005-07-26 US US11/190,581 patent/US7375235B2/en not_active Expired - Lifetime
-
2008
- 2008-04-11 US US12/101,226 patent/US7514568B2/en not_active Expired - Lifetime
-
2009
- 2009-03-26 US US12/411,589 patent/US7858773B2/en not_active Expired - Fee Related
-
2011
- 2011-04-21 JP JP2011095407A patent/JP5192061B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20090187015A1 (en) | 2009-07-23 |
| US20050261211A1 (en) | 2005-11-24 |
| US7514568B2 (en) | 2009-04-07 |
| JP2011173906A (ja) | 2011-09-08 |
| US7858773B2 (en) | 2010-12-28 |
| DE60111732T2 (de) | 2006-05-04 |
| AU2001256272A1 (en) | 2001-10-23 |
| ES2243488T3 (es) | 2005-12-01 |
| EP1272473B1 (de) | 2005-06-29 |
| JP2003530385A (ja) | 2003-10-14 |
| US7101994B2 (en) | 2006-09-05 |
| US20030191127A1 (en) | 2003-10-09 |
| JP5192061B2 (ja) | 2013-05-08 |
| GB0008939D0 (en) | 2000-05-31 |
| US7375235B2 (en) | 2008-05-20 |
| DE60111732D1 (de) | 2005-08-04 |
| JP4841793B2 (ja) | 2011-12-21 |
| WO2001077083A1 (en) | 2001-10-18 |
| US20080188668A1 (en) | 2008-08-07 |
| EP1584620A1 (de) | 2005-10-12 |
| EP1272473A1 (de) | 2003-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |