|
EP1413582B1
(de)
|
1998-08-27 |
2006-03-15 |
Spirogen Limited |
Dimere Pyrrolobenzodiazepine
|
|
GB9818731D0
(en)
*
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
GB9818732D0
(en)
*
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collection of compounds
|
|
GB9818730D0
(en)
*
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB0226593D0
(en)
*
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
EP1608664B1
(de)
*
|
2003-03-31 |
2009-01-28 |
Council of Scientific and Industrial Research |
Nichtvernetzende pyrrolo[2,1-c][1,4]benzodiazepine als potentielle antitumor-agentien und ihre herstellung
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
GB0416511D0
(en)
*
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
WO2005040170A2
(en)
*
|
2003-10-22 |
2005-05-06 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
|
|
WO2005040172A1
(ja)
*
|
2003-10-29 |
2005-05-06 |
Kyowa Hakko Kogyo Co., Ltd. |
三環性プロリン誘導体
|
|
AU2003300718A1
(en)
*
|
2003-12-31 |
2005-07-21 |
Council Of Scientific And Industrial Research |
Process for preparing pyrrolo(2, 1-c) (1, 4) benzodiazepine hybrids
|
|
AU2003300720A1
(en)
*
|
2003-12-31 |
2005-07-21 |
Council Of Scientific And Industrial Research |
C-8 linked pyrrolo(2,1-c)(1,4)benzodiazepine-acridone/acridine hybrids
|
|
GB0404574D0
(en)
*
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Amino acids
|
|
GB0404577D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0404578D0
(en)
*
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
JP4909258B2
(ja)
|
2004-03-01 |
2012-04-04 |
スピロゲン リミティッド |
C2置換ピロロベンゾジアゼピン類を調製するための主要な中間体としての11−ヒドロキシ−5H−ピロロ[2,1−c][1,4]ベンゾジアゼピン−5−オン誘導体
|
|
US7528126B2
(en)
|
2004-03-09 |
2009-05-05 |
Spirogen Limited |
Pyrrolobenzodiazepines
|
|
US6951853B1
(en)
|
2004-03-30 |
2005-10-04 |
Council Of Scientific And Industrial Research |
Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids
|
|
US7056913B2
(en)
|
2004-03-30 |
2006-06-06 |
Council Of Scientific And Industrial Research |
C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
|
|
FR2869231B1
(fr)
*
|
2004-04-27 |
2008-03-14 |
Sod Conseils Rech Applic |
Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
|
|
GB0410725D0
(en)
*
|
2004-05-13 |
2004-06-16 |
Spirogen Ltd |
Pyrrolobenzodiazepine therapeutic agents
|
|
GB0508084D0
(en)
*
|
2005-04-21 |
2005-06-01 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
AU2006238686B2
(en)
|
2005-04-21 |
2011-10-06 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
EP1931671B1
(de)
*
|
2005-10-05 |
2009-04-08 |
Spirogen Limited |
4-[4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo [2, 1-c][1,4]benzodiazepin-8-yloxy)-butyrylamino]-1h-pyrrol-2-carbonsäurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung
|
|
PT1813614E
(pt)
|
2006-01-25 |
2012-01-09 |
Sanofi Sa |
Agentes citotóxicos compreendendo novos derivados de tomaimicina
|
|
DE102006013678A1
(de)
*
|
2006-03-24 |
2007-09-27 |
Bayerische Motoren Werke Ag |
Gleit- oder Schmiermittel und Verfahren zum Aufziehen eines Fahrzeugreifens auf eine Felge
|
|
CA2658276A1
(en)
|
2006-07-18 |
2008-01-24 |
Sanofi-Aventis |
Antagonist antibody for the treatment of cancer
|
|
GB0619325D0
(en)
|
2006-09-30 |
2006-11-08 |
Univ Strathclyde |
New compounds
|
|
EP1914242A1
(de)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Neue Antikörper gegen CD38 zur Behandlung von Krebs
|
|
ES2435779T3
(es)
|
2007-07-19 |
2013-12-23 |
Sanofi |
Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
|
|
CA2722696C
(en)
|
2008-04-30 |
2021-08-10 |
Immunogen, Inc. |
Cross-linkers and their uses
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819097D0
(en)
*
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819095D0
(en)
*
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
AU2015224492B2
(en)
*
|
2009-02-05 |
2017-04-20 |
Immunogen, Inc. |
Novel benzodiazepine derivatives
|
|
CA2750519C
(en)
|
2009-02-05 |
2018-09-25 |
Immunogen, Inc. |
Benzodiazepine derivatives
|
|
RS58810B1
(sr)
|
2009-06-03 |
2019-07-31 |
Immunogen Inc |
Metodi konjugacije
|
|
FR2949469A1
(fr)
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
UY32914A
(es)
|
2009-10-02 |
2011-04-29 |
Sanofi Aventis |
Anticuerpos que se usan específicamente al receptor epha2
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
BR112012026410B8
(pt)
|
2010-04-15 |
2023-01-31 |
Spirogen Dev Sarl |
Composto e conjugado de pirrolobenzodiazepinas e usos dos mesmos
|
|
TWI540136B
(zh)
|
2010-04-15 |
2016-07-01 |
梅迪繆思有限公司 |
吡咯并苯并二氮呯及其共軛物
|
|
CN107019804A
(zh)
|
2010-04-15 |
2017-08-08 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
FR2963007B1
(fr)
|
2010-07-26 |
2013-04-05 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application therapeutique
|
|
SG191965A1
(en)
|
2011-02-15 |
2013-08-30 |
Immunogen Inc |
Methods of preparation of conjugates
|
|
FR2972006B1
(fr)
|
2011-02-24 |
2016-03-25 |
Centre Nat Rech Scient |
Nouveaux fragments d'il-33 superactifs et leurs utilisations
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
CN103987718A
(zh)
|
2011-09-20 |
2014-08-13 |
斯皮罗根有限公司 |
作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
|
|
AU2012322932B2
(en)
|
2011-10-14 |
2016-11-10 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
KR101961976B1
(ko)
|
2011-10-14 |
2019-03-25 |
시애틀 지네틱스, 인크. |
피롤로벤조디아제핀 및 표적 접합체
|
|
WO2013053872A1
(en)
|
2011-10-14 |
2013-04-18 |
Spirogen Sàrl |
Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
|
|
CA2850103C
(en)
|
2011-10-14 |
2019-09-10 |
Spirogen Sarl |
Pyrrolobenzodiazepines
|
|
CN103987384A
(zh)
|
2011-10-14 |
2014-08-13 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
BR112014009050B1
(pt)
|
2011-10-14 |
2022-06-21 |
Medimmune Limited |
Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas
|
|
PE20150091A1
(es)
|
2012-02-24 |
2015-02-16 |
Stem Centrx Inc |
Anticuerpos anti-sez6 y metodos de empleo
|
|
EP3093294A1
(de)
|
2012-02-24 |
2016-11-16 |
Stemcentrx, Inc. |
Dll3-antikörper und verfahren zur verwendung
|
|
AR090549A1
(es)
|
2012-03-30 |
2014-11-19 |
Genentech Inc |
Anticuerpos anti-lgr5 e inmunoconjugados
|
|
IN2014MN02175A
(de)
|
2012-04-30 |
2015-08-28 |
Ucl Business Plc |
|
|
NZ701290A
(en)
|
2012-04-30 |
2016-08-26 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
KR20150006000A
(ko)
|
2012-05-01 |
2015-01-15 |
제넨테크, 인크. |
항-pmel17 항체 및 면역접합체
|
|
IN2014DN10510A
(de)
|
2012-07-09 |
2015-08-21 |
Genentech Inc |
|
|
US20140030280A1
(en)
|
2012-07-09 |
2014-01-30 |
Genentech, Inc. |
Anti-cd79b antibodies and immunoconjugates
|
|
US9464141B2
(en)
|
2012-08-02 |
2016-10-11 |
Genentech, Inc. |
Anti-ETBR antibodies and immunoconjugates
|
|
WO2014031566A1
(en)
|
2012-08-22 |
2014-02-27 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
SMT202100265T1
(it)
|
2012-10-12 |
2021-07-12 |
Medimmune Ltd |
Pirrolobenzodiazepine e loro coniugati
|
|
SMT201800346T1
(it)
|
2012-10-12 |
2018-09-13 |
Medimmune Ltd |
Coniugati pirrolobenzodiazepina-anticorpo
|
|
JP6367204B2
(ja)
|
2012-10-12 |
2018-08-01 |
メドイミューン・リミテッドMedImmune Limited |
結合用のピロロベンゾジアゼピン誘導体の合成および中間体
|
|
WO2014057120A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
PL2906251T3
(pl)
|
2012-10-12 |
2018-02-28 |
Adc Therapeutics Sa |
Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22
|
|
EP2839860B1
(de)
|
2012-10-12 |
2019-05-01 |
MedImmune Limited |
Pyrrolobenzodiazepine und Konjugate davon
|
|
KR101995619B1
(ko)
|
2012-10-12 |
2019-07-03 |
에이디씨 테라퓨틱스 에스에이 |
피롤로벤조디아제핀-항체 컨주게이트
|
|
WO2014057114A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-anti-psma antibody conjugates
|
|
RS57694B1
(sr)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin - anti-psma konjugati antitela
|
|
CN105849086B
(zh)
|
2012-11-24 |
2018-07-31 |
杭州多禧生物科技有限公司 |
亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用
|
|
CN110452242A
(zh)
*
|
2012-12-21 |
2019-11-15 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
CN110627797A
(zh)
|
2012-12-21 |
2019-12-31 |
麦迪穆有限责任公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
SMT201900339T1
(it)
|
2013-02-22 |
2019-07-11 |
Medimmune Ltd |
Coniugati anticorpo anti-dll3/pbd e loro usi
|
|
EA027910B1
(ru)
|
2013-03-13 |
2017-09-29 |
Медимьюн Лимитед |
Пирролобензодиазепины и их конъюгаты
|
|
CA2904044C
(en)
|
2013-03-13 |
2020-03-31 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2014140174A1
(en)
|
2013-03-13 |
2014-09-18 |
Spirogen Sàrl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CN105189552B
(zh)
|
2013-03-14 |
2019-08-02 |
基因泰克公司 |
抗b7-h4抗体和免疫缀合物
|
|
US9562099B2
(en)
|
2013-03-14 |
2017-02-07 |
Genentech, Inc. |
Anti-B7-H4 antibodies and immunoconjugates
|
|
BR112016002829A2
(pt)
|
2013-08-12 |
2017-09-19 |
Genentech Inc |
Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi
|
|
WO2015031698A1
(en)
|
2013-08-28 |
2015-03-05 |
Stem Centrx, Inc. |
Site-specific antibody conjugation methods and compositions
|
|
CA2922529A1
(en)
|
2013-08-28 |
2015-03-05 |
Stemcentrx, Inc. |
Novel sez6 modulators and methods of use
|
|
EA201600252A1
(ru)
|
2013-09-12 |
2017-05-31 |
Галозим, Инк. |
Модифицированные антитела к рецепторам антиэпидермального фактора роста и способы их использования
|
|
JP2016537399A
(ja)
|
2013-09-17 |
2016-12-01 |
ジェネンテック, インコーポレイテッド |
抗lgr5抗体を使用する方法
|
|
US9950078B2
(en)
|
2013-10-11 |
2018-04-24 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP3054983B1
(de)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepin-antikörper-konjugate
|
|
EP3054986B1
(de)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepin-antikörper-konjugate
|
|
US10053511B2
(en)
|
2013-11-06 |
2018-08-21 |
Abbvie Stemcentrx Llc |
Anti-claudin antibodies and methods of use
|
|
AU2014354643B2
(en)
|
2013-11-27 |
2020-03-05 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
|
MX2016007369A
(es)
|
2013-12-12 |
2016-09-08 |
Stemcentrx Inc |
Nuevos anticuerpos anti-dpep3 y metodos de uso.
|
|
PE20160712A1
(es)
|
2013-12-13 |
2016-07-26 |
Genentech Inc |
Anticuerpos e inmunoconjugados anti-cd33
|
|
CA2929565A1
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
|
KR20170008202A
(ko)
|
2014-02-21 |
2017-01-23 |
애브비 스템센트알엑스 엘엘씨 |
흑색종에 사용하기 위한 항-dll3 항체 및 약물 접합체
|
|
CN114262344A
(zh)
|
2014-02-28 |
2022-04-01 |
杭州多禧生物科技有限公司 |
带电荷链接体及其在共轭反应上的应用
|
|
GB201407816D0
(en)
|
2014-05-02 |
2014-06-18 |
King S College London |
Pyrrolobenzodiazepine Compounds
|
|
KR20170003582A
(ko)
|
2014-05-22 |
2017-01-09 |
제넨테크, 인크. |
항-gpc3 항체 및 면역접합체
|
|
DK4074735T3
(da)
|
2014-08-28 |
2025-07-14 |
Bioatla Inc |
Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
|
|
TW201613930A
(en)
|
2014-09-03 |
2016-04-16 |
Immunogen Inc |
Cytotoxic benzodiazepine derivatives
|
|
KR20240023671A
(ko)
|
2014-09-03 |
2024-02-22 |
이뮤노젠 아이엔씨 |
세포독성 벤조다이아제핀 유도체
|
|
TW201617368A
(zh)
|
2014-09-05 |
2016-05-16 |
史坦森特瑞斯公司 |
新穎抗mfi2抗體及使用方法
|
|
EP3193940A1
(de)
|
2014-09-10 |
2017-07-26 |
Medimmune Limited |
Pyrrolobenzodiazepine und konjugate daraus
|
|
CN113698485A
(zh)
|
2014-09-12 |
2021-11-26 |
基因泰克公司 |
抗-b7-h4抗体及免疫缀合物
|
|
MX2017003126A
(es)
|
2014-09-12 |
2017-08-28 |
Genentech Inc |
Anticuerpos anti-her2 e inmunoconjugados.
|
|
CN107108724A
(zh)
|
2014-09-12 |
2017-08-29 |
豪夫迈·罗氏有限公司 |
半胱氨酸改造抗体和缀合物
|
|
SG11201701627PA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Anti-cll-1 antibodies and immunoconjugates
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
RU2727663C2
(ru)
|
2014-09-17 |
2020-07-22 |
Дженентек, Инк. |
Иммуноконъюгаты, содержащие антитела против her2 и пирролбензодиазепины
|
|
CN107148285B
(zh)
|
2014-11-25 |
2022-01-04 |
Adc治疗股份有限公司 |
吡咯并苯并二氮杂䓬-抗体缀合物
|
|
SI3333191T1
(sl)
|
2014-12-11 |
2021-03-31 |
Pierre Fabre Medicament |
Proti C10ORF54 protitelesa in uporaba le-teh
|
|
WO2016115191A1
(en)
|
2015-01-14 |
2016-07-21 |
Bristol-Myers Squibb Company |
Benzodiazepine dimers, conjugates thereof, and methods of making and using
|
|
TW201632532A
(zh)
|
2015-01-14 |
2016-09-16 |
必治妥美雅史谷比公司 |
伸雜芳基-橋聯苯并二氮呯二聚體,其共軛物及製造及使用方法
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
GB201510010D0
(en)
|
2015-06-09 |
2015-07-22 |
King S College London |
PDD and BPD compounds
|
|
AU2015242210A1
(en)
|
2015-06-15 |
2017-12-07 |
Hangzhou Dac Biotech Co., Ltd |
Hydrophilic linkers for conjugation
|
|
BR112017027258A2
(pt)
|
2015-06-23 |
2018-08-28 |
Bristol-Myers Squibb Company |
dímeros de benzodiazepina macrocíclicos, conjugados dos mesmos, preparação e usos
|
|
CA2991973C
(en)
|
2015-07-12 |
2021-12-07 |
Suzhou M-Conj Biotech Co., Ltd. |
Bridge linkers for conjugation of a cell-binding molecule
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
IL283355B
(en)
|
2015-07-21 |
2022-08-01 |
Immunogen Inc |
Methods for the preparation of cytotoxic benzodiazepine compounds
|
|
GB201514928D0
(en)
|
2015-08-21 |
2015-10-07 |
King S College London |
PDD compounds
|
|
US20180339985A1
(en)
|
2015-08-21 |
2018-11-29 |
Femtogenix Limited |
Pdd compounds
|
|
EP3350224B1
(de)
|
2015-09-20 |
2024-06-19 |
The United States of America, as Represented By the Secretary, Department of Health and Human Services |
Für fibroblastenwachstumsfaktor-rezeptor 4 (fgfr4) spezifische monoklonale antikörper und verfahren zu deren verwendung
|
|
MA43345A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
US12102689B2
(en)
|
2015-11-09 |
2024-10-01 |
R.P. Scherer Technologies, Llc |
Anti-CD22 antibody-maytansine conjugates and methods of use thereof
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
WO2017161206A1
(en)
|
2016-03-16 |
2017-09-21 |
Halozyme, Inc. |
Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
|
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
|
CN109563164A
(zh)
|
2016-04-15 |
2019-04-02 |
生物蛋白有限公司 |
抗axl抗体、抗体片段和它们的免疫缀合物以及其用途
|
|
AU2017254674A1
(en)
|
2016-04-21 |
2018-11-01 |
Abbvie Stemcentrx Llc |
Novel anti-BMPR1B antibodies and methods of use
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
WO2017196847A1
(en)
|
2016-05-10 |
2017-11-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens
|
|
WO2017194568A1
(en)
|
2016-05-11 |
2017-11-16 |
Sanofi |
Treatment regimen using anti-muc1 maytansinoid immunoconjugate antibody for the treatment of tumors
|
|
MX394735B
(es)
|
2016-05-13 |
2025-03-24 |
Bioatla Llc |
Anticuerpos anti-ror2, fragmentos de anticuerpos, sus inmunoconjugados y usos de los mismos.
|
|
JP7022080B2
(ja)
|
2016-05-27 |
2022-02-17 |
ジェネンテック, インコーポレイテッド |
部位特異的抗体-薬物複合体の特徴付けのための生化学分析的方法
|
|
WO2017214182A1
(en)
|
2016-06-07 |
2017-12-14 |
The United States Of America. As Represented By The Secretary, Department Of Health & Human Services |
Fully human antibody targeting pdi for cancer immunotherapy
|
|
AU2017305170A1
(en)
|
2016-08-02 |
2019-02-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof
|
|
CN109963871A
(zh)
|
2016-08-05 |
2019-07-02 |
豪夫迈·罗氏有限公司 |
具有激动活性的多价及多表位抗体以及使用方法
|
|
WO2018031662A1
(en)
|
2016-08-11 |
2018-02-15 |
Genentech, Inc. |
Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
|
|
EP3525829A1
(de)
|
2016-10-11 |
2019-08-21 |
Medimmune Limited |
Antikörper-wirkstoffkonjugate mit immunvermittelten therapiemitteln
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
NZ752394A
(en)
|
2016-11-14 |
2021-07-30 |
Hangzhou Dac Biotech Co Ltd |
Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
|
|
JP7313684B2
(ja)
|
2016-11-21 |
2023-07-25 |
キュレアブ ゲーエムベーハー |
抗gp73抗体及びイムノコンジュゲート
|
|
FR3059550B1
(fr)
|
2016-12-01 |
2020-01-03 |
Universite De Rouen Normandie |
Traitement des troubles causes par l'alcoolisation foetale (tcaf)
|
|
EP3559038B1
(de)
|
2016-12-21 |
2022-12-14 |
The United States of America as represented by The Secretary Department of Health and Human Services |
Menschliche antikörper spezifisch für flt3 und deren verwendungen
|
|
JP6671555B2
(ja)
|
2017-02-08 |
2020-03-25 |
アーデーセー セラピューティクス ソシエテ アノニム |
ピロロベンゾジアゼピン抗体複合体
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
CN110582505B
(zh)
*
|
2017-04-18 |
2021-04-02 |
免疫医疗有限公司 |
吡咯并苯并二氮杂*缀合物
|
|
US20180346488A1
(en)
|
2017-04-20 |
2018-12-06 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives and conjugates thereof
|
|
MX2019012464A
(es)
|
2017-04-20 |
2019-12-11 |
Adc Therapeutics Sa |
Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl.
|
|
CA3059472A1
(en)
|
2017-05-19 |
2018-11-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Human monoclonal antibody targeting tnfr2 for cancer immunotherapy
|
|
AU2018285562B2
(en)
|
2017-06-14 |
2024-01-18 |
Adc Therapeutics Sa |
Dosage regimes for the administration of an anti-CD19 ADC
|
|
WO2019005208A1
(en)
|
2017-06-30 |
2019-01-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
ANTIBODIES TO HUMAN MESOTHELIN AND USES IN ANTICANCER THERAPY
|
|
CA3066953A1
(en)
|
2017-06-30 |
2019-01-03 |
Lentigen Technology, Inc. |
Human monoclonal antibodies specific for cd33 and methods of their use
|
|
WO2019023247A1
(en)
|
2017-07-25 |
2019-01-31 |
Immutics, Inc. |
TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND
|
|
ES2906965T3
(es)
|
2017-08-18 |
2022-04-21 |
Medimmune Ltd |
Conjugados de pirrolobenzodiazepina
|
|
TWI820044B
(zh)
|
2017-09-29 |
2023-11-01 |
日商第一三共股份有限公司 |
抗體-吡咯并苯二氮呯衍生物複合體
|
|
EP3710066B1
(de)
|
2017-11-14 |
2022-06-08 |
Medimmune Limited |
Pyrrolobenzodiazepinkonjugate
|
|
JP2021506260A
(ja)
|
2017-12-15 |
2021-02-22 |
ジュノー セラピューティクス インコーポレイテッド |
抗cct5結合分子およびその使用方法
|
|
JP2021508714A
(ja)
|
2017-12-28 |
2021-03-11 |
イミュノジェン・インコーポレーテッド |
ベンゾジアゼピン誘導体
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP3801630A1
(de)
|
2018-05-25 |
2021-04-14 |
Medimmune Limited |
Pyrrolobenzodiazepinkonjugate
|
|
FR3081707A1
(fr)
|
2018-05-30 |
2019-12-06 |
Universite De Rouen Normandie |
Traitement des troubles neurologiques causes par l'alcoolisation foetale
|
|
CA3105694A1
(en)
|
2018-07-12 |
2020-01-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Affinity matured cd22-specific monoclonal antibody and uses thereof
|
|
CN112585163B
(zh)
|
2018-08-08 |
2025-03-25 |
美国政府(由卫生和人类服务部的部长所代表) |
靶向磷脂酰肌醇蛋白聚糖-2的高亲和力单克隆抗体及其用途
|
|
CA3115136A1
(en)
|
2018-10-19 |
2020-04-23 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
|
JP7259024B2
(ja)
|
2018-10-19 |
2023-04-17 |
メドイミューン・リミテッド |
ピロロベンゾジアゼピン複合体
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
WO2020146182A1
(en)
|
2019-01-08 |
2020-07-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cross-species single domain antibodies targeting mesothelin for treating solid tumors
|
|
CN113784987B
(zh)
|
2019-01-22 |
2024-09-13 |
美国政府(由卫生和人类服务部的部长所代表) |
靶向磷脂酰肌醇蛋白聚糖-1的高亲和力单克隆抗体和使用方法
|
|
JP2022523333A
(ja)
|
2019-01-30 |
2022-04-22 |
トゥルーバインディング,インコーポレイテッド |
抗gal3抗体およびその使用
|
|
ES2967878T3
(es)
|
2019-03-15 |
2024-05-06 |
Medimmune Ltd |
Dímeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento del cáncer
|
|
CN113661172A
(zh)
|
2019-03-29 |
2021-11-16 |
伊缪诺金公司 |
用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物
|
|
EP4031250A1
(de)
|
2019-10-22 |
2022-07-27 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Gegen b7h3 (cd276) gerichtete hochaffine nanokörper zur behandlung von multiplen soliden tumoren
|
|
EP4684799A2
(de)
|
2019-12-06 |
2026-01-28 |
TrueBinding, Inc. |
Antikörper zur unterbrechung der wechselwirkung von gal3 und insulinrezeptor oder integrinen und verfahren zur verwendung davon
|
|
AU2020402752A1
(en)
|
2019-12-12 |
2022-06-30 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Antibody-drug conjugates specific for CD276 and uses thereof
|
|
CA3172111A1
(en)
|
2020-03-19 |
2021-09-23 |
Barbora MALECOVA |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
|
EP4126066B1
(de)
|
2020-03-27 |
2025-11-19 |
Avidity Biosciences, Inc. |
Zusammensetzungen und verfahren zur behandlung von muskeldystrophie
|
|
EP4157338A4
(de)
|
2020-05-26 |
2024-11-13 |
TrueBinding, Inc. |
Verfahren zur behandlung von entzündungskrankheiten durch galectin-3-blockierung
|
|
US20230391852A1
(en)
|
2020-10-26 |
2023-12-07 |
The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Single domain antibodies targeting sars coronavirus spike protein and uses thereof
|
|
US20240218055A1
(en)
|
2021-04-29 |
2024-07-04 |
The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Lassa virus-specific nanobodies and methods of their use
|
|
US20240270851A1
(en)
|
2021-06-09 |
2024-08-15 |
The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Cross species single domain antibodies targeting pd-l1 for treating solid tumors
|
|
JP2024526764A
(ja)
|
2021-07-13 |
2024-07-19 |
トゥルーバインディング,インコーポレイテッド |
タンパク質凝集を防止する方法
|
|
CN118265544A
(zh)
|
2021-09-16 |
2024-06-28 |
艾维迪提生物科学公司 |
治疗面肩肱型肌营养不良的组合物和方法
|
|
KR20240095442A
(ko)
|
2021-11-03 |
2024-06-25 |
항저우 디에이씨 바이오테크 씨오, 엘티디 |
항체의 특이적 접합
|
|
EP4429701A4
(de)
|
2021-11-09 |
2025-12-31 |
Truebinding Inc |
Verfahren zur behandlung oder hemmung von herz-kreislauf-erkrankungen
|
|
CN119137157A
(zh)
|
2022-05-03 |
2024-12-13 |
基因泰克公司 |
抗Ly6E抗体、免疫缀合物及其用途
|
|
WO2025019228A1
(en)
|
2023-07-20 |
2025-01-23 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors
|
|
WO2025171238A1
(en)
|
2024-02-07 |
2025-08-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof
|