ATE290015T1 - Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen - Google Patents

Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen

Info

Publication number: ATE290015T1
Authority: AT; Austria
Prior art keywords: production; pharmaceutical preparations; cyclosporine derivatives; radical; derivatives
Prior art date: 1997-04-30

Application number

AT98922872T

Other languages

English (en)

Inventor

Michel Evers

Serge Mignani

Jean-Christophe Carry

Bruno Filoche

Georges Bashiardes

Claude Bensoussan

Jean-Christophe Gueguen

Jean-Claude Barriere

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-30

Filing date

1998-04-27

Publication date

2005-03-15

1998-04-27 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE290015T1 publication Critical patent/ATE290015T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98922872T 1997-04-30 1998-04-27 Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen ATE290015T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9705351A FR2762843B1 (fr)	1997-04-30	1997-04-30	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1998/000838 WO1998049193A1 (fr)	1997-04-30	1998-04-27	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE290015T1 true ATE290015T1 (de)	2005-03-15

Family

ID=9506467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98922872T ATE290015T1 (de)	1997-04-30	1998-04-27	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen

Country Status (13)

Country	Link
US (1)	US5977067A (de)
EP (1)	EP0979244B1 (de)
JP (1)	JP2001524105A (de)
AT (1)	ATE290015T1 (de)
AU (1)	AU7535798A (de)
DE (1)	DE69829175T2 (de)
ES (1)	ES2236902T3 (de)
FR (1)	FR2762843B1 (de)
MA (1)	MA26488A1 (de)
PT (1)	PT979244E (de)
TN (1)	TNSN98057A1 (de)
WO (1)	WO1998049193A1 (de)
ZA (1)	ZA983618B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
DE60233150D1 (de) *	2001-10-19	2009-09-10	Isotechnika Inc	Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
CN100334106C (zh)	2001-10-19	2007-08-29	伊索泰克尼卡股份有限公司	环孢菌素类似物的合成
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
ATE473011T1 (de) *	2002-08-30	2010-07-15	Biorexis Pharmaceutical Corp	Modifizierte transferrin-fusionsproteine mit doppelten transferrin-amino- oder carboxy- terminalen domänen
US7538084B2 (en)	2003-03-17	2009-05-26	Amr Technology, Inc.	Cyclosporins
US20050123514A1 (en) *	2003-05-05	2005-06-09	Brian Davis	Increased transduction using ABC transporter substrates and/or inhibitors
EP1809656A4 (de)	2004-09-29	2009-03-25	Amr Technology Inc	Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
WO2006039164A2 (en)	2004-09-29	2006-04-13	Amr Technology, Inc.	Novel cyclosporin analogues and their pharmaceutical uses
WO2006039668A2 (en) *	2004-10-01	2006-04-13	Scynexis, Inc	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
EP1812037A4 (de)	2004-10-06	2009-11-11	Amr Technology Inc	Neue cyclosporin-alkyne und ihre nutzung als pharmazeutishe mittel
DE602006020152D1 (de) *	2005-09-30	2011-03-31	Scynexis Inc	Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
NZ567262A (en) *	2005-09-30	2011-12-22	Scynexis Inc	Cyclosporin derivatives and their use for the treatment and prevention of hepatitis C infection
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
EP1937290A1 (de) *	2005-10-14	2008-07-02	Allergan, Inc.	Prävention und behandlung von arzneibedingten okulären nebenwirkungen mit einem cyclosporin
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
AU2007254148B2 (en)	2006-05-19	2013-02-07	Scynexis, Inc.	Method for the treatment and prevention of ocular disorders
WO2007141395A1 (fr) *	2006-06-02	2007-12-13	Claude Annie Perrichon	Gestion des electrons actifs
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
EP2280989B1 (de)	2008-06-06	2016-02-10	Scynexis, Inc.	Cyclosporinanaloge und ihre verwendung bei der behandlung von hcv-infektionen
CN102164948A (zh) *	2008-07-30	2011-08-24	伊索技术制药公司	非免疫抑制的环孢菌素类似分子
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (de) *	2008-12-31	2017-03-15	Cypralis Limited	Derivate von cyclosporin a
MX2011008000A (es)	2009-01-30	2011-09-15	Enanta Pharm Inc	Analogos de ciclosporina para la prevención o tratamiento de la infeccion de hepatitis c.
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
WO2010138422A1 (en) *	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for enhancing the growth of hair
JP2012528163A (ja) *	2009-05-27	2012-11-12	アラーガン、インコーポレイテッド	炎症性疾患および状態を処置するためのシクロスポリン誘導体
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
AU2010339460A1 (en) *	2009-12-30	2012-07-19	Scynexis Inc.	Cyclosporine analogues
BR112013008749A2 (pt)	2010-10-12	2019-09-24	Allergan Inc	análogos de ciclosporina
CA2814192A1 (en)	2010-10-12	2012-04-19	Allergan, Inc.	Cyclosporin analogs
CN107496902B (zh)	2010-12-15	2022-01-18	康卓维尔制药公司	在氨基酸1和3位修改的环孢菌素类似分子
DE102011111991A1 (de) *	2011-08-30	2013-02-28	Lead Discovery Center Gmbh	Neue Cyclosporin-Derivate
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
WO2014049540A2 (en)	2012-09-29	2014-04-03	Novartis Ag	Cyclic peptides and use as medicines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US4885276A (en) *	1987-06-03	1989-12-05	Merck & Co., Inc.	Cyclosporin analogs with modified "C-9 amino acids"
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
SK278808B6 (sk) *	1990-11-02	1998-03-04	Novartis Ag	Cyklosporíny, ich použitie pri príprave liečiva na
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
WO1997004005A2 (de) *	1995-07-17	1997-02-06	C-Chem Ag	Cyclosporin-derivate mit anti-hiv-wirkung

1997
- 1997-04-30 FR FR9705351A patent/FR2762843B1/fr not_active Expired - Fee Related
1998
- 1998-04-27 AU AU75357/98A patent/AU7535798A/en not_active Abandoned
- 1998-04-27 EP EP98922872A patent/EP0979244B1/de not_active Expired - Lifetime
- 1998-04-27 AT AT98922872T patent/ATE290015T1/de active
- 1998-04-27 DE DE69829175T patent/DE69829175T2/de not_active Expired - Lifetime
- 1998-04-27 WO PCT/FR1998/000838 patent/WO1998049193A1/fr not_active Ceased
- 1998-04-27 MA MA25048A patent/MA26488A1/fr unknown
- 1998-04-27 ES ES98922872T patent/ES2236902T3/es not_active Expired - Lifetime
- 1998-04-27 JP JP54666498A patent/JP2001524105A/ja active Pending
- 1998-04-27 PT PT98922872T patent/PT979244E/pt unknown
- 1998-04-29 ZA ZA983618A patent/ZA983618B/xx unknown
- 1998-04-29 TN TNTNSN98057A patent/TNSN98057A1/fr unknown
- 1998-04-30 US US09/069,959 patent/US5977067A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5977067A (en)	1999-11-02
JP2001524105A (ja)	2001-11-27
FR2762843B1 (fr)	1999-12-10
EP0979244B1 (de)	2005-03-02
MA26488A1 (fr)	2004-12-20
WO1998049193A1 (fr)	1998-11-05
TNSN98057A1 (fr)	2005-03-15
ES2236902T3 (es)	2005-07-16
FR2762843A1 (fr)	1998-11-06
DE69829175D1 (de)	2005-04-07
DE69829175T2 (de)	2006-02-16
PT979244E (pt)	2005-06-30
ZA983618B (en)	1998-11-04
EP0979244A1 (de)	2000-02-16
AU7535798A (en)	1998-11-24

Publication	Publication Date	Title
ATE290015T1 (de)	2005-03-15	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
DE69713148D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713152D1 (de)	2002-07-11	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
ATE218581T1 (de)	2002-06-15	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
BG103945A (en)	2000-07-31	Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
BG101118A (en)	1998-04-30	Therapeutical compounds
ATE188219T1 (de)	2000-01-15	Pharmazeutische dipeptid zusammensetzungen und verwendungsmethoden.
DE69720551D1 (de)	2003-05-08	Makrozyklische derivate von erythromycin a und b mit 13 ringatomen
KR0141913B1 (en)	1998-06-01	Anti-virus agents
AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
DE69302646D1 (de)	1996-06-20	Benzimidazolverbindungen als Antibiotika gegen Campylobacter pylon
DK0866791T3 (da)	2002-04-22	Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
BG103958A (en)	2000-07-31	Pharmaceutical compositions of thioxanide and nitazoxanide
MXPA02011533A (es)	2003-04-25	Nuevas formulaciones de alfa-2,4-disulfofenil-n-terc-butilnitrona.
TR200102009T2 (tr)	2002-01-21	Serebral işlemi profilaksı ve tedavisi için formül I'e göre bileşiklerin kullanımı
TR199900013T2 (xx)	1999-04-21	Yeni bile�ikler.
BR0213463A (pt)	2004-11-09	Composições farmacêuticas contendo macrólidos
ES2124844T3 (es)	1999-02-16	Palau'amina: un compuesto farmacologicamente activo aislado a partir de una esponja.
MX9605312A (es)	1998-02-28	Dipsipeptidos ciclicos antifungales.
IT1258939B (it)	1996-03-08	Analoghi esapeptidici lineari o ciclici delle tachichinine e loro sali farmaceuticamente accettabili, loro preparazione e composizioni farmaceutiche che li contengono

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2006-10-15	UEP	Publication of translation of european patent specification	Ref document number: 0979244 Country of ref document: EP

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