[go: up one dir, main page]

ATE218581T1 - Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung - Google Patents

Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Info

Publication number
ATE218581T1
ATE218581T1 AT97952997T AT97952997T ATE218581T1 AT E218581 T1 ATE218581 T1 AT E218581T1 AT 97952997 T AT97952997 T AT 97952997T AT 97952997 T AT97952997 T AT 97952997T AT E218581 T1 ATE218581 T1 AT E218581T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical composition
cyclosporine derivative
cyclosporine
derivative
Prior art date
Application number
AT97952997T
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE218581T1 publication Critical patent/ATE218581T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97952997T 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung ATE218581T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615954A FR2757520B1 (fr) 1996-12-24 1996-12-24 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
PCT/FR1997/002404 WO1998028328A1 (fr) 1996-12-24 1997-12-23 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number Publication Date
ATE218581T1 true ATE218581T1 (de) 2002-06-15

Family

ID=9499087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952997T ATE218581T1 (de) 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Country Status (11)

Country Link
US (1) US5948755A (de)
EP (1) EP0951473B1 (de)
JP (1) JP4104666B2 (de)
AT (1) ATE218581T1 (de)
AU (1) AU5669198A (de)
DE (1) DE69713151D1 (de)
DK (1) DK0951473T3 (de)
ES (1) ES2178036T3 (de)
FR (1) FR2757520B1 (de)
PT (1) PT951473E (de)
WO (1) WO1998028328A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2212583T3 (es) * 1998-06-12 2004-07-16 C-Chem Ag Nuevas ciclosporinas.
EP1091975B1 (de) 1998-07-01 2005-12-14 Debiopharm S.A. Neues cyclosporin mit verbesserter wirkung
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
CN100334106C (zh) 2001-10-19 2007-08-29 伊索泰克尼卡股份有限公司 环孢菌素类似物的合成
DE60233150D1 (de) * 2001-10-19 2009-09-10 Isotechnika Inc Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
WO2005061460A1 (en) * 2003-12-08 2005-07-07 Cytokinetics, Inc. Compounds, compositions, and methods
EP1809656A4 (de) 2004-09-29 2009-03-25 Amr Technology Inc Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
WO2006039164A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
WO2006039668A2 (en) * 2004-10-01 2006-04-13 Scynexis, Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
EP1793844B1 (de) 2004-10-01 2010-12-08 Debiopharm S.A. Verwendung von [d-meala]3-[etval]4-ciclosporin zur behandlung von hepatitis-c-infektion
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
EP1812037A4 (de) 2004-10-06 2009-11-11 Amr Technology Inc Neue cyclosporin-alkyne und ihre nutzung als pharmazeutishe mittel
NZ567262A (en) 2005-09-30 2011-12-22 Scynexis Inc Cyclosporin derivatives and their use for the treatment and prevention of hepatitis C infection
DE602006020152D1 (de) 2005-09-30 2011-03-31 Scynexis Inc Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
AU2007254148B2 (en) 2006-05-19 2013-02-07 Scynexis, Inc. Method for the treatment and prevention of ocular disorders
WO2007141395A1 (fr) * 2006-06-02 2007-12-13 Claude Annie Perrichon Gestion des electrons actifs
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
WO2009042892A1 (en) 2007-09-26 2009-04-02 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
EP2280989B1 (de) 2008-06-06 2016-02-10 Scynexis, Inc. Cyclosporinanaloge und ihre verwendung bei der behandlung von hcv-infektionen
AU2009268549B2 (en) * 2008-07-10 2015-07-16 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
EP2376524B1 (de) 2008-12-31 2017-03-15 Cypralis Limited Derivate von cyclosporin a
JP2012528163A (ja) * 2009-05-27 2012-11-12 アラーガン、インコーポレイテッド 炎症性疾患および状態を処置するためのシクロスポリン誘導体
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
AU2010339460A1 (en) 2009-12-30 2012-07-19 Scynexis Inc. Cyclosporine analogues
CN107496902B (zh) 2010-12-15 2022-01-18 康卓维尔制药公司 在氨基酸1和3位修改的环孢菌素类似分子
US9395551B2 (en) 2013-04-24 2016-07-19 Kamakura Koki Co., Ltd. Optical image stabilizer
TW201902507A (zh) * 2017-04-14 2019-01-16 美商康特維爾製藥公司 治療病毒感染之組合療法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
SK278808B6 (sk) * 1990-11-02 1998-03-04 Novartis Ag Cyklosporíny, ich použitie pri príprave liečiva na
WO1997004005A2 (de) * 1995-07-17 1997-02-06 C-Chem Ag Cyclosporin-derivate mit anti-hiv-wirkung

Also Published As

Publication number Publication date
JP4104666B2 (ja) 2008-06-18
AU5669198A (en) 1998-07-17
DE69713151D1 (de) 2002-07-11
FR2757520B1 (fr) 1999-01-29
PT951473E (pt) 2002-11-29
ES2178036T3 (es) 2002-12-16
EP0951473A1 (de) 1999-10-27
US5948755A (en) 1999-09-07
DK0951473T3 (da) 2002-09-16
FR2757520A1 (fr) 1998-06-26
EP0951473B1 (de) 2002-06-05
JP2001507016A (ja) 2001-05-29
WO1998028328A1 (fr) 1998-07-02

Similar Documents

Publication Publication Date Title
ATE218581T1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
DE69713148D1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713152D1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
ATE290015T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
SE9504661D0 (sv) New compounds
TW262461B (de)
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
DE60038183D1 (de) Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
FI964681A0 (fi) Ihmisperäiset Lactobacillus-kannat, niitä sisältävät valmisteet ja niiden käytöt
ATE272628T1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
TR199900661T2 (xx) Cilt enfeksiyonlar�n�n tedavisi amac�yla 1-hidroksi-2-piridonlar�n kullan�m�
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
SE0004101D0 (sv) New use
CA2340734A1 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
SE9504662D0 (sv) New compounds
AU4568400A (en) Sphingomyelinase inhibitor
FI932654A0 (fi) Hydroxamsyraderivat, som hindrar lipoxigenas
NZ504614A (en) Echinocandin derivatives and application as anti-fungal agents
MX9605312A (es) Dipsipeptidos ciclicos antifungales.
IL139317A0 (en) Benzimdazole and benzoxazole derivatives and pharmaceutical compositions contining the same
MX9708385A (es) Derivados novedosos de tetraciclina, composiciones que los contienen, y el uso de las mismas.