ATE290003T1 - Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon - Google Patents

Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon

Info

Publication number: ATE290003T1
Authority: AT; Austria
Prior art keywords: pyrimidine; ones; intermediate products; pyrazolo; producing
Prior art date: 1998-10-12

Application number

AT99307996T

Other languages

English (en)

Inventor

Peter James Dunn

Philip Charles Levett

Original Assignee

Pfizer Ireland Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-12

Filing date

1999-10-11

Publication date

2005-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE290003(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-10-11 Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE290003T1 publication Critical patent/ATE290003T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Reproductive Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gynecology & Obstetrics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT99307996T 1998-10-12 1999-10-11 Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon ATE290003T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9822238.3A GB9822238D0 (en)	1998-10-12	1998-10-12	Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number	Publication Date
ATE290003T1 true ATE290003T1 (de)	2005-03-15

Family

ID=10840421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99307996T ATE290003T1 (de)	1998-10-12	1999-10-11	Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon

Country Status (49)

Country	Link
US (3)	US6207829B1 (de)
EP (1)	EP0994115B1 (de)
JP (1)	JP3721021B2 (de)
KR (1)	KR100380954B1 (de)
CN (2)	CN1207295C (de)
AP (1)	AP1233A (de)
AR (1)	AR019244A1 (de)
AT (1)	ATE290003T1 (de)
AU (1)	AU756463B2 (de)
BG (1)	BG63205B1 (de)
BR (1)	BR9905092A (de)
CA (1)	CA2285733C (de)
CO (1)	CO5150214A1 (de)
CR (1)	CR6118A (de)
CU (1)	CU22928A3 (de)
CZ (1)	CZ296816B6 (de)
DE (1)	DE69923906T2 (de)
DK (1)	DK0994115T3 (de)
DZ (1)	DZ2912A1 (de)
EA (1)	EA003774B1 (de)
EE (1)	EE04192B1 (de)
EG (1)	EG22630A (de)
ES (1)	ES2237049T3 (de)
GB (1)	GB9822238D0 (de)
GE (1)	GEP20022700B (de)
GT (1)	GT199900172A (de)
HK (1)	HK1027559A1 (de)
HR (1)	HRP990318B1 (de)
HU (1)	HU226162B1 (de)
ID (1)	ID23351A (de)
IL (11)	IL132273A (de)
IS (1)	IS1951B (de)
MA (1)	MA25007A1 (de)
MY (1)	MY124620A (de)
NO (1)	NO313700B1 (de)
OA (1)	OA11165A (de)
PE (1)	PE20001086A1 (de)
PL (1)	PL198150B1 (de)
PT (1)	PT994115E (de)
RS (1)	RS49762B (de)
SG (1)	SG118060A1 (de)
SI (1)	SI0994115T1 (de)
SK (1)	SK285215B6 (de)
TN (1)	TNSN99189A1 (de)
TR (1)	TR199902541A2 (de)
TW (1)	TW589314B (de)
UA (1)	UA66787C2 (de)
UY (1)	UY25750A1 (de)
ZA (1)	ZA996412B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5204800A (en) *	1999-06-21	2001-01-09	Biochemical Pharmaceutical Factory of Zhuhai Sez, The	Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
AU6259701A (en) *	2000-06-22	2002-01-02	Dunn Peter James	Process for the preparation of pyrazolopyrimidinones
US6667398B2 (en)	2000-06-22	2003-12-23	Pfizer Inc	Process for the preparation of pyrazolopyrimidinones
EP1176147A1 (de) *	2000-07-28	2002-01-30	Pfizer Limited	Verfahren zur Herstellung von Pyrazolo[4,3-d]pyrimidin-7-onen und Zwischenprodukten davon
EP1176142A1 (de) *	2000-07-28	2002-01-30	Pfizer Inc.	Verfahren zur Herstellung von Pyrazolen
US6407259B1 (en)	2000-07-28	2002-06-18	Pfizer Inc.	Process for the preparation of pyrazoles
PE20020394A1 (es)	2000-08-18	2002-06-21	Agouron Pharma	Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
ES2337887T3 (es) *	2001-12-20	2010-04-30	Merck Serono Sa	Derivados de pirrolidina en calidad de moduladores de prostaglandina.
WO2003059258A2 (en) *	2001-12-21	2003-07-24	Cytokinetics, Inc.	Compositions and methods for treating heart failure
SI1509525T1 (sl)	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) *	2003-02-11	2004-08-26	Pfizer Limited	Hydrated and anhydrous sildenafil hemi-citrate compound
US7595322B2 (en)	2003-03-27	2009-09-29	Cytokinetics, Inc.	Heterocyclic sulfonamides as modulators of cardiac sarcomeres
CN100360531C (zh) *	2003-12-18	2008-01-09	中国人民解放军军事医学科学院放射与辐射医学研究所	用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) *	2005-06-27	2007-01-11	Meyer Jackson	Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) *	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (de) *	2006-06-05	2010-10-27	Matrix Lab Ltd	Neues verfahren zur herstellung von sildenafilcitrat
CZ308056B6 (cs) *	2015-07-20	2019-11-27	Ustav Experimentalni Botaniky Av Cr V V I	5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
CN107759603B (zh) *	2016-08-18	2020-09-01	四川科伦药物研究院有限公司	一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992441A (en) *	1972-12-26	1976-11-16	Pfizer Inc.	Sulfamylbenzoic acids
GB9013750D0 (en) *	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9612514D0 (en) *	1996-06-14	1996-08-14	Pfizer Ltd	Novel process
AU730670B2 (en) *	1997-04-25	2001-03-08	Pfizer Limited	Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction

1998
- 1998-10-12 GB GBGB9822238.3A patent/GB9822238D0/en not_active Ceased
1999
- 1999-09-22 CU CU1999142A patent/CU22928A3/es unknown
- 1999-09-22 TW TW088116306A patent/TW589314B/zh not_active IP Right Cessation
- 1999-09-27 RS YUP-489/99A patent/RS49762B/sr unknown
- 1999-10-05 GT GT199900172A patent/GT199900172A/es unknown
- 1999-10-06 CZ CZ0353299A patent/CZ296816B6/cs not_active IP Right Cessation
- 1999-10-07 CR CR6118A patent/CR6118A/es unknown
- 1999-10-07 IL IL13227399A patent/IL132273A/en not_active IP Right Cessation
- 1999-10-07 IL IL152928A patent/IL152928A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292699A patent/IL152926A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292799A patent/IL152927A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292499A patent/IL152924A/en not_active IP Right Cessation
- 1999-10-07 PE PE1999001016A patent/PE20001086A1/es not_active Application Discontinuation
- 1999-10-07 IL IL15292399A patent/IL152923A/en not_active IP Right Cessation
- 1999-10-07 AP APAP/P/1999/001672A patent/AP1233A/en active
- 1999-10-08 IS IS5209A patent/IS1951B/is unknown
- 1999-10-08 MY MYPI99004353A patent/MY124620A/en unknown
- 1999-10-08 OA OA9900224A patent/OA11165A/en unknown
- 1999-10-08 AR ARP990105109A patent/AR019244A1/es active IP Right Grant
- 1999-10-08 CA CA002285733A patent/CA2285733C/en not_active Expired - Lifetime
- 1999-10-08 SK SK1385-99A patent/SK285215B6/sk not_active IP Right Cessation
- 1999-10-08 US US09/415,440 patent/US6207829B1/en not_active Expired - Fee Related
- 1999-10-08 UA UA99105491A patent/UA66787C2/xx unknown
- 1999-10-09 CN CNB991239180A patent/CN1207295C/zh not_active Expired - Fee Related
- 1999-10-09 CN CNA031427383A patent/CN1473831A/zh active Pending
- 1999-10-11 PT PT99307996T patent/PT994115E/pt unknown
- 1999-10-11 DK DK99307996T patent/DK0994115T3/da active
- 1999-10-11 KR KR10-1999-0043836A patent/KR100380954B1/ko not_active IP Right Cessation
- 1999-10-11 AT AT99307996T patent/ATE290003T1/de active
- 1999-10-11 TN TNTNSN99189A patent/TNSN99189A1/fr unknown
- 1999-10-11 MA MA25812A patent/MA25007A1/fr unknown
- 1999-10-11 DZ DZ990212A patent/DZ2912A1/xx active
- 1999-10-11 BR BR9905092-7A patent/BR9905092A/pt not_active IP Right Cessation
- 1999-10-11 EA EA199900822A patent/EA003774B1/ru not_active IP Right Cessation
- 1999-10-11 ZA ZA9906412A patent/ZA996412B/xx unknown
- 1999-10-11 SI SI9930773T patent/SI0994115T1/xx unknown
- 1999-10-11 EG EG126999A patent/EG22630A/xx active
- 1999-10-11 ES ES99307996T patent/ES2237049T3/es not_active Expired - Lifetime
- 1999-10-11 HU HU9903469A patent/HU226162B1/hu not_active IP Right Cessation
- 1999-10-11 NO NO19994943A patent/NO313700B1/no not_active IP Right Cessation
- 1999-10-11 ID IDP990941A patent/ID23351A/id unknown
- 1999-10-11 AU AU53581/99A patent/AU756463B2/en not_active Ceased
- 1999-10-11 DE DE69923906T patent/DE69923906T2/de not_active Expired - Lifetime
- 1999-10-11 BG BG103794A patent/BG63205B1/bg unknown
- 1999-10-11 EP EP99307996A patent/EP0994115B1/de not_active Expired - Lifetime
- 1999-10-12 CO CO99064776A patent/CO5150214A1/es unknown
- 1999-10-12 GE GEAP19995027A patent/GEP20022700B/en unknown
- 1999-10-12 EE EEP199900507A patent/EE04192B1/xx not_active IP Right Cessation
- 1999-10-12 UY UY25750A patent/UY25750A1/es not_active Application Discontinuation
- 1999-10-12 TR TR1999/02541A patent/TR199902541A2/xx unknown
- 1999-10-12 JP JP29009999A patent/JP3721021B2/ja not_active Expired - Fee Related
- 1999-10-12 HR HR990318A patent/HRP990318B1/xx not_active IP Right Cessation
- 1999-10-12 PL PL335959A patent/PL198150B1/pl not_active IP Right Cessation
- 1999-10-12 SG SG1999005097A patent/SG118060A1/en unknown
2000
- 2000-10-10 HK HK00106399A patent/HK1027559A1/xx not_active IP Right Cessation
2001
- 2001-01-16 US US09/761,376 patent/US20010009962A1/en not_active Abandoned
2002
- 2002-09-23 US US10/253,029 patent/US20030069422A1/en not_active Abandoned
- 2002-11-18 IL IL15292802A patent/IL152928A0/xx active IP Right Grant
- 2002-11-18 IL IL15292302A patent/IL152923A0/xx unknown
- 2002-11-18 IL IL15292702A patent/IL152927A0/xx unknown
- 2002-11-18 IL IL15292602A patent/IL152926A0/xx unknown
- 2002-11-18 IL IL15292402A patent/IL152924A0/xx unknown

Also Published As

Publication number	Publication date
DE69923906T2 (de)	2006-04-06
TNSN99189A1 (fr)	2005-11-10
ES2237049T3 (es)	2005-07-16
PL198150B1 (pl)	2008-05-30
UA66787C2 (en)	2004-06-15
IL152924A0 (en)	2003-06-24
HUP9903469A3 (en)	2000-10-30
BG63205B1 (bg)	2001-06-29
YU48999A (sh)	2002-06-19
IL152927A (en)	2004-06-01
IL132273A0 (en)	2001-03-19
IL152924A (en)	2004-02-19
SG118060A1 (en)	2006-01-27
CN1207295C (zh)	2005-06-22
HU9903469D0 (en)	1999-12-28
KR20000028987A (ko)	2000-05-25
AR019244A1 (es)	2001-12-26
EP0994115B1 (de)	2005-03-02
HU226162B1 (en)	2008-05-28
EG22630A (en)	2003-05-31
MY124620A (en)	2006-06-30
US6207829B1 (en)	2001-03-27
GT199900172A (es)	2001-03-28
IL152927A0 (en)	2003-06-24
CA2285733C (en)	2004-08-24
GB9822238D0 (en)	1998-12-09
UY25750A1 (es)	2001-08-27
RS49762B (sr)	2008-04-04
CZ353299A3 (cs)	2000-05-17
BG103794A (en)	2000-09-29
MA25007A1 (fr)	2000-07-01
ZA996412B (en)	2001-04-11
DE69923906D1 (de)	2005-04-07
IL152928A0 (en)	2003-06-24
IL152926A0 (en)	2003-06-24
HUP9903469A2 (hu)	2000-08-28
JP2000119273A (ja)	2000-04-25
NO994943L (no)	2000-04-13
OA11165A (en)	2003-04-22
SK285215B6 (sk)	2006-09-07
AU5358199A (en)	2000-04-13
CZ296816B6 (cs)	2006-06-14
AP9901672A0 (en)	1999-12-31
GEP20022700B (en)	2002-05-27
BR9905092A (pt)	2000-08-08
HRP990318B1 (en)	2004-06-30
CR6118A (es)	2005-09-16
IL152923A0 (en)	2003-06-24
TR199902541A2 (xx)	2000-07-21
AP1233A (en)	2003-12-18
EE9900507A (et)	2000-06-15
EP0994115A3 (de)	2000-05-24
EA199900822A3 (ru)	2000-08-28
IS1951B (is)	2004-10-13
IL132273A (en)	2004-06-20
NO994943D0 (no)	1999-10-11
PL335959A1 (en)	2000-04-25
EA199900822A2 (ru)	2000-04-24
US20030069422A1 (en)	2003-04-10
HRP990318A2 (en)	2000-06-30
IL152928A (en)	2007-07-04
CO5150214A1 (es)	2002-04-29
HK1027559A1 (en)	2001-01-19
IL152923A (en)	2004-02-08
SI0994115T1 (de)	2005-08-31
ID23351A (id)	2000-04-13
JP3721021B2 (ja)	2005-11-30
PT994115E (pt)	2005-06-30
KR100380954B1 (ko)	2003-04-21
CN1473831A (zh)	2004-02-11
TW589314B (en)	2004-06-01
SK138599A3 (en)	2000-05-16
CA2285733A1 (en)	2000-04-12
PE20001086A1 (es)	2000-10-18
US20010009962A1 (en)	2001-07-26
EA003774B1 (ru)	2003-08-28
CN1255497A (zh)	2000-06-07
IS5209A (is)	2000-04-13
EP0994115A2 (de)	2000-04-19
DK0994115T3 (da)	2005-06-20
EE04192B1 (et)	2003-12-15
NO313700B1 (no)	2002-11-18
AU756463B2 (en)	2003-01-16
CU22928A3 (es)	2004-02-20
DZ2912A1 (fr)	2004-03-01
IL152926A (en)	2004-02-19

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